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Results: 28
Determinants of Non-paid Task Division in Gay-, Lesbian-, and Heterosexual-Parent Families With Infants Conceived Using Artificial Reproductive Techniques.
Loes Van Rijn-Van Gelderen, Kate Ellis-Davies, Marijke Huijzer-Engbrenghof, Terrence D Jorgensen, Martine Gross, Alice Winstanley, Berengere Rubio, Olivier Vecho, Michael E Lamb, Henny M Bos
Jul 29, 2020
Background: The division of non-paid labor in heterosexual parents in the West is usually still gender-based, with mothers taking on the majority of direct caregiving responsibilities. However, in same-sex couples, gender cannot...
Determinants of Non-paid Task Division in Gay-, Lesbian-, and Heterosexual-Parent Families With Infants Conceived Using Artificial Reproductive Techniques
Loes Van Rijn - Van Gelderen, Kate Ellis-Davies, Marijke Huijzer-Engbrenghof, Terrence D. Jorgensen, Martine Gross, Alice Winstanley, Berengere Rubio, Olivier Vecho, Michael E. Lamb, Henny M. Bos
May 27, 2020
Background: The division of non-paid labor in heterosexual parents in the West is usually still gender-based, with mothers taking on the majority of direct caregiving responsibilities. However, in same-sex couples, gender cannot...
A randomized controlled trial to pilot the efficacy of a computer-based intervention with elements of virtual reality and limited therapist assistance for the treatment of post-traumatic stress disorder.
Marieke van Meggelen, Nexhmedin Morina, Colin van der Heiden, Willem-Paul Brinkman, Iris E Yocarini, Myrthe L Tielman, Jan Rodenburg, Elisa van Ee, Kevin van Schie, Marijke E Broekman, Ingmar HA Franken
Dec 08, 2022
Although well-established therapies exist for post-traumatic stress disorder (PTSD), barriers to seek mental health care are high. Technology-based interventions may play a role in improving the reach of efforts to treat...
Role of Platelet Glycoprotein VI and Tyrosine Kinase Syk in Thrombus Formation on Collagen-Like Surfaces.
Natalie J Jooss, Ilaria De Simone, Isabella Provenzale, Delia I Fernández, Sanne LN Brouns, Richard W Farndale, Yvonne MC Henskens, Marijke JE Kuijpers, Hugo Ten Cate, Paola EJ van der Meijden, Rachel Cavill, Johan WM Heemskerk
Sep 11, 2019
Platelet interaction with collagens, via von Willebrand factor, is a potent trigger of shear-dependent thrombus formation mediated by subsequent engagement of the signaling collagen receptor glycoprotein (GP)VI, enforced by...
Regulation of a pentameric ligand-gated ion channel by a semiconserved cationic lipid-binding site.
Akshay Sridhar, Sarah CR Lummis, Diletta Pasini, Aujan Mehregan, Marijke Brams, Kumiko Kambara, Daniel Bertrand, Erik Lindahl, Rebecca J Howard, Chris Ulens
Sep 14, 2021
Pentameric ligand-gated ion channels (pLGICs) are crucial mediators of electrochemical signal transduction in various organisms from bacteria to humans. Lipids play an important role in regulating pLGIC function, yet the...
Proactive Career Behaviors and Subjective Career Success
Adam Smale, Silvia Bagdadli, Rick Cotton, Silvia Dello Russo, Michael Dickmann, Anders Dysvik, Martina Gianecchini, Robert Kaše, Mila Lazarova, Astrid Reichel, Paula Rozo, Marijke Verbruggen, Katharina Chudzikowski, et al.
