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Results: 78771
Cryo-EM structural analysis of FADD
Joanna L Fox, Michelle A Hughes, Xin Meng, Nikola A Sarnowska, Ian R Powley, Rebekah Jukes-Jones, David Dinsdale, Timothy J Ragan, Louise Fairall, John WR Schwabe, Nobuhiro Morone, Kelvin Cain, Marion MacFarlane
Mar 05, 2021
Regulated cell death is essential in development and cellular homeostasis. Multi-protein platforms, including the Death-Inducing Signaling Complex (DISC), co-ordinate cell fate via a core FADD:Caspase-8 complex and its...
CASP8 and FADD-Like Apoptosis Regulating Protein Caspase 8 Catalytic Domain Cloning Molecular Cryoelectron Microscopy Death Domain Receptor Signaling Adaptor Proteins Escherichia coli Fas-Associated Death Domain Protein Gene Expression Genetic Vectors HEK293 Cells Humans Models Molecular Protein Binding Protein Conformation alpha-Helical Protein Conformation beta-Strand Protein Interaction Domains and Motifs Protein Isoforms Protein Multimerization Receptor-Interacting Protein Serine-Threonine Kinases Recombinant Proteins Regulated Cell Death Tumor Necrosis Factor-alpha
Cryo-EM structural analysis of FADD
Joanna L. Fox, Michelle A. Hughes, Xin Meng, Nikola A. Sarnowska, Ian R. Powley, Rebekah Jukes-Jones, David Dinsdale, Timothy J. Ragan, Louise Fairall, John W. R. Schwabe, Nobuhiro Morone, Kelvin Cain, Marion MacFarlane
Feb 05, 2021
Abstract: Regulated cell death is essential in development and cellular homeostasis. Multi-protein platforms, including the Death-Inducing Signaling Complex (DISC), co-ordinate cell fate via a core FADD:Caspase-8 complex and its...
Two-step Procedure Based on the Least Squares and Instrumental Variable Methods for Simultaneous Estimation of von Bertalanffy Growth Parameters
Advanced in the present article is a Two-step procedure designed on the methods of the least squares (LS) and instrumental variable (IV) techniques for simultaneous estimation of the three unknown parameters L∞, K and t0, which...
Published by: IGI Global Scientific Publishing
High-flow nasal oxygen vs. standard oxygen therapy for patients undergoing transcatheter aortic valve replacement with conscious sedation
S Scheuermann, A Tan, P Govender, M Mckie, J Pack, G Martinez, F Falter, S George, A A. Klein
Apr 14, 2023
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
Variational Autoencoders for Cancer Data Integration
Nikola Simidjievski, Cristian Bodnar, Ifrah Tariq, Paul Scherer, Helena Andres Terre, Zohreh Shams, Mateja Jamnik, Pietro Liò
Jan 17, 2020
International initiatives such as the Molecular Taxonomy of Breast Cancer International Consortium are collecting multiple data sets at different genome-scales with the aim to identify novel cancer bio-markers and predict...
An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression.
Asis Palazon, Petros A Tyrakis, David Macias, Pedro Veliça, Helene Rundqvist, Susan Fitzpatrick, Nikola Vojnovic, Anthony T Phan, Niklas Loman, Ingrid Hedenfalk, Thomas Hatschek, John Lövrot, Theodoros Foukakis, Ananda W Goldrath, Jonas Bergh, Randall S Johnson
May 31, 2018
Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during adaptation to the hypoxic tumor microenvironment. Deletion analyses of the two key HIF isoforms found that HIF-1α, but not HIF-2α, was...
HIF transcription factors VEGF angiogenesis cytotoxic T cells Hypoxia Immunotherapy Animals Breast Neoplasms CD8-Positive T-Lymphocytes Cell Line Tumor Cells Cultured Disease Progression Female Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Hypoxia-Inducible Factor 1 alpha Subunit Mice Inbred C57BL Mice Knockout Neoplasms Experimental Neovascularization Pathologic T-Lymphocytes Cytotoxic Vascular Endothelial Growth Factor A
Launching of ships from horizontal berth by tipping tables – CFD simulation of wave generation
The paper considers the side launching of ships from a horizontal berth by tipping tables. The launching process is split into the six phases and a system of nonlinear di erential equations of motion is established. The system...
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect the patient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and if found...
Published by: IJHS Medical Association
A Model of Cloud Forensic Application With Assurance of Cloud Log
The key concepts of digital forensic investigation in cloud computing are examination and investigation. Cybercriminals target cloud-based web applications due to presence of vulnerabilities. Forensic investigation is a complex...
Published by: IGI Global Scientific Publishing
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect thepatient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and iffound...
Published by: IJHS Medical Association
Variational Autoencoders for Cancer Data Integration
Nikola Simidjievski, Cristian Bodnar, Ifrah Tariq, Paul Scherer, Helena Andres Terre, Zohreh Shams, Mateja Jamnik, Pietro Liò
Feb 10, 2020
International initiatives such as the Molecular Taxonomy of Breast Cancer International Consortium are collecting multiple data sets at different genome-scales with the aim to identify novel cancer bio-markers and predict...
