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Michael Heidelberger, 1933
Dr. Michael Heidelberger. Contributions of Chemistry of the Knowledge of Immune Processes Lecture delivered March 17th, 1933 Posted with permission
JEFFREY RAVETCH AND MICHAEL YOUNG
Congratulations to Jeffrey Ravetch and Michael Young, recipients of the 2012 Canada Gairdner International Award
Polymer Microarrays for the Discovery and Optimization of Robust Optical-Fiber-Based pH Sensors

Polymer microarrays were utilized for the high-throughput screening and discovery of optimal polymeric substrates capable of trapping functional ratiometric fluorescence-based pH sensors. This led to the identification of...

Polymer Microarrays for the Discovery and Optimization of Robust Optical-Fiber-Based pH Sensors

Polymer microarrays were utilized for the high-throughput screening and discovery of optimal polymeric substrates capable of trapping functional ratiometric fluorescence-based pH sensors. This led to the identification of...

Rigid analytic quantum groups and quantum Arens-Michael envelopes
Nicolas Dupré
Aug 19, 2019
We introduce a rigid analytification of the quantized coordinate algebra of a semisimple algebraic group and a quantized Arens-Michael envelope of the enveloping algebra of the corresponding Lie algebra, working over a...
Organocatalytic Enantioselective Sulfa-Michael Additions to α,β-Unsaturated Diazoketones

Enantioselective sulfa-Michael additions to α,β unsaturated diazocarbonyl compounds have been developed. Quinine-derived squaramide was found to be the best catalyst to promote C-S bond formation in a highly stereoselective...

G-Quadruplexes
Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention...
Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36.
Guanine-rich nucleic acid sequences challenge the replication, transcription, and translation machinery by spontaneously folding into G-quadruplexes, the unfolding of which requires forces greater than most polymerases can...
Review of: Karen Hunger Parshall, Michael T. Walton and Bruce T. Moran (eds.), Bridging Traditions
S Fransen
Mar 04, 2019
This collected volume is written in honour of Allen G. Debus (1926–2009), the famous historian of science. Trained as a chemist, his interest in the history of science and chemistry would guide his research and his output. As...
A hydrogel-based optical fibre fluorescent pH sensor for observing lung tumor tissue acidity

Technologies for measuring physiological parameters in vivo offer the possibility of the detection of disease and its progression due to the resulting changes in tissue pH, or temperature, etc. Here, a compact hydrogel-based...

Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams

A new generic synthesis method is presented for the production of a polyimide (PI)/adsorbent (80 wt% 13X zeolite) regenerable foam filter. The method uses a dual parallel reaction foaming process comprising CO 2...

Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams

A new generic synthesis method is presented for the production of a polyimide (PI)/adsorbent (80 wt% 13X zeolite) regenerable foam filter. The method uses a dual parallel reaction foaming process comprising CO 2...

Organocatalytic Enantioselective Sulfa-Michael Additions to α,β-Unsaturated Diazoketones

Enantioselective sulfa-Michael additions to α,β unsaturated diazocarbonyl compounds have been developed. Quinine-derived squaramide was found to be the best catalyst to promote C-S bond formation in a highly stereoselective...

Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
The extrudate swell singularity of Phan-Thien-Tanner and Giesekus fluids

The stress singularity for Phan-Thien-Tanner (PTT) and Giesekus viscoelastic fluids is determined for extrudate swell (commonly termed die swell). In the presence of a Newtonian solvent viscosity, the solvent stress dominates...

A hydrogel-based optical fibre fluorescent pH sensor for observing lung tumor tissue acidity

Technologies for measuring physiological parameters in vivo offer the possibility of the detection of disease and its progression due to the resulting changes in tissue pH, or temperature, etc. Here, a compact hydrogel-based...

RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia.
In hypoxic stress conditions, glycolysis enzymes assemble into singular cytoplasmic granules called glycolytic (G) bodies. G body formation in yeast correlates with increased glucose consumption and cell survival. However, the...
Density Functional Theory Transition-State Modeling for the Prediction of Ames Mutagenicity in 1,4 Michael Acceptors

Assessing the safety of new chemicals, without introducing the need for animal testing, is a task of great importance. The Ames test, a widely used bioassay to assess mutagenicity, can be an expensive, wasteful process with...

Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor.
Theoretical models of G protein-coupled receptor (GPCR) concentration-response relationships often assume an agonist producing a single functional response via a single active state of the receptor. These models have largely...
Density Functional Theory Transition-State Modeling for the Prediction of Ames Mutagenicity in 1,4 Michael Acceptors

Assessing the safety of new chemicals, without introducing the need for animal testing, is a task of great importance. The Ames test, a widely used bioassay to assess mutagenicity, can be an expensive, wasteful process with...

Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
Eliminating Transition State Calculations for Faster and More Accurate Reactivity Prediction in Sulfa-Michael Additions Relevant to Human Health and the Environment
Fast and accurate computational approaches to predicting reactivity in sulfa-Michael additions are required for high-throughput screening in toxicology (e.g., predicting excess aquatic toxicity and skin sensitization), chemical...

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