Jan 13, 2019
Although career proactivity has positive consequences for an individual's career success, studies mostly examine objective measures of success within single countries. This raises important questions about whether proactivity...
career self-management Career success national culture proactive career behaviors /dk/atira/pure/subjectarea/asjc/3200/3202 name=Applied Psychology /dk/atira/pure/subjectarea/asjc/3300/3312 name=Sociology and Political Science /dk/atira/pure/subjectarea/asjc/3200/3200 name=General Psychology /dk/atira/pure/subjectarea/asjc/1400/1407 name=Organizational Behavior and Human Resource Management
Proactive Career Behaviors and Subjective Career Success
Adam Smale, Silvia Bagdadli, Rick Cotton, Silvia Dello Russo, Michael Dickmann, Anders Dysvik, Martina Gianecchini, Robert Kaše, Mila Lazarova, Astrid Reichel, Paula Rozo, Marijke Verbruggen, Katharina Chudzikowski, et al.
Jan 13, 2019
Although career proactivity has positive consequences for an individual's career success, studies mostly examine objective measures of success within single countries. This raises important questions about whether proactivity...
career self-management Career success national culture proactive career behaviors /dk/atira/pure/subjectarea/asjc/3200/3202 name=Applied Psychology /dk/atira/pure/subjectarea/asjc/3300/3312 name=Sociology and Political Science /dk/atira/pure/subjectarea/asjc/3200/3200 name=General Psychology /dk/atira/pure/subjectarea/asjc/1400/1407 name=Organizational Behavior and Human Resource Management
A randomized controlled trial to pilot the efficacy of a computer-based intervention with elements of virtual reality and limited therapist assistance for the treatment of post-traumatic stress disorder.
Marieke van Meggelen, Nexhmedin Morina, Colin van der Heiden, Willem-Paul Brinkman, Iris E Yocarini, Myrthe L Tielman, Jan Rodenburg, Elisa van Ee, Kevin van Schie, Marijke E Broekman, Ingmar HA Franken
Nov 01, 2022
Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT 3 receptor via a common vestibule site
Marijke Brams, Cedric Govaerts, Kumiko Kambara, Kerry L Price, Radovan Spurny, Anant Gharpure, Els Pardon, Genevieve L Evans, Daniel Bertrand, Sarah CR Lummis, Ryan E Hibbs, Jan Steyaert, Chris Ulens
Feb 13, 2020
Neutron Radiation Dose Measurements in a Scanning Proton Therapy Room
Vladimir Mares, Jad Farah, Marijke De Saint-Hubert, Szymon Domański, Carles Domingo, Martin Dommert, Magdalena Kłodowska, Katarzyna Krzempek, Michał Kuć, Immaculada Martínez-Rovira, Edyta Michaś, Natalia Mojżeszek, Łukasz Murawski, Ondrej Ploc, Maite Romero-Expósito, Marco Tisi, François Trompier, Olivier Van Hoey, Laurent Van Ryckeghem, Marek Wielunski, Roger M Harrison, Liliana Stolarczyk, Pawel Olko
Jul 28, 2022
PURPOSE: This study aims to characterize the neutron radiation field inside a scanning proton therapy treatment room including the impact of different pediatric patient sizes. MATERIALS AND METHODS: Working Group 9 of the...
Career Success Schemas and their Contextual Embeddedness
Robert Kaše, Nicky Dries, Jon Briscoe, Richard D. Cotton, Eleni Apospori, Silvia Bagdadli, K. Övgü Çakmak-Otluoğlu, Katharina Chudzikowski, Anders Dysvik, Martina Gianecchini, Richa Saxena, Yan Shen, Marijke Verbruggen, Olusegun Babalola, Tania Casado, Jean-Luc Cerdin, Najung Kim, Sushanta Kumar Mishra, Fei Zhangfeng
Jul 01, 2020
We introduce career success schema as a critical concept for understanding how people in different contexts perceive and understand career success.
Using a comparative configurational approach, we show, in a study of...
Using a comparative configurational approach, we show, in a study of...
Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site.
