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Escherichia coli Heat-Labile Enterotoxin B Limits T Cells Activation by Promoting Immature Dendritic Cells and Enhancing Regulatory T Cell Function.
Treatments to limit T cell activation are essential for managing autoimmune and inflammatory disorders. The B subunit of Escherichia coli heat-labile enterotoxin (EtxB) is known to ameliorate inflammatory disease in vivo but the...
Dendritic cells freshly isolated from human blood express CD4 and mature into typical immtmostimulatory dendritic cells after culture in monocyte-conditioned medium
A procedure has been developed to isolate dendritic cells to a high degree of purity from fresh blood. Prior enrichment methods have relied upon an initial 1-2-d culture period. Purified fresh isolates lack the characteristic...
Published by: Rockefeller University
B-hadron production in NNLO QCD
We calculate, for the first time, the NNLO QCD corrections to identified
heavy hadron production at hadron colliders. The calculation is based on a
flexible numeric framework which allows the calculation of any distribution of
a...
Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells.
Meryem Aloulou, Edward J Carr, Mylène Gador, Alexandre Bignon, Roland S Liblau, Nicolas Fazilleau, Michelle A Linterman
Jun 24, 2019
T follicular regulatory (Tfr) cells are a subset of Foxp3(+) regulatory T (Treg) cells that form in response to immunization or infection, which localize to the germinal centre where they control the magnitude of the response....
Mice Deficient in Nucleoporin Nup210 Develop Peripheral T Cell Alterations.
Annemarie van Nieuwenhuijze, Oliver Burton, Pierre Lemaitre, Alice E Denton, Ana Cascalho, Rose E Goodchild, Bert Malengier-Devlies, Bénédicte Cauwe, Michelle A Linterman, Stephanie Humblet-Baron, Adrian Liston
Jun 14, 2019
The nucleopore is an essential structure of the eukaryotic cell, regulating passage between the nucleus and cytoplasm. While individual functions of core nucleopore proteins have been identified, the role of other components...
CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Nup210 nucleopore Spleen Thymus Gland Animals CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Female Homeostasis Male Mice Mice Inbred C57BL Mice Knockout Mice Mutant Strains Mutation Nuclear Pore Nuclear Pore Complex Proteins statistics Nonparametric Th1 Cells Th2 Cells Thymocytes Thymus Gland
Restriction endonuclease TseI cleaves A:A and T
Long Ma, Kai Chen, David J Clarke, Christopher P Nortcliffe, Geoffrey G Wilson, J Michael Edwardson, A Jennifer Morton, Anita C Jones, David TF Dryden
Feb 13, 2020
The type II restriction endonuclease TseI recognizes the DNA target sequence 5'-G^CWGC-3' (where W = A or T) and cleaves after the first G to produce fragments with three-base 5'-overhangs. We have determined that it is a...
Can follicular helper T cells be targeted to improve vaccine efficacy?
The success of most vaccines relies on the generation of antibodies to provide protection against subsequent infection; this in turn depends on a robust germinal centre (GC) response that culminates in the production of...
Interview with Booker T. Brown - OH 689
This interview was conducted by Dr. George Garrison with Booker T. Brown with a focus on the History of Emmett Scott High School. Emmett Scott was the segregated high school for African-Americans, which was named after Emmett...
Published by: Winthrop University
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4 + T Cells
Daisy H. Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T. Hawkins, Len R. Stephens, Simon T. Barry, Klaus Okkenhaug
Mar 22, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells.
Daisy H Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T Hawkins, Len R Stephens, Simon T Barry, Klaus Okkenhaug
Feb 03, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
CD4-Positive T-Lymphocytes Animals Mice Inbred C57BL Mice Multiprotein Complexes Receptors Antigen T-Cell Interleukin-2 Lymphocyte Activation Specific Pathogen-Free Organisms Signal Transduction Cell Differentiation Gene Knockout Techniques Class I Phosphatidylinositol 3-Kinases CRISPR-Cas Systems Gene Editing
Extracellular Lactate
James T Grist, Lorna B Jarvis, Zoya Georgieva, Sara Thompson, Harpreet Kaur Sandhu, Keith Burling, Ashley Clarke, Sarah Jackson, Mark Wills, Ferdia A Gallagher, Joanne L Jones
Feb 23, 2018
Following activation, T cells rapidly divide and acquire effector functions. This energetically demanding process depends upon the ability of T cells to undergo metabolic remodeling from oxidative phosphorylation to aerobic...
