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Poets in the Classroom
About the Poets:
Laurie Ann Guerrero is the author of Tongue in the Mouth of the Dying (University of Notre Dame Press 2013) and A Crown for Gumecindo (Aztlan Libre Press 2015). Her latest collection, I Have Eaten the...
Published by: Digital Commons @ Texas A&M University-San Antonio
Poets in the Classroom
About the Poets:
Laurie Ann Guerrero is the author of Tongue in the Mouth of the Dying (University of Notre Dame Press 2013) and A Crown for Gumecindo (Aztlan Libre Press 2015). Her latest collection, I Have Eaten the...
Published by: Digital Commons @ Texas A&M University-San Antonio
Poets in the Classroom
About the Poets:
Laurie Ann Guerrero is the author of Tongue in the Mouth of the Dying (University of Notre Dame Press 2013) and A Crown for Gumecindo (Aztlan Libre Press 2015). Her latest collection, I Have Eaten the...
Published by: Digital Commons @ Texas A&M University-San Antonio
Mind the Gap
The way organelles are viewed by cell biologists is quickly changing. For many years, these cellular entities were thought to be unique and singular structures that performed specific roles. However, in recent decades...
Blocking dPerk in the intestine suppresses neurodegeneration in a Drosophila model of Parkinson's disease.
Rebeka Popovic, Amrita Mukherjee, Nuno Santos Leal, Lydia Morris, Yizhou Yu, Samantha H Y Loh, L Miguel Martins
Apr 17, 2023
Parkinson's disease (PD) is characterised by selective death of dopaminergic (DA) neurons in the midbrain and motor function impairment. Gastrointestinal issues often precede motor deficits in PD, indicating that the gut-brain...
Animals Drosophila Drosophila melanogaster Parkinson Disease Drosophila Proteins Unfolded Protein Response Protein Serine-Threonine Kinases
Published by: Cell Death & Disease
dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective.
Neurons rely on mitochondria as their preferred source of energy. Mutations in PINK1 and PARKIN cause neuronal death in early-onset Parkinson's disease (PD), thought to be due to mitochondrial dysfunction. In Drosophila pink1...
Activating Transcription Factor 4 Animals Drosophila Drosophila Proteins Folic Acid Glycine Hydroxymethyltransferase Methylenetetrahydrofolate Dehydrogenase (NADP) Mitochondria Mutagenesis Neuroprotection Parkinson Disease Phenotype Protein Serine-Threonine Kinases RNA Interference RNA Small Interfering Ubiquitin-Protein Ligases Up-Regulation
Paracetamol Is Associated with a Lower Risk of COVID-19 Infection and Decreased ACE2 Protein Expression
Ibuprofen is a common over-the-counter drug taken for pain relief. However, recent studies have raised concerns about its potential toxic effect with coronavirus disease 2019 (COVID-19), which is caused by severe acute...
Alzheimer’s and Parkinson’s Diseases Predict Different COVID-19 Outcomes
In December 2019, a coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), began infecting humans, causing a novel disease, coronavirus disease 19 (COVID-19). This was first described in the Wuhan province of...
Parp mutations protect from mitochondrial toxicity in Alzheimer’s disease
Abstract: Alzheimer’s disease is the most common age-related neurodegenerative disorder. Familial forms of Alzheimer’s disease associated with the accumulation of a toxic form of amyloid-β (Aβ) peptides are linked to...
Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin.
Juan Garrido-Maraver, Ivana Celardo, Ana C Costa, Susann Lehmann, Samantha HY Loh, L Miguel Martins
Feb 27, 2019
Parp mutations protect from mitochondrial toxicity in Alzheimer's disease.
Alzheimer's disease is the most common age-related neurodegenerative disorder. Familial forms of Alzheimer's disease associated with the accumulation of a toxic form of amyloid-β (Aβ) peptides are linked to mitochondrial...
Published by: Cell Death & Disease
Parp mutations protect from mitochondrial toxicity in Alzheimer's disease.
Alzheimer's disease is the most common age-related neurodegenerative disorder. Familial forms of Alzheimer's disease associated with the accumulation of a toxic form of amyloid-β (Aβ) peptides are linked to mitochondrial...
Alzheimer Disease Amyloid beta-Peptides Animals Animals Genetically Modified Behavior Animal Disease Models Animal Drosophila Proteins Drosophila melanogaster Humans Metabolome Metabolomics Mitochondria Motor Activity Mutation NAD Nerve Degeneration Neurons Niacinamide Poly (ADP-Ribose) Polymerase-1 Polymorphism Single Nucleotide
Mitochondrial complex I derived ROS regulate stress adaptation in Drosophila melanogaster.
Filippo Scialò, Ashwin Sriram, Rhoda Stefanatos, Ruth V Spriggs, Samantha HY Loh, L Miguel Martins, Alberto Sanz
Feb 26, 2021
Reactive Oxygen Species (ROS) are essential cellular messengers required for cellular homeostasis and regulate the lifespan of several animal species. The main site of ROS production is the mitochondrion, and within it...
Alzheimer's and Parkinson's Diseases Predict Different COVID-19 Outcomes
In December 2019, a coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), began infecting humans, causing a novel disease, coronavirus disease 19 (COVID-19). This was first described in the Wuhan province of...
