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Results: 42
Chaotic-Integrable Transition in the Sachdev-Ye-Kitaev Model.
Quantum chaos is one of the distinctive features of the Sachdev-Ye-Kitaev (SYK) model, N Majorana fermions in 0+1 dimensions with infinite-range two-body interactions, which is attracting a lot of interest as a toy model for...
Role of BRCA1-associated protein (BRAP) variant in childhood pulmonary arterial hypertension
Ayako Chida-Nagai, Masaki Shintani, Hiroki Sato, Tomotaka Nakayama, Masaki Nii, Hiroyuki Akagawa, Toru Furukawa, Amer Rana, Yoshiyuki Furutani, Kei Inai, Shigeaki Nonoyama, Toshio Nakanishi
Mar 13, 2019
Pluripotency Deconstructed.
Pluripotency denotes the flexible capacity of single cells to give rise to all somatic lineages and typically also the germline. Mouse ES cells and post-implantation epiblast-derived stem cells (EpiSC) are widely used...
Spatiotemporal variability in dengue transmission intensity in Jakarta, Indonesia.
Megan O'Driscoll, Natsuko Imai, Neil M Ferguson, Sri Rezeki Hadinegoro, Hindra Irawan Satari, Clarence C Tam, Ilaria Dorigatti
Apr 20, 2020
BACKGROUND: Approximately 70% of the global burden of dengue disease occurs on the Asian continent, where many large urban centres provide optimal environments for sustained endemic transmission and periodic epidemic cycles....
Sox7 is dispensable for primitive endoderm differentiation from mouse ES cells.
BACKGROUND: Primitive endoderm is a cell lineage segregated from the epiblast in the blastocyst and gives rise to parietal and visceral endoderm. Sox7 is a member of the SoxF gene family that is specifically expressed in...
Chainchecker
2020 saw the continuation of the second largest outbreak of Ebola virus disease (EVD) in history. Determining epidemiological links between cases is a key part of outbreak control. However, due to the large quantity of data and...
Disabling de novo DNA methylation in embryonic stem cells allows an illegitimate fate trajectory.
Masaki Kinoshita, Meng Amy Li, Michael Barber, William Mansfield, Sabine Dietmann, Austin Smith
Sep 01, 2021
Genome remethylation is essential for mammalian development but specific reasons are unclear. Here we examined embryonic stem (ES) cell fate in the absence of de novo DNA methyltransferases. We observed that ES cells deficient...
Long-Term Fine-Grained Forecasts of Emergency Demand Using EMS Big Data and Population Estimates
In recent years, Japan has been facing a super-aging society, impacting various sectors. The issues of overcrowded emergency medical services and the increase in emergency transport cases are particularly severe, necessitating...
Published by: IGI Global Scientific Publishing
Selection of antigenically advanced variants of seasonal influenza viruses.
Chengjun Li, Masato Hatta, David F Burke, Jihui Ping, Ying Zhang, Makoto Ozawa, Andrew S Taft, Subash C Das, Anthony P Hanson, Jiasheng Song, Masaki Imai, Peter R Wilker, Tokiko Watanabe, Shinji Watanabe, Mutsumi Ito, Kiyoko Iwatsuki-Horimoto, Colin A Russell, Sarah L James, Eugene Skepner, Eileen A Maher, Gabriele Neumann, Alexander I Klimov, Anne Kelso, John McCauley, Dayan Wang, Yuelong Shu, Takato Odagiri, Masato Tashiro, Xiyan Xu, David E Wentworth, Jacqueline M Katz, Nancy J Cox, Derek J Smith, Yoshihiro Kawaoka
Apr 13, 2016
An Item Response Theory Approach to Enhance Peer Assessment Effectiveness in Massive Open Online Courses
Massive open on-line courses (MOOCs) are effective and flexible resources to educate, train, and empower populations. Peer assessment (PA) provides a powerful pedagogical strategy to support educational activities and foster...
Published by: IGI Global Scientific Publishing
Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency.
