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Results: 33
A Sphingosine 1-Phosphate Gradient Is Linked to the Cerebral Recruitment of T Helper and Regulatory T Helper Cells during Acute Ischemic Stroke.
Alexandra Lucaciu, Hannah Kuhn, Sandra Trautmann, Nerea Ferreirós, Helmuth Steinmetz, Josef Pfeilschifter, Robert Brunkhorst, Waltraud Pfeilschifter, Julien Subburayalu, Rajkumar Vutukuri
Aug 29, 2020
Emerging evidence suggests a complex relationship between sphingosine 1-phosphate (S1P) signaling and stroke. Here, we show the kinetics of S1P in the acute phase of ischemic stroke and highlight accompanying changes in immune...
Ceramides fingolimod regulatory T helper cells sphingosine 1-phosphate sphingosine 1-phosphate receptor sphingosine kinase stroke Animals Brain Disease Models Animal ischemic stroke Lysophospholipids Male Mice Mice Inbred C57BL Signal Transduction Sphingosine Sphingosine-1-Phosphate Receptors Spleen T-Lymphocytes Helper-Inducer T-Lymphocytes Regulatory
Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML.
Thomas Oellerich, Constanze Schneider, Dominique Thomas, Kirsten M Knecht, Olga Buzovetsky, Lars Kaderali, Christoph Schliemann, Hanibal Bohnenberger, Linus Angenendt, Wolfgang Hartmann, Eva Wardelmann, Tamara Rothenburger, Sebastian Mohr, Sebastian Scheich, Federico Comoglio, Anne Wilke, Philipp Ströbel, Hubert Serve, Martin Michaelis, Nerea Ferreirós, Gerd Geisslinger, Yong Xiong, Oliver T Keppler, Jindrich Cinatl
Aug 01, 2020
Hypomethylating agents decitabine and azacytidine are regarded as interchangeable in the treatment of acute myeloid leukemia (AML). However, their mechanisms of action remain incompletely understood, and predictive biomarkers...
Animals Antimetabolites Antineoplastic Azacitidine Biomarkers Tumor Bone Marrow Cell Line Tumor DNA Methylation Decitabine Drug Resistance Neoplasm Female Gene Expression Regulation Leukemic Humans Leukemia Myeloid Acute Mice Patient Selection Primary Cell Culture Retrospective Studies SAM Domain and HD Domain-Containing Protein 1 Treatment Outcome Xenograft Model Antitumor Assays
Zika Virus and Neuropathogenesis
Despite being perceived to be a relatively innocuous pathogen during its circulation in Africa in the 20th century, consequent outbreaks in French Polynesia and Latin America revealed the Zika virus (ZIKV) to be capable of...
Zika Virus and Neuropathogenesis
Despite being perceived to be a relatively innocuous pathogen during its circulation in Africa in the 20th century, consequent outbreaks in French Polynesia and Latin America revealed the Zika virus (ZIKV) to be capable of...
Conducting Polymer-Ionic Liquid Electrode Arrays for High-Density Surface Electromyography.
Santiago Velasco-Bosom, Nuzli Karam, Alejandro Carnicer-Lombarte, Johannes Gurke, Nerea Casado, Liliana C Tomé, David Mecerreyes, George G Malliaras
May 03, 2021
Surface electromyography (EMG) is used as a medical diagnostic and to control prosthetic limbs. Electrode arrays that provide large-area, high density recordings have the potential to yield significant improvements in both...
Conducting Polymer‐Ionic Liquid Electrode Arrays for High‐Density Surface Electromyography
Santiago Velasco‐Bosom, Nuzli Karam, Alejandro Carnicer‐Lombarte, Johannes Gurke, Nerea Casado, Liliana C. Tomé, David Mecerreyes, George G. Malliaras
May 20, 2021
Abstract: Surface electromyography (EMG) is used as a medical diagnostic and to control prosthetic limbs. Electrode arrays that provide large‐area, high density recordings have the potential to yield significant improvements in...
RESEARCH ARTICLE RESEARCH ARTICLES cutaneous electrophysiology Electromyography organic bioelectronics poly(3 4‐ethylenedioxythiophene) polystyrene sulfonate
Published by: Advanced Healthcare Materials
Liver organoids reproduce alpha-1 antitrypsin deficiency-related liver disease.
