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Michael Heidelberger, 1933
The Rockefeller University
Jan 01, 0001
Dr. Michael Heidelberger. Contributions of Chemistry of the Knowledge of Immune Processes
Lecture delivered March 17th, 1933
Posted with permission
Published by: The William & Wilkins Company
Remembering Michael Shute
Dedication to Michael Shute.
Published by: Memorial University of Newfoundland
JEFFREY RAVETCH AND MICHAEL YOUNG
The Rockefeller University
Jan 01, 0001
Congratulations to Jeffrey Ravetch and Michael Young, recipients of the 2012 Canada Gairdner International Award
Published by: The Rockefeller University
Remembering Michael Shute
Dedication to Michael Shute.
Published by: Memorial University of Newfoundland
Rigid analytic quantum groups and quantum Arens-Michael envelopes
Nicolas Dupré
Aug 19, 2019
We introduce a rigid analytification of the quantized coordinate algebra of a semisimple algebraic group and a quantized Arens-Michael envelope of the enveloping algebra of the corresponding Lie algebra, working over a...
Organocatalytic Enantioselective Sulfa-Michael Additions to α,β-Unsaturated Diazoketones
Patricia B Momo, Eduardo F Mizobuchi, Radell Echemendía, Isabel Baddeley, Matthew N Grayson, Antonio C B Burtoloso
Mar 04, 2022
Enantioselective sulfa-Michael additions to α,β unsaturated diazocarbonyl compounds have been developed. Quinine-derived squaramide was found to be the best catalyst to promote C-S bond formation in a highly stereoselective...
Screening for Atrial Fibrillation
Ben Freedman, John Camm, Hugh Calkins, Jeffrey S Healey, Mårten Rosenqvist, Jiguang Wang, Christine M Albert, Craig S Anderson, Sotiris Antoniou, Emelia J Benjamin, Giuseppe Boriani, Johannes Brachmann, Axel Brandes, Tze-Fan Chao, David Conen, Johan Engdahl, Laurent Fauchier, David A Fitzmaurice, Leif Friberg, Bernard J Gersh, David J Gladstone, Taya V Glotzer, Kylie Gwynne, Graeme J Hankey, Joseph Harbison, Graham S Hillis, Mellanie T Hills, Hooman Kamel, Paulus Kirchhof, Peter R Kowey, Derk Krieger, Vivian WY Lee, Lars-Åke Levin, Gregory YH Lip, Trudie Lobban, Nicole Lowres, Georges H Mairesse, Carlos Martinez, Lis Neubeck, Jessica Orchard, Jonathan P Piccini, Katrina Poppe, Tatjana S Potpara, Helmut Puererfellner, Michiel Rienstra, Roopinder K Sandhu, Renate B Schnabel, Chung-Wah Siu, Steven Steinhubl, Jesper H Svendsen, Emma Svennberg, Sakis Themistoclakis, Robert G Tieleman, Mintu P Turakhia, Arnljot Tveit, Steven B Uittenbogaart, Isabelle C Van Gelder, Atul Verma, Rolf Wachter, Bryan P Yan, AF-Screen Collaborators
May 03, 2018
Approximately 10% of ischemic strokes are associated with atrial fibrillation (AF) first diagnosed at the time of stroke. Detecting asymptomatic AF would provide an opportunity to prevent these strokes by instituting appropriate...
Screen Time and Executive Function in Toddlerhood
Technology is pervasive in homes with young children. Emerging evidence that electronic screen-based media use has adverse effects on executive functions may help explain negative relations between media use and early academic...
Organocatalytic Enantioselective Sulfa-Michael Additions to α,β-Unsaturated Diazoketones
Patricia B Momo, Eduardo F Mizobuchi, Radell Echemendía, Isabel Baddeley, Matthew N Grayson, Antonio C B Burtoloso
Mar 04, 2022
Enantioselective sulfa-Michael additions to α,β unsaturated diazocarbonyl compounds have been developed. Quinine-derived squaramide was found to be the best catalyst to promote C-S bond formation in a highly stereoselective...
The FUSION protein crystallization screen.
The success and speed of atomic structure determination of biological macromolecules by X-ray crystallography depends critically on the availability of diffraction-quality crystals. However, the process of screening...
Density Functional Theory Transition-State Modeling for the Prediction of Ames Mutagenicity in 1,4 Michael Acceptors
Assessing the safety of new chemicals, without introducing the need for animal testing, is a task of great importance. The Ames test, a widely used bioassay to assess mutagenicity, can be an expensive, wasteful process with...