T Lymphocytes in Histiocytic Sarcomas of Flat-Coated Retriever Dogs.
Flat-Coated Retriever dogs are predisposed to the development of histiocytic sarcoma (HS), a poorly differentiated, highly malignant neoplasm. The authors have previously documented a significant lymphocytic infiltrate in such...
The Grizzly, February 7, 1995
Marc Ellman, Mark Leiser, Jayson Blocksidge, Michelle Ryan, Phil Caiazzo, Amy K. Davenport, Tarik Qasim, Nicole D'orsaneo, Michael A. Pizzi, Doug Plitt, Fred Klee, Joel Schofer, Ellen Cosgrove, Charlie Weingroff
Jan 01, 0001
Faculty and Administrators Focus on Sophomore Concerns Survey of Ursinus Freshmen Voice of Ursinus Rings Clear Border Dispute Between Ecuador and Peru Tabby Buckingham Dies at 16 Ursinus Students Attend March for Life ...
Ursinus College Collegeville Pennsylvania newspaper gymnastics Basketball Swimming Bridget Cauley Ellen Cosgrove campus security WVOU radio station Abortion Tabby Buckingham Michelle Ryan CIRP Sophomore Week cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
The Calcineurin Inhibitor Tacrolimus Specifically Suppresses Human T Follicular Helper Cells.
BACKGROUND: T follicular helper (Tfh) cells are key players in the production of antibody-producing B cells via the germinal center reaction. Therapeutic strategies targeting Tfh cells are important where antibody formation is...
T follicular helper cells T follicular regulatory cells germinal centers immunosuppression Transplantation Immunology Adult Aged Antibody Formation B-Lymphocytes Calcineurin Inhibitors Cell Differentiation Cytokines Female Germinal Center Graft Rejection Humans Immunosuppressive Agents Kidney Transplantation Lymphocyte Activation Male Middle Aged T-Lymphocytes Helper-Inducer T-Lymphocytes Regulatory Tacrolimus Transplant Recipients
Relative Frequencies of Alloantigen-Specific Helper CD4 T Cells and B Cells Determine Mode of Antibody-Mediated Allograft Rejection.
Jawaher Alsughayyir, Manu Chhabra, M Saeed Qureshi, Mekhola Mallik, Jason M Ali, Ivonne Gamper, Ellen L Moseley, Sarah Peacock, Vasilis Kosmoliaptsis, Martin J Goddard, Michelle A Linterman, Reza Motallebzadeh, Gavin J Pettigrew
Feb 12, 2019
Humoral alloimmunity is now recognized as a major determinant of transplant outcome. MHC glycoprotein is considered a typical T-dependent antigen, but the nature of the T cell alloresponse that underpins alloantibody generation...
allograft extrafollicular B cell response germinal center (GC) humoral alloimmunity Transplantation vasculopathy Adoptive Transfer Allografts Animals B-Lymphocytes DNA-Binding Proteins Disease Models Animal Disease Progression Graft Rejection Heart Transplantation Humans Isoantibodies Isoantigens Lymphocyte Count Mice Mice Inbred BALB C Mice Inbred C57BL Mice Knockout Myocardium Receptors Antigen T-Cell alpha-beta Signaling Lymphocytic Activation Molecule Associated Protein T-Lymphocytes Helper-Inducer Transplantation Homologous
Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ.
Louise MC Webb, Sigrid Fra-Bido, Silvia Innocentin, Louise S Matheson, Noudjoud Attaf, Alexandre Bignon, Julien Novarino, Nicolas Fazilleau, Michelle A Linterman
Mar 01, 2021
Ageing profoundly changes our immune system and is thought to be a driving factor in the morbidity and mortality associated with infectious disease in older people. We have previously shown that the impaired immunity to...
High fidelity analysis to predict failure in T-joints
Composite T-joints and similar skin-stiffener joints have a central role in aerospace structures. However, their accurate numerical analysis is still a great challenge due to their complex geometry and stress state during...
The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling.
Donald T Gracias, Erietta Stelekati, Jennifer L Hope, Alina C Boesteanu, Travis A Doering, Jillian Norton, Yvonne M Mueller, Joseph A Fraietta, E John Wherry, Martin Turner, Peter D Katsikis
Aug 14, 2019
We found upregulation of expression of the microRNA miR-155 in primary effector and effector memory CD8(+) T cells, but low miR-155 expression in naive and central memory cells. Antiviral CD8(+) T cell responses and viral...