Gema Gómez-Mariano, Nerea Matamala, Selene Martínez, Iago Justo, Alberto Marcacuzco, Carlos Jimenez, Sara Monzón, Isabel Cuesta, Cristina Garfia, María Teresa Martínez, Meritxell Huch, Ignacio Pérez de Castro, Manuel Posada, Sabina Janciauskiene, Beatriz Martínez-Delgado
Dec 12, 2020
BACKGROUND AND AIMS: Alpha-1 antitrypsin (AAT) is a product of SERPINA1 gene mainly expressed by hepatocytes. Clinically relevant mutations in the SERPINA1 gene, such as Z (Glu342Lys), results in an expression of misfolded AAT...
Transcriptional and Translational Landscape of Equine Torovirus.
Hazel Stewart, Katherine Brown, Adam M Dinan, Nerea Irigoyen, Eric J Snijder, Andrew E Firth
Oct 10, 2018
The genus Torovirus (subfamily Torovirinae, family Coronaviridae, order Nidovirales) encompasses a range of species that infect domestic ungulates, including cattle, sheep, goats, pigs, and horses, causing an acute self-limiting...
Flickering nanometre-scale disorder in a crystal lattice tracked by plasmonic flare light emission.
Cloudy Carnegie, Mattin Urbieta, Rohit Chikkaraddy, Bart de Nijs, Jack Griffiths, William M Deacon, Marlous Kamp, Nerea Zabala, Javier Aizpurua, Jeremy J Baumberg
Dec 12, 2019
The dynamic restructuring of metal nanoparticle surfaces is known to greatly influence their catalytic, electronic transport, and chemical binding functionalities. Here we show for the first time that non-equilibrium...
Liver organoids reproduce alpha-1 antitrypsin deficiency-related liver disease
Gema Gómez-Mariano, Nerea Matamala, Selene Martínez, Iago Justo, Alberto Marcacuzco, Carlos Jimenez, Sara Monzón, Isabel Cuesta, Cristina Garfia, María Teresa Martínez, Meritxell Huch, Ignacio Pérez de Castro, Manuel Posada, Sabina Janciauskiene, Beatriz Martínez-Delgado
Jun 06, 2020
Abstract: Background and aims: Alpha-1 antitrypsin (AAT) is a product of SERPINA1 gene mainly expressed by hepatocytes. Clinically relevant mutations in the SERPINA1 gene, such as Z (Glu342Lys), results in an expression of...
Flickering nanometre-scale disorder in a crystal lattice tracked by plasmonic flare light emission
Cloudy Carnegie, Mattin Urbieta, Rohit Chikkaraddy, Bart de Nijs, Jack Griffiths, William M. Deacon, Marlous Kamp, Nerea Zabala, Javier Aizpurua, Jeremy J. Baumberg
Feb 02, 2021
Abstract: The dynamic restructuring of metal nanoparticle surfaces is known to greatly influence their catalytic, electronic transport, and chemical binding functionalities. Here we show for the first time that non-equilibrium...
Flickering nanometre-scale disorder in a crystal lattice tracked by plasmonic flare light emission.
Cloudy Carnegie, Mattin Urbieta, Rohit Chikkaraddy, Bart de Nijs, Jack Griffiths, William M Deacon, Marlous Kamp, Nerea Zabala, Javier Aizpurua, Jeremy J Baumberg
Mar 06, 2020
The dynamic restructuring of metal nanoparticle surfaces is known to greatly influence their catalytic, electronic transport, and chemical binding functionalities. Here we show for the first time that non-equilibrium...
Published by: Nature Communications
High-Resolution Analysis of Coronavirus Gene Expression by RNA Sequencing and Ribosome Profiling.
Nerea Irigoyen, Andrew E Firth, Joshua D Jones, Betty Y-W Chung, Stuart G Siddell, Ian Brierley
Feb 09, 2016
Animals Cell Line Frameshifting Ribosomal Gene Expression Profiling Gene Expression Regulation Viral Kinetics Mesocricetus Mice Murine hepatitis virus Open Reading Frames Protein Biosynthesis RNA Messenger RNA Viral Restriction Mapping Ribosomes Sequence Analysis RNA Transcription Genetic Transcriptome Viral Proteins Virus Physiological Phenomena
An upstream protein-coding region in enteroviruses modulates virus infection in gut epithelial cells.