Density Functional Theory Transition-State Modeling for the Prediction of Ames Mutagenicity in 1,4 Michael Acceptors
Assessing the safety of new chemicals, without introducing the need for animal testing, is a task of great importance. The Ames test, a widely used bioassay to assess mutagenicity, can be an expensive, wasteful process with...
Statistics project: Screen time within different Genders
A statistics project studying how different demographics affect screen time specifically with cell phones
Published by: Harrisburg University of Science and Technology
siRNA screen identifies QPCT as a druggable target for Huntington's disease.
Maria Jimenez-Sanchez, Wun Lam, Michael Hannus, Birte Sönnichsen, Sara Imarisio, Angeleen Fleming, Alessia Tarditi, Fiona Menzies, Teresa Ed Dami, Catherine Xu, Eduardo Gonzalez-Couto, Giulia Lazzeroni, Freddy Heitz, Daniela Diamanti, Luisa Massai, Venkata P Satagopam, Guido Marconi, Chiara Caramelli, Arianna Nencini, Matteo Andreini, Gian Luca Sardone, Nicola P Caradonna, Valentina Porcari, Carla Scali, Reinhard Schneider, Giuseppe Pollio, Cahir J O'Kane, Andrea Caricasole, David C Rubinsztein
Jan 10, 2018
Huntington's disease (HD) is a currently incurable neurodegenerative condition caused by an abnormally expanded polyglutamine tract in huntingtin (HTT). We identified new modifiers of mutant HTT toxicity by performing a...
Aminoacyltransferases Animals Cells Cultured Computational Biology Drosophila Drug Evaluation Preclinical Enzyme Inhibitors Green Fluorescent Proteins Humans Huntingtin Protein Huntington Disease Mice Mice Inbred C57BL Mutation Nerve Tissue Proteins Neurons RNA Small Interfering Zebrafish alpha-Crystallin B Chain
Physical activity, screen time, and sleep duration of children aged 6-9 years in 25 countries
Stephen Whiting, Marta Buoncristiano, Peter Gelius, Karim Abu-Omar, Mary Pattison, Jolanda Hyska, Vesselka Duleva, Sanja Musić Milanović, Hana Zamrazilová, Tatjana Hejgaard, Mette Rasmussen, Eha Nurk, Lela Shengelia, Cecily C. Kelleher, Mirjam M. Heinen, Angela Spinelli, Paola Nardone, Akbota Abildina, Shynar Abdrakhmanova, Gulmira Aitmurzaeva, Zhamyila Usuopva, Iveta Pudule, Aušra Petrauskiene, Victoria Farrugia Sant'Angelo, Enisa Kujundzic, Stevo Popovic, Anne Siri Fismen, Ingunn Holden Bergh, Anna Fijalkowska, Ana Isabel Rito, Alexandra Cucu, Lacramioara Aurelia Brinduse, Valentina Peterkova, Andrea Gualtieri, Marta García-Solano, Enrique Gutiérrez-González, Zulfinissio Abdurrahmonova, Khadichamo Boymatova, Nazan Yardim, Maya Tanrygulyyeva, Daniel Weghuber, Karin Schindler, Dragana Stojisavljević, Aida Filipović Hadžiomeragić, Eliza Markidou Ionnaidu, Wolfgang Ahrens, Maria Hassapidou, Viktoria Anna Kovacs, Sergej M. Ostojic, Lubica Ticha, Gregor Starc, Kenisha Russell Jonsson, Igor Spiroski, Harry Rutter, Romeu Mendes, Julianne Williams, Ivo Rakovac, João Breda
Mar 01, 2021
Background: Children are becoming less physically active as opportunities for safe active play, recreational activities, and active transport decrease. At the same time, sedentary screen-based activities both during school...
