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The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis.
Elisabete M Nascimento, Claire L Cox, Stewart MacArthur, Shobbir Hussain, Matthew Trotter, Sandra Blanco, Menon Suraj, Jennifer Nichols, Bernd Kübler, Salvador Aznar Benitah, Brian Hendrich, Duncan T Odom, Michaela Frye
Jan 31, 2020
How the proto-oncogene c-Myc balances the processes of stem-cell self-renewal, proliferation and differentiation in adult tissues is largely unknown. We explored c-Myc's transcriptional roles at the epidermal differentiation...
Animals Epidermal Cells epidermis Feedback Physiological Female Homeostasis Keratinocytes Kruppel-Like Factor 4 Male Mice Mice Inbred C57BL Mice Inbred CBA Mice Transgenic Primary Cell Culture Proto-Oncogene Proteins c-myc Repressor Proteins Sin3 Histone Deacetylase and Corepressor Complex Transcription Genetic
5-hydroxymethylcytosine and gene activity in mouse intestinal differentiation
Santiago Uribe-Lewis, Thomas Carroll, Suraj Menon, Anna Nicholson, Piotr J. Manasterski, Douglas J. Winton, Simon J. A. Buczacki, Adele Murrell
Jan 16, 2021
Abstract: Cytosine hydroxymethylation (5hmC) in mammalian DNA is the product of oxidation of methylated cytosines (5mC) by Ten-Eleven-Translocation (TET) enzymes. While it has been shown that the TETs influence 5mC metabolism...
Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions.
Lovorka Stojic, Malwina Niemczyk, Arturo Orjalo, Yoko Ito, Anna Elisabeth Maria Ruijter, Santiago Uribe-Lewis, Nimesh Joseph, Stephen Weston, Suraj Menon, Duncan T Odom, John Rinn, Fanni Gergely, Adele Murrell
Nov 24, 2015
5-hydroxymethylcytosine and gene activity in mouse intestinal differentiation.
Santiago Uribe-Lewis, Thomas Carroll, Suraj Menon, Anna Nicholson, Piotr J Manasterski, Douglas J Winton, Simon J A Buczacki, Adele Murrell
Feb 19, 2020
Cytosine hydroxymethylation (5hmC) in mammalian DNA is the product of oxidation of methylated cytosines (5mC) by Ten-Eleven-Translocation (TET) enzymes. While it has been shown that the TETs influence 5mC metabolism...
Published by: Scientific reports
Activating transcription factor-2 (ATF2) is a key determinant of resistance to endocrine treatment in an in vitro model of breast cancer.
Athina Giannoudis, Mohammed Imad Malki, Bharath Rudraraju, Hisham Mohhamed, Suraj Menon, Triantafillos Liloglou, Simak Ali, Jason S Carroll, Carlo Palmieri
Nov 30, 2020
BACKGROUND: Activating transcription factor-2 (ATF2), a member of the leucine zipper family of DNA binding proteins, has been implicated as a tumour suppressor in breast cancer. However, its exact role in breast cancer endocrine...
ATF2 Breast Cancer endocrine resistance Tamoxifen Activating Transcription Factor 2 Antineoplastic Agents Hormonal Breast Neoplasms Cell Movement Drug Resistance Neoplasm Female Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Knockdown Techniques Humans MCF-7 Cells Oligonucleotide Array Sequence Analysis Receptors Estrogen Tamoxifen
Activating transcription factor-2 (ATF2) is a key determinant of resistance to endocrine treatment in an in vitro model of breast cancer
Athina Giannoudis, Mohammed Imad Malki, Bharath Rudraraju, Hisham Mohhamed, Suraj Menon, Triantafillos Liloglou, Simak Ali, Jason S. Carroll, Carlo Palmieri
Nov 16, 2020
Abstract: Background: Activating transcription factor-2 (ATF2), a member of the leucine zipper family of DNA binding proteins, has been implicated as a tumour suppressor in breast cancer. However, its exact role in breast cancer...
Mammary stem cells have myoepithelial cell properties.
Michael D Prater, Valérie Petit, I Alasdair Russell, Rajshekhar R Giraddi, Mona Shehata, Suraj Menon, Reiner Schulte, Ivo Kalajzic, Nicola Rath, Michael F Olson, Daniel Metzger, Marisa M Faraldo, Marie-Ange Deugnier, Marina A Glukhova, John Stingl
Jul 16, 2014
Actins Animals Benzamides Cell Proliferation Cells Cultured Dioxoles Epithelial Cells Female Flow Cytometry Gene Expression Profiling Green Fluorescent Proteins Interleukin Receptor Common gamma Subunit Mammary Glands Animal Mice Inbred C57BL Mice Inbred CBA Mice Inbred NOD Mice SCID Mice Transgenic Microscopy Fluorescence Myocytes Smooth Muscle Oligonucleotide Array Sequence Analysis Receptors Transforming Growth Factor beta Reverse Transcriptase Polymerase Chain Reaction Stem Cells
Recombinant expression of insoluble enzymes in Escherichia coli
Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor.
Hisham Mohammed, Clive D'Santos, Aurelien A Serandour, H Raza Ali, Gordon D Brown, Alan Atkins, Oscar M Rueda, Kelly A Holmes, Vasiliki Theodorou, Jessica LL Robinson, Wilbert Zwart, Amel Saadi, Caryn S Ross-Innes, Suet-Feung Chin, Suraj Menon, John Stingl, Carlo Palmieri, Carlos Caldas, Jason S Carroll
Jan 18, 2021
Estrogen receptor-α (ER) is the driving transcription factor in most breast cancers, and its associated proteins can influence drug response, but direct methods for identifying interacting proteins have been limited. We purified...
