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Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians
Yang Luo, Sara Suliman, Samira Asgari, Tiffany Amariuta, Yuriy Baglaenko, Marta Martínez-Bonet, Kazuyoshi Ishigaki, Maria Gutierrez-Arcelus, Roger Calderon, Leonid Lecca, Segundo R. León, Judith Jimenez, Rosa Yataco, Carmen Contreras, Jerome T. Galea, Mercedes Becerra, Sergey Nejentsev, Peter A. Nigrovic, D. Branch Moody, Megan B. Murray, Soumya Raychaudhuri
Aug 20, 2020
Abstract: Of the 1.8 billion people worldwide infected with Mycobacterium tuberculosis, 5–15% will develop active tuberculosis (TB). Approximately half will progress to active TB within the first 18 months after infection...
Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians.
Yang Luo, Sara Suliman, Samira Asgari, Tiffany Amariuta, Yuriy Baglaenko, Marta Martínez-Bonet, Kazuyoshi Ishigaki, Maria Gutierrez-Arcelus, Roger Calderon, Leonid Lecca, Segundo R León, Judith Jimenez, Rosa Yataco, Carmen Contreras, Jerome T Galea, Mercedes Becerra, Sergey Nejentsev, Peter A Nigrovic, D Branch Moody, Megan B Murray, Soumya Raychaudhuri
Oct 22, 2019
Of the 1.8 billion people worldwide infected with Mycobacterium tuberculosis, 5-15% will develop active tuberculosis (TB). Approximately half will progress to active TB within the first 18 months after infection, presumably...
Irregular War, Local Community and Intimate Violence in Spain (1939-1952)
Spain was the first country where the anti-fascist resistance manifested itself through the violence of arms, in response to the military coup of 1936 which triggered a bloody civil war. It was also the last to lay down arms...
Intimate violence Irregular war Local community Post-war Primary groups Spain /dk/atira/pure/subjectarea/asjc/3300/3316 name=Cultural Studies /dk/atira/pure/subjectarea/asjc/1200/1202 name=History /dk/atira/pure/sustainabledevelopmentgoals/peace_justice_and_strong_institutions name=SDG 16 - Peace, Justice and Strong Institutions
Overexpression of chloroplast-targeted ferrochelatase 1 results in a genomes uncoupled chloroplast-to-nucleus retrograde signalling phenotype.
Conditional expression of PfAP2-G for controlled massive sexual conversion in Plasmodium falciparum.
Oriol Llorà-Batlle, Lucas Michel-Todó, Kathrin Witmer, Haruka Toda, Carmen Fernández-Becerra, Jake Baum, Alfred Cortés
Jul 06, 2020
Malaria transmission requires that some asexual parasites convert into sexual forms termed gametocytes. The initial stages of sexual development, including sexually committed schizonts and sexual rings, remain poorly...
Interwoven traditions in Bell Beaker metallurgy
Julia Montes-Landa, Mercedes Murillo-Barroso, Ignacio Montero-Ruiz, Salvador Rovira-Llorens, Marcos Martinón-Torres
Sep 13, 2021
Debates on early metallurgy in Western Europe have frequently focused on the social value of copper (between utilitarian and symbolic) and its purported role in the emergence and consolidation of hierarchies. Recent research...
Migration policy and international human rights frameworks in Morocco
In 2013, Morocco announced the adoption of a new, ‘humane’ migration policy. The implementation of the reform, however, has been characterised by an apparent contradiction: while Morocco has leveraged the humanitarian and...
Club convergence in European housing prices
This study aims to determine whether there is convergence in house prices across a sample of European economies, including members and non-members of the Eurozone. Overall the literature has found no evidence of convergence...
Smallpox vaccination induces a substantial increase in commensal skin bacteria that promote pathology and influence the host response.
Evgeniya Shmeleva, Mercedes Gomez de Agüero, Josef Wagner, Anton Enright, Andrew J Macpherson, Brian Ferguson, Geoffrey Smith
Apr 21, 2022
Interactions between pathogens, host microbiota and the immune system influence many physiological and pathological processes. In the 20th century, widespread dermal vaccination with vaccinia virus (VACV) led to the eradication...
Irregular War, Local Community and Intimate Violence in Spain (1939-1952)
Spain was the first country where the anti-fascist resistance manifested itself through the violence of arms, in response to the military coup of 1936 which triggered a bloody civil war. It was also the last to lay down arms...
Intimate violence Irregular war Local community Post-war Primary groups Spain /dk/atira/pure/subjectarea/asjc/3300/3316 name=Cultural Studies /dk/atira/pure/subjectarea/asjc/1200/1202 name=History /dk/atira/pure/sustainabledevelopmentgoals/peace_justice_and_strong_institutions name=SDG 16 - Peace, Justice and Strong Institutions
Club convergence in European housing prices
This study aims to determine whether there is convergence in house prices across a sample of European economies, including members and non-members of the Eurozone. Overall the literature has found no evidence of convergence...
Amber in prehistoric Iberia
Mercedes Murillo-Barroso, Enrique Peñalver, Primitiva Bueno, Rosa Barroso, Rodrigo de Balbín, Marcos Martinón-Torres
Nov 13, 2018
Provenancing exotic raw materials and reconstructing the nature and routes of exchange is a major concern of prehistoric archaeology. Amber has long been recognised as a key commodity of prehistoric exchange networks in Europe....
Interwoven traditions in Bell Beaker metallurgy
Julia Montes-Landa, Mercedes Murillo-Barroso, Ignacio Montero-Ruiz, Salvador Rovira-Llorens, Marcos Martinón-Torres
Sep 09, 2021
Debates on early metallurgy in Western Europe have frequently focused on the social value of copper (between utilitarian and symbolic) and its purported role in the emergence and consolidation of hierarchies. Recent research...