Physical activity, screen time, and sleep duration of children aged 6-9 years in 25 countries
Stephen Whiting, Marta Buoncristiano, Peter Gelius, Karim Abu-Omar, Mary Pattison, Jolanda Hyska, Vesselka Duleva, Sanja Musić Milanović, Hana Zamrazilová, Tatjana Hejgaard, Mette Rasmussen, Eha Nurk, Lela Shengelia, Cecily C. Kelleher, Mirjam M. Heinen, Angela Spinelli, Paola Nardone, Akbota Abildina, Shynar Abdrakhmanova, Gulmira Aitmurzaeva, Zhamyila Usuopva, Iveta Pudule, Aušra Petrauskiene, Victoria Farrugia Sant'Angelo, Enisa Kujundzic, Stevo Popovic, Anne Siri Fismen, Ingunn Holden Bergh, Anna Fijalkowska, Ana Isabel Rito, Alexandra Cucu, Lacramioara Aurelia Brinduse, Valentina Peterkova, Andrea Gualtieri, Marta García-Solano, Enrique Gutiérrez-González, Zulfinissio Abdurrahmonova, Khadichamo Boymatova, Nazan Yardim, Maya Tanrygulyyeva, Daniel Weghuber, Karin Schindler, Dragana Stojisavljević, Aida Filipović Hadžiomeragić, Eliza Markidou Ionnaidu, Wolfgang Ahrens, Maria Hassapidou, Viktoria Anna Kovacs, Sergej M. Ostojic, Lubica Ticha, Gregor Starc, Kenisha Russell Jonsson, Igor Spiroski, Harry Rutter, Romeu Mendes, Julianne Williams, Ivo Rakovac, João Breda
Mar 01, 2021
Background: Children are becoming less physically active as opportunities for safe active play, recreational activities, and active transport decrease. At the same time, sedentary screen-based activities both during school...
Eliminating Transition State Calculations for Faster and More Accurate Reactivity Prediction in Sulfa-Michael Additions Relevant to Human Health and the Environment
Fast and accurate computational approaches to predicting reactivity in sulfa-Michael additions are required for high-throughput screening in toxicology (e.g., predicting excess aquatic toxicity and skin sensitization), chemical...
Why won't she sleep? Screen exposure and sleep patterns in young infants.
The American Academy of Pediatrics recommends infants' exposure to electronic screen-based media be minimized; however, more research is needed to understand effects of viewing screen-based media. Here, we examine relations...
Parallel CRISPR-Cas9 screens clarify impacts of p53 on screen performance
Anne Ramsay Bowden, David A Morales-Juarez, Matylda Sczaniecka-Clift, Maria Martin Agudo, Natalia Lukashchuk, John Christopher Thomas, Stephen P Jackson
May 23, 2020
CRISPR-Cas9 genome engineering has revolutionised high-throughput functional genomic screens. However, recent work has raised concerns regarding the performance of CRISPR-Cas9 screens using TP53 wild-type human cells due to a...
Genome-Scale CRISPRa Screen Identifies Novel Factors for Cellular Reprogramming.
Jian Yang, Sandeep S Rajan, Mathias J Friedrich, Guocheng Lan, Xiangang Zou, Hannes Ponstingl, Dimitrios A Garyfallos, Pentao Liu, Allan Bradley, Emmanouil Metzakopian
Feb 25, 2019
Primed epiblast stem cells (EpiSCs) can be reverted to a pluripotent embryonic stem cell (ESC)-like state by expression of single reprogramming factor. We used CRISPR activation to perform a genome-scale, reprogramming screen in...
CRISPR activation CRISPR screen activation screen Epiblast stem cells gain-of-function genome-wide screen Induced Pluripotent Stem Cells reprogramming reprogramming pathways Animals Biomarkers CRISPR-Cas Systems Cell Line Cellular Reprogramming Clustered Regularly Interspaced Short Palindromic Repeats Gene Dosage Genome-Wide Association Study Germ Layers Humans Induced Pluripotent Stem Cells Mice Octamer Transcription Factor-3 Pluripotent Stem Cells Transcription Factors
Screen Time Weight-loss Intervention Targeting Children at Home (SWITCH)
Louise Foley, Cliona Ni Mhurchu, Samantha Marsh, Leonard H Epstein, Tim Olds, Ofa Dewes, Ihirangi Heke, Yannan Jiang, Ralph Maddison
Sep 29, 2016
Abstract
Background
The Screen Time Weight-loss Intervention Targeting Children at Home (SWITCH) trial tested a family intervention to reduce screen-based sedentary behaviour in...
Association of the Functional Movement Screen™ with match-injury burden in men’s community rugby union
Evidence supporting use of the Functional Movement Screen (FMSTM) to identify athletes’ risk of injury is equivocal. Furthermore, few studies account for exposure to risk during analysis. This study investigated the association...
Brexit and the Anglosphere
Brexit supporters often point to Anglophone countries as an obvious replacement for the UK’s relationship with the European Union. But where did this idea of an Anglosphere come from? And how significant is it? Michael Kenny and...
Association of the Functional Movement Screen™ with match-injury burden in men’s community rugby union
Evidence supporting use of the Functional Movement Screen (FMSTM) to identify athletes’ risk of injury is equivocal. Furthermore, few studies account for exposure to risk during analysis. This study investigated the association...
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