Valeria Lulla, Adam M Dinan, Myra Hosmillo, Yasmin Chaudhry, Lee Sherry, Nerea Irigoyen, Komal M Nayak, Nicola J Stonehouse, Matthias Zilbauer, Ian Goodfellow, Andrew E Firth
Dec 11, 2018
The use of duplex-specific nuclease in ribosome profiling and a user-friendly software package for Ribo-seq data analysis.
Betty Y Chung, Thomas J Hardcastle, Joshua D Jones, Nerea Irigoyen, Andrew E Firth, David C Baulcombe, Ian Brierley
Jan 22, 2016
Manipulation of the unfolded protein response
Liliana Echavarría-Consuegra, Georgia M Cook, Idoia Busnadiego, Charlotte Lefèvre, Sarah Keep, Katherine Brown, Nicole Doyle, Giulia Dowgier, Krzysztof Franaszek, Nathan A Moore, Stuart G Siddell, Erica Bickerton, Benjamin G Hale, Andrew E Firth, Ian Brierley, Nerea Irigoyen
Jul 28, 2021
Cell Line Vero Cells Animals Humans Mice Murine hepatitis virus Endoribonucleases Protein-Serine-Threonine Kinases Viral Proteins Antiviral Agents Drug Delivery Systems Virus Replication Activating Transcription Factor 6 Unfolded Protein Response HEK293 Cells RNA-seq Chlorocebus aethiops covid-19
Published by: PLoS pathogens
Manipulation of the unfolded protein response
Liliana Echavarría-Consuegra, Georgia M Cook, Idoia Busnadiego, Charlotte Lefèvre, Sarah Keep, Katherine Brown, Nicole Doyle, Giulia Dowgier, Krzysztof Franaszek, Nathan A Moore, Stuart G Siddell, Erica Bickerton, Benjamin G Hale, Andrew E Firth, Ian Brierley, Nerea Irigoyen
Aug 09, 2021
Coronavirus infection induces the unfolded protein response (UPR), a cellular signalling pathway composed of three branches, triggered by unfolded proteins in the endoplasmic reticulum (ER) due to high ER load. We have used RNA...
Activating Transcription Factor 6 Animals Antiviral Agents Cell Line Chlorocebus aethiops Drug Delivery Systems Endoribonucleases HEK293 Cells Humans Mice Murine hepatitis virus Protein Serine-Threonine Kinases RNA-seq Unfolded Protein Response Vero Cells Viral Proteins Virus Replication COVID-19 Drug Treatment
Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia.
Eliza Yankova, Wesley Blackaby, Mark Albertella, Justyna Rak, Etienne De Braekeleer, Georgia Tsagkogeorga, Ewa S Pilka, Demetrios Aspris, Dan Leggate, Alan G Hendrick, Natalie A Webster, Byron Andrews, Richard Fosbeary, Patrick Guest, Nerea Irigoyen, Maria Eleftheriou, Malgorzata Gozdecka, Joao ML Dias, Andrew J Bannister, Binje Vick, Irmela Jeremias, George S Vassiliou, Oliver Rausch, Konstantinos Tzelepis, Tony Kouzarides
May 10, 2021
N6-methyladenosine (m6A) is an abundant internal RNA modification1,2 that is catalysed predominantly by the METTL3-METTL14 methyltransferase complex3,4. The m6A methyltransferase METTL3 has been linked to the initiation and...
Manipulation of the unfolded protein response
Liliana Echavarría-Consuegra, Georgia M. Cook, Idoia Busnadiego, Charlotte Lefèvre, Sarah Keep, Katherine Brown, Nicole Doyle, Giulia Dowgier, Krzysztof Franaszek, Nathan A. Moore, Stuart G. Siddell, Erica Bickerton, Benjamin G. Hale, Andrew E. Firth, Ian Brierley, Nerea Irigoyen
Jun 17, 2021
Opportunities and Challenges in Functional Genomics Research in Osteoporosis
Jonathan H Tobias, Emma L Duncan, Erika Kague, Chrissy L Hammond, Celia L Gregson, Duncan Bassett, Graham R Williams, Josine L Min, Tom R Gaunt, David Karasik, Claes Ohlsson, Fernando Rivadeneira, James R Edwards, Fadil M Hannan, John P Kemp, Sophie J Gilbert, Nerea Alonso, Neelam Hassan, Juliet E Compston, Stuart H Ralston
Mar 15, 2021
The discovery that sclerostin is the defective protein underlying the rare heritable bone mass disorder, sclerosteosis, ultimately led to development of anti-sclerostin antibodies as a new treatment for osteoporosis. In the era...
