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Circularization of flavivirus genomic RNA inhibits de novo translation initiation.
Members of the Flaviviridae family, including dengue virus (DENV) and yellow fever virus, cause serious disease in humans, whilst maternal infection with Zika virus (ZIKV) can induce microcephaly in newborns. Following...
Nicolas Sarkozy's legitimization of the Front National
Aurelien Mondon
Feb 01, 2013
In the 'poor' result achieved by Jean-Marie Le Pen in the 2007 presidential elections, many commentators saw the demise of the Front National. However, when asked by a journalist whether it was the end of her father's political...
Nicolas Sarkozy's legitimization of the Front National
Aurelien Mondon
Feb 01, 2013
In the 'poor' result achieved by Jean-Marie Le Pen in the 2007 presidential elections, many commentators saw the demise of the Front National. However, when asked by a journalist whether it was the end of her father's political...
Norovirus translation requires an interaction between the C Terminus of the genome-linked viral protein VPg and eukaryotic translation initiation factor 4G.
Liliane Chung, Dalan Bailey, Eoin N Leen, Edward P Emmott, Yasmin Chaudhry, Lisa O Roberts, Stephen Curry, Nicolas Locker, Ian G Goodfellow
Jul 09, 2014
Eukaryotic Translation Initiation Factor 4E (eIF4E) Norovirus Plus-stranded RNA Virus Translation Translation Initiation Factor VPg Virus eIF4G Base Sequence Chromatography Affinity DNA Primers Eukaryotic Initiation Factor-4G Genome Viral Norovirus Polymerase Chain Reaction Protein Binding Protein Biosynthesis Proteomics Viral Proteins
Feline Calicivirus Infection Disrupts Assembly of Cytoplasmic Stress Granules and Induces G3BP1 Cleavage.
Majid N Humoud, Nicole Doyle, Elizabeth Royall, Margaret M Willcocks, Frederic Sorgeloos, Frank van Kuppeveld, Lisa O Roberts, Ian G Goodfellow, Martijn A Langereis, Nicolas Locker
Nov 20, 2017
UNLABELLED: In response to stress such as virus infection, cells can stall translation by storing mRNAs away in cellular compartments called stress granules (SGs). This defense mechanism favors cell survival by limiting the use...
3C Viral Proteases Animals Caliciviridae Infections calicivirus Feline Carrier Proteins Cats Cysteine Endopeptidases Cytoplasmic Granules DNA Helicases Eukaryotic Initiation Factor-2 HeLa Cells Host-Pathogen Interactions Humans Mitogen-Activated Protein Kinases Phosphorylation Poly-ADP-Ribose Binding Proteins RNA Helicases RNA Recognition Motif Proteins Viral Proteins Virus Replication
Norovirus infection results in eIF2α independent host translation shut-off and remodels the G3BP1 interactome evading stress granule formation.
Michèle Brocard, Valentina Iadevaia, Philipp Klein, Belinda Hall, Glenys Lewis, Jia Lu, James Burke, Margaret M Willcocks, Roy Parker, Ian G Goodfellow, Alessia Ruggieri, Nicolas Locker
Jan 31, 2020
Viral infections impose major stress on the host cell. In response, stress pathways can rapidly deploy defence mechanisms by shutting off the protein synthesis machinery and triggering the accumulation of mRNAs into stress...
Animals Caliciviridae Infections Cell Line Cytoplasmic Granules DNA Helicases Eukaryotic Initiation Factor-2 Humans Mice Mice Inbred C57BL Norovirus Poly-ADP-Ribose Binding Proteins Protein Biosynthesis RAW 264.7 Cells RNA RNA Helicases RNA Recognition Motif Proteins Signal Transduction Virus Replication
Norovirus infection results in eIF2α independent host translation shut-off and remodels the G3BP1 interactome evading stress granule formation
Michèle Brocard, Valentina Iadevaia, Philipp Klein, Belinda Hall, Glenys Lewis, Jia Lu, James Burke, Margaret M. Willcocks, Roy Parker, Ian G. Goodfellow, Alessia Ruggieri, Nicolas Locker
Jan 16, 2020
Viral infections impose major stress on the host cell. In response, stress pathways can rapidly deploy defence mechanisms by shutting off the protein synthesis machinery and triggering the accumulation of mRNAs into stress...
Norovirus infection results in eIF2α independent host translation shut-off and remodels the G3BP1 interactome evading stress granule formation.
Michèle Brocard, Valentina Iadevaia, Philipp Klein, Belinda Hall, Glenys Lewis, Jia Lu, James Burke, Margaret M Willcocks, Roy Parker, Ian G Goodfellow, Alessia Ruggieri, Nicolas Locker
Feb 06, 2020
Viral infections impose major stress on the host cell. In response, stress pathways can rapidly deploy defence mechanisms by shutting off the protein synthesis machinery and triggering the accumulation of mRNAs into stress...
Published by: PLoS pathogens
Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation.
Myra Hosmillo, Jia Lu, Michael R McAllaster, James B Eaglesham, Xinjie Wang, Edward Emmott, Patricia Domingues, Yasmin Chaudhry, Tim J Fitzmaurice, Matthew Kh Tung, Marc Dominik Panas, Gerald McInerney, Nicolas Locker, Craig B Wilen, Ian G Goodfellow
Aug 20, 2019
Knowledge of the host factors required for norovirus replication has been hindered by the challenges associated with culturing human noroviruses. We have combined proteomic analysis of the viral translation and replication...