Marijke Brams, Cedric Govaerts, Kumiko Kambara, Kerry L Price, Radovan Spurny, Anant Gharpure, Els Pardon, Genevieve L Evans, Daniel Bertrand, Sarah CR Lummis, Ryan E Hibbs, Jan Steyaert, Chris Ulens
Feb 28, 2020
Pentameric ligand-gated ion channels (pLGICs) or Cys-loop receptors are involved in fast synaptic signaling in the nervous system. Allosteric modulators bind to sites that are remote from the neurotransmitter binding site, but...
human neuroscience allosteric modulation structural biology Ligand-Gated Ion Channels molecular biophysics
Published by: eLife
Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site.
Marijke Brams, Cedric Govaerts, Kumiko Kambara, Kerry L Price, Radovan Spurny, Anant Gharpure, Els Pardon, Genevieve L Evans, Daniel Bertrand, Sarah CR Lummis, Ryan E Hibbs, Jan Steyaert, Chris Ulens
Apr 17, 2020
Pentameric ligand-gated ion channels (pLGICs) or Cys-loop receptors are involved in fast synaptic signaling in the nervous system. Allosteric modulators bind to sites that are remote from the neurotransmitter binding site, but...
Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome.
Johanna P van Geffen, Frauke Swieringa, Kim van Kuijk, Bibian ME Tullemans, Fiorella A Solari, Bing Peng, Kenneth J Clemetson, Richard W Farndale, Ludwig J Dubois, Albert Sickmann, René P Zahedi, Robert Ahrends, Erik AL Biessen, Judith C Sluimer, Johan WM Heemskerk, Marijke JE Kuijpers
Feb 12, 2021
Hyperlipidemia is a well-established risk factor for cardiovascular diseases. Millions of people worldwide display mildly elevated levels of plasma lipids and cholesterol linked to diet and life-style. While the prothrombotic...
Career Success Schemas and their Contextual Embeddedness
Robert Kaše, Nicky Dries, Jon Briscoe, Richard D. Cotton, Eleni Apospori, Silvia Bagdadli, K. Övgü Çakmak-Otluoğlu, Katharina Chudzikowski, Anders Dysvik, Martina Gianecchini, Richa Saxena, Yan Shen, Marijke Verbruggen, Olusegun Babalola, Tania Casado, Jean-Luc Cerdin, Najung Kim, Sushanta Kumar Mishra, Fei Zhangfeng
Jul 01, 2020
We introduce career success schema as a critical concept for understanding how people in different contexts perceive and understand career success.
Using a comparative configurational approach, we show, in a study of...
Using a comparative configurational approach, we show, in a study of...
High-throughput elucidation of thrombus formation reveals sources of platelet function variability.
Johanna P van Geffen, Sanne LN Brouns, Joana Batista, Harriet McKinney, Carly Kempster, Magdolna Nagy, Suthesh Sivapalaratnam, Constance CFMJ Baaten, Nikki Bourry, Mattia Frontini, Kerstin Jurk, Manuela Krause, Daniele Pillitteri, Frauke Swieringa, Remco Verdoold, Rachel Cavill, Marijke JE Kuijpers, Willem H Ouwehand, Kate Downes, Johan WM Heemskerk
Oct 31, 2019
In combination with microspotting, whole-blood microfluidics can provide high-throughput information on multiple platelet functions in thrombus formation. Based on assessment of the inter- and intra-subject variability in...
Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis.
Mitchell J Geer, Johanna P van Geffen, Piraveen Gopalasingam, Timo Vögtle, Christopher W Smith, Silke Heising, Marijke JE Kuijpers, Bibian ME Tullemans, Gavin E Jarvis, Johannes A Eble, Mark Jeeves, Michael Overduin, Johan WM Heemskerk, Alexandra Mazharian, Yotis A Senis
Oct 10, 2018
The immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptor G6b-B has emerged as a key regulator of platelet homeostasis. However, it remains unclear how it mediates its effects. Tyrosine phosphorylation of...
