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Results: 81
Theory and Practice of Integrating Machine Learning and Conventional Statistics in Medical Data Analysis.
Sarinder Kaur Dhillon, Mogana Darshini Ganggayah, Siamala Sinnadurai, Pietro Lio, Nur Aishah Taib
Nov 04, 2022
Predicting factors for survival of breast cancer patients using machine learning techniques.
Mogana Darshini Ganggayah, Nur Aishah Taib, Yip Cheng Har, Pietro Lio, Sarinder Kaur Dhillon
Apr 05, 2019
Purification and Characterization of Nickel Uptake Regulator (NUR) and Single NUR Mutants from <em>Streptomyces coelicolor</em>
The Nickel Uptake Regulator (NUR) is a metalloregulatory protein found in the microorganism Streptomyces coelicolor. S.coelicolor is a gram-positive bacterium that plays an important role in antibiotic production. NUR is...
Published by: Winthrop University
Cloning and characterization of nickel uptake regulator NUR mutants from <em>Streptomyces coelicolor</em>
Sufficient concentrations of metal within a cell are required for proper cellular function; however, metals become toxic at very high concentrations. Therefore, it is important for an organism to have a mechanism for maintaining...
Published by: Winthrop University
Epidemiological and ES cell-based functional evaluation of BRCA2 variants identified in families with breast cancer.
Teresa Sullivan, Eswary Thirthagiri, Chan-Eng Chong, Stacey Stauffer, Susan Reid, Eileen Southon, Tiara Hassan, Aravind Ravichandran, Eldarina Wijaya, Joanna Lim, Nur Aishah Mohd Taib, Farhana Fadzli, Cheng Har Yip, Mikael Hartman, Jingmei Li, Rob M van Dam, Susan L North, Ranabir Das, Douglas F Easton, Kajal Biswas, Soo-Hwang Teo, Shyam K Sharan, SGBCC Investigators, MYBRCA Investigators
Dec 23, 2020
The discovery of high-risk breast cancer susceptibility genes, such as Breast cancer associated gene 1 (BRCA1) and Breast cancer associated gene 2 (BRCA2) has led to accurate identification of individuals for risk management and...
Characterisation of protein-truncating and missense variants in PALB2 in 15 768 women from Malaysia and Singapore.
Pei Sze Ng, Rick ACM Boonen, Eldarina Wijaya, Chan Eng Chong, Milan Sharma, Sabine Knaup, Shivaani Mariapun, Weang Kee Ho, Joanna Lim, Sook-Yee Yoon, Nur Aishah Mohd Taib, Mee Hoong See, Jingmei Li, Swee Ho Lim, Ern Yu Tan, Benita Kiat-Tee Tan, Su-Ming Tan, Veronique Kiat-Mien Tan, Rob Martinus van Dam, Kartini Rahmat, Cheng Har Yip, Sara Carvalho, Craig Luccarini, Caroline Baynes, Alison M Dunning, Antonis Antoniou, Haico Van Attikum, Douglas F Easton, Mikael Hartman, Soo Hwang Teo
May 13, 2021
BACKGROUND: Rare protein-truncating variants (PTVs) in partner and localiser of BRCA2 (PALB2) confer increased risk to breast cancer, but relatively few studies have reported the prevalence in South-East Asian populations. Here...
Inherited mutations in BRCA1 and BRCA2 in an unselected multiethnic cohort of Asian patients with breast cancer and healthy controls from Malaysia.
Wei Xiong Wen, Jamie Allen, Kah Nyin Lai, Shivaani Mariapun, Siti Norhidayu Hasan, Pei Sze Ng, Daphne Shin-Chi Lee, Sheau Yee Lee, Sook-Yee Yoon, Joanna Lim, Shao Yan Lau, Brennan Decker, Karen Pooley, Leila Dorling, Craig Luccarini, Caroline Baynes, Don M Conroy, Patricia Harrington, Jacques Simard, Cheng Har Yip, Nur Aishah Mohd Taib, Weang Kee Ho, Antonis C Antoniou, Alison M Dunning, Douglas F Easton, Soo Hwang Teo
Jan 19, 2018
BACKGROUND: Genetic testing for BRCA1 and BRCA2 is offered typically to selected women based on age of onset and family history of cancer. However, current internationally accepted genetic testing referral guidelines are built...