Animals Breast Neoplasms Cell Line Tumor Chromatin Chromatin Immunoprecipitation Estrogen Receptor alpha Female Gene Expression Regulation Neoplastic Humans MCF-7 Cells Mice Mice SCID Neoplasm Proteins Protein Interaction Maps RNA Interference RNA Small Interfering Transcription Genetic Transplantation Heterologous
A Scientometric Analysis of COVID-19 and Social Media Marketing
This study gives a comprehensive picture of various trends of worldwide scientific research on the impact of COVID-19 on social media marketing from 2019 to early 2022. Relevant articles were retrieved from the Scopus database...
Published by: IGI Global Scientific Publishing
An Approach to Prevent Air Pollution and Generate Electricity Using Nanostructured Carbon Materials
Pollution is one of the major threats for the environment as well as society. It causes severe problems for the living organisms and can gives birth of various unknown issues. Different sources like cars, industrial belts...
Published by: IGI Global Scientific Publishing
Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53.
Kristina Kirschner, Shamith A Samarajiwa, Jonathan M Cairns, Suraj Menon, Pedro A Pérez-Mancera, Kosuke Tomimatsu, Camino Bermejo-Rodriguez, Yoko Ito, Tamir Chandra, Masako Narita, Scott K Lyons, Andy G Lynch, Hiroshi Kimura, Tetsuya Ohbayashi, Simon Tavaré, Masashi Narita
May 08, 2015
Transcriptomic profiling reveals three molecular phenotypes of adenocarcinoma at the gastroesophageal junction.
Jan Bornschein, Lorenz Wernisch, Maria Secrier, Ahmad Miremadi, Juliane Perner, Shona MacRae, Maria O'Donovan, Richard Newton, Suraj Menon, Lawrence Bower, Matthew D Eldridge, Ginny Devonshire, Calvin Cheah, Richard Turkington, Richard H Hardwick, Michael Selgrad, Marino Venerito, Peter Malfertheiner, OCCAMS consortium, Rebecca C Fitzgerald
Jun 19, 2019
Progesterone receptor modulates ERα action in breast cancer.
Hisham Mohammed, I Alasdair Russell, Rory Stark, Oscar M Rueda, Theresa E Hickey, Gerard A Tarulli, Aurelien A Serandour, Stephen N Birrell, Alejandra Bruna, Amel Saadi, Suraj Menon, James Hadfield, Michelle Pugh, Ganesh V Raj, Gordon D Brown, Clive D'Santos, Jessica LL Robinson, Grace Silva, Rosalind Launchbury, Charles M Perou, John Stingl, Carlos Caldas, Wayne D Tilley, Jason S Carroll
Aug 13, 2015
Animals Breast Neoplasms Cell Line Tumor Cell Proliferation Chromatin DNA Copy Number Variations Disease Progression Estrogen Receptor alpha Estrogens Female Gene Expression Regulation Neoplastic Humans Ligands Mice Progesterone Protein Binding Receptors Progesterone Transcription Genetic Xenograft Model Antitumor Assays
Topological active matter
In active matter systems, individual constituents convert energy into non-conservative forces or motion at the microscale, leading to morphological features and transport properties that do not occur in equilibrium and that...
Topological active matter
In active matter systems, individual constituents convert energy into non-conservative forces or motion at the microscale, leading to morphological features and transport properties that do not occur in equilibrium and that...
A reciprocal feedback between the PDZ binding kinase and androgen receptor drives prostate cancer.
Anne Y Warren, Charlie E Massie, Kate Watt, Katarina Luko, Folake Orafidiya, Luke A Selth, Hisham Mohammed, Brinder S Chohan, Suraj Menon, Ajoeb Baridi, Wanfeng Zhao, Carles Escriu, Thanakorn Pungsrinont, Clive D'Santos, Xiaoping Yang, Chris Taylor, Arham Qureshi, Vincent R Zecchini, Greg L Shaw, Scott M Dehm, Ian G Mills, Jason S Carroll, Wayne D Tilley, Iain J McEwan, Aria Baniahmad, David E Neal, Mohammad Asim
Nov 16, 2018
Elucidation of mechanisms underlying the increased androgen receptor (AR) activity and subsequent development of aggressive prostate cancer (PrCa) is pivotal in developing new therapies. Using a systems biology approach, we...
Critical care management of traumatic brain injury.
Traumatic brain injury (TBI) is a growing global problem, which is responsible for a substantial burden of disability and death, and which generates substantial healthcare costs. High-quality intensive care can save lives and...
Investigating the Prediction of Breast Cancer Diagnosis by Use of Support Vector Machines
A. Maanav, K. Mithun, T. Naparajith, K. Maarvin Abiram Suraj, Regin Bose, Belwin Brearley
Jan 01, 2023
This study examines the use of support vector machine (SVM) learning algorithms in predictive analytics models for the detection of breast cancer. This study uses the breast cancer Wisconsin dataset and evaluates the model's...
Published by: IGI Global Scientific Publishing
ICU Structure and Outcomes Following Traumatic Brain Injury.
We read with interest the paper from McCredie et al in Critical Care Medicine. The authors retrospectively analysed data from 9773 patients from 134 intensive care units (ICUs), obtained between 2011 and 2013, extracted from a...
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