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Results: 637
Histone modifiers are oxygen sensors.
Hypoxia signals directly to chromatin via histone demethylases to alter gene expression
High prevalence of heparin induced thrombocytopenia with thrombosis among patients with essential thrombocytemia carrying V617F mutation.
Roberto Castelli, Paolo Gallipoli, Riccardo Schiavon, Thomas Teatini, Giorgio Lambertenghi Deliliers, Luigi Bergamaschini
Dec 12, 2018
Arterial and venous complications are major causes of morbidity and mortality in myeloproliferative neoplasms (MPNs). MPNs patients, frequently receive heparin. Heparin-induced thrombocytopenia (HIT) is a rare but potentially...
Essential thrombocythemia Heparin treatment Heparin-induced thrombocytopenia (HIT) Myeloproliferative neoplasms (MPNs) V617F mutation Adult Aged Antibodies Female Heparin Humans Janus Kinase 2 Male Middle Aged Mutation Missense Platelet Count prevalence Retrospective Studies Thrombocythemia Essential Thrombocytopenia Thrombosis
JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34+ cells in vitro and in vivo.
Paolo Gallipoli, Amy Cook, Susan Rhodes, Lisa Hopcroft, Helen Wheadon, Anthony D Whetton, Heather G Jørgensen, Ravi Bhatia, Tessa L Holyoake
Aug 11, 2017
Animals Antigens CD34 Antineoplastic Combined Chemotherapy Protocols Apoptosis Drug Synergism Fusion Proteins bcr-abl Humans Janus Kinase 2 Leukemia Myelogenous Chronic BCR-ABL Positive Mice Mice Inbred NOD Mice SCID Protein Kinase Inhibitors Pyrazoles Pyrimidines STAT5 Transcription Factor Signal Transduction Tumor Cells Cultured Tumor Stem Cell Assay Xenograft Model Antitumor Assays
Autocrine TNF-α production supports CML stem and progenitor cell survival and enhances their proliferation.
Paolo Gallipoli, Francesca Pellicano, Heather Morrison, Kamilla Laidlaw, Elaine K Allan, Ravi Bhatia, Mhairi Copland, Heather G Jørgensen, Tessa L Holyoake
Aug 11, 2017
Apoptosis Cell Proliferation Cell Survival Chromones Gene Expression Regulation Leukemic Humans Indoles Interleukin-3 Leukemia Myelogenous Chronic BCR-ABL Positive NF-kappa B Neoplastic Stem Cells Primary Cell Culture Protein Kinase Inhibitors Pyrimidines Receptors Interleukin-3 Signal Transduction Tumor Necrosis Factor-alpha
CML cells actively evade host immune surveillance through cytokine-mediated downregulation of MHC-II expression.
Anuradha Tarafdar, Lisa EM Hopcroft, Paolo Gallipoli, Francesca Pellicano, Jennifer Cassels, Alan Hair, Koorosh Korfi, Heather G Jørgensen, David Vetrie, Tessa L Holyoake, Alison M Michie
Aug 16, 2017
Cells Cultured Cytokines Down-Regulation Female Flow Cytometry Gene Expression Regulation Histocompatibility Antigens Class II Humans Leukemia Myelogenous Chronic BCR-ABL Positive Lymphocyte Culture Test Mixed Male Neoplastic Stem Cells Oligonucleotide Array Sequence Analysis Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Tumor Escape
Safety and efficacy of pulsed imatinib with or without G-CSF versus continuous imatinib in chronic phase chronic myeloid leukaemia patients at 5 years follow-up.
Paolo Gallipoli, Jon Stobo, Nicholas Heaney, Franck E Nicolini, Richard Clark, George Wilson, Jane Tighe, Lorna McLintock, Timothy Hughes, Franziska Michor, James Paul, Mark Drummond, Tessa L Holyoake
Nov 23, 2018
BCR-ABL1 chronic myeloid leukaemia Stem Cells Therapy Trials Benzamides Cell Cycle Dasatinib Drug Substitution Drug Synergism Follow-Up Studies Fusion Proteins bcr-abl Granulocyte Colony-Stimulating Factor Humans Imatinib Mesylate Leukemia Myeloid Chronic-Phase Piperazines Protein Kinase Inhibitors Pulse Therapy Drug Pyrimidines Thiazoles Treatment Outcome
A New Digital Approach to Strategic Activities
Paolo Bongarzoni
Apr 01, 2020
As automation increasingly influences businesses, digitalization technologies and tools such as artificial intelligence, machine learning, etc., become essential to support the definition and implementation of strategy...
