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De Sitter microstates from T T¯ + Λ<inf>2</inf> and the Hawking-Page transition
We obtain microstates accounting for the Gibbons-Hawking entropy in $dS_3$,
along with a subleading logarithmic correction, from the solvable $T\bar
T+\Lambda_2$ deformation of a seed CFT with sparse light spectrum....
Tumors induce de novo steroid biosynthesis in T cells to evade immunity
Bidesh Mahata, Jhuma Pramanik, Louise van der Weyden, Krzysztof Polanski, Gozde Kar, Angela Riedel, Xi Chen, Nuno A. Fonseca, Kousik Kundu, Lia S. Campos, Edward Ryder, Graham Duddy, Izabela Walczak, Klaus Okkenhaug, David J. Adams, Jacqueline D. Shields, Sarah A. Teichmann
Jul 17, 2020
Abstract: Tumors subvert immune cell function to evade immune responses, yet the complex mechanisms driving immune evasion remain poorly understood. Here we show that tumors induce de novo steroidogenesis in T lymphocytes to...
de Sitter Microstates from $T\bar T+Λ_2$ and the Hawking-Page
Transition
Evan Coleman, Edward A Mazenc, Vasudev Shyam, Eva Silverstein, Ronak Soni, Gonzalo Torroba, Sungyeon Yang
Jul 28, 2022
We obtain microstates accounting for the Gibbons-Hawking entropy in $dS_3$,
along with a subleading logarithmic correction, from the solvable $T\bar
T+\Lambda_2$ deformation of a seed CFT with sparse light spectrum....
Published by: Springer Berlin Heidelberg
Tumors induce de novo steroid biosynthesis in T cells to evade immunity
Bidesh Mahata, Jhuma Pramanik, Louise van der Weyden, Krzysztof Polanski, Gozde Kar, Angela Riedel, Xi Chen, Nuno A. Fonseca, Kousik Kundu, Lia S. Campos, Edward Ryder, Graham Duddy, Izabela Walczak, Klaus Okkenhaug, David J. Adams, Jacqueline D. Shields, Sarah A. Teichmann
Jul 28, 2021
Abstract: Tumors subvert immune cell function to evade immune responses, yet the complex mechanisms driving immune evasion remain poorly understood. Here we show that tumors induce de novo steroidogenesis in T lymphocytes to...
Measurement of the t(t)over-bar production cross section in p(p)over-bar collisions at root s=1.96 TeV
A Abulencia, D Acosta, J Adelman, T Affolder, T Akimoto, MG Albrow, D Ambrose, S Amerio, D Amidei, A Anastassov, K Anikeev, A Annovi, J Antos, M Aoki, G Apollinari, JF Arguin, T Arisawa, A Artikov, W Ashmanskas, A Attal, F Azfar, P Azzi-Bacchetta, P Azzurri, N Bacchetta, H Bachacou, W Badgett, A Barbaro-Galtieri, VE Barnes, BA Barnett, S Baroiant, V Bartsch, G Bauer, F Bedeschi, S Behari, S Belforte, G Bellettini, J Bellinger, A Belloni, E Ben Haim, D Benjamin, A Beretvas, J Beringer, T Berry, A Bhatti, M Binkley, D Bisello, RE Blair, C Blocker, B Blumenfeld, A Bocci, A Bodek, V Boisvert, G Bolla, A Bolshov, D Bortoletto, J Boudreau, A Boveia, B Brau, C Bromberg, E Brubaker, J Budagov, HS Budd, S Budd, K Burkett, G Busetto, P Bussey, KL Byrum, S Cabrera, M Campanelli, M Campbell, F Canelli, A Canepa, D