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Interview with Ruth Erline Mathis Martin
In her June 1984 interview with Michael Cooke, Ruth Erline Mathis Martin (1934-2020) discussed her time as a DHEC employee in the sickle cell anemia program. She covered topics of DHEC's involvement with community groups, sickle...
sickle cell anemia Department of Health and Environmental Control James R. Clark Sickle Cell Foundation community groups Oral History
Published by: Winthrop University
Cell-autonomous programming of rat adipose tissue insulin signalling proteins by maternal nutrition.
Adipose Tissue Cell-autonomous mechanisms developmental programming Insulin signalling Low birthweight maternal diet Protein restriction Type 2 diabetes Adipocytes Adipose Tissue Animals Cell Size Cells Cultured Diet Protein-Restricted Female Insulin Insulin Resistance Male Maternal Nutritional Physiological Phenomena MicroRNAs Pregnancy Rats Signal Transduction
Martin Peerson and Greville’s Caelica’
GR Alexander
Mar 27, 2017
This article assesses the relations between Martin Peerson’s Mottects or Grave Chamber Musique (1630) and Fulke Greville’s lyric sequence Caelica.1 It focuses on two particular questions: what kind of an interpretation or...
Cell-autonomous programming of rat adipose tissue insulin signalling proteins by maternal nutrition.
Malgorzata S Martin-Gronert, Denise S Fernandez-Twinn, Martin Bushell, Kenneth Siddle, Susan E Ozanne
Aug 09, 2017
Adipose Tissue Cell-autonomous mechanisms developmental programming Insulin signalling Low birthweight maternal diet Protein restriction Type 2 diabetes Adipocytes Adipose Tissue Animals Cell Size Cells Cultured Diet Protein-Restricted Female Insulin Insulin Resistance Male Maternal Nutritional Physiological Phenomena MicroRNAs Pregnancy Rats Signal Transduction
Martin Luther King Jr. Activities Planned for Jan. 16
Winthrop University
Jan 01, 0001
Winthrop will celebrate Martin Luther King Jr. Day on Jan. 16 with a number of activities including a prayer breakfast, a candlelight vigil, a unity rally and more.
Published by: Winthrop University
Codon optimality in cancer.
A key characteristic of cancer cells is their increased proliferative capacity, which requires elevated levels of protein synthesis. The process of protein synthesis involves the translation of codons within the mRNA coding...
Downregulation of IRS-1 in adipose tissue of offspring of obese mice is programmed cell-autonomously through post-transcriptional mechanisms.
Denise S Fernandez-Twinn, Maria Z Alfaradhi, Malgorzata S Martin-Gronert, Daniella E Duque-Guimaraes, Ana Piekarz, David Ferland-McCollough, Martin Bushell, Susan E Ozanne
Feb 26, 2020
We determined the effects of maternal diet-induced obesity on offspring adipose tissue insulin signalling and miRNA expression in the aetiology of insulin resistance in later life. Although body composition and glucose tolerance...
What role should the commercial food system play in promoting health through better diet?
Martin White, Emilie Aguirre, Diane T Finegood, Chris Holmes, Gary Sacks, Richard Smith
Mar 27, 2020
Martin White and coauthors consider that the commercial food system has the potential to show leadership and support for dietary public health, but systemic change is needed first and this is likely to require governmental action
IPR Policy Brief - A very large gamble
Quantitative Easing (QE) has been used in the UK and US as an unconventional monetary policy response to the financial crisis. QE involves large scale asset purchases by Central Banks, amounting to $3 trillion in the US and £375...
Published by: University of Bath
IPR Policy Brief - A very large gamble
Quantitative Easing (QE) has been used in the UK and US as an unconventional monetary policy response to the financial crisis. QE involves large scale asset purchases by Central Banks, amounting to $3 trillion in the US and £375...
Published by: University of Bath
Investigating Lunar Secondary Cratering in the Tycho and Copernicus Regions
Sarah Marchione
Jan 01, 0001
Primary craters are created by objects impacting on the surface a terrestrial body. The ejecta caused by primary impacts make smaller, secondary craters. The number of primary craters on a surface indicate how long that surface...
craters cratering lunar surface moon surface Age age of moon Physical Sciences and Mathematics Physics The Sun and the Solar System
Published by: Ursinus College
The human insulin receptor mRNA contains a functional internal ribosome entry segment.
Keith A Spriggs, Laura C Cobbold, Simon H Ridley, Mark Coldwell, Andrew Bottley, Martin Bushell, Anne E Willis, Kenneth Siddle
Nov 29, 2018
Regulation of mRNA translation is an important mechanism determining the level of expression of proteins in eukaryotic cells. Translation is most commonly initiated by cap-dependent scanning, but many eukaryotic mRNAs contain...
Maternal obesity during pregnancy leads to adipose tissue ER stress in mice via miR-126-mediated reduction in Lunapark
Juliana de Almeida-Faria, Daniella E. Duque-Guimarães, Thomas P. Ong, Lucas C. Pantaleão, Asha A. Carpenter, Elena Loche, Laura C. Kusinski, Thomas J. Ashmore, Robin Antrobus, Martin Bushell, Denise S. Fernandez-Twinn, Susan E. Ozanne
Mar 08, 2021
Abstract: Aims/hypothesis: Levels of the microRNA (miRNA) miR-126-3p are programmed cell-autonomously in visceral adipose tissue of adult offspring born to obese female C57BL/6J mice. The spectrum of miR-126-3p targets and thus...
