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THE DICTIONARY OF NEWFOUNDLAND ENGLISH
Jeff A. Webb
Jan 09, 2014
IN THE FALL OF 1982 the Dictionary of Newfoundland English (DNE) arrived in bookshops. It was the culmination of about 30 years of effort on the part of George Story, William Kirwin and John Widdowson, and was the greatest...
G-Quadruplexes
Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention...
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THE DICTIONARY OF NEWFOUNDLAND ENGLISH
Jeff A. Webb
Jan 09, 2014
IN THE FALL OF 1982 the Dictionary of Newfoundland English (DNE) arrived in bookshops. It was the culmination of about 30 years of effort on the part of George Story, William Kirwin and John Widdowson, and was the greatest...
Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
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RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia.
In hypoxic stress conditions, glycolysis enzymes assemble into singular cytoplasmic granules called glycolytic (G) bodies. G body formation in yeast correlates with increased glucose consumption and cell survival. However, the...
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Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
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Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor.
Theoretical models of G protein-coupled receptor (GPCR) concentration-response relationships often assume an agonist producing a single functional response via a single active state of the receptor. These models have largely...
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Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders

The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...

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Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders

The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...

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The Given: Experience and Its Content, by Michelle Montague. Oxford: Oxford University Press, 2016, xii + 250 pp. ISBN 13
Ori Beck
Oct 10, 2018
Michelle Montague's The Given invites us to rethink what mental content is. Rather than accept a traditional notion of mental content—on which unconscious mental states (i.e., mental states that lack phenomenal character) can...
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Single-cell sequencing of genomic DNA resolves sub-clonal heterogeneity in a melanoma cell line
Abstract: We performed shallow single-cell sequencing of genomic DNA across 1475 cells from a cell-line, COLO829, to resolve overall complexity and clonality. This melanoma tumor-line has been previously characterized by...
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