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Results: 169
Targeted surveillance strategies for efficient detection of novel antibiotic resistance variants.
Allison L Hicks, Stephen M Kissler, Tatum D Mortimer, Kevin C Ma, George Taiaroa, Melinda Ashcroft, Deborah A Williamson, Marc Lipsitch, Yonatan H Grad
Aug 18, 2020
Genotype-based diagnostics for antibiotic resistance represent a promising alternative to empiric therapy, reducing inappropriate antibiotic use. However, because such assays infer resistance based on known genetic markers...
Language Teaching, Language Learning, and Virtual Exchange in an Age of Complexity
Melinda Dooly
Jul 01, 2022
As the introduction to this special issue on virtual exchange (VE), this paper presents a glimpse back at the development of VE through the lens of the central definitions that have been historically associated with VE and how...
Published by: IGI Global Scientific Publishing
Exploring the molecular interface between hypoxia-inducible factor signalling and mitochondria.
Oxygen is required for the survival of the majority of eukaryotic organisms, as it is important for many cellular processes. Eukaryotic cells utilize oxygen for the production of biochemical energy in the form of adenosine...
Structural and Molecular Correlates of Individual Differences in Anxiety Behavior and the Stress Response
Melinda Miller
Jan 01, 0001
Although many people are exposed to stressful experiences during their lifetime, only 5-35% will be diagnosed with Post-Traumatic Stress Disorder (PTSD). While most animal models of stress are effective at producing behavioral...
Post-Traumatic Stress Disorder (PTSD) human stress response Neuropeptide Y Anxiety Amygdala CART neuropeptide Life Sciences
Published by: Rockefeller University
Akt2
Metastasis in breast cancer significantly increases morbidity and mortality. The 5-year survival rate reduces from 90% for localised disease to about 20% once metastasis has taken place. The phosphoinositide 3-kinase/Akt...
The Contextual Essentiality of Mitochondrial Genes in Cancer
Mitochondria are key organelles in eukaryotic evolution that perform crucial roles as metabolic and cellular signaling hubs. Mitochondrial function and dysfunction are associated with a range of diseases, including cancer....
Analysis of Novel Genes Whose mRNAs Are Enriched in the HVC-Associated Telencephalon of Songbirds
Julia Melinda George
Jan 01, 0001
7 cloned cDNAs were selected for analysis due to the enrichment of their corresponding RNAs in the canary HAT, a telencephalic region immediately surrounding and including song nucleus HVC. The goal of the analysis was to...
Published by: Rockefeller University
Insights into Electroreceptor Development and Evolution from Molecular Comparisons with Hair Cells.
The vertebrate lateral line system comprises a mechanosensory division, with neuromasts containing hair cells that detect local water movement ("distant touch"); and an electrosensory division, with electrosensory organs that...
Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma
The DNA-damaging agent camptothecin (CPT) and its analogs demonstrate clinical utility for the treatment of advanced solid tumors, and CPT-based nanopharmaceuticals are currently in clinical trials for advanced kidney cancer;...
Apigenin Apoptosis Basic Helix-Loop-Helix Transcription Factors camptothecin Carcinoma Renal Cell Cell Hypoxia Cell Line Tumor DNA Damage endothelin-1 Gene Expression Regulation Neoplastic Humans Hypoxia-Inducible Factor 1 alpha Subunit Kidney Neoplasms Mechanistic Target of Rapamycin Complex 1 Mechanistic Target of Rapamycin Complex 2 Multiprotein Complexes Protein Biosynthesis RNA Messenger Signal Transduction TOR Serine-Threonine Kinases Tumor Suppressor Protein p53
Inactivation of the von Hippel-Lindau tumour suppressor gene induces Neuromedin U expression in renal cancer cells.
BACKGROUND: 209 000 new cases of renal carcinoma are diagnosed each year worldwide and new therapeutic targets are urgently required. The great majority of clear cell renal cancer involves inactivation of VHL, which acts as a...
Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1.
We have recently shown that induction of the p53 tumour suppressor protein by the small-molecule RITA (reactivation of p53 and induction of tumour cell apoptosis; 2,5-bis(5-hydroxymethyl-2-thienyl)furan) inhibits...
