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Results: 164
C. elegans genome-wide analysis reveals DNA repair pathways that act cooperatively to preserve genome integrity upon ionizing radiation.
Bettina Meier, Nadezda V Volkova, Bin Wang, Víctor González-Huici, Simone Bertolini, Peter J Campbell, Moritz Gerstung, Anton Gartner
Nov 06, 2021
Ionizing radiation (IR) is widely used in cancer therapy and accidental or environmental exposure is a major concern. However, little is known about the genome-wide effects IR exerts on germ cells and the relative contribution...
C. elegans genome-wide analysis reveals DNA repair pathways that act cooperatively to preserve genome integrity upon ionizing radiation
Bettina Meier, Nadezda V. Volkova, Bin Wang, Víctor González-Huici, Simone Bertolini, Peter J. Campbell, Moritz Gerstung, Anton Gartner
Oct 06, 2021
Ionizing radiation (IR) is widely used in cancer therapy and accidental or environmental exposure is a major concern. However, little is known about the genome-wide effects IR exerts on germ cells and the relative contribution...
p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition.
p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition.
Kasumi Murai, Stefan Dentro, Swee Hoe Ong, Roshan Sood, David Fernandez-Antoran, Albert Herms, Vasiliki Kostiou, Irina Abnizova, Benjamin A Hall, Moritz Gerstung, Philip H Jones
Nov 20, 2022
Aging normal human oesophagus accumulates TP53 mutant clones. These are the origin of most oesophageal squamous carcinomas, in which biallelic TP53 disruption is almost universal. However, how p53 mutant clones expand and...
Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth.
Emilie Abby, Stefan C Dentro, Michael WJ Hall, Joanna C Fowler, Swee Hoe Ong, Roshan Sood, Albert Herms, Gabriel Piedrafita, Irina Abnizova, Christian W Siebel, Moritz Gerstung, Benjamin A Hall, Philip H Jones
Feb 19, 2023
NOTCH1 mutant clones occupy the majority of normal human esophagus by middle age but are comparatively rare in esophageal cancers, suggesting NOTCH1 mutations drive clonal expansion but impede carcinogenesis. Here we test this...
Protection of the C. elegans germ cell genome depends on diverse DNA repair pathways during normal proliferation.
Bettina Meier, Nadezda V Volkova, Ye Hong, Simone Bertolini, Víctor González-Huici, Tsvetana Petrova, Simon Boulton, Peter J Campbell, Moritz Gerstung, Anton Gartner
Apr 27, 2021
Maintaining genome integrity is particularly important in germ cells to ensure faithful transmission of genetic information across generations. Here we systematically describe germ cell mutagenesis in wild-type and 61 DNA repair...
Animals Caenorhabditis elegans Caenorhabditis elegans Proteins Cell Proliferation Chromosome Mapping DNA Damage DNA Helicases DNA Repair DNA Replication DNA Helminth DNA-Directed DNA Polymerase Deoxyribonucleases Endonucleases Gene Expression Regulation Genome Helminth Germ Cells Isoenzymes Mutation Rad51 Recombinase
Mutational signatures are jointly shaped by DNA damage and repair
Nadezda V. Volkova, Bettina Meier, Víctor González-Huici, Simone Bertolini, Santiago Gonzalez, Harald Vöhringer, Federico Abascal, Iñigo Martincorena, Peter J. Campbell, Anton Gartner, Moritz Gerstung
Dec 22, 2020
Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth.
Emilie Abby, Stefan C Dentro, Michael WJ Hall, Joanna C Fowler, Swee Hoe Ong, Roshan Sood, Albert Herms, Gabriel Piedrafita, Irina Abnizova, Christian W Siebel, Moritz Gerstung, Benjamin A Hall, Philip H Jones
Feb 16, 2023
NOTCH1 mutant clones occupy the majority of normal human esophagus by middle age but are comparatively rare in esophageal cancers, suggesting NOTCH1 mutations drive clonal expansion but impede carcinogenesis. Here we test this...
Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies.