Masaki Kinoshita, Michael Barber, William Mansfield, Yingzhi Cui, Daniel Spindlow, Giuliano Giuseppe Stirparo, Sabine Dietmann, Jennifer Nichols, Austin Smith
Nov 12, 2020
The Nucleosome Remodelling and Deacetylation complex suppresses transcriptional noise during lineage commitment.
Thomas Burgold, Michael Barber, Susan Kloet, Julie Cramard, Sarah Gharbi, Robin Floyd, Masaki Kinoshita, Meryem Ralser, Michiel Vermeulen, Nicola Reynolds, Sabine Dietmann, Brian Hendrich
Apr 12, 2019
ES cell NuRD Chromatin Lineage commitment Transcription Animals Cell Differentiation Cell Lineage Cells Cultured Cellular Reprogramming DNA-Binding Proteins Embryo Mammalian Gene Expression Regulation Developmental Mi-2 Nucleosome Remodeling and Deacetylase Complex Mice Mice Knockout Mouse embryonic stem cells Neoplasm Proteins Repressor Proteins Signal-To-Noise Ratio Trans-Activators Transcription Factors Transcription Genetic
Estimating dengue transmission intensity from serological data
Victoria Cox, Megan O'Driscoll, Natsuko Imai, Ari Prayitno, Sri Rezeki Hadinegoro, Anne-Frieda Taurel, Laurent Coudeville, Ilaria Dorigatti
Jul 21, 2022
Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation.
Sanae Hamanaka, Ayumi Umino, Hideyuki Sato, Tomonari Hayama, Ayaka Yanagida, Naoaki Mizuno, Toshihiro Kobayashi, Mariko Kasai, Fabian Patrik Suchy, Satoshi Yamazaki, Hideki Masaki, Tomoyuki Yamaguchi, Hiromitsu Nakauchi
Dec 13, 2018
In the case of organ transplantation accompanied by vascular anastomosis, major histocompatibility complex mismatched vascular endothelial cells become a target for graft rejection. Production of a rejection-free, transplantable...
blastocyst complementation hematopoietic cells Pluripotent Stem Cells tissue regeneration vascular endothelial cells aging Animals Blastocyst Chimera Endothelial Cells Hematopoietic Stem Cells Induced Pluripotent Stem Cells Mice Inbred C57BL Mice Knockout Neovascularization Physiologic Pericytes Phenotype Platelet Endothelial Cell Adhesion Molecule-1 Vascular Endothelial Growth Factor Receptor-2
A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis
Tadasuke Tsukiyama, Juqi Zou, Jihoon Kim, Shohei Ogamino, Yuki Shino, Takamasa Masuda, Alessandra Merenda, Masaki Matsumoto, Yoichiro Fujioka, Tomonori Hirose, Sayuri Terai, Hidehisa Takahashi, Tohru Ishitani, Keiichi I. Nakayama, Yusuke Ohba, Bon-Kyoung Koo, Shigetsugu Hatakeyama
Sep 15, 2020
A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis.
Tadasuke Tsukiyama, Juqi Zou, Jihoon Kim, Shohei Ogamino, Yuki Shino, Takamasa Masuda, Alessandra Merenda, Masaki Matsumoto, Yoichiro Fujioka, Tomonori Hirose, Sayuri Terai, Hidehisa Takahashi, Tohru Ishitani, Keiichi I Nakayama, Yusuke Ohba, Bon-Kyoung Koo, Shigetsugu Hatakeyama
Sep 15, 2021
The Naming of Names
John L Bowman, Takashi Araki, Mario A Arteaga-Vazquez, Frederic Berger, Liam Dolan, Jim Haseloff, Kimitsune Ishizaki, Junko Kyozuka, Shih-Shun Lin, Hideki Nagasaki, Hirofumi Nakagami, Keiji Nakajima, Yasukazu Nakamura, Kyoko Ohashi-Ito, Shinichiro Sawa, Masaki Shimamura, Roberto Solano, Hirokazu Tsukaya, Takashi Ueda, Yuichiro Watanabe, Katsuyuki T Yamato, Sabine Zachgo, Takayuki Kohchi
Sep 15, 2021
While Marchantia polymorpha has been utilized as a model system to investigate fundamental biological questions for over almost two centuries, there is renewed interest in M. polymorpha as a model genetic organism in the...
