The AlphaFold2 results in the 14th edition of Critical Assessment of Structure Prediction (CASP14) showed that accurate (low root-mean-square deviation) in silico models of protein structure domains are on the horizon, whether...
The AlphaFold2 results in the 14th edition of Critical Assessment of Structure Prediction (CASP14) showed that accurate (low root-mean-square deviation) in silico models of protein structure domains are on the horizon, whether...
Performance in the template-based modeling (TBM) category of CASP13 is assessed here, using a variety of metrics. Performance of the predictor groups that participated is ranked using the primary ranking score that was developed...
The analysis of large structural databases reveals general features and relationships among proteins, providing useful insight. A different approach is required to characterize ubiquitous secondary-structure elements, where...
The analysis of large structural databases reveals general features and relationships among proteins, providing useful insight. A different approach is required to characterize ubiquitous secondary-structure elements, where...
Good prior estimates of the effective root-mean-square deviation (r.m.s.d.) between the atomic coordinates of the model and the target optimize the signal in molecular replacement, thereby increasing the success rate in...
Good prior estimates of the effective root-mean-square deviation (r.m.s.d.) between the atomic coordinates of the model and the target optimize the signal in molecular replacement, thereby increasing the success rate in...
Descriptions are given of the maximum-likelihood gyre method implemented in Phaser for optimizing the orientation and relative position of rigid-body fragments of a model after the orientation of the model has been identified...
Detection of translational noncrystallographic symmetry (TNCS) can be critical for success in crystallographic phasing, particularly when molecular-replacement models are poor or anomalous phasing information is weak. If the...
BACKGROUND: Randomised trials of vitamin D supplementation for cardiovascular disease and all-cause mortality have generally reported null findings. However, generalisability of results to individuals with low vitamin D status...
Crystallographic phasing strategies increasingly require the exploration and ranking of many hypotheses about the number, types and positions of atoms, molecules and/or molecular fragments in the unit cell, each with only a...
Nuclear hormone receptors are cytoplasm-based transcription factors that bind a ligand, translate to the nucleus and initiate gene transcription in complex with a co-activator such as TIF2 (transcriptional intermediary factor...
Ab initio phasing of macromolecular structures, from the native intensities alone with no experimental phase information or previous particular structural knowledge, has been the object of a long quest, limited by two main...
Abstract: A measurement of four branching-fraction ratios for three-body decays of B mesons involving two open-charm hadrons in the final state is presented. Run 1 and Run 2 pp collision data are used, recorded by the LHCb...
Abstract: The first full angular analysis of the B0→D∗−Ds∗+ decay is performed using 6 fb−1 of pp collision data collected with the LHCb experiment at a centre-of-mass energy of 13 TeV. The Ds∗+→Ds+γ and D*− → D¯0π− vector meson...
Abstract: The decay-time-dependent CP asymmetry in B0→ D∗±D∓ decays is mea- sured using a data set corresponding to an integrated luminosity of 9 fb−1 recorded by the LHCb detector in proton-proton collisions at centre-of-mass...
A measurement of four branching-fraction ratios for three-body decays of $B$
mesons involving two open-charm hadrons in the final state is presented. Run 1
and Run 2 $pp$ collision data are used, recorded by the LHCb experiment...
The assessment of CASP models for utility in molecular replacement is a measure of their use in a valuable real-world application. In CASP7, the metric for molecular replacement assessment involved full likelihood-based...
Abstract: The decay-time-dependent CP asymmetry in B0→ D∗±D∓ decays is mea- sured using a data set corresponding to an integrated luminosity of 9 fb−1 recorded by the LHCb detector in proton-proton collisions at centre-of-mass...
Abstract: The decay-time-dependent CP asymmetry in B0→ D∗±D∓ decays is mea- sured using a data set corresponding to an integrated luminosity of 9 fb−1 recorded by the LHCb detector in proton-proton collisions at centre-of-mass...
ARCIMBOLDO solves the phase problem by combining the location of small model fragments using Phaser with density modification and autotracing using SHELXE. Mainly helical structures constitute favourable cases, which can be...
Abstract: Measurements of CP observables in B± → D(*)K± and B± → D(*)π± decays are presented, where D(∗) indicates a neutral D or D∗ meson that is an admixture of meson and anti-meson states. Decays of the D(∗) meson to the Dπ0...