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How far can skills-talk take us?
Neil Kenny
Feb 02, 2018
In this article, Neil Kenny, Lead Fellow for Languages at the British Academy, argues that the broadened notion of skill proposed by a new British Academy project, The Right Skills, provides a framework for articulating more...
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G-Quadruplexes
Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention...
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THE CONCISE GUIDE TO PHARMACOLOGY 2017/18
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access...
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Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
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Berry–Esseen theorem and quantitative homogenization for the random conductance model with degenerate conductances
We study the random conductance model on the lattice $Z^d$, i.e. we consider a linear, finite-difference, divergence-form operator with random coefficients and the associated random walk under random conductances. We allow the...
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RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia.
In hypoxic stress conditions, glycolysis enzymes assemble into singular cytoplasmic granules called glycolytic (G) bodies. G body formation in yeast correlates with increased glucose consumption and cell survival. However, the...
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Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
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Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor.
Theoretical models of G protein-coupled receptor (GPCR) concentration-response relationships often assume an agonist producing a single functional response via a single active state of the receptor. These models have largely...
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Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders

The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...

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Correction to
The article "The effect of cationically modified phosphorylcholine polymers on human osteoblasts in vitro and their effect on bone formation in vivo", written by Jonathan M. Lawton, Mariam Habib, Bingkui Ma, Roger A. Brooks...
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Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders

The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...

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Parabolic induction for Springer fibres
Neil Saunders, Lewis Topley
Aug 01, 2023

Let G be a reductive group satisfying the standard hypotheses, with Lie algebra g. For each nilpotent orbit O 0 in a Levi subalgebra g 0 we can consider the induced orbit O defined by Lusztig and...

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Parabolic induction for Springer fibres
Neil Saunders, Lewis Topley
Aug 01, 2023

Let G be a reductive group satisfying the standard hypotheses, with Lie algebra g. For each nilpotent orbit O 0 in a Levi subalgebra g 0 we can consider the induced orbit O defined by Lusztig and...

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Secondary students’ values and perceptions of science-related careers
Abstract: There has been concern about the attractiveness of science-based careers to many adolescent learners, and it has been suggested that school science may not always recognise or engage personal values that are important...
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