Artificial Intelligence Machine Learning Deep learning multi-omic analysis variational autoencoder bioinformactics cancer–breast cancer integrative data analyses
Published by: Frontiers in genetics
Gorab is a Golgi protein required for structure and duplication of Drosophila centrioles.
Levente Kovacs, Jennifer Chao-Chu, Sandra Schneider, Marco Gottardo, George Tzolovsky, Nikola S Dzhindzhev, Maria Giovanna Riparbelli, Giuliano Callaini, David M Glover
Mar 07, 2019
Sentiment Analysis on Movie Reviews Dataset Using Support Vector Machines and Ensemble Learning
The internet makes it easier for people to connect to each other and has become a platform to express ideas and share information with the world. The growth of the internet has indirectly led to the development of social...
Published by: IGI Global Scientific Publishing
Two-step phosphorylation of Ana2 by Plk4 is required for the sequential loading of Ana2 and Sas6 to initiate procentriole formation.
Nikola S Dzhindzhev, George Tzolovsky, Zoltan Lipinszki, Mohammed Abdelaziz, Janus Debski, Michal Dadlez, David M Glover
Apr 20, 2018
The conserved process of centriole duplication requires Plk4 kinase to recruit and promote interactions between Sas6 and Sas5/Ana2/STIL (respective nomenclature of worms/flies/humans). Plk4-mediated phosphorylation of Ana2/STIL...
Right sided eventration of diaphragm with clinodactyly
A. Sareen and K. Mahajan
Apr 21, 2015
Diaphragmatic hernia can be of two types-absence or deficiency of the diaphragm, or eventration resulting in elevation of a portion of the diaphragm as a result of incomplete muscularization. Complete eventration almost...
Published by: IJHS Medical Association
Knowledge and Attitude among High School Students towards HIV / AIDS in Rural areas of Belagavi–A Cross Sectional Study
Asha A. Bellad and Rajesh R Kulkarni
Mar 25, 2015
Introduction Since its emergence in 1981, the HIV/AIDS pandemic, which poses a serious challenge to mankind, without doubt, has become one of the most serious infectious diseases. Many adolescents around the world are sexually...
Published by: IJHS Medical Association
Knowledge and Attitude among High School Students towards HIV / AIDS in Rural areas of Belagavi–A Cross Sectional Study
Asha A. Bellad and Rajesh R Kulkarni
Mar 25, 2015
Introduction Since its emergence in 1981, the HIV/AIDS pandemic, which poses a serious challenge to mankind, without doubt, has become one of the most serious infectious diseases. Many adolescents around the world are sexually...
Published by: IJHS Medical Association
Variational Autoencoders for Cancer Data Integration
Nikola Simidjievski, Cristian Bodnar, Ifrah Tariq, Paul Scherer, Helena Andres Terre, Zohreh Shams, Mateja Jamnik, Pietro Liò
Dec 25, 2019
International initiatives such as the Molecular Taxonomy of Breast Cancer International Consortium are collecting multiple data sets at different genome-scales with the aim to identify novel cancer bio-markers and predict...
Sustainable Supply Chain Management Practices in Ghana
The study assessed the sustainable supply chain management (SSCM) practices of 303 manufacturing firms in Ghana with an annual turnover of not less than $1,000,000, which were purposively selected for the study. A questionnaire...
Published by: Indonesia Strategic Sustainability
Vibration induced refrigeration using ferroelectric materials.
Anuruddh Kumar, Aditya Chauhan, Satyanarayan Patel, Nikola Novak, Rajeev Kumar, Rahul Vaish
May 09, 2019
This article aims to propose a cantilever based cooling device employing non-axis symmetric placement of bulk ferroelectric patches. Ambient mechanical vibrations produce large stresses in cantilevers resulting in elastocaloric...
Right sided eventration of diaphragm with clinodactyly
A. Sareen and K. Mahajan
Apr 21, 2015
Diaphragmatic hernia can be of two types-absence or deficiency of the diaphragm, or eventration resulting in elevation of a portion of the diaphragm as a result of incomplete muscularization. Complete eventration almost...
Published by: IJHS Medical Association
Physical Exercise (Riyazat) a Boon for Expecting Mothers
Creation has endowed the female of the species with the gift of pro-creation. Therefore this unique gift is the greatest happiness for a woman, who is aware that she and her kind are the ones who have brought mankind in this...
Published by: IJHS Medical Association
Students' Performance Prediction in Higher Education Using Multi-Agent Framework-Based Distributed Data Mining Approach
An effective educational program warrants the inclusion of an innovative construction that enhances the higher education efficacy in such a way that accelerates the achievement of desired results and reduces the risk of...
Published by: IGI Global Scientific Publishing
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