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Results: 10109
Mice Deficient in Nucleoporin Nup210 Develop Peripheral T Cell Alterations.
Annemarie van Nieuwenhuijze, Oliver Burton, Pierre Lemaitre, Alice E Denton, Ana Cascalho, Rose E Goodchild, Bert Malengier-Devlies, Bénédicte Cauwe, Michelle A Linterman, Stephanie Humblet-Baron, Adrian Liston
Jun 14, 2019
The nucleopore is an essential structure of the eukaryotic cell, regulating passage between the nucleus and cytoplasm. While individual functions of core nucleopore proteins have been identified, the role of other components...
CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Nup210 nucleopore Spleen Thymus Gland Animals CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Female Homeostasis Male Mice Mice Inbred C57BL Mice Knockout Mice Mutant Strains Mutation Nuclear Pore Nuclear Pore Complex Proteins statistics Nonparametric Th1 Cells Th2 Cells Thymocytes Thymus Gland
Certified/Trained Birth Doulas Impact for Successful Breastfeeding Rates for Women of Color In North Carolina
The purpose of this literature review is to determine the impact Certified/Trained Birth Doulas (CTBD) can have for impacting successful breastfeeding rates for women of color in North Carolina. We want to collect data from...
Published by: Winthrop University
Increased IL-10-producing regulatory T cells are characteristic of severe cases of COVID-19.
Julika Neumann, Teresa Prezzemolo, Lore Vanderbeke, Carlos P Roca, Margaux Gerbaux, Silke Janssens, Mathijs Willemsen, Oliver Burton, Pierre Van Mol, Yannick Van Herck, CONTAGIOUS co‐authors, Joost Wauters, Els Wauters, Adrian Liston, Stephanie Humblet-Baron
Jan 08, 2021
OBJECTIVES: The pandemic spread of the coronavirus SARS-CoV-2 is due, in part, to the immunological properties of the host-virus interaction. The clinical presentation varies from individual to individual, with asymptomatic...
Does the PI3K pathway promote or antagonize regulatory T cell development and function?
Regulatory T cells (Tregs) prevent autoimmunity and inflammation by suppressing the activation of other T cells and antigen presenting cells. The role of phosphoinositide 3-kinase (PI3K) signaling in Treg is controversial. Some...
Problem formulation for theorizing at the frontier
Ostensibly, the evolving science of strategic management is geared towards addressing vexing
managerial problems. In practice, however, scholars in the field have a marked tendency to formulate problems to fit existing...
managerial problems. In practice, however, scholars in the field have a marked tendency to formulate problems to fit existing...
Transcutaneous vagus nerve stimulation (t-VNS)
Katherine E Manning, Jessica A Beresford-Webb, Lucie C S Aman, Howard A Ring, Peter C Watson, Stephen W Porges, Chris Oliver, Sally R Jennings, Anthony J Holland
Jan 06, 2020
Temper outbursts are a severe problem for people with Prader-Willi Syndrome (PWS). Previous reports indicate that vagus nerve stimulation (VNS) may reduce maladaptive behaviour in neurodevelopmental disorders, including PWS. We...
On the stability of travelling waves with vorticity obtained by minimization
We modify the approach of Burton and Toland Comm. Pure Appl. Math. (2011) to show the existence of periodic surface water waves with vorticity in order that it becomes suited to a stability analysis. This is achieved by...
The Ursinus Weekly, November 18, 1918
Math group spends delightful evening "Victory parade" a remarkable occasion Letter received from "over there" Hockey game Ursinus versus Navy Contributed article: A prophecy Y.W.C.A. week of prayer S. A. T. C. notes ...
Ursinus College Collegeville Pennsylvania newspaper Frank Glendenning Student Army Training Corps YMCA YWCA Zwinglian literary society Schaff literary society cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
On the stability of travelling waves with vorticity obtained by minimization
We modify the approach of Burton and Toland Comm. Pure Appl. Math. (2011) to show the existence of periodic surface water waves with vorticity in order that it becomes suited to a stability analysis. This is achieved by...
