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Composition of Corroded Reinforcing Steel Surface in Solutions Simulating the Electrolytic Environments in the Micropores of Concrete in the Propagation Period
In the present work, the composition of a corroded reinforcing steel surface is studied at different pH values (related to different degrees of development in the corroding zones of the corrosion process) in solutions...
Composition of Corroded Reinforcing Steel Surface in Solutions Simulating the Electrolytic Environments in the Micropores of Concrete in the Propagation Period
In the present work, the composition of a corroded reinforcing steel surface is studied at different pH values (related to different degrees of development in the corroding zones of the corrosion process) in solutions...
A systematic review of the uses and spread of corpora and data-driven learning in CALL research during 2011–2015
Pascual Pérez-Paredes
Nov 21, 2019
This research uses the theoretical framework of CALL normalisation developed by Bax (2003) and Chambers and Bax (2006) to offer a systematic review (Gough et al., 2012) of the uses and spread of data-driven learning (DDL) and...
Bootstrapping Q Methodology to Improve the Understanding of Human Perspectives.
Q is a semi-qualitative methodology to identify typologies of perspectives. It is appropriate to address questions concerning diverse viewpoints, plurality of discourses, or participation processes across disciplines....
Dancing With Storks
The institutional change induced by payments for ecosystem services (PES) schemes is a ‘messy’ process. The uptake and outcomes of PES schemes cannot be fully explained from a rational choice perspective. The notion of...
Calibration of the comprehensive NDHA-N<sub>2</sub>O dynamics model for nitrifier-enriched biomass using targeted respirometric assays
Carlos Domingo-Félez, Maria Calderó-pascual, Gürkan Sin, Benedek G. Plósz, Barth F. Smets
Dec 01, 2017
The NDHA model comprehensively describes nitrous oxide (N2O) producing pathways by both autotrophic ammonium oxidizing and heterotrophic bacteria. The model was calibrated via a set of targeted extant respirometric assays using...
Calibration of the comprehensive NDHA-N<sub>2</sub>O dynamics model for nitrifier-enriched biomass using targeted respirometric assays
Carlos Domingo-Félez, Maria Calderó-pascual, Gürkan Sin, Benedek G. Plósz, Barth F. Smets
Dec 01, 2017
The NDHA model comprehensively describes nitrous oxide (N2O) producing pathways by both autotrophic ammonium oxidizing and heterotrophic bacteria. The model was calibrated via a set of targeted extant respirometric assays using...
The equivalence of multi-axis spine systems
Timothy Holsgrove, Dhara Amin, Sonia Ramos Pascual, Boyin Ding, William Welch, Sabina Gheduzzi, Anthony Miles, Beth Winkelstein, John Costi
Mar 21, 2018
The complexity of multi-axis spine testing often makes it challenging to compare results from different studies. The aim of this work was to develop and implement a standardized testing protocol across three six-axis spine...
Multi-axis Six-axis Spine simulator Spine testing Test machines Test systems /dk/atira/pure/subjectarea/asjc/1300/1304 name=Biophysics /dk/atira/pure/subjectarea/asjc/2700/2732 name=Orthopedics and Sports Medicine /dk/atira/pure/subjectarea/asjc/2200/2204 name=Biomedical Engineering /dk/atira/pure/subjectarea/asjc/2700/2742 name=Rehabilitation
The equivalence of multi-axis spine systems
Timothy Holsgrove, Dhara Amin, Sonia Ramos Pascual, Boyin Ding, William Welch, Sabina Gheduzzi, Anthony Miles, Beth Winkelstein, John Costi
Mar 21, 2018
The complexity of multi-axis spine testing often makes it challenging to compare results from different studies. The aim of this work was to develop and implement a standardized testing protocol across three six-axis spine...