Germline breast cancer susceptibility genes, tumor characteristics, and survival
Peh Joo Ho, Alexis J. Khng, Hui Wen Loh, Weang-Kee Ho, Cheng Har Yip, Nur Aishah Mohd-Taib, Veronique Kiak Mien Tan, Benita Kiat-Tee Tan, Su-Ming Tan, Ern Yu Tan, Swee Ho Lim, Suniza Jamaris, Yirong Sim, Fuh Yong Wong, Joanne Ngeow, Elaine Hsuen Lim, Mei Chee Tai, Eldarina Azfar Wijaya, Soo Chin Lee, Ching Wan Chan, Shaik Ahmad Buhari, Patrick M. Y. Chan, Juliana J. C. Chen, Jaime Chin Mui Seah, Wai Peng Lee, Chi Wei Mok, Geok Hoon Lim, Evan Woo, Sung-Won Kim, Jong Won Lee, Min Hyuk Lee, Sue K. Park, Alison M. Dunning, Douglas F. Easton, Marjanka K. Schmidt, Soo-Hwang Teo, Jingmei Li, Mikael Hartman
Dec 15, 2021
Abstract: Background: Mutations in certain genes are known to increase breast cancer risk. We study the relevance of rare protein-truncating variants (PTVs) that may result in loss-of-function in breast cancer susceptibility...
Germline breast cancer susceptibility genes, tumor characteristics, and survival.
Peh Joo Ho, Alexis J Khng, Hui Wen Loh, Weang-Kee Ho, Cheng Har Yip, Nur Aishah Mohd-Taib, Veronique Kiak Mien Tan, Benita Kiat-Tee Tan, Su-Ming Tan, Ern Yu Tan, Swee Ho Lim, Suniza Jamaris, Yirong Sim, Fuh Yong Wong, Joanne Ngeow, Elaine Hsuen Lim, Mei Chee Tai, Eldarina Azfar Wijaya, Soo Chin Lee, Ching Wan Chan, Shaik Ahmad Buhari, Patrick MY Chan, Juliana JC Chen, Jaime Chin Mui Seah, Wai Peng Lee, Chi Wei Mok, Geok Hoon Lim, Evan Woo, Sung-Won Kim, Jong Won Lee, Min Hyuk Lee, Sue K Park, Alison M Dunning, Douglas F Easton, Marjanka K Schmidt, Soo-Hwang Teo, Jingmei Li, Mikael Hartman
Jan 10, 2022
BACKGROUND: Mutations in certain genes are known to increase breast cancer risk. We study the relevance of rare protein-truncating variants (PTVs) that may result in loss-of-function in breast cancer susceptibility genes on...
Overlap of high-risk individuals predicted by family history, and genetic and non-genetic breast cancer risk prediction models
Peh Joo Ho, Weang Kee Ho, Alexis J Khng, Yen Shing Yeoh, Benita Kiat-Tee Tan, Ern Yu Tan, Geok Hoon Lim, Su-Ming Tan, Veronique Kiak Mien Tan, Cheng-Har Yip, Nur-Aishah Mohd-Taib, Fuh Yong Wong, Elaine Hsuen Lim, Joanne Ngeow, Wen Yee Chay, Lester Chee Hao Leong, Wei Sean Yong, Chin Mui Seah, Siau Wei Tang, Celene Wei Qi Ng, Zhiyan Yan, Jung Ah Lee, Kartini Rahmat, Tania Islam, Tiara Hassan, Mei-Chee Tai, Chiea Chuen Khor, Jian-Min Yuan, Woon-Puay Koh, Xueling Sim, Alison M Dunning, Manjeet K Bolla, Antonis Antoniou, Soo-Hwang Teo, Jingmei Li, Mikael Hartman
Apr 26, 2022
BACKGROUND: Family history, and genetic and non-genetic risk factors can stratify women according to their individual risk of developing breast cancer. The extent of overlap between these risk predictors is not clear. METHODS...
Characterisation of protein-truncating and missense variants in PALB2 in 15 768 women from Malaysia and Singapore
Pei Sze Ng, Rick ACM Boonen, Eldarina Wijaya, Chan Eng Chong, Milan Sharma, Sabine Knaup, Shivaani Mariapun, Weang Kee Ho, Joanna Lim, Sook-Yee Yoon, Nur Aishah Mohd Taib, Mee Hoong See, Jingmei Li, Swee Ho Lim, Ern Yu Tan, Benita Kiat-Tee Tan, Su-Ming Tan, Veronique Kiat-Mien Tan, Rob Martinus van Dam, Kartini Rahmat, Cheng Har Yip, Sara Carvalho, Craig Luccarini, Caroline Baynes, Alison M Dunning, Antonis Antoniou, Haico Van Attikum, Douglas F Easton, Mikael Hartman, Soo Hwang Teo
Apr 07, 2021
Factor Influence Mental In Adolences
The mental condition of adolescents and children in Indonesia is currently alarming. Adolescents are vulnerable to various problems at the stage of development, such as mental and emotional problems related to emotional...
