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Results: 159
An unexpected role reversal
Abstract
In 1862, the collector Pavel Tretyakov made his second visit to Britain, and lent three paintings to the International Exhibition held in London that year. Then aged just thirty, he had...
RP Blakesley
Apr 19, 2017
Mammalian autophagy and the plasma membrane.
Autophagy (literally 'self-eating') is an evolutionarily conserved degradation process where cytoplasmic components are engulfed by vesicles called autophagosomes, which are then delivered to lysosomes, where their contents are...
Cell type-specific YAP1-WWTR1/TAZ transcriptional responses after autophagy perturbations are determined by levels of α-catenins (CTNNA1 and CTNNA3).
Autophagy Induction as a Therapeutic Strategy for Neurodegenerative Diseases.
Alvin Djajadikerta, Swati Keshri, Mariana Pavel, Ryan Prestil, Laura Ryan, David C Rubinsztein
Dec 11, 2019
Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic contents to lysosomes for degradation. Genetic studies have revealed extensive links between autophagy and neurodegenerative disease, and...
Using an Interaction Parameter in Model-Based Phase I Trials for Combination Treatments? A Simulation Study.
There is growing interest in Phase I dose-finding studies studying several doses of more than one agent simultaneously. A number of combination dose-finding designs were recently proposed to guide escalation/de-escalation...
Vinexin contributes to autophagic decline in brain ageing across species.
So Jung Park, Rebecca A Frake, Cansu Karabiyik, Sung Min Son, Farah H Siddiqi, Carla F Bento, Peter Sterk, Mariella Vicinanza, Mariana Pavel, David C Rubinsztein
May 10, 2022
Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis.
An order restricted multi-arm multi-stage clinical trial design.
One family of designs that can noticeably improve efficiency in later stages of drug development are multi-arm multi-stage (MAMS) designs. They allow several arms to be studied concurrently and gain efficiency by dropping poorly...
Right Engel-type subgroups and length parameters of finite groups
Let be an element of a finite group and let be the subgroup generated by all the right Engel values over. In the case when is soluble we prove that if, for some, the Fitting height of is equal to, then belongs to the th...
Using an Interaction Parameter in Model-Based Phase I Trials for Combination Treatments? A Simulation Study
There is growing interest in Phase I dose-finding studies studying several doses of more than one agent simultaneously. A number of combination dose-finding designs were recently proposed to guide escalation/de-escalation...
Practical recommendations for implementing a Bayesian adaptive phase I design during a pandemic.
BACKGROUND: Modern designs for dose-finding studies (e.g., model-based designs such as continual reassessment method) have been shown to substantially improve the ability to determine a suitable dose for efficacy testing when...
Obstacles to detecting isoforms using full-length scRNA-seq data
Abstract: Background: Early single-cell RNA-seq (scRNA-seq) studies suggested that it was unusual to see more than one isoform being produced from a gene in a single cell, even when multiple isoforms were detected in matched...
Practical recommendations for implementing a Bayesian adaptive phase I design during a pandemic.
BACKGROUND: Modern designs for dose-finding studies (e.g., model-based designs such as continual reassessment method) have been shown to substantially improve the ability to determine a suitable dose for efficacy testing when...
Groups with boundedly many commutator of maximal order
By a result of Cocke and Venkataraman we know that if G is a group with at most m elements of maximal order, then is m-bounded. In this paper we consider the following related setting. Suppose G is a group with at most m...
A Hybrid Hierarchical Heuristic-ACO With Local Search Applied to Travelling Salesman Problem, AS-FA-Ls
The combinatorial optimization problem is attracting research because they have a wide variety of applications ranging from route planning and supply chain optimization to industrial scheduling and the IoT. Solving such problems...
Published by: IGI Global Scientific Publishing
Obstacles to detecting isoforms using full-length scRNA-seq data.
BACKGROUND:Early single-cell RNA-seq (scRNA-seq) studies suggested that it was unusual to see more than one isoform being produced from a gene in a single cell, even when multiple isoforms were detected in matched bulk RNA-seq...
Published by: Genome biology
Organizing Students' Online Teamwork for Sustainable Development
The article tackles the problem of developing students' teamwork competence in e-learning environments. The aim of the study is to substantiate the methodological foundations for successful organization of students' online...
Published by: IGI Global Scientific Publishing
High-throughput assay for determining enantiomeric excess of chiral diols, amino alcohols, and amines and for direct asymmetric reaction screening
Determining enantiomeric excess (e.e.) in chiral compounds is key to development of chiral catalyst auxiliaries and chiral drugs. Here we describe a sensitive and robust fluorescence-based assay for determining e.e. in...
Controlled Oil/Water Partitioning of Hydrophobic Substrates Extending the Bioanalytical Applications of Droplet-Based Microfluidics.
Tomas Buryska, Michal Vasina, Fabrice Gielen, Pavel Vanacek, Liisa van Vliet, Jan Jezek, Zdenek Pilat, Pavel Zemanek, Jiri Damborsky, Florian Hollfelder, Zbynek Prokop
Jun 27, 2019
Groups with boundedly many commutator of maximal order
By a result of Cocke and Venkataraman we know that if G is a group with at most m elements of maximal order, then is m-bounded. In this paper we consider the following related setting. Suppose G is a group with at most m...
Obstacles to detecting isoforms using full-length scRNA-seq data
Abstract: Background: Early single-cell RNA-seq (scRNA-seq) studies suggested that it was unusual to see more than one isoform being produced from a gene in a single cell, even when multiple isoforms were detected in matched...
Morphology of the earliest reconstructable tetrapod Parmastega aelidae.
The known diversity of tetrapods of the Devonian period has increased markedly in recent decades, but their fossil record consists mostly of tantalizing fragments1-15. The framework for interpreting the morphology and...
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