Multi-axis Six-axis Spine simulator Spine testing Test machines Test systems /dk/atira/pure/subjectarea/asjc/1300/1304 name=Biophysics /dk/atira/pure/subjectarea/asjc/2700/2732 name=Orthopedics and Sports Medicine /dk/atira/pure/subjectarea/asjc/2200/2204 name=Biomedical Engineering /dk/atira/pure/subjectarea/asjc/2700/2742 name=Rehabilitation
POSEIDON Trial Phase 1b Results
Richard D Baird, Annelot GJ van Rossum, Mafalda Oliveira, Karin Beelen, Meiling Gao, Mariette Schrier, Ingrid AM Mandjes, Javier Garcia-Corbacho, Anne-Laure Vallier, Greig Dougall, Erik Van Werkhoven, Constanza Linossi, Sanjeev Kumar, Harm van Tinteren, Maurizio Callari, Emma Beddowes, José-Manuel Perez-Garcia, Hilde Rosing, Else Platte, Petra Nederlof, Margaret Schot, Aurelia de Vries Schultink, René Bernards, Cristina Saura, William Gallagher, Javier Cortès, Carlos Caldas, Sabine C Linn
Oct 02, 2019
PURPOSE: The strategy of combining endocrine therapy with PI3K-mTOR inhibition has shown promise in estrogen receptor (ER)-positive breast cancer, but new agents and combinations with a better therapeutic index are urgently...
Adult Aged Aged 80 and over Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor Breast Neoplasms Circulating Tumor DNA Female Humans Imidazoles Middle Aged Mutation Neoplasm Metastasis Neoplasm Staging Oxazepines Receptors Estrogen Receptors Progesterone Retreatment Tamoxifen Treatment Outcome
GPER and ERα mediate estradiol enhancement of mitochondrial function in inflamed adipocytes through a PKA dependent mechanism.
Marco Bauzá-Thorbrügge, Sergio Rodríguez-Cuenca, Antonio Vidal-Puig, Bel M Galmés-Pascual, Miquel Sbert-Roig, Magdalena Gianotti, Isabel Lladó, Ana M Proenza
Dec 10, 2018
Obesity is associated with inflammation, dysregulated adipokine secretion, and disrupted adipose tissue mitochondrial function. Estradiol (E2) has been previously reported to increase mitochondrial function and biogenesis in...
17beta-estradiol G protein-coupled oestrogen receptor adipocyte Mitochondrial function Oestrogen receptor alpha PKA 3T3 Cells Adipocytes Animals Cell Line Cyclic AMP-Dependent Protein Kinases Estradiol Estrogen Receptor alpha Estrogen Receptor beta Female Inflammation Interleukin-6 Male Mice Mice Inbred C57BL Mitochondria obesity Rats Rats Wistar Receptors G-Protein-Coupled
The Cdc14 Phosphatase Controls Resolution of Recombination Intermediates and Crossover Formation during Meiosis.
Paula Alonso-Ramos, David Álvarez-Melo, Katerina Strouhalova, Carolina Pascual-Silva, George B Garside, Meret Arter, Teresa Bermejo, Rokas Grigaitis, Rahel Wettstein, Marta Fernández-Díaz, Joao Matos, Marco Geymonat, Pedro A San-Segundo, Jesús A Carballo
Sep 13, 2021
Meiotic defects derived from incorrect DNA repair during gametogenesis can lead to mutations, aneuploidies and infertility. The coordinated resolution of meiotic recombination intermediates is required for crossover formation...
CDK1 Cdc14 Cdc20 Cdc5 Holliday junction Mus81 Ndt80 Sgs1 Yen1 Aneuploidy meiotic recombination CDC2 Protein Kinase Cell Cycle Proteins Chromosome Segregation Crossing Over Genetic DNA Repair DNA Cruciform Gametogenesis Holliday Junction Resolvases homologous recombination Meiosis Mutation Phosphorylation Protein Tyrosine Phosphatases Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins
Using nonhuman culture in conservation requires careful and concerted action
Susana Carvalho, Erin G Wessling, Ekwoge E Abwe, Katarina Almeida‐Warren, Mimi Arandjelovic, Christophe Boesch, Emmanuel Danquah, Mamadou Saliou Diallo, Catherine Hobaiter, Kimberley Hockings, Tatyana Humle, Rachel Ashegbofe Ikemeh, Ammie K Kalan, Lydia Luncz, Gaku Ohashi, Alejandra Pascual‐Garrido, Alex Piel, Liran Samuni, Serge Soiret, Crickette Sanz, Kathelijne Koops
Jan 10, 2022
Abstract: Discussions of how animal culture can aid the conservation crisis are burgeoning. As scientists and conservationists working to protect endangered species, we call for reflection on how the culture concept may be...
