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Results: 11121
B-hadron production in NNLO QCD
We calculate, for the first time, the NNLO QCD corrections to identified
heavy hadron production at hadron colliders. The calculation is based on a
flexible numeric framework which allows the calculation of any distribution of
a...
Restriction endonuclease TseI cleaves A:A and T
Long Ma, Kai Chen, David J Clarke, Christopher P Nortcliffe, Geoffrey G Wilson, J Michael Edwardson, A Jennifer Morton, Anita C Jones, David TF Dryden
Feb 13, 2020
The type II restriction endonuclease TseI recognizes the DNA target sequence 5'-G^CWGC-3' (where W = A or T) and cleaves after the first G to produce fragments with three-base 5'-overhangs. We have determined that it is a...
A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia.
Padma Akkapeddi, Rita Fragoso, Julie A Hixon, Ana Sofia Ramalho, Mariana L Oliveira, Tânia Carvalho, Andreas Gloger, Mattia Matasci, Francisco Corzana, Scott K Durum, Dario Neri, Gonçalo JL Bernardes, João T Barata
Mar 19, 2019
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological cancer for which treatment options often result in incomplete therapeutic efficacy and long-term side-effects. Interleukin 7 (IL-7) and its receptor...
Interview with Booker T. Brown - OH 689
This interview was conducted by Dr. George Garrison with Booker T. Brown with a focus on the History of Emmett Scott High School. Emmett Scott was the segregated high school for African-Americans, which was named after Emmett...
Published by: Winthrop University
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4 + T Cells
Daisy H. Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T. Hawkins, Len R. Stephens, Simon T. Barry, Klaus Okkenhaug
Mar 22, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells.
Daisy H Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T Hawkins, Len R Stephens, Simon T Barry, Klaus Okkenhaug
Feb 03, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
CD4-Positive T-Lymphocytes Animals Mice Inbred C57BL Mice Multiprotein Complexes Receptors Antigen T-Cell Interleukin-2 Lymphocyte Activation Specific Pathogen-Free Organisms Signal Transduction Cell Differentiation Gene Knockout Techniques Class I Phosphatidylinositol 3-Kinases CRISPR-Cas Systems Gene Editing
Transcutaneous vagus nerve stimulation (t-VNS)
Katherine E Manning, Jessica A Beresford-Webb, Lucie C S Aman, Howard A Ring, Peter C Watson, Stephen W Porges, Chris Oliver, Sally R Jennings, Anthony J Holland
Jan 06, 2020
Temper outbursts are a severe problem for people with Prader-Willi Syndrome (PWS). Previous reports indicate that vagus nerve stimulation (VNS) may reduce maladaptive behaviour in neurodevelopmental disorders, including PWS. We...
Measurement of the t(t)over-bar production cross section in p(p)over-bar collisions at root s=1.96 TeV
A Abulencia, D Acosta, J Adelman, T Affolder, T Akimoto, MG Albrow, D Ambrose, S Amerio, D Amidei, A Anastassov, K Anikeev, A Annovi, J Antos, M Aoki, G Apollinari, JF Arguin, T Arisawa, A Artikov, W Ashmanskas, A Attal, F Azfar, P Azzi-Bacchetta, P Azzurri, N Bacchetta, H Bachacou, W Badgett, A Barbaro-Galtieri, VE Barnes, BA Barnett, S Baroiant, V Bartsch, G Bauer, F Bedeschi, S Behari, S Belforte, G Bellettini, J Bellinger, A Belloni, E Ben Haim, D Benjamin, A Beretvas, J Beringer, T Berry, A Bhatti, M Binkley, D Bisello, RE Blair, C Blocker, B Blumenfeld, A Bocci, A Bodek, V Boisvert, G Bolla, A Bolshov, D Bortoletto, J Boudreau, A Boveia, B Brau, C Bromberg, E Brubaker, J Budagov, HS Budd, S Budd, K Burkett, G Busetto, P Bussey, KL Byrum, S Cabrera, M Campanelli, M Campbell, F Canelli, A Canepa, D Carlsmith, R Carosi, S Carron, M Casarsa, A Castro, P Catastini, D