Carlsmith, R Carosi, S Carron, M Casarsa, A Castro, P Catastini, D Cauz, M Cavalli-Sforza, A Cerri, L Cerrito, SH Chang, J Chapman, YC Chen, M Chertok, G Chiarelli, G Chlachidze, F Chlebana, I Cho, K Cho, D Chokheli, JP Chou, PH Chu, SH Chuang, K Chung, WH Chung, YS Chung, M Ciljak, CI Ciobanu, MA Ciocci, A Clark, D Clark, M Coca, G Compostella, ME Convery, J Conway, B Cooper, K Copic, M Cordelli, G Cortiana, F Cresciolo, A Cruz, CC Almenar, J Cuevas, R Culbertson, D Cyr, S DaRonco, S D'Auria, M D'Onofrio, D Dagenhart, P de Barbaro, S De Cecco, A Deisher, G De Lentdecker, M Dell'Orso, FD Paoli, S Demers, L Demortier, J Deng, M Deninno, D De Pedis, PF Derwent, C Dionisi, JR Dittmann, P DiTuro, C Dorr, S Donati, M Donega, P Dong, J Donini, T Dorigo, S Dube, K Ebina, J Efron, J Ehlers, R Erbacher, D Errede, S Errede, R Eusebi, HC Fang, S Farrington, I Fedorko, WT Fedorko, RG Feild, M Feindt, JP Fernandez, R Field, G Flanagan, LR Flores-Castillo, A Foland, S Forrester, GW Foster, M Franklin, JC Freeman, I Furic, M Gallinaro, J Galyardt, JE Garcia, MG Sciveres, AF Garfinkel, C Gay, H Gerberich, D Gerdes, S Giagu, P Giannetti, A Gibson, K Gibson, C Ginsburg, N Giokaris, K Giolo, M Giordani, P Giromini, M Giunta, G Giurgiu, V Glagolev, D Glenzinski, M Gold, N Goldschmidt, J Goldstein, G Gomez, G Gomez-Ceballos, M Goncharov, O Gonzalez, I Gorelov, AT Goshaw, Y Gotra, K Goulianos, A Gresele, M Griffiths, S Grinstein, C Grosso-Pilcher, RC Group, U Grundler, JG da Costa, Z Gunay-Unalan, C Haber, SR Hahn, K Hahn, E Halkiadakis, A Hamilton, BY Han, JY Han, R Handler, F Happacher, K Hara, M Hare, S Harper, RF Harr, RM Harris, K Hatakeyama, J Hauser, C Hays, A Heijboer, B Heinemann, J Heinrich, M Herndon, D Hidas, CS Hill, D Hirschbuehl, A Hocker, A Holloway, S Hou, M Houlden, SC Hsu, BT Huffman, RE Hughes, J Huston, J Incandela, G Introzzi, M Iori, Y Ishizawa, A Ivanov, B Iyutin, E James, D Jang, B Jayatilaka, D Jeans, H Jensen, EJ Jeon, S Jindariani, M Jones, KK Joo, SY Jun, TR Junk, T Kamon, J Kang, PE Karchin, Y Kato, Y Kemp, R Kephart, U Kerzel, V Khotilovich, B Kilminster, DH Kim, HS Kim, JE Kim, MJ Kim, SB Kim, SH Kim, YK Kim, L Kirsch, S Klimenko, M Klute, B Knuteson, BR Ko, H Kobayashi, K Kondo, DJ Kong, J Konigsberg, A Korytov, AV Kotwal, A Kovalev, A Kraan, J Kraus, I Kravchenko, M Kreps, J Kroll, N Krumnack, M Kruse, V Krutelyov, SE Kuhlmann, Y Kusakabe, S Kwang, AT Laasanen, S Lai, S Lami, S Lammel, M Lancaster, RL Lander, K Lannon, A Lath, G Latino, I Lazzizzera, T LeCompte, J Lee, J Lee, YJ Lee, SW Lee, R Lefevre, N Leonardo, S Leone, S Levy, JD Lewis, C Lin, CS Lin, M Lindgren, E Lipeles, TM Liss, A Lister, DO Litvintsev, T Liu, NS Lockyer, A Loginov, M Loreti, P Loverre, RS Lu, D Lucchesi, P Lujan, P Lukens, G Lungu, L Lyons, J Lys, R Lysak, E Lytken, P Mack, D MacQueen, R Madrak, K Maeshima, T Maki, P Maksimovic, S Malde, G Manca, F