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Results: 61
Culture Matters in Communicating the Global Response to COVID-19.
CO Airhihenbuwa, J Iwelunmor, D Munodawafa, CL Ford, T Oni, C Agyemang, C Mota, OB Ikuomola, L Simbayi, MP Fallah, Z Qian, B Makinwa, C Niang, I Okosun
May 17, 2021
Current communication messages in the COVID-19 pandemic tend to focus more on individual risks than community risks resulting from existing inequities. Culture is central to an effective community-engaged public health...
Diet-Induced Obese Mice and Leptin-Deficient Lepob/ob Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms.
Eunyoung Lee, Emily L Miedzybrodzka, Xilin Zhang, Ryo Hatano, Junki Miyamoto, Ikuo Kimura, Kosuke Fujimoto, Satoshi Uematsu, Sergio Rodriguez-Cuenca, Antonio Vidal-Puig, Fiona M Gribble, Frank Reimann, Takashi Miki
Dec 11, 2019
As glucose-dependent insulinotropic polypeptide (GIP) possesses pro-adipogenic action, the suppression of the GIP hypersecretion seen in obesity might represent a novel therapeutic approach to the treatment of obesity. However...
Lepob/ob diet-induced obese (DIO) mice Glucose-dependent insulinotropic polypeptide (GIP) High-fat diet interleukin-1 receptor antagonist (IL-1Ra) Leptin Animals Diet High-Fat Gastric Inhibitory Polypeptide Gene Expression Interleukin 1 Receptor Antagonist Protein Leptin Male Mice Inbred C57BL Mice Obese obesity Receptors G-Protein-Coupled Receptors Gastrointestinal Hormone
Increased hepatic oxidative metabolism distinguishes the action of Peroxisome proliferator-activated receptor delta from Peroxisome proliferator-activated receptor gamma in the ob/ob mouse.
Lee D Roberts, David G Hassall, Deborah A Winegar, John N Haselden, Andrew W Nicholls, Julian L Griffin
Jun 17, 2011
BACKGROUND: The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors and members of the nuclear receptor superfamily. The PPAR family consists of three members: PPARalpha, PPARgamma, and...
Maternal Metformin Intervention during Obese Glucose-Intolerant Pregnancy Affects Adiposity in Young Adult Mouse Offspring in a Sex-Specific Manner
Josca M. Schoonejans, Heather L. Blackmore, Thomas J. Ashmore, Catherine E. Aiken, Denise S. Fernandez-Twinn, Susan E. Ozanne
Jul 29, 2021
Background: Metformin is commonly used to treat gestational diabetes mellitus. This study investigated the effect of maternal metformin intervention during obese glucose-intolerant pregnancy on the gonadal white adipose tissue...
The Identification of a Leptin Dependent Neural Pathway Regulating Adipose Tissue Innervation
Putianqi Wang
Jan 01, 0001
Leptin, secreted by the adipose tissue, is an afferent signal of a negative feedback loop that regulates body weight balance through its effects on feeding and energy expenditure. Mutations in the leptin gene or its cognate...
Published by: Rockefeller University
Maternal Metformin Intervention during Obese Glucose-Intolerant Pregnancy Affects Adiposity in Young Adult Mouse Offspring in a Sex-Specific Manner.
Josca M Schoonejans, Heather L Blackmore, Thomas J Ashmore, Catherine E Aiken, Denise S Fernandez-Twinn, Susan E Ozanne
Sep 08, 2021
Background
Metformin is commonly used to treat gestational diabetes mellitus. This study investigated the effect of maternal metformin intervention during obese glucose-intolerant pregnancy on the gonadal white adipose...
Metformin Sex differences Gestational diabetes White adipose tissue Maternal obesity Foetal programming
Published by: International journal of molecular sciences
Maternal Metformin Intervention during Obese Glucose-Intolerant Pregnancy Affects Adiposity in Young Adult Mouse Offspring in a Sex-Specific Manner.
