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Murine Kupffer cells: mononuclear phagocytes deficient in the generation of reactive oxygen intermediates
Lepay, D.A., Nathan, C.F., Steinman, R.M., Murray, H.W., and Cohn, Z.A. Murine Kupffer cells: mononuclear phagocytes deficient in the generation of reactive oxygen intermediates. J. Exp. Med. 161: 1079-1096, 1985
Published by: The Rockefeller University Press
FCHO controls AP2’s initiating role in endocytosis through a PtdIns4,5P2 -dependent switch
David Owen, Nathan Zaccai, Zuzana Kadlecova, Veronica Kane Dickson, Kaufman Jonathan, Gray Sally, Kelly Bernard
Jun 07, 2022
Clathrin-mediated endocytosis (CME) is the main mechanism by which mammalian cells control their cell surface proteome. Proper operation of the pivotal CME cargo-adaptor AP2 requires membrane-localised FCHO. Here, live-cell...
Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD
Luke A. Perera, Steffen Preissler, Nathan R. Zaccai, Sylvain Prévost, Juliette M. Devos, Michael Haertlein, David Ron
Aug 18, 2021
Abstract: The endoplasmic reticulum (ER) Hsp70 chaperone BiP is regulated by AMPylation, a reversible inactivating post-translational modification. Both BiP AMPylation and deAMPylation are catalysed by a single ER-localised...
Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD.
Luke A Perera, Steffen Preissler, Nathan R Zaccai, Sylvain Prévost, Juliette M Devos, Michael Haertlein, David Ron
Jul 19, 2021
The endoplasmic reticulum (ER) Hsp70 chaperone BiP is regulated by AMPylation, a reversible inactivating post-translational modification. Both BiP AMPylation and deAMPylation are catalysed by a single ER-localised enzyme, FICD....
Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD.
Luke A Perera, Steffen Preissler, Nathan R Zaccai, Sylvain Prévost, Juliette M Devos, Michael Haertlein, David Ron
Sep 19, 2021
The endoplasmic reticulum (ER) Hsp70 chaperone BiP is regulated by AMPylation, a reversible inactivating post-translational modification. Both BiP AMPylation and deAMPylation are catalysed by a single ER-localised enzyme, FICD....
Humans Nucleotidyltransferases HEAT-SHOCK PROTEINS Membrane Proteins Adenosine Monophosphate Adenosine Triphosphate Protein Processing Post-Translational Amino Acid Motifs Dimerization Biocatalysis
Published by: Nature Communications
Contribution of the clathrin adaptor AP-1 subunit µ1 to acidic cluster protein sorting.
Paloma Navarro Negredo, James R Edgar, Antoni G Wrobel, Nathan R Zaccai, Robin Antrobus, David J Owen, Margaret S Robinson
Sep 11, 2018
Acidic clusters act as sorting signals for packaging cargo into clathrin-coated vesicles (CCVs), and also facilitate down-regulation of MHC-I by HIV-1 Nef. To find acidic cluster sorting machinery, we performed a gene-trap...
Adaptor Protein Complex 1 Adaptor Protein Complex mu Subunits CRISPR-Cas Systems Clathrin-Coated Vesicles Flow Cytometry Gene Knockdown Techniques Genotype HEK293 Cells HIV-1 HeLa Cells Histocompatibility Antigens Class I Host-Pathogen Interactions Humans Models Molecular Mutation Phenotype Protein Binding Protein Interaction Domains and Motifs Protein Transport Structure-Activity Relationship Time Factors Transfection nef Gene Products Human Immunodeficiency Virus
Outer membrane β-barrel protein folding is physically controlled by periplasmic lipid head groups and BamA.
Dennis Gessmann, Yong Hee Chung, Emily J Danoff, Ashlee M Plummer, Clifford W Sandlin, Nathan R Zaccai, Karen G Fleming
Jul 04, 2016
beta-barrel transmembrane protein membrane protein folding Bacterial Outer Membrane Proteins Biocatalysis Cell Membrane Escherichia coli Escherichia coli Proteins Kinetics Lipids Models Biological Periplasm Phenylalanine Phosphatidylethanolamines Phosphatidylglycerols Protein Folding Protein Structure Secondary
Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
A central cavity within the holo-translocon suggests a mechanism for membrane protein insertion.
Mathieu Botte, Nathan R Zaccai, Jelger Lycklama À Nijeholt, Remy Martin, Kèvin Knoops, Gabor Papai, Juan Zou, Aurélien Deniaud, Manikandan Karuppasamy, Qiyang Jiang, Abhishek Singha Roy, Klaus Schulten, Patrick Schultz, Juri Rappsilber, Giuseppe Zaccai, Imre Berger, Ian Collinson, Christiane Schaffitzel
Dec 01, 2017
The conserved SecYEG protein-conducting channel and the accessory proteins SecDF-YajC and YidC constitute the bacterial holo-translocon (HTL), capable of protein-secretion and membrane-protein insertion. By employing an...
Binding Sites Cloning Molecular Cryoelectron Microscopy Escherichia coli Escherichia coli Proteins Gene Expression Genetic Vectors Membrane Transport Proteins Methanocaldococcus Models Molecular neutron diffraction Protein Binding Protein Conformation alpha-Helical Protein Conformation beta-Strand Protein Interaction Domains and Motifs Protein Transport Recombinant Proteins SEC Translocation Channels SCATTERING Small Angle Structural Homology Protein Substrate Specificity Thermus thermophilus
Mechanism and evolution of the Zn-fingernail required for interaction of VARP with VPS29
Strikingly Different Roles of SARS-CoV-2 Fusion Peptides Uncovered by Neutron Scattering.
Mechanism and evolution of the Zn-fingernail required for interaction of VARP with VPS29
Mechanism and evolution of the Zn-fingernail required for interaction of VARP with VPS29.
Stable endocytic structures navigate the complex pellicle of apicomplexan parasites
Population-based neuropathological studies of dementia
BACKGROUND: Prospective population-based neuropathological studies have a special place in dementia research which is under emphasised. METHODS: A systematic review of the methods of population-based neuropathological studies of...
Archives Moving From Dacus Library and Will Reopen on Jan. 2
Winthrop University
Jan 01, 0001
Researchers, scholars, genealogists and others are expected to flock to the archives to pore over its contents, which number more than six million items. Some of the most popular draws will be the 5,000-year-old cuneiform...
Published by: Winthrop University
SIFE Team Declared as 2012 Charlotte Regional Champions
Winthrop University
Jan 01, 0001
This makes the eighth straight year that Winthrop's team has taken first place at regionals. Team members are Deja Frederick, a senior integrated marketing communication major; Kayla Dugger, a junior digital information design...
Published by: Winthrop University
Genetic approaches to understand cellular responses to oxygen availability.
Oxygen-sensing mechanisms have evolved to allow organisms to respond and adapt to oxygen availability. In metazoans, oxygen-sensing is predominantly mediated by the hypoxia inducible factors (HIFs). These transcription factors...
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