Margaroli, R Marginean, C Marino, A Martin, V Martin, M Martinez, T Maruyama, P Mastrandrea, H Matsunaga, ME Mattson, R Mazini, P Mazzanti, KS McFarland, M McFarlane, P McIntyre, R McNulty, A Mehta, S Menzemer, A Menzione, P Merkel, C Mesropian, A Messina, M von der Mey, T Miao, N Miladinovic, J Miles, R Miller, JS Miller, C Mills, M Milnik, R Miquel, A Mitra, G Mitselmakher, A Miyamoto, N Moggi, B Mohr, R Moore, M Morello, PM Fernandez, J Mulmenstadt, A Mukherjee, T Muller, R Mumford, P Murat, J Nachtman, J Naganoma, S Nahn, I Nakano, A Napier, D Naumov, V Necula, C Neu, MS Neubauer, J Nielsen, T Nigmanov, L Nodulman, O Norniella, E Nurse, T Ogawa, SH Oh, YD Oh, T Okusawa, R Oldeman, R Orava, K Osterberg, C Pagliarone, E Palencia, R Paoletti, V Papadimitriou, AA Paramonov, B Parks, S Pashapour, J Patrick, G Pauletta, M Paulini, C Paus, DE Pellett, A Penzo, TJ Phillips, G Piacentino, J Piedra, L Pinera, K Pitts, C Plager, L Pondrom, X Portell, O Poukhov, N Pounder, F Prakoshyn, A Pronko, J Proudfoot, F Ptohos, G Punzi, J Pursley, J Rademacker, A Rahaman, A Rakitin, S Rappoccio, F Ratnikov, B Reisert, V Rekovic, N van Remortel, P Renton, M Rescigno, S Richter, F Rimondi, L Ristori, WJ Robertson, A Robson, T Rodrigo, E Rogers, S Rolli, R Roser, M Rossi, R Rossin, C Rott, A Ruiz, J Russ, V Rusu, H Saarikko, S Sabik, A Safonov, WK Sakumoto, G Salamanna, O Salto, D Saltzberg, C Sanchez, L Santi, S Sarkar, L Sartori, K Sato, P Savard, A Savoy-Navarro, T Scheidle, P Schlabach, EE Schmidt, P Schmidt, M Schmitt, T Schwarz, L Scodellaro, AL Scott, A Scribano, F Scuri, A Sedov, S Seidel, Y Seiya, A Semenov, L Sexton-Kennedy, I Sfiligoi, MD Shapiro, T Shears, PF Shepard, D Sherman, M Shimojima, M Shochet, Y Shon, I Shreyber, A Sidoti, P Sinervo, A Sisakyan, J Sjolin, A Skiba, AJ Slaughter, K Sliwa, JR Smith, FD Snider, R Snihur, M Soderberg, A Soha, S Somalwar, V Sorin, J Spalding, M Spezziga, F Spinella, T Spreitzer, P Squillacioti, M Stanitzki, A Staveris-Polykalas, RS Denis, B Stelzer, O Stelzer-Chilton, D Stentz, J Strologas, D Stuart, JS Suh, A Sukhanov, K Sumorok, H Sun, T Suzuki, A Taffard, R Takashima, Y Takeuchi, K Takikawa, M Tanaka, R Tanaka, N Tanimoto, M Tecchio, PK Teng, K Terashi, S Tether, J Thom, AS Thompson, E Thomson, P Tipton, V Tiwari, S Tkaczyk, D Toback, S Tokar, K Tollefson, T Tomura, D Tonelli, M Tonnesmann, S Torre, D Torretta, S Tourneur, W Trischuk, R Tsuchiya, S Tsuno, N Turini, F Ukegawa, T Unverhau, S Uozumi, D Usynin, A Vaiciulis, S Vallecorsa, A Varganov, E Vataga, G Velev, G Veramendi, V Veszpremi, R Vidal, I Vila, R Vilar, T Vine, I Vollrath, I Volobouev, G Volpi, F Wurthwein, P Wagner, RG Wagner, RL Wagner, W Wagner, R Wallny, T Walter, Z Wan, SM Wang, A Warburton, S Waschke, D Waters, WC Wester, B Whitehouse, D Whiteson, AB Wicklund, E Wicklund, G Williams, HH Williams, P Wilson, BL Winer, P Wittich, S Wolbers, C Wolfe, T Wright, X Wu, SM Wynne, A Yagil, K Yamamoto, J Yamaoka, T Yamashita, C Yang, UK Yang, YC Yang, WM Yao, GP Yeh, J Yoh, K Yorita, T Yoshida, GB Yu, I Yu, SS Yu, JC Yun, L Zanello, A Zanetti, I Zaw, F Zetti, X Zhang, J Zhou, S Zucchelli, CDF Collaboration
