Search
Results: 1004
Unveiling (-)-Englerin A as a Modulator of L-Type Calcium Channels.
Tiago Rodrigues, Florian Sieglitz, Víctor J Somovilla, Pedro MSD Cal, Antony Galione, Francisco Corzana, Gonçalo JL Bernardes
Jul 06, 2016
PEDRo
K Garwood, T McLaughlin, C Garwood, S Joens, N Morrison, CF Taylor, K Carroll, C Evans, AD Whetton, S Hart, D Stead, Z Yin, AJP Brown, A Hesketh, K Chater, L Hansson, M Mewissen, P Ghazal, J Howard, KS Lilley, SJ Gaskell, A Brass, SJ Hubbard, SG Oliver, NW Paton
Jun 16, 2011
Abstract Background Proteomics is rapidly evolving into a high-throughput technology, in which substantial and systematic studies are conducted on samples from a wide range of physiological, developmental, or pathological...
Animals Arabidopsis Proteins Bacterial Proteins Candida albicans Candida glabrata Computational Biology Database Management Systems Databases Protein Fungal Proteins Helminth Proteins Jejunal Diseases Mice Proteins Proteomics Saccharomyces cerevisiae Proteins Software Design Streptomyces coelicolor Trichinella spiralis Trichinellosis
Evaluation of linker length effects on a BET bromodomain probe.
Rui Traquete, Elizabeth Henderson, Sarah Picaud, Pedro MSD Cal, Florian Sieglitz, Tiago Rodrigues, Rudi Oliveira, Panagis Filippakopoulos, Gonçalo JL Bernardes
Sep 05, 2019
Arylethynyltrifluoroborate Dienophiles for on Demand Activation of IEDDA Reactions.
Zbigniew Zawada, Zijian Guo, Bruno L Oliveira, Claudio D Navo, He Li, Pedro MSD Cal, Francisco Corzana, Gonzalo Jiménez-Osés, Gonçalo JL Bernardes
Jul 08, 2021
Strained alkenes and alkynes are the predominant dienophiles used in inverse electron demand Diels-Alder (IEDDA) reactions. However, their instability, cross-reactivity, and accessibility are problematic. Unstrained dienophiles...
A microfluidic serial dilutor (MSD)
Huanhuan Shi, Zhihao Xie, Yu Cao, Yali Zhao, Congxuan Zhang, Zhen Chen, Nuno M. Reis, Zhengchun Liu
Dec 14, 2022
Dilution of a sample over several orders of magnitude in concentration is a routine procedure in many analytical, bioanalytical, diagnostics, and formulation laboratories. Microfluidics offer the opportunity to automate the...
Absorbance measurement Liposome nanoparticle Micro-mixing Microfluidic dilutor Tunable fabrication /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
A microfluidic serial dilutor (MSD)
Huanhuan Shi, Zhihao Xie, Yu Cao, Yali Zhao, Congxuan Zhang, Zhen Chen, Nuno M. Reis, Zhengchun Liu
Dec 14, 2022
Dilution of a sample over several orders of magnitude in concentration is a routine procedure in many analytical, bioanalytical, diagnostics, and formulation laboratories. Microfluidics offer the opportunity to automate the...
Absorbance measurement Liposome nanoparticle Micro-mixing Microfluidic dilutor Tunable fabrication /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Azabicyclic vinyl sulfones for residue-specific dual protein labelling.
Enrique Gil de Montes, Ester Jiménez-Moreno, Bruno L Oliveira, Claudio D Navo, Pedro MSD Cal, Gonzalo Jiménez-Osés, Inmaculada Robina, Antonio J Moreno-Vargas, Gonçalo JL Bernardes
Mar 28, 2019
We have developed [2.2.1]azabicyclic vinyl sulfone reagents that simultaneously enable cysteine-selective protein modification and introduce a handle for further bioorthogonal ligation. The reaction is fast and selective for...
Chemo- and Regioselective Lysine Modification on Native Proteins.
Maria J Matos, Bruno L Oliveira, Nuria Martínez-Sáez, Ana Guerreiro, Pedro MSD Cal, Jean Bertoldo, María Maneiro, Elizabeth Perkins, Julie Howard, Michael J Deery, Justin M Chalker, Francisco Corzana, Gonzalo Jiménez-Osés, Gonçalo JL Bernardes
May 11, 2018
Site-selective chemical conjugation of synthetic molecules to proteins expands their functional and therapeutic capacity. Current protein modification methods, based on synthetic and biochemical technologies, can achieve site...
Brain-Sparing Sympathofacilitators Mitigate Obesity without Adverse Cardiovascular Effects.
Inês Mahú, Andreia Barateiro, Eva Rial-Pensado, Noelia Martinéz-Sánchez, Sandra H Vaz, Pedro MSD Cal, Benjamin Jenkins, Tiago Rodrigues, Carlos Cordeiro, Miguel F Costa, Raquel Mendes, Elsa Seixas, Mafalda MA Pereira, Nadiya Kubasova, Vitka Gres, Imogen Morris, Carolina Temporão, Marta Olivares, Yolanda Sanz, Albert Koulman, Francisco Corzana, Ana M Sebastião, Miguel López, Gonçalo JL Bernardes, Ana I Domingos
May 29, 2020
Anti-obesity drugs in the amphetamine (AMPH) class act in the brain to reduce appetite and increase locomotion. They are also characterized by adverse cardiovascular effects with origin that, despite absence of any in...
Unexpected Phenotype Reversion and Survival in a Zebrafish Model of Multiple Sulfatase Deficiency.