Josca M Schoonejans, Heather L Blackmore, Thomas J Ashmore, Catherine E Aiken, Denise S Fernandez-Twinn, Susan E Ozanne
Jul 27, 2021
BACKGROUND: Metformin is commonly used to treat gestational diabetes mellitus. This study investigated the effect of maternal metformin intervention during obese glucose-intolerant pregnancy on the gonadal white adipose tissue...
Plasma from pre-pubertal obese children impairs insulin stimulated Nitric Oxide (NO) bioavailability in endothelial cells
Natalia Di Pietro, M Loredana Marcovecchio, Sara Di Silvestre, Tommaso de Giorgis, Vincenzo Giuseppe Pio Cordone, Paola Lanuti, Francesco Chiarelli, Giuseppina Bologna, Angelika Mohn, Assunta Pandolfi
Aug 01, 2018
Childhood obesity is commonly associated with early signs of endothelial dysfunction, characterized by impairment of insulin signaling and vascular Nitric Oxide (NO) availability. However, the underlying mechanisms remain to be...
ER stress Endothelial dysfunction Insulin Resistance Nitric oxide obesity Activating Transcription Factor 6 Biological Availability Biomarkers Cell Nucleus Child Cyclic GMP Endoplasmic Reticulum Chaperone BiP Endoplasmic reticulum stress Human Umbilical Vein Endothelial Cells Humans Insulin Models Biological NF-kappa B Nitric oxide Nitric Oxide Synthase Type III obesity Phosphorylation Protein Transport Proto-Oncogene Proteins c-akt Puberty
Leptin and the Control of Body Weight and Metabolism: Role for Stearoyl CoA Desaturase-1 and Other Leptin-Regulated Genes in the Liver
Paul Cohen
Jan 01, 0001
Leptin is an adipocyte-derived hormone that regulates energy balance, metabolism, and the neuroendocrine response to altered nutrition. Mice lacking leptin (ob/ob) or its receptor (db/db) are massively obese and hyperphagic....
Published by: Rockefeller University
Leptin Signaling in the Ovary of Diet-Induced Obese Mice Regulates Activation of NOD-Like Receptor Protein 3 Inflammasome.
Marek Adamowski, Karolina Wołodko, Joana Oliveira, Juan Castillo-Fernandez, Daniel Murta, Gavin Kelsey, António M Galvão
Nov 22, 2021
Obesity leads to ovarian dysfunction and the establishment of local leptin resistance. The aim of our study was to characterize the levels of NOD-like receptor protein 3 (NLRP3) inflammasome activation in ovaries and liver of...
A Fast Algorithm for Analysis of Molecular Communication in Artificial Synapse
In this paper we analyse molecular communications (MC) in a proposed artificial synapse (AS), whose main difference from biological synapses (BSs) is that it is closed, i.e., transmitter molecules cannot diffuse out from AS....
Diffusion-Based Model for Synaptic Molecular Communication Channel
Computational methods have been extensively used to understand the underlying dynamics of molecular communication methods employed by nature. One very effective and popular approach is to utilize a Monte Carlo simulation....
Restriction of Food Intake by Dorsomedial Hypothalamus
Caner Caglar
Jan 01, 0001
Leptin deficient ob/ob mice eat voraciously and their food intake is markedly reduced by leptin treatment. Leptin acts in part by regulating the activity of AGRP neurons and POMC neurons in the arcuate nucleus and neurons in...
Published by: Rockefeller University
Olfactory bulb hypoplasia in Prokr2 null mice stems from defective neuronal progenitor migration and differentiation.
New neurons are added on a daily basis to the olfactory bulb (OB) of a mammal, and this phenomenon exists throughout its lifetime. These new cells are born in the subventricular zone and migrate to the OB via the rostral...
