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Michael Heidelberger, 1933
The Rockefeller University
Jan 01, 0001
Dr. Michael Heidelberger. Contributions of Chemistry of the Knowledge of Immune Processes
Lecture delivered March 17th, 1933
Posted with permission
Published by: The William & Wilkins Company
Remembering Michael Shute
Dedication to Michael Shute.
Published by: Memorial University of Newfoundland
JEFFREY RAVETCH AND MICHAEL YOUNG
The Rockefeller University
Jan 01, 0001
Congratulations to Jeffrey Ravetch and Michael Young, recipients of the 2012 Canada Gairdner International Award
Published by: The Rockefeller University
Remembering Michael Shute
Dedication to Michael Shute.
Published by: Memorial University of Newfoundland
Rigid analytic quantum groups and quantum Arens-Michael envelopes
Nicolas Dupré
Aug 19, 2019
We introduce a rigid analytification of the quantized coordinate algebra of a semisimple algebraic group and a quantized Arens-Michael envelope of the enveloping algebra of the corresponding Lie algebra, working over a...
Organocatalytic Enantioselective Sulfa-Michael Additions to α,β-Unsaturated Diazoketones
Patricia B Momo, Eduardo F Mizobuchi, Radell Echemendía, Isabel Baddeley, Matthew N Grayson, Antonio C B Burtoloso
Mar 04, 2022
Enantioselective sulfa-Michael additions to α,β unsaturated diazocarbonyl compounds have been developed. Quinine-derived squaramide was found to be the best catalyst to promote C-S bond formation in a highly stereoselective...
Organocatalytic Enantioselective Sulfa-Michael Additions to α,β-Unsaturated Diazoketones
Patricia B Momo, Eduardo F Mizobuchi, Radell Echemendía, Isabel Baddeley, Matthew N Grayson, Antonio C B Burtoloso
Mar 04, 2022
Enantioselective sulfa-Michael additions to α,β unsaturated diazocarbonyl compounds have been developed. Quinine-derived squaramide was found to be the best catalyst to promote C-S bond formation in a highly stereoselective...
Density Functional Theory Transition-State Modeling for the Prediction of Ames Mutagenicity in 1,4 Michael Acceptors
Assessing the safety of new chemicals, without introducing the need for animal testing, is a task of great importance. The Ames test, a widely used bioassay to assess mutagenicity, can be an expensive, wasteful process with...
5-Aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of the poly(ADP-ribose)polymerases (PARPs)
Michael D. Threadgill
Nov 01, 2015
5-Aminoisoquinolin-1-one (5-AIQ) is a water-soluble inhibitor of the poly(ADP-ribose)polymerases (PARPs), lacking isoform-selectivity. Although of only moderate potency in vitro against PARP-1, it is highly active in many assays...
5-Aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of the poly(ADP-ribose)polymerases (PARPs)
Michael D. Threadgill
Nov 01, 2015
5-Aminoisoquinolin-1-one (5-AIQ) is a water-soluble inhibitor of the poly(ADP-ribose)polymerases (PARPs), lacking isoform-selectivity. Although of only moderate potency in vitro against PARP-1, it is highly active in many assays...
Density Functional Theory Transition-State Modeling for the Prediction of Ames Mutagenicity in 1,4 Michael Acceptors
Assessing the safety of new chemicals, without introducing the need for animal testing, is a task of great importance. The Ames test, a widely used bioassay to assess mutagenicity, can be an expensive, wasteful process with...
Observation by NMR of cationic Wheland-like intermediates in the deiodination of protected 1-iodo-naphthalene-2,4-diamines in acidic media
1-Iodonaphthalene-2,4-diamines in trifluoroacetic acid / chloroform give stable Wheland-like tetrahedral cationic species observable by NMR, through an initial intramolecular protonation. Dynamic equilibria allow...
Eliminating Transition State Calculations for Faster and More Accurate Reactivity Prediction in Sulfa-Michael Additions Relevant to Human Health and the Environment
Fast and accurate computational approaches to predicting reactivity in sulfa-Michael additions are required for high-throughput screening in toxicology (e.g., predicting excess aquatic toxicity and skin sensitization), chemical...