A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation.
Marta Castroviejo-Bermejo, Cristina Cruz, Alba Llop-Guevara, Sara Gutiérrez-Enríquez, Mandy Ducy, Yasir Hussein Ibrahim, Albert Gris-Oliver, Benedetta Pellegrino, Alejandra Bruna, Marta Guzmán, Olga Rodríguez, Judit Grueso, Sandra Bonache, Alejandro Moles-Fernández, Guillermo Villacampa, Cristina Viaplana, Patricia Gómez, Maria Vidal, Vicente Peg, Xavier Serres-Créixams, Graham Dellaire, Jacques Simard, Paolo Nuciforo, Isabel T Rubio, Rodrigo Dienstmann, J Carl Barrett, Carlos Caldas, José Baselga, Cristina Saura, Javier Cortés, Olivier Déas, Jos Jonkers, Jean-Yves Masson, Stefano Cairo, Jean-Gabriel Judde, Mark J O'Connor, Orland Díez, Judith Balmaña, Violeta Serra
Apr 29, 2019
Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi) are effective in cancers with defective homologous recombination DNA repair (HRR), including BRCA1/2-related cancers. A test to identify additional HRR-deficient tumors will...
RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer.
C Cruz, M Castroviejo-Bermejo, S Gutiérrez-Enríquez, A Llop-Guevara, YH Ibrahim, A Gris-Oliver, S Bonache, B Morancho, A Bruna, OM Rueda, Z Lai, UM Polanska, GN Jones, P Kristel, L de Bustos, M Guzman, O Rodríguez, J Grueso, G Montalban, G Caratú, F Mancuso, R Fasani, J Jiménez, WJ Howat, B Dougherty, A Vivancos, P Nuciforo, X Serres-Créixams, IT Rubio, A Oaknin, E Cadogan, JC Barrett, C Caldas, J Baselga, C Saura, J Cortés, J Arribas, J Jonkers, O Díez, MJ O'Connor, J Balmaña, V Serra
Jul 16, 2018
BACKGROUND: BRCA1 and BRCA2 (BRCA1/2)-deficient tumors display impaired homologous recombination repair (HRR) and enhanced sensitivity to DNA damaging agents or to poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi). Their...
Animals BRCA1 Protein BRCA2 Protein Biomarkers Tumor Breast Breast Neoplasms Drug Resistance Neoplasm Female Germ-Line Mutation Humans Mice Mice Nude Poly(ADP-ribose) Polymerase Inhibitors Rad51 Recombinase Recombinational DNA Repair Retrospective Studies Treatment Outcome Xenograft Model Antitumor Assays
The Astropy Project
Abstract
The Astropy Project supports and fosters the development of open-source and openly developed Python packages that provide commonly needed...
