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Optimal strategies to protect a sub-population at risk due to an established epidemic.
Epidemics can particularly threaten certain sub-populations. For example, for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the elderly are often preferentially protected. For diseases of plants and animals...
Mutational signatures
Mutational signatures provide a powerful alternative for understanding the pathophysiology of cancer. Currently, experimental efforts aimed at validating and understanding the etiologies of cancer-derived mutational signatures...
Published by: Genome biology
An ecophysiological model of plant-pest interactions
Empirical studies have shown that particular irrigation/fertilization regimes can reduce pest populations in agroecosystems. This appears to promise that the ecological concept of bottom-up control can be applied to pest...
Holistic cancer genome profiling for every patient.
Technological advances in the ability to read the human genome have accelerated the speed of sequencing, such that today we can perform whole genome sequencing (WGS) in one day. Until recently, genomic studies have largely been...
Modelling quantitative fungicide resistance and breakdown of resistant cultivars
Plant pathogens respond to selection pressures exerted by disease management strategies. This can lead to fungicide resistance and/or the breakdown of disease-resistant cultivars, each of which significantly threaten food...
Triticum Plant Leaves Fungicides Industrial Plant Diseases Multifactorial Inheritance Disease Resistance
Published by: PLoS computational biology
How the epidemiology of disease-resistant and disease-tolerant varieties affects grower behaviour.
Population-scale effects of resistant or tolerant crop varieties have received little consideration from epidemiologists. When growers deploy tolerant crop, population-scale disease pressures are often unaffected. This only...
When Does Spatial Diversification Usefully Maximize the Durability of Crop Disease Resistance?
Maximizing the durability of crop disease resistance genes in the face of pathogen evolution is a major challenge in modern agricultural epidemiology. Spatial diversification in the deployment of resistance genes, where...
Using 'sentinel' plants to improve early detection of invasive plant pathogens.
Infectious diseases of plants present an ongoing and increasing threat to international biosecurity, with wide-ranging implications. An important challenge in plant disease management is achieving early detection of invading...
Published by: PLoS computational biology
From genome integrity to cancer.
Serena Nik-Zainal
Mar 04, 2019
The genome in each of our normal cells acquires somatic genetic changes throughout life [1]. The burden of DNA damage from exogenous and endogenous sources is considerable, but highly competent DNA repair pathways operate in...
How growers make decisions impacts plant disease control.
While the spread of plant disease depends strongly on biological factors driving transmission, it also has a human dimension. Disease control depends on decisions made by individual growers, who are in turn influenced by a broad...
Epidemiological and ecological consequences of virus manipulation of host and vector in plant virus transmission.
Many plant viruses are transmitted by insect vectors. Transmission can be described as persistent or non-persistent depending on rates of acquisition, retention, and inoculation of virus. Much experimental evidence has...
Education, secularism, and illiberalism
Laïcité, France’s idiosyncratic principle of secularism, is a unique term that today engenders state forms of illiberalism, especially against marginalised communities in France. French Muslims experience instances of...
Jonathan Hauser
May 12, 2021
Optimal strategies to protect a sub-population at risk due to an established epidemic.
Epidemics can particularly threaten certain sub-populations. For example, for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the elderly are often preferentially protected. For diseases of plants and animals...
Person-centredness in the care of older adults
Mark Wilberforce, David Challis, Linda Davies, Michael P Kelly, Chris Roberts, Nik Loynes
Sep 29, 2016
Abstract
Background
Person-centredness is promoted as a central feature of the long-term care of older adults. Measures are needed to assist researchers, service planners and...
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