Problem formulation for theorizing at the frontier
Ostensibly, the evolving science of strategic management is geared towards addressing vexing
managerial problems. In practice, however, scholars in the field have a marked tendency to formulate problems to fit existing...
managerial problems. In practice, however, scholars in the field have a marked tendency to formulate problems to fit existing...
B-hadron production in NNLO QCD
We calculate, for the first time, the NNLO QCD corrections to identified
heavy hadron production at hadron colliders. The calculation is based on a
flexible numeric framework which allows the calculation of any distribution of
a...
Oliver Cromwell and the People of God
DL Smith
Jul 01, 2019
On 21 April 1657, in one of the speeches to Parliament’s representatives in which he meditated on their offer of the kingship, Oliver Cromwell offered these words of praise for those who had framed the Humble Petition and...
Latent cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise
James E. Turner, Sarah Aldred, Oliver C. Witard, Mark T. Drayson, Paul M. Moss, Jos A. Bosch
Nov 01, 2010
Exercise induces mobilisation of CD8(+) T lymphocytes (CD8TL) into the peripheral blood. This response is largely confined to effector-memory CD8TLs: antigen experienced cells which have a strong tissue-homing and effector...
Defective lymphoid organogenesis underlies the immune deficiency caused by a heterozygous S32I mutation in IκBα.
Jana L Mooster, Severine Le Bras, Michel J Massaad, Haifa Jabara, Juhan Yoon, Claire Galand, Balthasar A Heesters, Oliver T Burton, Hamid Mattoo, John Manis, Raif S Geha
Jun 27, 2019
Patients with ectodermal dysplasia with immunodeficiency (ED-ID) caused by mutations in the inhibitor of NF-κB α (IκBα) are susceptible to severe recurrent infections, despite normal T and B cell numbers and intact in vitro...
Animals Antibody Formation B-Lymphocytes Codon Dermatitis Contact Disease Models Animal Heterozygote Hypersensitivity Delayed I-kappa B Proteins Immunologic Deficiency Syndromes Lymphoid Tissue Mice Mice Transgenic Mutation NF-KappaB Inhibitor alpha Organogenesis Phosphorylation Proteolysis T-Lymphocyte Subsets Toll-Like Receptors Tumor Necrosis Factors
Restriction endonuclease TseI cleaves A:A and T
Long Ma, Kai Chen, David J Clarke, Christopher P Nortcliffe, Geoffrey G Wilson, J Michael Edwardson, A Jennifer Morton, Anita C Jones, David TF Dryden
Feb 13, 2020
The type II restriction endonuclease TseI recognizes the DNA target sequence 5'-G^CWGC-3' (where W = A or T) and cleaves after the first G to produce fragments with three-base 5'-overhangs. We have determined that it is a...
Interview with Booker T. Brown - OH 689
This interview was conducted by Dr. George Garrison with Booker T. Brown with a focus on the History of Emmett Scott High School. Emmett Scott was the segregated high school for African-Americans, which was named after Emmett...
Published by: Winthrop University
Immune modulation by Schistosoma mansoni antigens in NOD mice
Paola Zaccone, Oliver T Burton, Sarah Gibbs, Nigel Miller, Frances M Jones, David W Dunne, Anne Cooke
Oct 03, 2017
Adaptive Immunity Animals Antigens Helminth Cell Proliferation Cytokines Dendritic Cells Diabetes mellitus Type 1 Female Forkhead Transcription Factors host-parasite interactions Immunity Innate MACROPHAGES Mice Mice Inbred NOD Models Immunological Phenotype Schistosoma mansoni Schistosomiasis mansoni statistics Nonparametric T-Lymphocytes Regulatory Th2 Cells Transforming Growth Factor beta
CCR8 marks highly suppressive Treg cells within tumours but is dispensable for their accumulation and suppressive function.