A novel method for poly(A) fractionation reveals a large population of mRNAs with a short poly(A) tail in mammalian cells.
Hedda A Meijer, Martin Bushell, Kirsti Hill, Timothy W Gant, Anne E Willis, Peter Jones, Cornelia H de Moor
Mar 01, 2021
The length of the poly(A) tail of an mRNA plays an important role in translational efficiency, mRNA stability and mRNA degradation. Regulated polyadenylation and deadenylation of specific mRNAs is involved in oogenesis...
Nick Martin's Communism
This project examines the life and career of Hungarian-born athlete Nick Martin. It explores the opportunities available to Martin via his success as an Olympic athlete.
Nick Martin water polo 1956 Olympics Cold War Oral History Sports Illustrated sport history Hungary Melbourne Digital Humanities European History Oral History political history Sports Studies
Published by: Ursinus College
Maternal obesity during pregnancy leads to adipose tissue ER stress in mice via miR-126-mediated reduction in Lunapark.
Juliana de Almeida-Faria, Daniella E Duque-Guimarães, Thomas P Ong, Lucas C Pantaleão, Asha A Carpenter, Elena Loche, Laura C Kusinski, Thomas J Ashmore, Robin Antrobus, Martin Bushell, Denise S Fernandez-Twinn, Susan E Ozanne
Oct 30, 2020
ER stress glucose metabolism Lunapark Maternal obesity Nutritional programming miR-126-3p 3T3-L1 Cells Adipocytes Adipose Tissue Animals Blood Glucose Disease Models Animal Down-Regulation Endoplasmic reticulum stress Female Homeodomain Proteins Insulin Receptor Substrate Proteins Insulin Resistance Mice Mice Inbred C57BL MicroRNAs obesity Maternal Phenotype Pregnancy prenatal exposure delayed effects Signal Transduction
Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice.
Mark Halliday, Helois Radford, Karlijn AM Zents, Collin Molloy, Julie A Moreno, Nicholas C Verity, Ewan Smith, Catharine A Ortori, David A Barrett, Martin Bushell, Giovanna R Mallucci
Nov 16, 2017
See Mercado and Hetz (doi:10.1093/brain/awx107) for a scientific commentary on this article.Signalling through the PERK/eIF2α-P branch of the unfolded protein response plays a critical role in controlling protein synthesis...
Mixed matrix membranes based on MIL-101 metal–organic frameworks in polymer of intrinsic microporosity PIM-1
Muhanned Khdhayyer, Alexandra F. Bushell, Peter M. Budd, Martin P. Attfield, Dongmei Jiang, Andrew D. Burrows, Elisa Esposito, Paola Bernardo, Marcello Monteleone, Alessio Fuoco, Gabriele Clarizia, Fabio Bazzarelli, Amalia Gordano, Johannes C. Jansen
Apr 01, 2019
This work presents a study on mixed matrix membranes (MMMs) of the polymer of intrinsic microporosity PIM-1, embedding the crystalline Cr-terephthalate metal-organic framework (MOF), known as MIL-101. Different kinds of...
mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity.
Joseph A Waldron, David C Tack, Laura E Ritchey, Sarah L Gillen, Ania Wilczynska, Ernest Turro, Philip C Bevilacqua, Sarah M Assmann, Martin Bushell, John Le Quesne
Feb 02, 2020
Translation Cancer RNA structure Translation initiation DMS G-Quadruplexes eIF4A Polysome profiling Hippuristanol Structure-seq
Published by: Genome biology, volume 20, issue 1
RTN3 Is a Novel Cold-Induced Protein and Mediates Neuroprotective Effects of RBM3.
Amandine Bastide, Diego Peretti, John RP Knight, Stefano Grosso, Ruth V Spriggs, Xavier Pichon, Thomas Sbarrato, Anne Roobol, Jo Roobol, Davide Vito, Martin Bushell, Tobias von der Haar, C Mark Smales, Giovanna R Mallucci, Anne E Willis
Sep 05, 2018
Cooling and hypothermia are profoundly neuroprotective, mediated, at least in part, by the cold shock protein, RBM3. However, the neuroprotective effector proteins induced by RBM3 and the mechanisms by which mRNAs encoding cold...
The Effect of Convective Injection of Ice on Stratospheric Water Vapor in a Changing Climate
Abstract: Stratospheric water vapor affects the Earth's radiative balance and stratospheric chemistry, yet its future changes are uncertain and not fully understood. The influence of deep convection on stratospheric water vapor...
Maternal diet-induced obesity during pregnancy alters lipid supply to mouse E18.5 fetuses and changes the cardiac tissue lipidome in a sex- dependent manner
mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity
Joseph A. Waldron, David C. Tack, Laura E. Ritchey, Sarah L. Gillen, Ania Wilczynska, Ernest Turro, Philip C. Bevilacqua, Sarah M. Assmann, Martin Bushell, John Le Quesne
Dec 29, 2020
Abstract: Background: The RNA helicase eIF4A1 is a key component of the translation initiation machinery and is required for the translation of many pro-oncogenic mRNAs. There is increasing interest in targeting eIF4A1...
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