CRISPR G3BP1 Norovirus infectious disease microbiology stress granule Translation Virus Animals Caliciviridae Infections Cell Line DNA Helicases Host-Pathogen Interactions Humans Mice Norovirus Poly-ADP-Ribose Binding Proteins Protein Biosynthesis RNA Helicases RNA Recognition Motif Proteins Viral Proteins
Towards a Multidimensional Ontology Model for DIH-Based Organisations
Digital innovation hubs are of utmost importance when they sustain cooperation in innovative technological domains like the cyber-physical system. In this paper, the authors introduce, in the first part, a DIH ontology that they...
Published by: IGI Global Scientific Publishing
Knowledge Transfer in Information Security Capacity Building for Community-Based Organizations
Community-based organizations (CBOs) in the health and human services sector handle very sensitive client information, such as psychiatric, HIV testing, criminal justice, and financial records. With annual revenue often in the...
Published by: IGI Global Scientific Publishing
QSAR Analysis for the Inhibition of the Mutagenic Activity by Anthocyanin Derivatives
Flavonoid compounds modulate the cytochrome P450 3A4 enzyme activity and inhibit the mutagenic activity of mammalian cells, preventing carcinogen activation and cellular DNA damage. In this work, the quantitative...
Published by: IGI Global Scientific Publishing
Trajectory and uniqueness of mutational signatures in yeast mutators.
Sophie Loeillet, Mareike Herzog, Fabio Puddu, Patricia Legoix, Sylvain Baulande, Stephen P Jackson, Alain G Nicolas
Aug 28, 2020
The acquisition of mutations plays critical roles in adaptation, evolution, senescence, and tumorigenesis. Massive genome sequencing has allowed extraction of specific features of many mutational landscapes but it remains...
Pol zeta dynamics of mutation accumulation Loss of Heterozygosity mutational profiles mutator genes Acetyltransferases BRCA1 Protein BRCA2 Protein Breast Neoplasms Carcinogenesis DNA Damage DNA-Directed DNA Polymerase Diploidy Female Flap Endonucleases Genome Fungal Humans Loss of Heterozygosity Membrane Proteins Mutation Peroxiredoxins Rad51 Recombinase Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins whole genome sequencing
Rigid analytic quantum groups and quantum Arens-Michael envelopes
Nicolas Dupré
Aug 19, 2019
We introduce a rigid analytification of the quantized coordinate algebra of a semisimple algebraic group and a quantized Arens-Michael envelope of the enveloping algebra of the corresponding Lie algebra, working over a...
The divergence history of European blue mussel species reconstructed from Approximate Bayesian Computation
Christelle Fraïsse, Camille Roux, Pierre-Alexandre Gagnaire, Jonathan Romiguier, Nicolas Faivre, John J Welch, Nicolas Bierne
Oct 18, 2018
Genome-scale diversity data are increasingly available in a variety of biological systems, and can be used to reconstruct the past evolutionary history of species divergence. However, extracting the full demographic information...
Fixing France's broken social model?
Susan Milner
Sep 01, 2012
Taking as its starting point the programme and campaign of Nicolas Sarkozy in the presidential election of 2007 around the ‘value of work’, this article reviews and assesses the main reforms undertaken during the period of his...
Fixing France's broken social model?
Susan Milner
Sep 01, 2012
Taking as its starting point the programme and campaign of Nicolas Sarkozy in the presidential election of 2007 around the ‘value of work’, this article reviews and assesses the main reforms undertaken during the period of his...
Multi-Omics and Genome-Scale Modeling Reveal a Metabolic Shift During C. elegans Aging.
Janna Hastings, Abraham Mains, Bhupinder Virk, Nicolas Rodriguez, Sharlene Murdoch, Juliette Pearce, Sven Bergmann, Nicolas Le Novère, Olivia Casanueva
Jul 01, 2019
In this contribution, we describe a multi-omics systems biology study of the metabolic changes that occur during aging in Caenorhabditis elegans. Sampling several time points from young adulthood until early old age, our study...
The Ursinus Weekly, February 12, 1962
John Swinton, Elizabeth Yost, Sharon Rothenberger, Robin L. Stevenson, Ted Wilf, David Hudnut, Gerald Morita, Benjamin Fisher
Jan 01, 0001
Immortalized in fiction, poetry, Lorelei lends name to Ursinus Two theologians visit U.C. campus this week; Seminary president, Convocation guest to speak College President banquet speaker Spring rushing periods begin Auden...
Ursinus College Collegeville Pennsylvania newspaper Lorelei Donald L. Helfferich rushing fraternities sororities Lionel Arnold Robert V. Moss Troy Chapman PSEA Paul M. Merkel student government W. H. Auden Jules Feiffer Basketball wrestling Red Cross Maurice W. Armstrong European Tour Reed and Barton Silversmiths cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Embodying a Virtual Agent in a Self-Driving Car
Clarisse Lawson-Guidigbe, Nicolas Louveton, Kahina Amokrane-Ferka, Benoît Le Blanc, Jean-Marc André
Jan 01, 2023
This article considers the visual appearance of a virtual agent designed to take over the driving task in a highly automated car, to answer the question of which visual appearance is appropriate for a virtual agent in a driving...
Published by: IGI Global Scientific Publishing
Computing diffusivities from particle models out of equilibrium
A new method is proposed to numerically extract the diffusivity of a (typically nonlinear) diffusion equation from underlying stochastic particle systems. The proposed strategy requires the system to be in local equilibrium and...
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