Published by: IGI Global Scientific Publishing
Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies.
Daniel Sasca, Haiyang Yun, George Giotopoulos, Jakub Szybinski, Theo Evan, Nicola K Wilson, Moritz Gerstung, Paolo Gallipoli, Anthony R Green, Robert Hills, Nigel Russell, Cameron S Osborne, Elli Papaemmanuil, Berthold Göttgens, Peter Campbell, Brian JP Huntly
Oct 03, 2019
Cohesin complex disruption alters gene expression, and cohesin mutations are common in myeloid neoplasia, suggesting a critical role in hematopoiesis. Here, we explore cohesin dynamics and regulation of hematopoietic stem cell...
Biomarkers Tumor Cell Cycle Proteins Cell Line Tumor Chromosomal Proteins Non-Histone Female Gene Dosage Gene Expression Regulation Leukemic Hematopoietic Stem Cells Histones Humans Male Mutation Myeloproliferative Disorders Neoplasm Grading Protein Binding Proto-Oncogene Proteins c-ets Regulatory Sequences Nucleic Acid Repressor Proteins
Glutaminolysis is a metabolic dependency in FLT3ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition.
Paolo Gallipoli, George Giotopoulos, Konstantinos Tzelepis, Ana SH Costa, Shabana Vohra, Paula Medina-Perez, Faisal Basheer, Ludovica Marando, Lorena Di Lisio, Joao ML Dias, Haiyang Yun, Daniel Sasca, Sarah J Horton, George Vassiliou, Christian Frezza, Brian JP Huntly
May 08, 2018
George Giotopoulos, Louise van der Weyden, Hikari Osaki, Alistair G Rust, Paolo Gallipoli, Eshwar Meduri, Sarah J Horton, Wai-In Chan, Donna Foster, Rab K Prinjha, John E Pimanda, Daniel G Tenen, George S Vassiliou, Steffen Koschmieder, David J Adams, Brian JP Huntly
Sep 08, 2015
Animals DNA Transposable Elements Fusion Proteins bcr-abl Gene Expression Regulation Leukemic Genes myb Hematopoietic Stem Cells Humans Leukemia Experimental Leukemia Myelogenous Chronic BCR-ABL Positive Mice Transgenic Molecular Targeted Therapy Mutagenesis Insertional Mutation Tumor Cells Cultured Vascular Endothelial Growth Factor C
Epigenetic Reprogramming Sensitizes CML Stem Cells to Combined EZH2 and Tyrosine Kinase Inhibition.
Mary T Scott, Koorosh Korfi, Peter Saffrey, Lisa EM Hopcroft, Ross Kinstrie, Francesca Pellicano, Carla Guenther, Paolo Gallipoli, Michelle Cruz, Karen Dunn, Heather G Jorgensen, Jennifer E Cassels, Ashley Hamilton, Andrew Crossan, Amy Sinclair, Tessa L Holyoake, David Vetrie
Aug 15, 2017
UNLABELLED: A major obstacle to curing chronic myeloid leukemia (CML) is residual disease maintained by tyrosine kinase inhibitor (TKI)-persistent leukemic stem cells (LSC). These are BCR-ABL1 kinase independent, refractory to...
Hunger Drives Hysterical Action in Newest Shakespeare Carolina Production
Winthrop University
Jan 01, 0001
Show times are 8 p.m. July 16-18 and July 22-25. Truffaldino is hungry. That's the driving force behind Carlo Goldoni's "The Servant of Two Masters," translated and adapted by Jeffery Hatcher and Paolo Landi. Shakespeare...