Observation by NMR of cationic Wheland-like intermediates in the deiodination of protected 1-iodo-naphthalene-2,4-diamines in acidic media
1-Iodonaphthalene-2,4-diamines in trifluoroacetic acid / chloroform give stable Wheland-like tetrahedral cationic species observable by NMR, through an initial intramolecular protonation. Dynamic equilibria allow...
Isolation, identification and quantitation of hydroxycinnamic acid conjugates, potential platform chemicals, in the leaves and stems of Miscanthus x giganteus using LC-ESI-MS(n)
Miscanthus x giganteus is a source of platform chemicals and bioethanol through fermentation. Cinnamates in leaves and stems were analysed by LC-ESI-MS(n). Free phenols were extracted and separated chromatographically. More than...
S-2-Amino-4-cyanobutanoic acid (β-cyanomethyl-L-Ala) as an atom-efficient solubilising synthon for L-glutamine
Glutamine (Gln) is often a difficult amino acid to incorporate during solution-phase peptide synthesis, owing to poor solubility and unwanted dehydrations as side-reactions. Current approaches to solving these problems are...
Structure-based design, synthesis and evaluation <em>in vitro</em> of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases
Katerina Kumpan, Amit Nathubhai, Chenlu Zhang, Pauline J. Wood, Matthew D. Lloyd, Andrew S. Thompson, Teemu Haikarainen, Lari Lehtio, Michael D. Threadgill
Jul 01, 2015
The tankyrases are members of the PARP superfamily; they poly(ADP-ribosyl)ate their target proteins using NAD+ as a source of electrophilic ADP-ribosyl units. The three principal protein substrates of the tankyrases...
Potential sources of high value chemicals from leaves, stems and flowers of <em>Miscanthus sinensis</em> 'Goliath' and <em>Miscanthus sacchariflorus</em>
Ifat Parveen, Thomas Wilson, Iain Donnison, A.R. Cookson, Barbara Hauck, Michael Threadgill
Jan 01, 0001
Society demands chemicals from sustainable sources. Identification of commercially important chemicals in crops increases value in biorefineries and reduces reliance on petrochemicals. Miscanthus sinensis...
Brexit and the Anglosphere
Brexit supporters often point to Anglophone countries as an obvious replacement for the UK’s relationship with the European Union. But where did this idea of an Anglosphere come from? And how significant is it? Michael Kenny and...
S-2-Amino-4-cyanobutanoic acid (β-cyanomethyl-L-Ala) as an atom-efficient solubilising synthon for L-glutamine
Glutamine (Gln) is often a difficult amino acid to incorporate during solution-phase peptide synthesis, owing to poor solubility and unwanted dehydrations as side-reactions. Current approaches to solving these problems are...
Brexit and the Anglosphere
Brexit supporters often point to Anglophone countries as an obvious replacement for the UK’s relationship with the European Union. But where did this idea of an Anglosphere come from? And how significant is it? Michael Kenny and...
The Ursinus College Investment Management Company Newsletter, Fall 2022
Inside this issue:
At a Glance
Letter from Jessica Gutekunst '23
Letter from Michael Magargee '23
Investment Team Strategies and Updates
UCIMCO Investment Performance and Analysis
Endowment Outlook
Stock Selection Picks
Women's...
UCIMCO Endowment portfolio management stock selection Investment performance Ursinus College Business Finance and Financial Management Portfolio and Security Analysis
Published by: Ursinus College
Eliminating Transition State Calculations for Faster and More Accurate Reactivity Prediction in Sulfa-Michael Additions Relevant to Human Health and the Environment
Fast and accurate computational approaches to predicting reactivity in sulfa-Michael additions are required for high-throughput screening in toxicology (e.g., predicting excess aquatic toxicity and skin sensitization), chemical...
Seeking the Wealth of Self
Michael George
Mar 16, 2022
Michael George teaches Religion and Culture, and Ethics at St. Thomas University in Fredericton, New Brunswick. He is interested in helping to promote the project of Integrative Bioethics, which he considers to be a possible...
Published by: Memorial University of Newfoundland
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