Sarah K Whiteside, Francis M Grant, David S Gyori, Alberto G Conti, Charlotte J Imianowski, Paula Kuo, Rabab Nasrallah, Firas Sadiyah, Sergio A Lira, Frank Tacke, Robert L Eil, Oliver T Burton, James Dooley, Adrian Liston, Klaus Okkenhaug, Jie Yang, Rahul Roychoudhuri
May 10, 2021
CD4+ regulatory T (Treg) cells, dependent upon the transcription factor Foxp3, contribute to tumour immunosuppression but are also required for immune homeostasis. There is interest in developing therapies that selectively...
CCR8 CD4+ T cells CD8+ T cells FOXP3 Treg Cancer Immunotherapy Adenocarcinoma Animals Colorectal Neoplasms Forkhead Transcription Factors Humans Immune Tolerance Lymphocytes Tumor-Infiltrating Melanoma Melanoma Experimental Mice Mice Inbred C57BL Mice Knockout Receptors CCR8 Skin Neoplasms T-Lymphocytes Regulatory
Glycolysis promotes caspase-3 activation in lipid rafts in T cells.
Michael A Secinaro, Karen A Fortner, Oliver Dienz, Angela Logan, Michael P Murphy, Vikas Anathy, Jonathan E Boyson, Ralph C Budd
Jun 12, 2018
Resting T cells undergo a rapid metabolic shift to glycolysis upon activation in the presence of interleukin (IL)-2, in contrast to oxidative mitochondrial respiration with IL-15. Paralleling these different metabolic states are...
Latent cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise
James E. Turner, Sarah Aldred, Oliver C. Witard, Mark T. Drayson, Paul M. Moss, Jos A. Bosch
Nov 01, 2010
Exercise induces mobilisation of CD8(+) T lymphocytes (CD8TL) into the peripheral blood. This response is largely confined to effector-memory CD8TLs: antigen experienced cells which have a strong tissue-homing and effector...
Sceptical Perspectives on Melancholy
C Tilmouth
May 17, 2017
This article examines common features in Swift, Pope and Sterne’s responses to Burton’s Anatomy of Melancholy and the wider humoral tradition. It documents the willingness of Swift and Pope simultaneously to take the latter...
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4 + T Cells
Daisy H. Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T. Hawkins, Len R. Stephens, Simon T. Barry, Klaus Okkenhaug
Mar 22, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells.
Daisy H Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T Hawkins, Len R Stephens, Simon T Barry, Klaus Okkenhaug
Feb 03, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
CD4-Positive T-Lymphocytes Animals Mice Inbred C57BL Mice Multiprotein Complexes Receptors Antigen T-Cell Interleukin-2 Lymphocyte Activation Specific Pathogen-Free Organisms Signal Transduction Cell Differentiation Gene Knockout Techniques Class I Phosphatidylinositol 3-Kinases CRISPR-Cas Systems Gene Editing
Tunable Anion-Selective Transport through Monolayer Graphene and Hexagonal Boron Nitride.
Mustafa Caglar, Inese Silkina, Bertram T Brown, Alice L Thorneywork, Oliver J Burton, Vitaliy Babenko, Stephen Matthew Gilbert, Alex Zettl, Stephan Hofmann, Ulrich F Keyser
Jan 06, 2020
Membranes that selectively filter for both anions and cations are central to technological applications from clean energy generation to desalination devices. 2D materials have immense potential as these ion-selective membranes...
Extracellular Lactate
James T Grist, Lorna B Jarvis, Zoya Georgieva, Sara Thompson, Harpreet Kaur Sandhu, Keith Burling, Ashley Clarke, Sarah Jackson, Mark Wills, Ferdia A Gallagher, Joanne L Jones
Feb 23, 2018
Following activation, T cells rapidly divide and acquire effector functions. This energetically demanding process depends upon the ability of T cells to undergo metabolic remodeling from oxidative phosphorylation to aerobic...
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