A Zonca, AM Price-Whelan, PL Lim, N Earl, N Starkman, L Bradley, DL Shupe, AA Patil, L Corrales, CE Brasseur, M Nöthe, A Donath, E Tollerud, BM Morris, A Ginsburg, E Vaher, BA Weaver, J Tocknell, W Jamieson, MH van Kerkwijk, TP Robitaille, B Merry, M Bachetti, HM Günther, C Zhang, TL Aldcroft, JA Alvarado-Montes, AM Archibald, A Bódi, S Bapat, G Barentsen, J Bazán, M Biswas, M Boquien, DJ Burke, D Cara, M Cara, KE Conroy, S Conseil, MW Craig, RM Cross, KL Cruz, F D’Eugenio, N Dencheva, HAR Devillepoix, JP Dietrich, AD Eigenbrot, T Erben, L Ferreira, D Foreman-Mackey, R Fox, N Freij, S Garg, R Geda, L Glattly, Y Gondhalekar, KD Gordon, D Grant, P Greenfield, AM Groener, S Guest, S Gurovich, R Handberg, A Hart, Z Hatfield-Dodds, D Homeier, G Hosseinzadeh, T Jenness, CK Jones, P Joseph, JB Kalmbach, E Karamehmetoglu, M Kałuszyński, MSP Kelley, N Kern, WE Kerzendorf, EW Koch, S Kulumani, A Lee, C Ly, Z Ma, C MacBride, JM Maljaars, D Muna, NA Murphy, H Norman, R O’Steen, KA Oman, C Pacifici, S Pascual, J Pascual-Granado, RR Patil, GI Perren, TE Pickering, T Rastogi, BR Roulston, DF Ryan, ES Rykoff, J Sabater, P Sakurikar
Aug 24, 2022
Atlas of lesion locations and postsurgical seizure freedom in focal cortical dysplasia
Konrad Wagstyl, Kirstie Whitaker, Armin Raznahan, Jakob Seidlitz, Petra E Vértes, Stephen Foldes, Zachary Humphreys, Wenhan Hu, Jiajie Mo, Marcus Likeman, Shirin Davies, Matteo Lenge, Nathan T Cohen, Yingying Tang, Shan Wang, Mathilde Ripart, Aswin Chari, Martin Tisdall, Nuria Bargallo, Estefanía Conde-Blanco, Jose Carlos Pariente, Saül Pascual-Diaz, Ignacio Delgado-Martínez, Carmen Pérez-Enríquez, Ilaria Lagorio, Eugenio Abela, Nandini Mullatti, Jonathan O'Muircheartaigh, Katy Vecchiato, Yawu Liu, Maria Caligiuri, Ben Sinclair, Lucy Vivash, Anna Willard, Jothy Kandasamy, Ailsa McLellan, Drahoslav Sokol, Mira Semmelroch, Ane Kloster, Giske Opheim, Clarissa Yasuda, Kai Zhang, Khalid Hamandi, Carmen Barba, Renzo Guerrini, William Davis Gaillard, Xiaozhen You, Irene Wang, Sofía González-Ortiz, Mariasavina Severino, Pasquale Striano, Domenico Tortora, Reetta Kalviainen, Antonio Gambardella, Angelo Labate, Patricia Desmond, Elaine Lui, Terry O'Brien, Jay Shetty, Graeme Jackson, John S Duncan, Gavin P Winston, Lars Pinborg, Fernando Cendes, Judith Helen Cross, Torsten Baldeweg, Sophie Adler
Jan 10, 2022
An open-access database and analysis tool for perovskite solar cells based on the FAIR data principles
Abstract Large datasets are now ubiquitous as technology enables higher-throughput experiments, but rarely can a research field truly benefit from the research data generated due to inconsistent...
TJ Jacobsson, A Hultqvist, A García-Fernández, A Anand, A Al-Ashouri, A Hagfeldt, A Crovetto, A Abate, AG Ricciardulli, A Vijayan, A Kulkarni, AY Anderson, BP Darwich, B Yang, BL Coles, CAR Perini, C Rehermann, D Ramirez, D Fairen-Jimenez, D Di Girolamo, D Jia, E Avila, EJ Juarez-Perez, F Baumann, F Mathies, GSA González, G Boschloo, G Nasti, G Paramasivam, G Martínez-Denegri, H Näsström, H Michaels, H Köbler, H Wu, I Benesperi, MI Dar, I Bayrak Pehlivan, IE Gould, JN Vagott, J Dagar, J Kettle, J Yang, J Li, JA Smith, J Pascual, JJ Jerónimo-Rendón, JF Montoya, JP Correa-Baena, J Qiu, J Wang, K Sveinbjörnsson, K Hirselandt, K Dey, K Frohna, L Mathies, LA Castriotta, MH Aldamasy, M Vasquez-Montoya, MA Ruiz-Preciado, MA Flatken, MV Khenkin, M Grischek, M Kedia, M Saliba, M Anaya, M Veldhoen, N Arora, O Shargaieva, O Maus, OS Game, O Yudilevich, P Fassl, Q Zhou, R Betancur, R Munir, R Patidar, SD Stranks, S Alam, S Kar, T Unold, T Abzieher, T Edvinsson, TW David, UW Paetzold, W Zia, W Fu, W Zuo, VRF Schröder, W Tress, X Zhang, YH Chiang, Z Iqbal, Z Xie, E Unger
Jan 29, 2022
A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.