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity.
Hiroaki Semba, Norihiko Takeda, Takayuki Isagawa, Yuki Sugiura, Kurara Honda, Masaki Wake, Hidenobu Miyazawa, Yoshifumi Yamaguchi, Masayuki Miura, Dana MR Jenkins, Hyunsung Choi, Jung-Whan Kim, Masataka Asagiri, Andrew S Cowburn, Hajime Abe, Katsura Soma, Katsuhiro Koyama, Manami Katoh, Keimon Sayama, Nobuhito Goda, Randall S Johnson, Ichiro Manabe, Ryozo Nagai, Issei Komuro
May 04, 2018
In severely hypoxic condition, HIF-1α-mediated induction of Pdk1 was found to regulate glucose oxidation by preventing the entry of pyruvate into the tricarboxylic cycle. Monocyte-derived macrophages, however, encounter a...
Age-dependent formation of TMEM106B amyloid filaments in human brains.
Manuel Schweighauser, Diana Arseni, Mehtap Bacioglu, Melissa Huang, Sofia Lövestam, Yang Shi, Yang Yang, Wenjuan Zhang, Abhay Kotecha, Holly J Garringer, Ruben Vidal, Grace I Hallinan, Kathy L Newell, Airi Tarutani, Shigeo Murayama, Masayuki Miyazaki, Yuko Saito, Mari Yoshida, Kazuko Hasegawa, Tammaryn Lashley, Tamas Revesz, Gabor G Kovacs, John van Swieten, Masaki Takao, Masato Hasegawa, Bernardino Ghetti, Maria Grazia Spillantini, Benjamin Ryskeldi-Falcon, Alexey G Murzin, Michel Goedert, Sjors HW Scheres
May 12, 2022
Many age-dependent neurodegenerative diseases, such as Alzheimer's and Parkinson's, are characterized by abundant inclusions of amyloid filaments. Filamentous inclusions of the proteins tau, amyloid-β, α-synuclein and...
Age-dependent formation of TMEM106B amyloid filaments in human brains.
Manuel Schweighauser, Diana Arseni, Mehtap Bacioglu, Melissa Huang, Sofia Lövestam, Yang Shi, Yang Yang, Wenjuan Zhang, Abhay Kotecha, Holly J Garringer, Ruben Vidal, Grace I Hallinan, Kathy L Newell, Airi Tarutani, Shigeo Murayama, Masayuki Miyazaki, Yuko Saito, Mari Yoshida, Kazuko Hasegawa, Tammaryn Lashley, Tamas Revesz, Gabor G Kovacs, John van Swieten, Masaki Takao, Masato Hasegawa, Bernardino Ghetti, Maria Grazia Spillantini, Benjamin Ryskeldi-Falcon, Alexey G Murzin, Michel Goedert, Sjors HW Scheres
May 11, 2022
Many age-dependent neurodegenerative diseases, such as Alzheimer's and Parkinson's, are characterized by abundant inclusions of amyloid filaments. Filamentous inclusions of the proteins tau, amyloid-β, α-synuclein and...
Distinct Molecular Trajectories Converge to Induce Naive Pluripotency.
Hannah T Stuart, Giuliano G Stirparo, Tim Lohoff, Lawrence E Bates, Masaki Kinoshita, Chee Y Lim, Elsa J Sousa, Katsiaryna Maskalenka, Aliaksandra Radzisheuskaya, Andrew A Malcolm, Mariana RP Alves, Rebecca L Lloyd, Sonia Nestorowa, Peter Humphreys, William Mansfield, Wolf Reik, Paul Bertone, Jennifer Nichols, Berthold Göttgens, José CR Silva
May 29, 2019
cell identity transitions Pluripotency reprogramming signaling transcriptional networks Animals Blastocyst Inner Cell Mass Cell Differentiation Cell Line Cell Plasticity Cellular Reprogramming Female Gene Expression Regulation Developmental Gene Regulatory Networks Germ Layers Mice Mice Inbred C57BL Octamer Transcription Factor-3 Pluripotent Stem Cells Signal Transduction
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