Animals Binding Sites Blood Platelets Homeostasis Mice Mice Inbred C57BL Mice Transgenic Models Molecular Phosphorylation Point Mutation Protein Interaction Maps Protein Tyrosine Phosphatase Non-Receptor Type 11 Protein Tyrosine Phosphatase Non-Receptor Type 6 Receptors Immunologic Signal Transduction Thrombocytopenia src Homology Domains
A mutation of the human EPHB2 gene leads to a major platelet functional defect.
Eliane Berrou, Christelle Soukaseum, Rémi Favier, Frédéric Adam, Ziane Elaib, Alexandre Kauskot, Jean-Claude Bordet, Paola Ballerini, Stephane Loyau, Miao Feng, Karine Dias, Abbas Muheidli, Stephane Girault, Alan T Nurden, Ernest Turro, Willem H Ouwehand, Cécile V Denis, Martine Jandrot-Perrus, Jean-Philippe Rosa, Paquita Nurden, Marijke Bryckaert
Nov 22, 2018
The ephrin transmembrane receptor family of tyrosine kinases is involved in platelet function. We report the first EPHB2 variant affecting platelets in 2 siblings (P1 and P2) from a consanguineous family with recurrent bleeding...
Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice.
Inga Hofmann, Mitchell J Geer, Timo Vögtle, Andrew Crispin, Dean R Campagna, Alastair Barr, Monica L Calicchio, Silke Heising, Johanna P van Geffen, Marijke JE Kuijpers, Johan WM Heemskerk, Johannes A Eble, Klaus Schmitz-Abe, Esther A Obeng, Michael Douglas, Kathleen Freson, Corinne Pondarré, Rémi Favier, Gavin E Jarvis, Kyriacos Markianos, Ernest Turro, Willem H Ouwehand, Alexandra Mazharian, Mark D Fleming, Yotis A Senis
Oct 10, 2018
Unlike primary myelofibrosis (PMF) in adults, myelofibrosis in children is rare. Congenital (inherited) forms of myelofibrosis (cMF) have been described, but the underlying genetic mechanisms remain elusive. Here we describe 4...
Platelet-primed interactions of coagulation and anticoagulation pathways in flow-dependent thrombus formation.
Sanne LN Brouns, Johanna P van Geffen, Elena Campello, Frauke Swieringa, Luca Spiezia, René van Oerle, Isabella Provenzale, Remco Verdoold, Richard W Farndale, Kenneth J Clemetson, Henri MH Spronk, Paola EJ van der Meijden, Rachel Cavill, Marijke JE Kuijpers, Elisabetta Castoldi, Paolo Simioni, Johan WM Heemskerk
Sep 09, 2020
In haemostasis and thrombosis, platelet, coagulation and anticoagulation pathways act together to produce fibrin-containing thrombi. We developed a microspot-based technique, in which we assessed platelet adhesion, platelet...
Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148.
Jun Mori, Zoltan Nagy, Giada Di Nunzio, Christopher W Smith, Mitchell J Geer, Rashid Al Ghaithi, Johanna P van Geffen, Silke Heising, Luke Boothman, Bibian ME Tullemans, Joao N Correia, Louise Tee, Marijke JE Kuijpers, Paul Harrison, Johan WM Heemskerk, Gavin E Jarvis, Alexander Tarakhovsky, Arthur Weiss, Alexandra Mazharian, Yotis A Senis
Mar 16, 2018
Src family kinases (SFKs) coordinate the initiating and propagating activation signals in platelets, but it remains unclear how they are regulated. Here, we show that ablation of C-terminal Src kinase (Csk) and receptor-like...