Combined Transcriptomic and Proteomic Analysis of Perk Toxicity Pathways
Rebeka Popovic, Ivana Celardo, Yizhou Yu, Ana C. Costa, Samantha H. Y. Loh, L. Miguel Martins
Apr 29, 2021
In Drosophila, endoplasmic reticulum (ER) stress activates the protein kinase R-like endoplasmic reticulum kinase (dPerk). dPerk can also be activated by defective mitochondria in fly models of Parkinson’s disease caused by...
Parp mutations protect from mitochondrial toxicity in Alzheimer’s disease
Abstract: Alzheimer’s disease is the most common age-related neurodegenerative disorder. Familial forms of Alzheimer’s disease associated with the accumulation of a toxic form of amyloid-β (Aβ) peptides are linked to...
Early detection of pre-malignant lesions in a KRASG12D-driven mouse lung cancer model by monitoring circulating free DNA.
Callum P Rakhit, Ricky M Trigg, John Le Quesne, Michael Kelly, Jacqueline A Shaw, Catrin Pritchard, L Miguel Martins
Feb 07, 2019
Circulating free DNA Early detection KRASG12D Lung adenocarcinoma mouse model cfDNA Alleles Animals Cell-Free Nucleic Acids Disease Models Animal Early Detection of Cancer Female Integrases Lung Neoplasms Male Mice Inbred C57BL Mutation Precancerous Conditions Proto-Oncogene Proteins p21(ras) Recombination Genetic Reproducibility of Results Tumor Burden X-Ray Microtomography
Links between air pollution and COVID-19 in England.
Marco Travaglio, Yizhou Yu, Rebeka Popovic, Liza Selley, Nuno Santos Leal, Luis Miguel Martins
Feb 26, 2021
In December 2019, a novel disease, coronavirus disease 19 (COVID-19), emerged in Wuhan, People's Republic of China. COVID-19 is caused by a novel coronavirus (SARS-CoV-2) presumed to have jumped species from another mammal to...
Increased cysteine metabolism in PINK1 models of Parkinson's disease.
Marco Travaglio, Filippos Michopoulos, Yizhou Yu, Rebeka Popovic, Edmund Foster, Muireann Coen, L Miguel Martins
Jan 25, 2023
Parp mutations protect from mitochondrial toxicity in Alzheimer’s disease
Abstract: Alzheimer’s disease is the most common age-related neurodegenerative disorder. Familial forms of Alzheimer’s disease associated with the accumulation of a toxic form of amyloid-β (Aβ) peptides are linked to...
Combined Transcriptomic and Proteomic Analysis of Perk Toxicity Pathways.
Rebeka Popovic, Ivana Celardo, Yizhou Yu, Ana C Costa, Samantha HY Loh, L Miguel Martins
Jul 20, 2021
In Drosophila, endoplasmic reticulum (ER) stress activates the protein kinase R-like endoplasmic reticulum kinase (dPerk). dPerk can also be activated by defective mitochondria in fly models of Parkinson's disease caused by...
Drosophila Drosophila protein kinase RNA (PKR)-like ER kinase (dPerk) ER stress activating transcription factor 4 (ATF4) Unfolded Protein Response Activating Transcription Factor 4 Animals Cell Cycle Proteins Computational Biology Drosophila Proteins Drosophila melanogaster Endoplasmic Reticulum Endoplasmic reticulum stress Eukaryotic Initiation Factor-2 HEAT-SHOCK PROTEINS Mitochondria Neurodegenerative Diseases Phosphorylation Protein Processing Post-Translational Protein Serine-Threonine Kinases Proteomics Signal Transduction Transcription Factors Transcriptome Ubiquitin-Protein Ligases Unfolded Protein Response eIF-2 Kinase
Novel PLCG2 Mutation in a Patient With APLAID and Cutis Laxa.
João Farela Neves, Rainer Doffinger, Gabriela Barcena-Morales, Catarina Martins, Olivier Papapietro, Vincent Plagnol, James Curtis, Marta Martins, Dinakantha Kumararatne, Ana Isabel Cordeiro, Conceição Neves, Luis Miguel Borrego, Matilda Katan, Sergey Nejentsev
Jan 09, 2019
Background: The auto-inflammation and phospholipase Cγ2 (PLCγ2)-associated antibody deficiency and immune dysregulation (APLAID) syndrome is a rare primary immunodeficiency caused by a gain-of-function mutation S707Y in the...
APLAID IL-10 IL-1b PLCγ2 auto-inflammatory syndromes cutis laxa sensorineural deafness Amino Acid Sequence Base Sequence Cutis Laxa DNA Mutational Analysis Female Hereditary Autoinflammatory Diseases Humans Immunologic Deficiency Syndromes Infant Newborn Inflammatory Bowel Diseases Male Mutation Missense Pedigree Phospholipase C gamma Sequence Homology Amino Acid
ATR and CDK4/6 inhibition target the growth of methotrexate-resistant choriocarcinoma
Gold nanoparticles functionalised with fast water exchanging Gd3+ chelates
Miguel F Ferreira, Janaina Gonçalves, Bibimaryam Mousavi, Maria IM Prata, Sérgio PJ Rodrigues, Daniel Calle, Pilar López-Larrubia, Sebastian Cerdan, Tiago B Rodrigues, Paula M Ferreira, Lothar Helm, José A Martins, Carlos FGC Geraldes
Jul 02, 2015
ATR and CDK4/6 inhibition target the growth of methotrexate-resistant choriocarcinoma.
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