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Intrinsic transcriptional heterogeneity in B cells controls early class switching to IgE.
Noncoding transcripts originating upstream of the immunoglobulin constant region (I transcripts) are required to direct activation-induced deaminase to initiate class switching in B cells. Differential regulation of Iε and Iγ1...
Are cells from a snowman realistic? Cryopreserved tissues as a source for single-cell RNA-sequencing experiments.
A recently published study in Genome Biology shows that cells isolated from cryopreserved tissues are a reliable source of genetic material for single-cell RNA-sequencing experiments.Please see related Method article...
T cell fate and clonality inference from single-cell transcriptomes.
Michael JT Stubbington, Tapio Lönnberg, Valentina Proserpio, Simon Clare, Anneliese O Speak, Gordon Dougan, Sarah A Teichmann
May 16, 2019
We developed TraCeR, a computational method to reconstruct full-length, paired T cell receptor (TCR) sequences from T lymphocyte single-cell RNA sequence data. TraCeR links T cell specificity with functional response by...
Michael Heidelberger, 1933
The Rockefeller University
Jan 01, 0001
Dr. Michael Heidelberger. Contributions of Chemistry of the Knowledge of Immune Processes
Lecture delivered March 17th, 1933
Posted with permission
Published by: The William & Wilkins Company
Remembering Michael Shute
Dedication to Michael Shute.
Published by: Memorial University of Newfoundland
An atlas of mouse CD4(+) T cell transcriptomes.
Michael JT Stubbington, Bidesh Mahata, Valentine Svensson, Andrew Deonarine, Jesper K Nissen, Alexander G Betz, Sarah A Teichmann
May 16, 2019
BACKGROUND: CD4(+) T cells are key regulators of the adaptive immune system and can be divided into T helper (Th) cells and regulatory T (Treg) cells. During an immune response Th cells mature from a naive state into one of...
Alternative Splicing Animals Cell Differentiation Cluster Analysis Flow Cytometry Gene Expression Profiling Gene Expression Regulation Immune System Mice Mice Inbred C57BL principal component analysis Protein Isoforms RNA Messenger Sequence Analysis RNA Signal Transduction T-Lymphocytes Helper-Inducer T-Lymphocytes Regulatory Th17 Cells Transcriptome Up-Regulation
The Regulatory T Cell Lineage Factor Foxp3 Regulates Gene Expression through Several Distinct Mechanisms Mostly Independent of Direct DNA Binding.
Xin Xie, Michael JT Stubbington, Jesper K Nissen, Kristian G Andersen, Daniel Hebenstreit, Sarah A Teichmann, Alexander G Betz
May 16, 2019
The lineage factor Foxp3 is essential for the development and maintenance of regulatory T cells, but little is known about the mechanisms involved. Here, we demonstrate that an N-terminal proline-rich interaction region is...
JEFFREY RAVETCH AND MICHAEL YOUNG
The Rockefeller University
Jan 01, 0001
Congratulations to Jeffrey Ravetch and Michael Young, recipients of the 2012 Canada Gairdner International Award
Published by: The Rockefeller University
Remembering Michael Shute
Dedication to Michael Shute.
Published by: Memorial University of Newfoundland
Rigid analytic quantum groups and quantum Arens-Michael envelopes
Nicolas Dupré
Aug 19, 2019
We introduce a rigid analytification of the quantized coordinate algebra of a semisimple algebraic group and a quantized Arens-Michael envelope of the enveloping algebra of the corresponding Lie algebra, working over a...
Organocatalytic Enantioselective Sulfa-Michael Additions to α,β-Unsaturated Diazoketones
Patricia B Momo, Eduardo F Mizobuchi, Radell Echemendía, Isabel Baddeley, Matthew N Grayson, Antonio C B Burtoloso
Mar 04, 2022
Enantioselective sulfa-Michael additions to α,β unsaturated diazocarbonyl compounds have been developed. Quinine-derived squaramide was found to be the best catalyst to promote C-S bond formation in a highly stereoselective...
Organocatalytic Enantioselective Sulfa-Michael Additions to α,β-Unsaturated Diazoketones
Patricia B Momo, Eduardo F Mizobuchi, Radell Echemendía, Isabel Baddeley, Matthew N Grayson, Antonio C B Burtoloso
Mar 04, 2022
Enantioselective sulfa-Michael additions to α,β unsaturated diazocarbonyl compounds have been developed. Quinine-derived squaramide was found to be the best catalyst to promote C-S bond formation in a highly stereoselective...
Density Functional Theory Transition-State Modeling for the Prediction of Ames Mutagenicity in 1,4 Michael Acceptors
Assessing the safety of new chemicals, without introducing the need for animal testing, is a task of great importance. The Ames test, a widely used bioassay to assess mutagenicity, can be an expensive, wasteful process with...
Density Functional Theory Transition-State Modeling for the Prediction of Ames Mutagenicity in 1,4 Michael Acceptors
Assessing the safety of new chemicals, without introducing the need for animal testing, is a task of great importance. The Ames test, a widely used bioassay to assess mutagenicity, can be an expensive, wasteful process with...