Angeleen Fleming, Low Zhe Xuan, Gentzane Sanchez-Elexpuru, Sarah V Williams, Dylan Windell, Michael H Gelb, Zackary M Herbst, Lars Schlotawa, David C Rubinsztein
Jul 20, 2022
Multiple sulfatase deficiency (MSD) is a rare recessively inherited Mendelian disorder that manifests with developmental delay, neurodegeneration, skeletal deformities, facial dysmorphism, congenital growth retardation, and...
How to facilitate critical action learning
Critical Action Learning (CAL) is a well-established approach to action learning. However, it has not necessarily been clear to action learning practitioners what makes CAL ‘critical’ and what are the implications in...
Unexpected Phenotype Reversion and Survival in a Zebrafish Model of Multiple Sulfatase Deficiency.
Angeleen Fleming, Low Zhe Xuan, Gentzane Sanchez-Elexpuru, Sarah V Williams, Dylan Windell, Michael H Gelb, Zackary M Herbst, Lars Schlotawa, David Rubinsztein
Jun 16, 2022
Multiple sulfatase deficiency (MSD) is a rare recessively inherited Mendelian disorder that manifests with developmental delay, neurodegeneration, skeletal deformities, facial dysmorphism, congenital growth retardation, and...
Trends in therapeutic drug conjugates for bacterial diseases
INTRODUCTION: Drug conjugates are trend topics in Chemical Biology. These entities are an emerging class of highly potent biopharmaceutical drugs, best known in the field of oncology, that have been also designed as a targeted...
Infinite-dimensional fermionic symmetry in supersymmetric gauge theories
We establish the existence of an infinite-dimensional fermionic symmetry in
four-dimensional supersymmetric gauge theories by analyzing semiclassical
photino dynamics in abelian ${\cal N}=1$ theories with charged matter....
How to facilitate critical action learning
Critical Action Learning (CAL) is a well-established approach to action learning. However, it has not necessarily been clear to action learning practitioners what makes CAL ‘critical’ and what are the implications in...
Enhanced glacial discharge from the eastern Antarctic Peninsula since the 1700s associated with a positive Southern Annular Mode.
WA Dickens, G Kuhn, MJ Leng, AGC Graham, JA Dowdeswell, MP Meredith, C-D Hillenbrand, DA Hodgson, SJ Roberts, H Sloane, JA Smith
Dec 11, 2019
The Antarctic Peninsula Ice Sheet is currently experiencing sustained and accelerating loss of ice. Determining when these changes were initiated and identifying the main drivers is hampered by the short instrumental record...
Spanish Professor Selected as Thompson Scholar
Winthrop University
Jan 01, 0001
Spanish professor Pedro Muñoz has been chosen as the new Thompson Scholar. Muñoz, a native of Spain, will spend a year researching service learning courses for at-risk Hispanic students.
Published by: Winthrop University
Late Holocene environmental change and anthropogenic
East African ecosystems have been shaped by long-term socio-ecological-environmental interactions. Although much previous work on human-environment interrelationships have emphasised the negative impacts of human interventions...
Enhanced glacial discharge from the eastern Antarctic Peninsula since the 1700s associated with a positive Southern Annular Mode
W. A. Dickens, G. Kuhn, M. J. Leng, A. G. C. Graham, J. A. Dowdeswell, M. P. Meredith, C.-D. Hillenbrand, D. A. Hodgson, S. J. Roberts, H. Sloane, J. A. Smith
Oct 23, 2020
Abstract: The Antarctic Peninsula Ice Sheet is currently experiencing sustained and accelerating loss of ice. Determining when these changes were initiated and identifying the main drivers is hampered by the short instrumental...
Genome-Wide Linkage and Association Mapping of Halo Blight Resistance in Common Bean to Race 6 of the Globally Important Bacterial Pathogen.
Andrew J Tock, Deidré Fourie, Peter G Walley, Eric B Holub, Alvaro Soler, Karen A Cichy, Marcial A Pastor-Corrales, Qijian Song, Timothy G Porch, John P Hart, Renato CC Vasconcellos, Joana G Vicente, Guy C Barker, Phillip N Miklas
Jun 05, 2018
Pseudomonas syringae pv. phaseolicola (Psph) Race 6 is a globally prevalent and broadly virulent bacterial pathogen with devastating impact causing halo blight of common bean (Phaseolus vulgaris L.). Common bean lines PI 150414...
Revisiting afro-alpine Lake Garba Guracha in the Bale Mountains of Ethiopia
L. Bittner, M. Bliedtner, D. Grady, G. Gil-Romera, C. Martin-Jones, B. Lemma, B. Mekonnen, H. F. Lamb, H. Yang, B. Glaser, S. Szidat, G. Salazar, N. L. Rose, L. Opgenoorth, G. Miehe, W. Zech, M. Zech
Aug 31, 2020
Abstract: Previous paleolimnological studies demonstrated that the sediments of Garba Guracha, situated at 3950 m asl in the afro-alpine zone of the Bale Mountains of Ethiopia, provide a complete Late Glacial and Holocene...
Cultural politics and the role of the action learning facilitator:
This empirical study contributes to critical action learning (CAL) research by theorizing the role of an action learning facilitator from a cultural perspective. Our paper adds to CAL by conceptualizing the dynamics of...
Cultural politics and the role of the action learning facilitator:
This empirical study contributes to critical action learning (CAL) research by theorizing the role of an action learning facilitator from a cultural perspective. Our paper adds to CAL by conceptualizing the dynamics of...
Late Holocene environmental change and anthropogenic
East African ecosystems have been shaped by long-term socio-ecological-environmental interactions. Although much previous work on human-environment interrelationships have emphasised the negative impacts of human interventions...
kinisi
kinisi is a Python package for estimating transport coefficients—e.g., self-diffusion coefficients, D*—and their corresponding uncertainties from molecular dynamics simulation data: it includes an implementation of the...
|
|< |
< |
1 |