Dec 15, 2021
The production cross-sections of $J/\psi$ mesons in proton-proton collisions
at a centre-of-mass energy of $\sqrt{s}=5$ TeV are measured using a data sample
corresponding to an integrated luminosity of...
Tumors induce de novo steroid biosynthesis in T cells to evade immunity.
Bidesh Mahata, Jhuma Pramanik, Louise van der Weyden, Krzysztof Polanski, Gozde Kar, Angela Riedel, Xi Chen, Nuno A Fonseca, Kousik Kundu, Lia S Campos, Edward Ryder, Graham Duddy, Izabela Walczak, Klaus Okkenhaug, David J Adams, Jacqueline D Shields, Sarah A Teichmann
Jul 30, 2020
Tumors subvert immune cell function to evade immune responses, yet the complex mechanisms driving immune evasion remain poorly understood. Here we show that tumors induce de novo steroidogenesis in T lymphocytes to evade...
De Sitter microstates from T T¯ + Λ<inf>2</inf> and the Hawking-Page transition
We obtain microstates accounting for the Gibbons-Hawking entropy in $dS_3$,
along with a subleading logarithmic correction, from the solvable $T\bar
T+\Lambda_2$ deformation of a seed CFT with sparse light spectrum....
Desgarraduras del cuerpo y degolladuras de la voz
B Epps
Aug 24, 2017
El mismo mar de todos los veranos de Esther Tusquets narra la tormentosa relación erótica y emocional de una mujer de la alta burguesía catalana, casada y desencantada, que ejerce de profesora de literatura, con una joven...
Restriction endonuclease TseI cleaves A:A and T
Long Ma, Kai Chen, David J Clarke, Christopher P Nortcliffe, Geoffrey G Wilson, J Michael Edwardson, A Jennifer Morton, Anita C Jones, David TF Dryden
Feb 13, 2020
The type II restriction endonuclease TseI recognizes the DNA target sequence 5'-G^CWGC-3' (where W = A or T) and cleaves after the first G to produce fragments with three-base 5'-overhangs. We have determined that it is a...
Infancy‐onset diabetes caused by de‐regulated
<scp>AMPylation</scp>
of the human endoplasmic reticulum chaperone
<scp>BiP</scp>
Luke A Perera, Andrew T Hattersley, Heather P Harding, Matthew N Wakeling, Sarah E Flanagan, Ibrahim Mohsina, Jamal Raza, Alice Gardham, David Ron, Elisa De Franco
Jan 27, 2023
Dysfunction of the endoplasmic reticulum (ER) in insulin‐producing beta cells results in cell loss and diabetes mellitus. Here we report on five individuals from three different consanguineous families with infancy‐onset...
De-globalisation and decoupling
P Williamson
Feb 19, 2021
It has become fashionable to argue that the post-coronavirus world will see an acceleration in de-globalisation and decoupling and that companies will substantively re-localise their supply chains (Javorcik, 2020; McKinsey...