Published by: PLOS ONE
Interwoven traditions in Bell Beaker metallurgy
Julia Montes-Landa, Mercedes Murillo-Barroso, Ignacio Montero-Ruiz, Salvador Rovira-Llorens, Marcos Martinón-Torres
Aug 11, 2021
Debates on early metallurgy in Western Europe have frequently focused on the social value of copper (between utilitarian and symbolic) and its purported role in the emergence and consolidation of hierarchies. Recent research...
Stem and progenitor cell division kinetics during postnatal mouse mammary gland development.
Rajshekhar R Giraddi, Mona Shehata, Mercedes Gallardo, Maria A Blasco, Benjamin D Simons, John Stingl
Dec 04, 2015
Interactions between callose and cellulose revealed through the analysis of biopolymer mixtures.
Radwa H Abou-Saleh, Mercedes C Hernandez-Gomez, Sam Amsbury, Candelas Paniagua, Matthieu Bourdon, Shunsuke Miyashima, Ykä Helariutta, Martin Fuller, Tatiana Budtova, Simon D Connell, Michael E Ries, Yoselin Benitez-Alfonso
Dec 18, 2018
The properties of (1,3)-β-glucans (i.e., callose) remain largely unknown despite their importance in plant development and defence. Here we use mixtures of (1,3)-β-glucan and cellulose, in ionic liquid solution and hydrogels, as...
Epirubicin, Cisplatin, and Capecitabine for Primary Platinum-Resistant or Platinum-Refractory Epithelial Ovarian Cancer
Karen Sayal, Ioannis Gounaris, Bristi Basu, Sue Freeman, Penny Moyle, Karen Hosking, Mahesh Iddawela, Mercedes Jimenez-Linan, Jean Abraham, James Brenton, Helen Hatcher, Helena Earl, Christine Parkinson
Oct 26, 2020
OBJECTIVE: Primary platinum-resistant epithelial ovarian cancer (EOC) is an area of unmet medical need. There is limited evidence from small studies that platinum-based combinations can overcome "resistance" in a proportion of...
Adenocarcinoma Clear Cell Adult Aged Antineoplastic Combined Chemotherapy Protocols Capecitabine cisplatin Cystadenocarcinoma Serous Drug Resistance Neoplasm Endometrial Neoplasms Epirubicin Female Follow-Up Studies Humans Middle Aged Neoplasm Grading Neoplasm Invasiveness Neoplasm Staging Ovarian Neoplasms Prognosis Retrospective Studies Survival Rate
Diagnostic interpretation of non-contrast qualitative MR imaging features for characterisation of uterine leiomyosarcoma.
Hilal Sahin, Janette Smith, Jeries Paolo Zawaideh, Amreen Shakur, Luca Carmisciano, Iztok Caglic, Annemarie Bruining, Mercedes Jimenez-Linan, Sue Freeman, Helen Addley
May 31, 2021
OBJECTIVE: To assess the value of non-contrast MRI features for characterisation of uterine leiomyosarcoma (LMS) and differentiation from atypical benign leiomyomas. METHODS: This study included 57 atypical leiomyomas and 16 LMS...
Minigene-based splicing analysis and ACMG/AMP-based tentative classification of 56 ATM variants.
Elena Bueno-Martínez, Lara Sanoguera-Miralles, Alberto Valenzuela-Palomo, Ada Esteban-Sánchez, Víctor Lorca, Inés Llinares-Burguet, Jamie Allen, Alicia García-Álvarez, Pedro Pérez-Segura, Mercedes Durán, Douglas F Easton, Peter Devilee, Maaike PG Vreeswijk, Miguel de la Hoya, Eladio A Velasco-Sampedro
Jul 15, 2022
The ataxia telangiectasia-mutated (ATM) protein is a major coordinator of the DNA damage response pathway. ATM loss-of-function variants are associated with 2-fold increased breast cancer risk. We aimed at identifying and...
Oxidative Stress and Inflammatory Markers in Abdominal Aortic Aneurysm.
David Sánchez-Infantes, Meritxell Nus, Miquel Navas-Madroñal, Joan Fité, Belén Pérez, Antonio J Barros-Membrilla, Begoña Soto, José Martínez-González, Mercedes Camacho, Cristina Rodriguez, Ziad Mallat, María Galán
Apr 19, 2021
Abdominal aortic aneurysm (AAA) is increasing due to aging of the population and is a major cause of death among the elderly. Ultrasound screening programs are useful in early diagnosis, but aneurysm size is not always a good...
Cannabis Use Induces Distinctive Proteomic Alterations in Olfactory Neuroepithelial Cells of Schizophrenia Patients.
Marta Barrera-Conde, Karina Ausin, Mercedes Lachén-Montes, Joaquín Fernández-Irigoyen, Liliana Galindo, Aida Cuenca-Royo, Cristina Fernández-Avilés, Víctor Pérez, Rafael de la Torre, Enrique Santamaría, Patricia Robledo
Feb 26, 2021
A close epidemiological link has been reported between cannabis use and schizophrenia (SCZ). However, biochemical markers in living humans related to the impact of cannabis in this disease are still missing. Olfactory...
Smallpox vaccination induces a substantial increase in commensal skin bacteria that promote pathology and influence the host response.
Evgeniya V Shmeleva, Mercedes Gomez de Agüero, Josef Wagner, Anton J Enright, Andrew J Macpherson, Brian J Ferguson, Geoffrey L Smith
May 22, 2022
Interactions between pathogens, host microbiota and the immune system influence many physiological and pathological processes. In the 20th century, widespread dermal vaccination with vaccinia virus (VACV) led to the eradication...
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