Published by: Winthrop University
Clonal haematopoiesis is not prevalent in survivors of childhood cancer
G Collord, N Park, M Podestà, M Dagnino, D Cilloni, D Jones, I Varela, F Frassoni, GS Vassiliou
May 03, 2017
This project was funded by the Wellcome Trust Sanger Institute (grant number WT098051). G.S.V. is funded by a Wellcome Trust Senior Fellowship in Clinical Science (WT095663MA). F.F. is funded by Compagnia di San Paolo Grant: “Le...
Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death.
Keith Woodley, Laura S Dillingh, George Giotopoulos, Pedro Madrigal, Kevin M Rattigan, Céline Philippe, Vilma Dembitz, Aoife MS Magee, Ryan Asby, Louie N van de Lagemaat, Christopher Mapperley, Sophie C James, Jochen HM Prehn, Konstantinos Tzelepis, Kevin Rouault-Pierre, George S Vassiliou, Kamil R Kranc, G Vignir Helgason, Brian JP Huntly, Paolo Gallipoli
Apr 14, 2023
Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression.
Haiyang Yun, Nisha Narayan, Shabana Vohra, George Giotopoulos, Annalisa Mupo, Pedro Madrigal, Daniel Sasca, David Lara-Astiaso, Sarah J Horton, Shuchi Agrawal-Singh, Eshwar Meduri, Faisal Basheer, Ludovica Marando, Malgorzata Gozdecka, Oliver M Dovey, Aracely Castillo-Venzor, Xiaonan Wang, Paolo Gallipoli, Carsten Müller-Tidow, Cameron S Osborne, George S Vassiliou, Brian JP Huntly
Aug 12, 2021
Animals Base Sequence Chromatin Assembly and Disassembly DNA Neoplasm Disease Models Animal Enhancer Elements Genetic Gene Expression Regulation Leukemic Gene Regulatory Networks Genetic Loci Histones Humans Leukemia Myeloid Acute Mice Inbred C57BL Mutation Nuclear Proteins Nucleophosmin principal component analysis Protein Processing Post-Translational RNA Messenger Transcription Genetic fms-Like Tyrosine Kinase 3
Evaluating the Effectiveness of Boxing Headguards in Mitigating Head Impact Accelerations That Cause Concussions by Using a Dynamic Head Model
Boxing headguards offer a form of head protection to minimize the risk of head injuries for athletes. Existing literature, however, lacks information regarding the protective capabilities of boxing headguards. This study...
Published by: IGI Global Scientific Publishing
Enabling Interoperability in the Internet of Things
Semantic Web technologies act as an interoperability glue among different formats, protocols and platforms, providing a uniform vision of heterogeneous devices and services in the Internet of Things (IoT). Semantic Web...
Published by: IGI Global Scientific Publishing
The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia.
G Giotopoulos, W-I Chan, SJ Horton, D Ruau, P Gallipoli, A Fowler, C Crawley, E Papaemmanuil, PJ Campbell, B Göttgens, JM Van Deursen, PA Cole, BJP Huntly
May 18, 2015
Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy.
Dorian Forte, María García-Fernández, Abel Sánchez-Aguilera, Vaia Stavropoulou, Claire Fielding, Daniel Martín-Pérez, Juan Antonio López, Ana SH Costa, Laura Tronci, Efterpi Nikitopoulou, Michael Barber, Paolo Gallipoli, Ludovica Marando, Carlos López Fernández de Castillejo, Alexandar Tzankov, Sabine Dietmann, Michele Cavo, Lucia Catani, Antonio Curti, Jesús Vázquez, Christian Frezza, Brian J Huntly, Juerg Schwaller, Simón Méndez-Ferrer
Sep 03, 2020
OXPHOS TCA cycle acute myeloid leukemia antioxidant bone marrow mesenchymal stem cells Chemotherapy Glutathione hematopoietic stem cell niche metabolic adaptation microenvironment Animals Antineoplastic Agents antioxidants Bone Marrow Cells Cultured Energy Metabolism Female Humans Leukemia Myeloid Acute Male Mesenchymal Stem Cells Mice Mice Inbred C57BL Middle Aged
A discrete choice model of transitions to sustainable technologies
Paolo Zeppini
Apr 10, 2015
We propose a discrete choice model of sustainable transitions from dirty to clean technologies. Agents can adopt one technology or the other, under the influence of social interactions and network externalities. Sustainable...
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