Pre-diagnostic metabolite concentrations and prostate cancer risk in 1077 cases and 1077 matched controls in the European Prospective Investigation into Cancer and Nutrition.
Julie A Schmidt, Georgina K Fensom, Sabina Rinaldi, Augustin Scalbert, Paul N Appleby, David Achaintre, Audrey Gicquiau, Marc J Gunter, Pietro Ferrari, Rudolf Kaaks, Tilman Kühn, Anna Floegel, Heiner Boeing, Antonia Trichopoulou, Pagona Lagiou, Eleutherios Anifantis, Claudia Agnoli, Domenico Palli, Morena Trevisan, Rosario Tumino, H Bas Bueno-De-Mesquita, Antonio Agudo, Nerea Larrañaga, Daniel Redondo-Sánchez, Aurelio Barricarte, José Maria Huerta, J Ramón Quirós, Nick Wareham, Kay-Tee Khaw, Aurora Perez-Cornago, Mattias Johansson, Amanda J Cross, Konstantinos K Tsilidis, Elio Riboli, Timothy J Key, Ruth C Travis
Jul 05, 2017
BACKGROUND: Little is known about how pre-diagnostic metabolites in blood relate to risk of prostate cancer. We aimed to investigate the prospective association between plasma metabolite concentrations and risk of prostate...
Acylcarnitines Amino Acids Biogenic amines European Prospective Investigation into Cancer and Nutrition (EPIC) Glycerophospholipids Hexose Mass Spectrometry Metabolomics prospective study prostate cancer risk sphingolipids Aged Biomarkers Case-Control Studies Cohort Studies Follow-Up Studies Humans Logistic Models Male Mass Spectrometry Middle Aged Nutritional Status Odds Ratio Prospective Studies Prostatic Neoplasms
Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models
Renée T Fortner, Allison F Vitonis, Helena Schock, Anika Hüsing, Theron Johnson, Raina N Fichorova, Titilayo Fashemi, Hidemi S Yamamoto, Anne Tjønneland, Louise Hansen, Kim Overvad, Marie-Christine Boutron-Ruault, Marina Kvaskoff, Gianluca Severi, Heiner Boeing, Antonia Trichopoulou, Vassiliki Benetou, Carlo La Vecchia, Domenico Palli, Sabina Sieri, Rosario Tumino, Giuseppe Matullo, Amalia Mattiello, N Charlotte Onland-Moret, Petra H Peeters, Elisabete Weiderpass, Inger Torhild Gram, Mie Jareid, J Ramón Quirós, Eric J Duell, Maria-Jose Sánchez, María Dolores Chirlaque, Eva Ardanaz, Nerea Larrañaga, Björn Nodin, Jenny Brändstedt, Annika Idahl, Kay-Tee Khaw, Naomi Allen, Marc Gunter, Mattias Johansson, Laure Dossus, Melissa A Merritt, Elio Riboli, Daniel W Cramer, Rudolf Kaaks, Kathryn L Terry
May 05, 2017
BACKGROUND: Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women, limiting their utility for screening. METHODS: We evaluated cross-sectional relationships between lifestyle and...
A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study
Nikos Papadimitriou, David Muller, Piet A. van den Brandt, Milan Geybels, Chirag J. Patel, Marc J. Gunter, David S. Lopez, Timothy J. Key, Aurora Perez-Cornago, Pietro Ferrari, Paolo Vineis, Elisabete Weiderpass, Heiner Boeing, Antonio Agudo, María-José Sánchez, Kim Overvad, Tilman Kühn, Renee T. Fortner, Domenico Palli, Isabel Drake, Anders Bjartell, Carmen Santiuste, Bas H. Bueno-de-Mesquita, Vittorio Krogh, Anne Tjønneland, Dorthe Furstrand Lauritzen, Aurelio Barricarte Gurrea, José Ramón Quirós, Pär Stattin, Antonia Trichopoulou, Georgia Martimianaki, Anna Karakatsani, Elin Thysell, Ingegerd Johansson, Fulvio Ricceri, Rosario Tumino, Nerea Larrañaga, Kay Tee Khaw, Elio Riboli, Ioanna Tzoulaki, Konstantinos K. Tsilidis
Sep 18, 2020
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