Sven J van der Lee, Olivia J Conway, Iris Jansen, Minerva M Carrasquillo, Luca Kleineidam, Erik van den Akker, Isabel Hernández, Kristel R van Eijk, Najada Stringa, Jason A Chen, Anna Zettergren, Till FM Andlauer, Monica Diez-Fairen, Javier Simon-Sanchez, Alberto Lleó, Henrik Zetterberg, Marianne Nygaard, Cornelis Blauwendraat, Jeanne E Savage, Jonas Mengel-From, Sonia Moreno-Grau, Michael Wagner, Juan Fortea, Michael J Keogh, Kaj Blennow, Ingmar Skoog, Manuel A Friese, Olga Pletnikova, Miren Zulaica, Carmen Lage, Itziar de Rojas, Steffi Riedel-Heller, Ignacio Illán-Gala, Wei Wei, Bernard Jeune, Adelina Orellana, Florian Then Bergh, Xue Wang, Marc Hulsman, Nina Beker, Niccolo Tesi, Christopher M Morris, Begoña Indakoetxea, Lyduine E Collij, Martin Scherer, Estrella Morenas-Rodríguez, James W Ironside, Bart NM van Berckel, Daniel Alcolea, Heinz Wiendl, Samantha L Strickland, Pau Pastor, Eloy Rodríguez Rodríguez, EADB (Alzheimer Disease European DNA biobank) DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank), IPDGC (The International Parkinson Disease Genomics Consortium) IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia), Netherlands Brain Bank (NBB), Bradley F Boeve, Ronald C Petersen, Tanis J Ferman, Jay A van Gerpen, Marcel JT Reinders, Ryan J Uitti, Lluís Tárraga, Wolfgang Maier, Oriol Dols-Icardo, Amit Kawalia, Maria Carolina Dalmasso, Mercè Boada, Uwe K Zettl, Natasja M van Schoor, Marian Beekman, Mariet Allen, Eliezer Masliah, Adolfo López de Munain, Alexander Pantelyat, Zbigniew K Wszolek, Owen A Ross, Dennis W Dickson, Neill R Graff-Radford, David Knopman, Rosa Rademakers, Afina W Lemstra, Yolande AL Pijnenburg, Philip Scheltens, Thomas Gasser, Patrick F Chinnery, Bernhard Hemmer, Martijn A Huisman, Juan Troncoso, Fermin Moreno, Ellen A Nohr, Thorkild IA Sørensen, Peter Heutink, Pascual Sánchez-Juan, Danielle Posthuma, GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group, Jordi Clarimón, Kaare Christensen, Nilüfer Ertekin-Taner, Sonja W Scholz, Alfredo Ramirez, Agustín Ruiz, Eline Slagboom, Wiesje M van der Flier, Henne Holstege
Jun 06, 2020
The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer's disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other...
Alzheimer’s disease Amyotrophic Lateral Sclerosis dementia with Lewy bodies frontotemporal dementia longevity Multiple Sclerosis Neurodegenerative disease PLCG2 Parkinson’s disease Phospholipase C Gamma 2 progressive supranuclear palsy Alleles Alzheimer Disease Amyotrophic Lateral Sclerosis Brain Dementia frontotemporal dementia Genetic Predisposition to Disease Genome-Wide Association Study Humans Lewy Body Disease longevity Microglia Multiple Sclerosis Mutation Neuroimaging Parkinson Disease Phospholipase C gamma risk
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