Daniel Sasca, Haiyang Yun, George Giotopoulos, Jakub Szybinski, Theo Evan, Nicola K Wilson, Moritz Gerstung, Paolo Gallipoli, Anthony R Green, Robert Hills, Nigel Russell, Cameron S Osborne, Elli Papaemmanuil, Berthold Göttgens, Peter Campbell, Brian JP Huntly
Oct 03, 2019
Cohesin complex disruption alters gene expression, and cohesin mutations are common in myeloid neoplasia, suggesting a critical role in hematopoiesis. Here, we explore cohesin dynamics and regulation of hematopoietic stem cell...
Biomarkers Tumor Cell Cycle Proteins Cell Line Tumor Chromosomal Proteins Non-Histone Female Gene Dosage Gene Expression Regulation Leukemic Hematopoietic Stem Cells Histones Humans Male Mutation Myeloproliferative Disorders Neoplasm Grading Protein Binding Proto-Oncogene Proteins c-ets Regulatory Sequences Nucleic Acid Repressor Proteins
Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium.
Bartomeu Colom, Maria P Alcolea, Gabriel Piedrafita, Michael WJ Hall, Agnieszka Wabik, Stefan C Dentro, Joanna C Fowler, Albert Herms, Charlotte King, Swee Hoe Ong, Roshan K Sood, Moritz Gerstung, Inigo Martincorena, Benjamin A Hall, Philip H Jones
Apr 28, 2020
ADAM10 Protein Amyloid Precursor Protein Secretases Animals Cell Lineage Diethylnitrosamine Epithelium esophagus Female High-Throughput Nucleotide Sequencing Male Membrane Proteins Mice Inbred C57BL Mice Transgenic Mutation Receptor Notch1 Receptor Notch2 Reproducibility of Results Tumor Suppressor Protein p53
Evolution of Initiation Rites During the Austronesian Dispersal
As adaptive systems, kinship and its accompanying rules have co-evolved with elements of complex societies, including wealth inheritance, subsistence, and power relations. Here we consider an aspect of kinship evolution in the...
Published by: Digital Commons @ Texas A&M University-San Antonio
Evolution of Initiation Rites During the Austronesian Dispersal
As adaptive systems, kinship and its accompanying rules have co-evolved with elements of complex societies, including wealth inheritance, subsistence, and power relations. Here we consider an aspect of kinship evolution in the...
Published by: Digital Commons @ Texas A&M University-San Antonio
The longitudinal dynamics and natural history of clonal haematopoiesis.
Margarete A Fabre, José Guilherme de Almeida, Edoardo Fiorillo, Emily Mitchell, Aristi Damaskou, Justyna Rak, Valeria Orrù, Michele Marongiu, Michael Spencer Chapman, MS Vijayabaskar, Joanna Baxter, Claire Hardy, Federico Abascal, Nicholas Williams, Jyoti Nangalia, Iñigo Martincorena, Peter J Campbell, Eoin F McKinney, Francesco Cucca, Moritz Gerstung, George S Vassiliou
Jul 02, 2022
Identification of prognostic phenotypes of esophageal adenocarcinoma in two independent cohorts.
Tarek Sawas, Sarah Killcoyne, Prasad G Iyer, Kenneth K Wang, Thomas C Smyrk, John B Kisiel, Yi Qin, David A Ahlquist, Anil K Rustgi, OCCAMS consortium, Rui J Costa, Moritz Gerstung, Rebecca C Fitzgerald, David A Katzka
Nov 23, 2018
BACKGROUND & AIMS: Most patients with esophageal adenocarcinoma (EAC) present de novo. Although this may be due to inadequate screening strategies, the precise reason for this observation is not clear.. We compared survival of...
Evolution of Initiation Rites During the Austronesian Dispersal
As adaptive systems, kinship and its accompanying rules have co-evolved with elements of complex societies, including wealth inheritance, subsistence, and power relations. Here we consider an aspect of kinship evolution in the...
Published by: Digital Commons @ Texas A&M University-San Antonio
Selection of oncogenic mutant clones in normal human skin varies with body site.