Poor CD4+ T Cell Immunogenicity Limits Humoral Immunity to P. falciparum Transmission-Blocking Candidate Pfs25 in Humans.
Marija Zaric, Arianna Marini, Carolyn M Nielsen, Gaurav Gupta, David Mekhaiel, Thao P Pham, Sean C Elias, Iona J Taylor, Hans de Graaf, Ruth O Payne, Yuanyuan Li, Sarah E Silk, Chris Williams, Adrian VS Hill, Carole A Long, Kazutoyo Miura, Sumi Biswas
Nov 25, 2021
Plasmodium falciparum transmission-blocking vaccines (TBVs) targeting the Pfs25 antigen have shown promise in mice but the same efficacy has never been achieved in humans. We have previously published pre-clinical data related...
CD4+ P. falciparum Pfs25 transmission blocking vaccine Adolescent Adult Animals Antibodies Protozoan B-Lymphocytes CD4-Positive T-Lymphocytes Cells Cultured Disease Models Animal Epitopes Female Humans Immunity Humoral Immunogenicity Vaccine Malaria Vaccines Malaria Falciparum Male Mice Mice Inbred BALB C Middle Aged Plasmodium falciparum Protozoan Proteins Recombinant Proteins Species Specificity Vaccination Young Adult
De la philosophie de la religion dans l’oeuvre de Landgrebe
Sylvain Camilleri
Apr 22, 2021
Nombreux sont les premiers disciples de Husserl à s’être intéressés de prèsà la religion. Landgrebe ne fait pas exception à la règle, même si j’entendsmontrer qu’il constitue plutôt un cas à part. Pourquoi donc ? Parce que...
Published by: Memorial University of Newfoundland
Millikelvin de Haas–van Alphen and magnetotransport studies of graphite
Recent studies of the electronic properties of graphite have produced conflicting results regarding the positions of the different carrier types within the Brillouin zone, and the possible presence of Dirac fermions. In this...
De la philosophie de la religion dans l’oeuvre de Landgrebe
Sylvain Camilleri
Apr 22, 2021
Nombreux sont les premiers disciples de Husserl à s’être intéressés de prèsà la religion. Landgrebe ne fait pas exception à la règle, même si j’entendsmontrer qu’il constitue plutôt un cas à part. Pourquoi donc ? Parce que...
Published by: Memorial University of Newfoundland
B-hadron production in NNLO QCD
We calculate, for the first time, the NNLO QCD corrections to identified
heavy hadron production at hadron colliders. The calculation is based on a
flexible numeric framework which allows the calculation of any distribution of
a...
Millikelvin de Haas–van Alphen and magnetotransport studies of graphite
Recent studies of the electronic properties of graphite have produced conflicting results regarding the positions of the different carrier types within the Brillouin zone, and the possible presence of Dirac fermions. In this...
Immunophenotype of Gastric Tumors Unveils a Pleiotropic Role of Regulatory T Cells in Tumor Development.
Sara Rocha, Afonso P Basto, Marieke E Ijsselsteijn, Sara P Teles, Maria M Azevedo, Gilza Gonçalves, Irene Gullo, Gabriela M Almeida, Joaquín J Maqueda, Marta I Oliveira, Fátima Carneiro, João T Barata, Luís Graça, Noel FCC de Miranda, Joana Carvalho, Carla Oliveira
Jan 24, 2021
Gastric cancer (GC) patients display increased regulatory T cell (Tregs) numbers in peripheral blood and among tumor-infiltrating lymphocytes. Nevertheless, the role of Tregs in GC progression remains controversial. Here, we...
Time-dependent compactification to de Sitter space
Abstract: It is known that the Einstein gravitational field equations in D > 4 spacetime dimensions have no time-independent non-singular compactification solutions to de Sitter space if the D-dimensional stress tensor satisfies...
The Standard Model quiver in de Sitter string compactifications
We argue that the Standard Model quiver can be embedded into compact
Calabi-Yau geometries through orientifolded D3-branes at del Pezzo
singularities $\mathrm{dP}_n$ with $n\geq 5$ in a framework including moduli
stabilisation....