Published by: Indonesia Strategic Sustainability
A stochastic programming approach for chemotherapy appointment scheduling
Chemotherapy appointment scheduling is a challenging problem due to the uncertainty in premedication and infusion durations. In this paper, we formulate a two‐stage stochastic mixed integer programming model for the chemotherapy...
appointment scheduling Chemotherapy progressive hedging scheduling stochastic programming /dk/atira/pure/subjectarea/asjc/2200/2212 name=Ocean Engineering /dk/atira/pure/subjectarea/asjc/2600/2611 name=Modelling and Simulation /dk/atira/pure/subjectarea/asjc/1800/1803 name=Management Science and Operations Research
A stochastic programming approach for chemotherapy appointment scheduling
Chemotherapy appointment scheduling is a challenging problem due to the uncertainty in premedication and infusion durations. In this paper, we formulate a two‐stage stochastic mixed integer programming model for the chemotherapy...
appointment scheduling Chemotherapy progressive hedging scheduling stochastic programming /dk/atira/pure/subjectarea/asjc/2200/2212 name=Ocean Engineering /dk/atira/pure/subjectarea/asjc/2600/2611 name=Modelling and Simulation /dk/atira/pure/subjectarea/asjc/1800/1803 name=Management Science and Operations Research
Behaviour and Bot Analysis on Online Social Networks
The internet is home to a multitude of social networks that provide users with a sense of community and connection across the world. Among these, Twitter and Reddit are two of the most popular. While Twitter users follow and...
Published by: IGI Global Scientific Publishing
European polygenic risk score for prediction of breast cancer shows similar performance in Asian women
Weang-Kee Ho, Min-Min Tan, Nasim Mavaddat, Mei-Chee Tai, Shivaani Mariapun, Jingmei Li, Peh-Joo Ho, Joe Dennis, Jonathan P. Tyrer, Manjeet K. Bolla, Kyriaki Michailidou, Qin Wang, Daehee Kang, Ji-Yeob Choi, Suniza Jamaris, Xiao-Ou Shu, Sook-Yee Yoon, Sue K. Park, Sung-Won Kim, Chen-Yang Shen, Jyh-Cherng Yu, Ern Yu Tan, Patrick Mun Yew Chan, Kenneth Muir, Artitaya Lophatananon, Anna H. Wu, Daniel O. Stram, Keitaro Matsuo, Hidemi Ito, Ching Wan Chan, Joanne Ngeow, Wei Sean Yong, Swee Ho Lim, Geok Hoon Lim, Ava Kwong, Tsun L. Chan, Su Ming Tan, Jaime Seah, Esther M. John, Allison W. Kurian, Woon-Puay Koh, Chiea Chuen Khor, Motoki Iwasaki, Taiki Yamaji, Kiak Mien Veronique Tan, Kiat Tee Benita Tan, John J. Spinelli, Kristan J. Aronson, Siti Norhidayu Hasan, Kartini Rahmat, Anushya Vijayananthan, Xueling Sim, Paul D. P. Pharoah, Wei Zheng, Alison M. Dunning, Jacques Simard, Rob Martinus van Dam, Cheng-Har Yip, Nur Aishah Mohd Taib, Mikael Hartman, Douglas F. Easton, Soo-Hwang Teo, Antonis C. Antoniou
Jul 31, 2020
Abstract: Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data...
Factor Influence Mental In Adolences
The mental condition of adolescents and children in Indonesia is currently alarming. Adolescents are vulnerable to various problems at the stage of development, such as mental and emotional problems related to emotional...
Published by: Indonesia Strategic Sustainability
Training Effectiveness in Times of Austerity
Due to the fall in oil price, many companies are looking into ways to cut cost. Despite such cost-cutting efforts fuelled by the constant pressure for companies to stay competitive, the importance of training is still widely...