Joanna C Fowler, Charlotte King, Christopher Bryant, Michael Hall, Roshan Sood, Swee Hoe Ong, Eleanor Earp, David Fernandez-Antoran, Jonas Koeppel, Stefan C Dentro, David Shorthouse, Amer Durrani, Kate Fife, Edward Rytina, Doreen Milne, Amit Roshan, Krishnaa Mahububani, Kourosh Saeb-Parsy, Benjamin A Hall, Moritz Gerstung, Philip H Jones
Oct 23, 2020
Skin cancer risk varies substantially across the body, yet how this relates to the mutations found in normal skin is unknown. Here we mapped mutant clones in skin from high and low risk sites. The density of mutations varied by...
The longitudinal dynamics and natural history of clonal haematopoiesis.
Margarete A Fabre, José Guilherme de Almeida, Edoardo Fiorillo, Emily Mitchell, Aristi Damaskou, Justyna Rak, Valeria Orrù, Michele Marongiu, Michael Spencer Chapman, MS Vijayabaskar, Joanna Baxter, Claire Hardy, Federico Abascal, Nicholas Williams, Jyoti Nangalia, Iñigo Martincorena, Peter J Campbell, Eoin F McKinney, Francesco Cucca, Moritz Gerstung, George Vassiliou
Jun 09, 2022
Clonal expansions driven by somatic mutations become pervasive across human tissues with age, including in the haematopoietic system, where the phenomenon is termed clonal haematopoiesis1-4. The understanding of how and when...
The longitudinal dynamics and natural history of clonal haematopoiesis.
Margarete A Fabre, José Guilherme de Almeida, Edoardo Fiorillo, Emily Mitchell, Aristi Damaskou, Justyna Rak, Valeria Orrù, Michele Marongiu, Michael Spencer Chapman, MS Vijayabaskar, Joanna Baxter, Claire Hardy, Federico Abascal, Nicholas Williams, Jyoti Nangalia, Iñigo Martincorena, Peter J Campbell, Eoin F McKinney, Francesco Cucca, Moritz Gerstung, George Vassiliou
Jun 08, 2022
Clonal expansions driven by somatic mutations become pervasive across human tissues with age, including in the haematopoietic system, where the phenomenon is termed clonal haematopoiesis1-4. The understanding of how and when...
The Ursinus Weekly, June 8, 1964
Craig S. Hill, Valerie Moritz, John Wirth, Candace Sprecher, Sally Campbell, Constance Laughlin
Jan 01, 0001
Dr. Sturgis retires from faculty after 40 years; Honored by alumni, Saturday 222 seniors receive degrees at Commencement today; Dr. John Ciardi addresses class and guests Dr. Roger Staiger given US patent Whitians select...
Ursinus College Collegeville Pennsylvania newspaper Russell D. Sturgis Placement Office John Ciardi Roger Staiger Whitians Alpha Phi Omega Summer Assembly Women's Athletic Association Paul R. Wagner Paul I. Guest student government commencement rules and customs Donald H. Fortnum fraternities sororities Walter W. Marsteller Campus Chest Memorial Library Wismer Hall Freeland Hall cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Targeting earlier diagnosis
Colin F Munro, Ratko Yurac, Zipser Carl Moritz, Michael G Fehlings, Ricardo Rodrigues-Pinto, James Milligan, Konstantinos Margetis, Mark RN Kotter, Benjamin M Davies
Mar 31, 2023
BACKGROUND: Degenerative cervical myelopathy (DCM) is a common and disabling condition. Early effective treatment is limited by late diagnosis. Conventional descriptions of DCM focus on motor and sensory limb disability...
Dissecting Synaptic Vesicle Endocytosis
Moritz Armbruster
Jan 01, 0001
Synaptic vesicle endocytosis is critical for ensuring rapid local recycling of synaptic vesicles to enable ongoing neuronal activity. We utilized the sensitivity and robustness of the pHluorin assay of synaptic vesicle recycling...
Published by: Rockefeller University
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