Apoptosis Ataxia Telangiectasia Breast Neoplasms Cell Cycle Proteins Cell Line Tumor Checkpoint Kinase 1 Colorectal Neoplasms DNA Damage DNA Replication Female Furans Gene Knockdown Techniques Histones Humans Hypoxia Hypoxia-Inducible Factor 1 alpha Subunit Osteosarcoma Phosphorylation Protein Kinase Inhibitors Protein Kinases Replication Origin S Phase Signal Transduction Transfection Tumor Suppressor Protein p53
Epigenetic Mechanisms of ART-Related Imprinting Disorders
The rising frequency of ART-conceived births is accompanied by the need for an improved understanding of the implications of ART on gametes and embryos. Increasing evidence from mouse models and human epidemiological data...
Communication, Apology, and Resolution
Communication and resolution programs are gaining acceptance as an alternative to more traditional deny-and-defend practices after a patient is harmed during medical care. In Massachusetts, the Betsy Lehman Center for Patient...
Published by: IGI Global Scientific Publishing
2013 LEWIS THOMAS PRIZE
The Rockefeller University
Jan 01, 0001
Frances Ashcroft, Ph.D., recipient of the 2013 Lewis Thomas Prize
Singing the Body Electric
The Lewis Thomas Prize for Writing about Science is an international award that honors the "scientist as poet" and recognizes "the rare...
Published by: The Rockefeller University
The Grizzly, October 25, 2018
Courtney A DuChene, Shelsea Deravil, Madison Rodak, Mark LeDuc, Kevin Leon, Sophia DiBattista, Daniel Walker, Gabriela Howell, Sam Rosenthal
Jan 01, 0001
New Discriminatory Act Policy Draws Criticism Radium Girls Will Take the Stage this November Good and Bad News on Campus Safety Dr. Tristan Ashcroft Receives Teaching Excellence Award L.A.X. Strives to Meet the Need for...
Ursinus College Collegeville Pennsylvania newspaper discrimination theater Meghan Brodie campus safety Tristan Ashcroft Latinx Quinn Gilman-Forlini Rugby Football Kirk Cherneskie cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Spatial distribution of clinical computer systems in primary care in England in 2016 and implications for primary care electronic medical record databases
Evangelos Kontopantelis, Richard John Stevens, Peter J Helms, Duncan Edwards, Tim Doran, Darren M Ashcroft
Jul 18, 2018
OBJECTIVES: UK primary care databases (PCDs) are used by researchers worldwide to inform clinical practice. These databases have been primarily tied to single clinical computer systems, but little is known about the adoption of...
Solid state NMR - An indispensable tool in organic-inorganic biocomposite characterization; refining the structure of octacalcium phosphate composites with the linear metabolic di-acids succinate and adipate.
Epigenetic Mechanisms of ART-Related Imprinting Disorders
The rising frequency of ART-conceived births is accompanied by the need for an improved understanding of the implications of ART on gametes and embryos. Increasing evidence from mouse models and human epidemiological data...
DNA Methylation assisted reproductive technology Genomic Imprinting iPSCs Imprinting disorders Mouse models Animals DNA Methylation Epigenesis Genetic Female Genetic Diseases Inborn Genomic Imprinting Humans Induced Pluripotent Stem Cells Male Mice Models Animal Pregnancy Reproductive Techniques Assisted
Developmental evidence for serial homology of the vertebrate jaw and gill arch skeleton.
Gegenbaur's classical hypothesis of jaw-gill arch serial homology is widely cited, but remains unsupported by either palaeontological evidence (for example, a series of fossils reflecting the stepwise transformation of a gill...
Hypoxia-induced nitric oxide production and tumour perfusion is inhibited by pegylated arginine deiminase (ADI-PEG20).
Natalie Burrows, Gaelle Cane, Mathew Robson, Edoardo Gaude, William J Howat, Peter W Szlosarek, R Barbara Pedley, Christian Frezza, Margaret Ashcroft, Patrick H Maxwell
Mar 01, 2016
Animals Arginine Argininosuccinate Synthase Basic Helix-Loop-Helix Transcription Factors Blotting Western Cell Hypoxia Cell Line Tumor HCT116 Cells Humans Hydrolases Hypoxia Hypoxia-Inducible Factor 1 alpha Subunit Mechanistic Target of Rapamycin Complex 1 Mice SCID Multiprotein Complexes Neoplasms Nitric oxide Nitric Oxide Synthase Type II Perfusion Polyethylene Glycols TOR Serine-Threonine Kinases Tumor Burden Unfolded Protein Response Vascular Endothelial Growth Factor A Xenograft Model Antitumor Assays
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