Published by: IGI Global Scientific Publishing
Flow Experience and Consumer Willingness to Pay in Online Mass Customization Processes
This research aims to identify the effects of perceived product value and flow experience during product design on willingness to pay (WTP) and purchase probability in online mass customization. The participants were asked to...
Published by: IGI Global Scientific Publishing
The functional ALDH2 polymorphism is associated with breast cancer risk
Tomotaka Ugai, Roger L Milne, Hidemi Ito, Kristan J Aronson, Manjeet K Bolla, Tsun Chan, Ching W Chan, Ji-Yeob Choi, Don M Conroy, Joe Dennis, Alison M Dunning, Douglas F Easton, Valerie Gaborieau, Anna Gonzalez-Neira, Mikael Hartman, Catherine S Healey, Motoki Iwasaki, Esther M John, Daehee Kang, Sung-Won Kim, Ava Kwong, Artitaya Lophatananon, Kyriaki Michailidou, Nur Aishah Mohd Taib, Kenneth Muir, Sue K Park, Paul DP Pharoah, Suleeporn Sangrajrang, Chen-Yang Shen, Xiao-Ou Shu, John J Spinelli, Soo H Teo, Daniel C Tessier, Chiu-Chen Tseng, Shoichiro Tsugane, Daniel Vincent, Qin Wang, Anna H Wu, Pei-Ei Wu, Wei Zheng, Keitaro Matsuo
Jun 18, 2019
Overlap of high-risk individuals predicted by family history, and genetic and non-genetic breast cancer risk prediction models
Peh Joo Ho, Weang Kee Ho, Alexis J Khng, Yen Shing Yeoh, Benita Kiat-Tee Tan, Ern Yu Tan, Geok Hoon Lim, Su-Ming Tan, Veronique Kiak Mien Tan, Cheng-Har Yip, Nur-Aishah Mohd-Taib, Fuh Yong Wong, Elaine Hsuen Lim, Joanne Ngeow, Wen Yee Chay, Lester Chee Hao Leong, Wei Sean Yong, Chin Mui Seah, Siau Wei Tang, Celene Wei Qi Ng, Zhiyan Yan, Jung Ah Lee, Kartini Rahmat, Tania Islam, Tiara Hassan, Mei-Chee Tai, Chiea Chuen Khor, Jian-Min Yuan, Woon-Puay Koh, Xueling Sim, Alison M Dunning, Manjeet K Bolla, Antonis C Antoniou, Soo-Hwang Teo, Jingmei Li, Mikael Hartman
May 27, 2022
BACKGROUND: Family history, and genetic and non-genetic risk factors can stratify women according to their individual risk of developing breast cancer. The extent of overlap between these risk predictors is not clear. METHODS...
Relevance of the MHC region for breast cancer susceptibility in Asians.
Peh Joo Ho, Alexis Jiaying Khng, Benita Kiat-Tee Tan, Ern Yu Tan, Su-Ming Tan, Veronique Kiak Mien Tan, Geok Hoon Lim, Kristan J Aronson, Tsun L Chan, Ji-Yeob Choi, Joe Dennis, Weang-Kee Ho, Ming-Feng Hou, Hidemi Ito, Motoki Iwasaki, Esther M John, Daehee Kang, Sung-Won Kim, Allison W Kurian, Ava Kwong, Artitaya Lophatananon, Keitaro Matsuo, Nur Aishah Mohd-Taib, Kenneth Muir, Rachel A Murphy, Sue K Park, Chen-Yang Shen, Xiao-Ou Shu, Soo Hwang Teo, Qin Wang, Taiki Yamaji, Wei Zheng, Manjeet K Bolla, Alison M Dunning, Douglas F Easton, Paul DP Pharoah, Mikael Hartman, Jingmei Li
Aug 18, 2022
BACKGROUND: Human leukocyte antigen (HLA) genes play critical roles in immune surveillance, an important defence against tumors. Imputing HLA genotypes from existing single-nucleotide polymorphism datasets is low-cost and...
Accounting Information Systems (AIS) in SMEs
Small-medium enterprises (SMEs) have always been considered to be the backbone of Brunei's economy. As published by the OECD in 2006, SMEs constitute a high percentage of businesses, where they account for 98% of all active...
Published by: IGI Global Scientific Publishing
P2DF
The extensive use of digital devices by individuals generates a significant amount of private data which creates challenges for investigation agencies to protect suspects' privacy. Existing digital forensics models illustrate...
Published by: IGI Global Scientific Publishing
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