Animals CD8-Positive T-Lymphocytes Cell Proliferation Flow Cytometry Gene Expression Profiling Gene Regulatory Networks Immunoblotting Immunologic Memory Interferon Regulatory Factor-7 Interferons Mice Mice Inbred C57BL Mice Knockout MicroRNAs Oligonucleotide Array Sequence Analysis Orthomyxoviridae Orthomyxoviridae Infections RNA Interference Reverse Transcriptase Polymerase Chain Reaction STAT1 Transcription Factor Signal Transduction Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling Proteins
High fidelity analysis to predict failure in T-joints
Composite T-joints and similar skin-stiffener joints have a central role in aerospace structures. However, their accurate numerical analysis is still a great challenge due to their complex geometry and stress state during...
An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression.
Asis Palazon, Petros A Tyrakis, David Macias, Pedro Veliça, Helene Rundqvist, Susan Fitzpatrick, Nikola Vojnovic, Anthony T Phan, Niklas Loman, Ingrid Hedenfalk, Thomas Hatschek, John Lövrot, Theodoros Foukakis, Ananda W Goldrath, Jonas Bergh, Randall S Johnson
May 31, 2018
Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during adaptation to the hypoxic tumor microenvironment. Deletion analyses of the two key HIF isoforms found that HIF-1α, but not HIF-2α, was...
HIF transcription factors VEGF angiogenesis cytotoxic T cells Hypoxia Immunotherapy Animals Breast Neoplasms CD8-Positive T-Lymphocytes Cell Line Tumor Cells Cultured Disease Progression Female Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Hypoxia-Inducible Factor 1 alpha Subunit Mice Inbred C57BL Mice Knockout Neoplasms Experimental Neovascularization Pathologic T-Lymphocytes Cytotoxic Vascular Endothelial Growth Factor A
Carcinomas assemble a filamentous CXCL12-keratin-19 coating that suppresses T cell-mediated immune attack.
Zhikai Wang, Philip Moresco, Ran Yan, Jiayun Li, Ya Gao, Daniele Biasci, Min Yao, Jordan Pearson, Jaclyn F Hechtman, Tobias Janowitz, Raza M Zaidi, Matthew J Weiss, Douglas T Fearon
Feb 20, 2022
Cancer immunotherapy frequently fails because most carcinomas have few T cells, suggesting that cancers can suppress T cell infiltration. Here, we show that cancer cells of human pancreatic ductal adenocarcinoma (PDA)...
The Given: Experience and Its Content, by Michelle Montague. Oxford: Oxford University Press, 2016, xii + 250 pp. ISBN 13
Ori Beck
Oct 10, 2018
Michelle Montague's The Given invites us to rethink what mental content is. Rather than accept a traditional notion of mental content—on which unconscious mental states (i.e., mental states that lack phenomenal character) can...
Does the PI3K pathway promote or antagonize regulatory T cell development and function?
Regulatory T cells (Tregs) prevent autoimmunity and inflammation by suppressing the activation of other T cells and antigen presenting cells. The role of phosphoinositide 3-kinase (PI3K) signaling in Treg is controversial. Some...
S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate.
Petros A Tyrakis, Asis Palazon, David Macias, Kian L Lee, Anthony T Phan, Pedro Veliça, Jia You, Grace S Chia, Jingwei Sim, Andrew Doedens, Alice Abelanet, Colin E Evans, John R Griffiths, Lorenz Poellinger, Ananda W Goldrath, Randall S Johnson
Dec 14, 2016
R-2-hydroxyglutarate accumulates to millimolar levels in cancer cells with gain-of-function isocitrate dehydrogenase 1/2 mutations. These levels of R-2-hydroxyglutarate affect 2-oxoglutarate-dependent dioxygenases. Both...
Animals CD8-Positive T-Lymphocytes Cell Differentiation DNA DNA Methylation Dioxygenases Glutarates Histones Homeostasis Hypoxia Hypoxia-Inducible Factor 1 alpha Subunit Ketoglutaric Acids Lymphocyte Activation Lysine Mice Oxygen Protein Stability Receptors Antigen T-Cell Von Hippel-Lindau Tumor Suppressor Protein
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