Search
Results: 294
Adjusting trial results for biases in meta-analysis
KM Rhodes, J Savović, R Elbers, HE Jones, JPT Higgins, JAC Sterne, NJ Welton, RM Turner
Jan 27, 2020
Flaws in the conduct of randomized trials can lead to biased estimation of the intervention effect. Methods for adjustment of within-trial biases in meta-analysis include the use of empirical evidence from an external collection...
Using Parameter Constraints to Choose State Structures in Cost-Effectiveness Modelling.
BACKGROUND: This article addresses the choice of state structure in a cost-effectiveness multi-state model. Key model outputs, such as treatment recommendations and prioritisation of future research, may be sensitive to state...
Recapture or precapture? Fallibility of standard capture-recapture methods in the presence of referrals between sources.
Hayley E Jones, Matthew Hickman, Nicky J Welton, Daniela De Angelis, Ross J Harris, AE Ades
Aug 16, 2018
Capture-recapture methods, largely developed in ecology, are now commonly used in epidemiology to adjust for incomplete registries and to estimate the size of difficult-to-reach populations such as problem drug users....
Bias log-linear models model selection parameter identifiability prevalence estimation problem drug use Bias Data Collection Data Interpretation Statistical England Epidemiologic Research Design Humans Linear Models Models Statistical Population Density Referral and Consultation Substance-Related Disorders
Multilevel and Quasi Monte Carlo Methods for the Calculation of the Expected Value of Partial Perfect Information.
Wei Fang, Zhenru Wang, Michael B Giles, Chris H Jackson, Nicky J Welton, Christophe Andrieu, Howard Thom
Jan 28, 2022
The expected value of partial perfect information (EVPPI) provides an upper bound on the value of collecting further evidence on a set of inputs to a cost-effectiveness decision model. Standard Monte Carlo estimation of EVPPI is...
Retromer and the cation-independent mannose 6-phosphate receptor-Time for a trial separation?
Matthew NJ Seaman
Feb 02, 2018
The retromer cargo-selective complex (CSC) comprising Vps35, Vps29 and Vps26 mediates the endosome-to-Golgi retrieval of the cation-independent mannose 6-phosphate receptor (CIMPR). Or does it? Recently published data have...
Hydrogel as a Medium for Fluid-Driven Fracture Study
In this paper we describe how to construct polyacrylamide hydrogels to study the processes linked with hydraulic fracturing. These transparent, linearly elastic and brittle gels permit fracturing at low pressures and speeds...
Efficient diode-pumped mid-infrared emission from acetylene-filled hollow-core fiber
We report 3.1-3.2 μm mid-infrared emission from acetylene-filled low loss antiresonant hollow-core fiber pumped with an amplified, modulated, narrowband, tunable 1.5 μm diode laser. The maximum power conversion efficiency of...
Radiofrequency properties of two different Licox® parenchymal brain tissue oxygen probe designs.
Ari Ercole
May 29, 2018
Neuroimaging and continuous multimodality neuromonitoring are both central to the intensive care management of patients with severe traumatic brain injury. Guidelines recommend the use of multimodality monitors including brain...
What is the optimal management of potentially resectable stage III-N2 NSCLC? Results of a fixed-effects network meta-analysis and economic modelling.
Matthew Evison, Ross Maconachie, Toby Mercer, Caitlin H Daly, Nicky J Welton, Shahzeena Aslam, Doug West, Neal Navani
Apr 17, 2023
INTRODUCTION: There is a critical need to understand the optimal treatment regimen in patients with potentially resectable stage III-N2 nonsmall cell lung cancer (NSCLC). METHODS: A systematic review of randomised controlled...
Using epidemiological principles to explain fungicide resistance management tactics
Whether fungicide resistance management is optimised by spraying chemicals with different modes of action as a mixture (i.e. simultaneously) or in alternation (i.e. sequentially) has been studied by experimenters and modellers...
Large-Scale Tectonic Forcing of the African Landscape
Abstract: Successful inverse modeling of observed longitudinal river profiles suggests that fluvial landscapes are responsive to continent‐wide tectonic forcing. However, inversion algorithms make simplifying assumptions about...
Illicit and pharmaceutical drug consumption estimated via wastewater analysis. Part B: Placing back-calculations in a formal statistical framework
Hayley E Jones, Matthew Hickman, Barbara Kasprzyk-Hordern, Nicky J . Welton, David R. Baker, A. E Ades
Jul 15, 2014
Concentrations of metabolites of illicit drugs in sewage water can be measured with great accuracy and precision, thanks to the development of sensitive and robust analytical methods. Based on assumptions about factors including...
Illicit and pharmaceutical drug consumption estimated via wastewater analysis. Part B: Placing back-calculations in a formal statistical framework
Hayley E Jones, Matthew Hickman, Barbara Kasprzyk-Hordern, Nicky J . Welton, David R. Baker, A. E Ades
Jul 15, 2014
Concentrations of metabolites of illicit drugs in sewage water can be measured with great accuracy and precision, thanks to the development of sensitive and robust analytical methods. Based on assumptions about factors including...
Evaluation of secondary spontaneous pneumothorax with multidetector CT.
The purpose of this article is to review the underlying causes of secondary pneumothoraces as observed on multidetector computed tomography (MDCT). Using examples from our institutional experience, we shall illustrate important...
Navigating the Controversies of Retromer-Mediated Endosomal Protein Sorting.
The retromer complex was first identified more than 20 years ago through studies conducted in the yeast Saccharomyces cerevisiae. Data obtained using many different model systems have revealed that retromer is a key component of...
Vertical Mixing and Heat Fluxes Conditioned by a Seismically Imaged Oceanic Front
The southwest Atlantic gyre connects several distinct water masses, which means that this oceanic region is characterized by a complex frontal system and enhanced water mass modification. Despite its significance, the...
Tm-doped fiber laser mode-locked by graphene-polymer composite.
M Zhang, EJR Kelleher, F Torrisi, Z Sun, T Hasan, D Popa, F Wang, AC Ferrari, SV Popov, JR Taylor
Sep 08, 2018
We demonstrate mode-locking of a thulium-doped fiber laser operating at 1.94 μm, using a graphene-polymer based saturable absorber. The laser outputs 3.6 ps pulses, with ~0.4 nJ energy and an amplitude fluctuation ~0.5%, at 6.46...
A new species of early Cambrian arthropod reconstructed from exceptionally preserved mandibles and associated small carbonaceous fossils (SCFs)
Abstract: Mandibulate arthropods (myriapods, hexapods and crustaceans) account for a major component of extant animal diversity but their origins remain unclear. Here, we re‐examine the record of exceptionally preserved...
Label-invariant models for the analysis of meta-epidemiological data.
Rich meta-epidemiological data sets have been collected to explore associations between intervention effect estimates and study-level characteristics. Welton et al proposed models for the analysis of meta-epidemiological data...
The Retromer Complex
Matthew NJ Seaman
Jan 12, 2021
The retromer complex has a well-established role in endosomal protein sorting, being necessary for maintaining the dynamic localisation of hundreds of membrane proteins that traverse the endocytic system. Retromer function and...
|
|< |
< |
1 |