Eliminating Transition State Calculations for Faster and More Accurate Reactivity Prediction in Sulfa-Michael Additions Relevant to Human Health and the Environment
Fast and accurate computational approaches to predicting reactivity in sulfa-Michael additions are required for high-throughput screening in toxicology (e.g., predicting excess aquatic toxicity and skin sensitization), chemical...
Circulating and Tissue-Resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation.
Ahmed N Hegazy, Nathaniel R West, Michael JT Stubbington, Emily Wendt, Kim IM Suijker, Angeliki Datsi, Sebastien This, Camille Danne, Suzanne Campion, Sylvia H Duncan, Benjamin MJ Owens, Holm H Uhlig, Andrew McMichael, Oxford IBD Cohort Investigators, Andreas Bergthaler, Sarah A Teichmann, Satish Keshav, Fiona Powrie
May 14, 2019
BACKGROUND & AIMS: Interactions between commensal microbes and the immune system are tightly regulated and maintain intestinal homeostasis, but little is known about these interactions in humans. We investigated responses of...
Cytokines immune regulation Microbiota Tissue-resident Memory T cells Bacteria CD4 Lymphocyte Count CD4-Positive T-Lymphocytes Case-Control Studies Cell Line Colitis Ulcerative Crohn Disease Gastrointestinal Microbiome Host-Pathogen Interactions Humans Immunity mucosal Immunologic Memory Interleukin-17 Intestines Phenotype Receptors Antigen T-Cell alpha-beta Th17 Cells
Single-cell RNA-seq and computational analysis using temporal mixture modelling resolves Th1/Tfh fate bifurcation in malaria.
Tapio Lönnberg, Valentine Svensson, Kylie R James, Daniel Fernandez-Ruiz, Ismail Sebina, Ruddy Montandon, Megan SF Soon, Lily G Fogg, Arya Sheela Nair, Urijah Liligeto, Michael JT Stubbington, Lam-Ha Ly, Frederik Otzen Bagger, Max Zwiessele, Neil D Lawrence, Fernando Souza-Fonseca-Guimaraes, Patrick T Bunn, Christian R Engwerda, William R Heath, Oliver Billker, Oliver Stegle, Ashraful Haque, Sarah A Teichmann
Sep 18, 2020
Differentiation of naïve CD4+ T cells into functionally distinct T helper subsets is crucial for the orchestration of immune responses. Due to extensive heterogeneity and multiple overlapping transcriptional programs in...
Brexit and the Anglosphere
Brexit supporters often point to Anglophone countries as an obvious replacement for the UK’s relationship with the European Union. But where did this idea of an Anglosphere come from? And how significant is it? Michael Kenny and...
Brexit and the Anglosphere
Brexit supporters often point to Anglophone countries as an obvious replacement for the UK’s relationship with the European Union. But where did this idea of an Anglosphere come from? And how significant is it? Michael Kenny and...
The Ursinus College Investment Management Company Newsletter, Fall 2022
Inside this issue:
At a Glance
Letter from Jessica Gutekunst '23
Letter from Michael Magargee '23
Investment Team Strategies and Updates
UCIMCO Investment Performance and Analysis
Endowment Outlook
Stock Selection Picks
Women's...
UCIMCO Endowment portfolio management stock selection Investment performance Ursinus College Business Finance and Financial Management Portfolio and Security Analysis
Published by: Ursinus College
Seeking the Wealth of Self
Michael George
Mar 16, 2022
Michael George teaches Religion and Culture, and Ethics at St. Thomas University in Fredericton, New Brunswick. He is interested in helping to promote the project of Integrative Bioethics, which he considers to be a possible...
Published by: Memorial University of Newfoundland
Eliminating Transition State Calculations for Faster and More Accurate Reactivity Prediction in Sulfa-Michael Additions Relevant to Human Health and the Environment
Fast and accurate computational approaches to predicting reactivity in sulfa-Michael additions are required for high-throughput screening in toxicology (e.g., predicting excess aquatic toxicity and skin sensitization), chemical...
Remembering Philip McShane
Michael Vertin
Mar 16, 2022
Michael Vertin is Professor Emeritus of Philosophy, Study of Religion, and Theology at St. Michael’s College in the University of Toronto. He is a longtime student of Lonergan’s work and has edited four volumes of studies by...
Published by: Memorial University of Newfoundland
Resident Students' Association Honors Long-time Advisor
Winthrop University
Jan 01, 0001
The Resident Students' Association has created a scholarship to honor John "JT" Timmons, assistant director of residence life. Timmons served as advisor for RSA for 13 years.
Published by: Winthrop University
Seeking the Wealth of Self
Michael George
Mar 16, 2022
Michael George teaches Religion and Culture, and Ethics at St. Thomas University in Fredericton, New Brunswick. He is interested in helping to promote the project of Integrative Bioethics, which he considers to be a possible...
Published by: Memorial University of Newfoundland
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