Animals Animals Newborn Bromodeoxyuridine Cell Count Cell Differentiation Cell Movement Doublecortin Domain Proteins Female Gastrointestinal Hormones Homozygote Humans Lactation Mice Mice Inbred C57BL Mice Knockout Microtubule-Associated Proteins Neural Cell Adhesion Molecule L1 Neurons Neuropeptides Olfactory Bulb Receptors G-Protein-Coupled Receptors Peptide Recombinant Proteins Sialic Acids Spheroids Cellular Stem Cells Tyrosine 3-Monooxygenase
Phenotypic characterization of Adig null mice suggests roles for adipogenin in the regulation of fat mass accrual and leptin secretion.
Anna Alvarez-Guaita, Satish Patel, Koini Lim, Afreen Haider, Liang Dong, Olivia J Conway, Marcella Kl Ma, Davide Chiarugi, Vladimir Saudek, Stephen O'Rahilly, David B Savage
Feb 11, 2021
Adipogenin (Adig) is an adipocyte-enriched transmembrane protein. Its expression is induced during adipogenesis in rodent cells, and a recent genome-wide association study associated body mass index (BMI)-adjusted leptin levels...
Single-cell lineage tracing in the mammary gland reveals stochastic clonal dispersion of stem/progenitor cell progeny.
Organizations and efficiency in public services
Abstract: Foundational debates about public service provision originate with the study of private lighthouses in England and Wales. We provide a new empirical assessment of cost and technical efficiency of competing lighthouse...
Modelling local variables
Local variables in imperative languages have been given denotational semantics in at least two fundamentally different ways. One is by use of functor categories, focusing on the idea of possible worlds. The other might be termed...
Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence.
Sara Kohnke, Sophie Buller, Danae Nuzzaci, Katherine Ridley, Brian Lam, Helena Pivonkova, Marie A Bentsen, Kimberly M Alonge, Chao Zhao, John Tadross, Staffan Holmqvist, Takahiro Shimizu, Hannah Hathaway, Huiliang Li, Wendy Macklin, Michael W Schwartz, William D Richardson, Giles SH Yeo, Robin Jm Franklin, Ragnhildur T Karadottir, David H Rowitch, Clemence Blouet
May 11, 2021
The mediobasal hypothalamus (MBH; arcuate nucleus of the hypothalamus [ARH] and median eminence [ME]) is a key nutrient sensing site for the production of the complex homeostatic feedback responses required for the maintenance...
Energy balance Glucose homeostasis Hypothalamus Median eminence Nutrition obesity oligodendrocyte Perineuronal nets plasticity Adult Animals Cell Differentiation Cell Lineage Cell Proliferation Humans Male Mechanistic Target of Rapamycin Complex 1 Median eminence Mice Inbred C57BL Nerve Net Nutritional Physiological Phenomena Oligodendroglia Single-Cell Analysis Transcriptome
Modelling local variables
Local variables in imperative languages have been given denotational semantics in at least two fundamentally different ways. One is by use of functor categories, focusing on the idea of possible worlds. The other might be termed...
Brain tissue stiffness is a sensitive marker for acidosis.
Kathrin Holtzmann, Hélène OB Gautier, Andreas F Christ, Jochen Guck, Ragnhildur Thóra Káradóttir, Kristian Franze
Aug 15, 2016
Life Without GPR7, the Neuropeptide W1 Receptor: Regulation of Energy Homeostasis by GPR7 and its Endogenous Neuropeptide Ligands
Makoto Ishii
Jan 01, 0001
Classic lesion experiments from the 1940s have established the hypothalamus as playing an essential role in controlling energy homeostasis. Gold-thioglucose (GTG) induces lesions in the ventromedial nucleus of the hypothalamus...
Published by: Rockefeller University
A Hybrid Moth-Flame Optimization Technique for Feature Selection in Brain Image Classification and Image Denoising by Improved Log Gabor Filter
In brain image classification, feature set reduction is essential to build an optimised feature subset that will lead to precise measurement. In this paper, an improved technique for feature selection by Moth Flame Optimization...
Computer Vision & Image Processing Computer Science and Information Technology Computer Vision and Machine Perception
Published by: IGI Global Scientific Publishing
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