Amino Acid Motifs Animals Blood Platelets CSK Tyrosine-Protein Kinase Homeostasis Mice Mice Knockout Platelet Membrane Glycoproteins Protein Tyrosine Phosphatase Non-Receptor Type 11 Protein Tyrosine Phosphatase Non-Receptor Type 6 Receptor-Like Protein Tyrosine Phosphatases Class 3 Thrombosis src-Family Kinases
Platelet-primed interactions of coagulation and anticoagulation pathways in flow-dependent thrombus formation
Sanne L. N. Brouns, Johanna P. van Geffen, Elena Campello, Frauke Swieringa, Luca Spiezia, René van Oerle, Isabella Provenzale, Remco Verdoold, Richard W. Farndale, Kenneth J. Clemetson, Henri M. H. Spronk, Paola E. J. van der Meijden, Rachel Cavill, Marijke J. E. Kuijpers, Elisabetta Castoldi, Paolo Simioni, Johan W. M. Heemskerk
Jul 17, 2020
Abstract: In haemostasis and thrombosis, platelet, coagulation and anticoagulation pathways act together to produce fibrin-containing thrombi. We developed a microspot-based technique, in which we assessed platelet adhesion...
Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome
Johanna P. van Geffen, Frauke Swieringa, Kim van Kuijk, Bibian M. E. Tullemans, Fiorella A. Solari, Bing Peng, Kenneth J. Clemetson, Richard W. Farndale, Ludwig J. Dubois, Albert Sickmann, René P. Zahedi, Robert Ahrends, Erik A. L. Biessen, Judith C. Sluimer, Johan W. M. Heemskerk, Marijke J. E. Kuijpers
Dec 08, 2020
Platelet-primed interactions of coagulation and anticoagulation pathways in flow-dependent thrombus formation
Sanne L. N. Brouns, Johanna P. van Geffen, Elena Campello, Frauke Swieringa, Luca Spiezia, René van Oerle, Isabella Provenzale, Remco Verdoold, Richard W. Farndale, Kenneth J. Clemetson, Henri M. H. Spronk, Paola E. J. van der Meijden, Rachel Cavill, Marijke J. E. Kuijpers, Elisabetta Castoldi, Paolo Simioni, Johan W. M. Heemskerk
Jul 28, 2021
Abstract: In haemostasis and thrombosis, platelet, coagulation and anticoagulation pathways act together to produce fibrin-containing thrombi. We developed a microspot-based technique, in which we assessed platelet adhesion...
Here, There, & Everywhere
Jon P. Briscoe, Robert Kaše, Nicky Dries, Anders Dysvik, Julie Unite, Ifedapo Adeleye, Maike Andresen, Eleni Apospori, Olusegun Babalola, Silvia Bagdadli, K. Övgü Çakmak-Otluoğlu, Tania Casado, Jean-Luc Cerdin, Jong-Seok Cha, Katharina Chudzikowski, Silvia Della Russo, Petra Eggenhofer-Rehart, Fei Zhangfeng, Martina Gianecchini, Martin Gubler, Tim (Douglas) Hall, Ruth Imose, Ida Rosnita Ismail, Svetlana Khapova, Najung Kim, Philip Lehmann, Evgenia Lysova, Sergio Madero, Debbie Mandel, Wolfgang Mayrhofer, Biljana Bogićević Milikić, Sushanta Kumar Mishra, Chikae Naito, Ana D. Nikodijević, Astrid Reichel, Noreen Saher, Richa Saxena, Nanni Schleicher, Florian Schramm, Yan Shen, Adam Smale, Vivien Supangco, Pamela Agata Suzanne, Mami Taniguchi, Marijke Verbruggen, Jelena Zikic
Oct 01, 2021
Subjective career success continues to be a critical topic in careers scholarship due to ever changing organizational and societal contexts that make reliance upon external definitions of success untenable or undesirable. While...
Career success Cross-cultural Scale development /dk/atira/pure/subjectarea/asjc/3300/3304 name=Education /dk/atira/pure/subjectarea/asjc/3200/3202 name=Applied Psychology /dk/atira/pure/subjectarea/asjc/1400/1407 name=Organizational Behavior and Human Resource Management /dk/atira/pure/subjectarea/asjc/3300/3319 name=Life-span and Life-course Studies
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