The Standard Model quiver in de Sitter string compactifications
Abstract: We argue that the Standard Model quiver can be embedded into compact Calabi-Yau geometries through orientifolded D3-branes at del Pezzo singularities dPn with n ≥ 5 in a framework including moduli stabilisation. To...
Measurement of the η<inf>c</inf>(1 S) production cross-section in p p collisions at √s=13TeV
R Aaij, CA Beteta, T Ackernley, B Adeva, M Adinolfi, H Afsharnia, CA Aidala, S Aiola, Z Ajaltouni, S Akar, P Albicocco, J Albrecht, F Alessio, M Alexander, AA Albero, G Alkhazov, PA Cartelle, AA Alves, S Amato, Y Amhis, L An, L Anderlini, G Andreassi, M Andreotti, F Archilli, P d’Argent, JA Romeu, A Artamonov, M Artuso, K Arzymatov, E Aslanides, M Atzeni, B Audurier, S Bachmann, JJ Back, S Baker, V Balagura, W Baldini, A Baranov, RJ Barlow, S Barsuk, W Barter, M Bartolini, F Baryshnikov, G Bassi, V Batozskaya, B Batsukh, A Battig, V Battista, A Bay, M Becker, F Bedeschi, I Bediaga, A Beiter, LJ Bel, V Belavin, S Belin, N Beliy, V Bellee, K Belous, I Belyaev, E Ben-Haim, G Bencivenni, S Benson, S Beranek, A Berezhnoy, R Bernet, D Berninghoff, HC Bernstein, E Bertholet, A Bertolin, C Betancourt, F Betti, MO Bettler, MV Beuzekom, I Bezshyiko, S Bhasin, J Bhom, MS Bieker, S Bifani, P Billoir, A Birnkraut, A Bizzeti, M Bjørn, MP Blago, T Blake, F Blanc, S Blusk, D Bobulska, V Bocci, OB Garcia, T Boettcher, A Boldyrev, A Bondar, N Bondar, S Borghi, M Borisyak, M Borsato, JT Borsuk, M Boubdir
Mar 02, 2021
Using a data sample corresponding to an integrated luminosity of
$2.0\,fb^{-1}$, collected by the LHCb experiment, the production of the
$\eta_c(1S)$ state in proton-proton collisions at a centre-of-mass energy of
$\sqrt{s}=13...
Serine Is an Essential Metabolite for Effector T Cell Expansion.
Eric H Ma, Glenn Bantug, Takla Griss, Stephanie Condotta, Radia M Johnson, Bozena Samborska, Nello Mainolfi, Vipin Suri, Hannah Guak, Maria L Balmer, Mark J Verway, Thomas C Raissi, Harmony Tsui, Giselle Boukhaled, Sofia Henriques da Costa, Christian Frezza, Connie M Krawczyk, Adam Friedman, Mark Manfredi, Martin J Richer, Christoph Hess, Russell G Jones
Jan 12, 2018
During immune challenge, T lymphocytes engage pathways of anabolic metabolism to support clonal expansion and the development of effector functions. Here we report a critical role for the non-essential amino acid serine in...
Phgdh Shmt T cell Glycolysis immunometabolism Immunotherapy Metabolic reprogramming metabolism Serine serine biosynthesis Animals Carbon Cell Cycle Checkpoints Cell Proliferation Diet Energy Metabolism Extracellular Space Glycine Listeria monocytogenes Metabolic Networks and Pathways Metabolome Mice Inbred C57BL Purine Nucleotides Serine T-Lymphocytes
Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ
T cells recognize peptides that are bound to MHC molecules on the surface of different types of antigen-presenting cells (APC). Antigen presentation most often is studied using T cells that have undergone priming in situ, or...
Antigen Presentation dendritic cell Immunogenicity major histocompatibility complex restriction t lymphocyte activation
Published by: Rockefeller University
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