Cauz, M Cavalli-Sforza, A Cerri, L Cerrito, SH Chang, J Chapman, YC Chen, M Chertok, G Chiarelli, G Chlachidze, F Chlebana, I Cho, K Cho, D Chokheli, JP Chou, PH Chu, SH Chuang, K Chung, WH Chung, YS Chung, M Ciljak, CI Ciobanu, MA Ciocci, A Clark, D Clark, M Coca, G Compostella, ME Convery, J Conway, B Cooper, K Copic, M Cordelli, G Cortiana, F Cresciolo, A Cruz, CC Almenar, J Cuevas, R Culbertson, D Cyr, S DaRonco, S D'Auria, M D'Onofrio, D Dagenhart, P de Barbaro, S De Cecco, A Deisher, G De Lentdecker, M Dell'Orso, FD Paoli, S Demers, L Demortier, J Deng, M Deninno, D De Pedis, PF Derwent, C Dionisi, JR Dittmann, P DiTuro, C Dorr, S Donati, M Donega, P Dong, J Donini, T Dorigo, S Dube, K Ebina, J Efron, J Ehlers, R Erbacher, D Errede, S Errede, R Eusebi, HC Fang, S Farrington, I Fedorko, WT Fedorko, RG Feild, M Feindt, JP Fernandez, R Field, G Flanagan, LR Flores-Castillo, A Foland, S Forrester, GW Foster, M Franklin, JC Freeman, I Furic, M Gallinaro, J Galyardt, JE Garcia, MG Sciveres, AF Garfinkel, C Gay, H Gerberich, D Gerdes, S Giagu, P Giannetti, A Gibson, K Gibson, C Ginsburg, N Giokaris, K Giolo, M Giordani, P Giromini, M Giunta, G Giurgiu, V Glagolev, D Glenzinski, M Gold, N Goldschmidt, J Goldstein, G Gomez, G Gomez-Ceballos, M Goncharov, O Gonzalez, I Gorelov, AT Goshaw, Y Gotra, K Goulianos, A Gresele, M Griffiths, S Grinstein, C Grosso-Pilcher, RC Group, U Grundler, JG da Costa, Z Gunay-Unalan, C Haber, SR Hahn, K Hahn, E Halkiadakis, A Hamilton, BY Han, JY Han, R Handler, F Happacher, K Hara, M Hare, S Harper, RF Harr, RM Harris, K Hatakeyama, J Hauser, C Hays, A Heijboer, B Heinemann, J Heinrich, M Herndon, D Hidas, CS Hill, D Hirschbuehl, A Hocker, A Holloway, S Hou, M Houlden, SC Hsu, BT Huffman, RE Hughes, J Huston, J Incandela, G Introzzi, M Iori, Y Ishizawa, A Ivanov, B Iyutin, E James, D Jang, B Jayatilaka, D Jeans, H Jensen, EJ Jeon, S Jindariani, M Jones, KK Joo, SY Jun, TR Junk, T Kamon, J Kang, PE Karchin, Y Kato, Y Kemp, R Kephart, U Kerzel, V Khotilovich, B Kilminster, DH Kim, HS Kim, JE Kim, MJ Kim, SB Kim, SH Kim, YK Kim, L Kirsch, S Klimenko, M Klute, B Knuteson, BR Ko, H Kobayashi, K Kondo, DJ Kong, J Konigsberg, A Korytov, AV Kotwal, A Kovalev, A Kraan, J Kraus, I Kravchenko, M Kreps, J Kroll, N Krumnack, M Kruse, V Krutelyov, SE Kuhlmann, Y Kusakabe, S Kwang, AT Laasanen, S Lai, S Lami, S Lammel, M Lancaster, RL Lander, K Lannon, A Lath, G Latino, I Lazzizzera, T LeCompte, J Lee, J Lee, YJ Lee, SW Lee, R Lefevre, N Leonardo, S Leone, S Levy, JD Lewis, C Lin, CS Lin, M Lindgren, E Lipeles, TM Liss, A Lister, DO Litvintsev, T Liu, NS Lockyer, A Loginov, M Loreti, P Loverre, RS Lu, D Lucchesi, P Lujan, P Lukens, G Lungu, L Lyons, J Lys, R Lysak, E Lytken, P Mack, D MacQueen, R Madrak, K Maeshima, T Maki, P Maksimovic, S Malde, G Manca, F Margaroli, R Marginean, C Marino, A Martin, V Martin, M Martinez, T Maruyama, P Mastrandrea, H Matsunaga, ME Mattson, R Mazini, P Mazzanti, KS McFarland, M McFarlane, P McIntyre, R McNulty, A Mehta, S Menzemer, A Menzione, P Merkel, C Mesropian, A Messina, M von der Mey, T Miao, N Miladinovic, J Miles, R Miller, JS Miller, C Mills, M Milnik, R Miquel, A Mitra, G Mitselmakher, A Miyamoto, N Moggi, B Mohr, R Moore, M Morello, PM Fernandez, J Mulmenstadt, A Mukherjee, T Muller, R Mumford, P Murat, J Nachtman, J Naganoma, S Nahn, I Nakano, A Napier, D Naumov, V Necula, C Neu, MS Neubauer, J Nielsen, T Nigmanov, L Nodulman, O Norniella, E Nurse, T Ogawa, SH Oh, YD Oh, T Okusawa, R Oldeman, R Orava, K Osterberg, C Pagliarone, E Palencia, R Paoletti, V Papadimitriou, AA Paramonov, B Parks, S Pashapour, J Patrick, G Pauletta, M Paulini, C Paus, DE Pellett, A Penzo, TJ Phillips, G Piacentino, J Piedra, L Pinera, K Pitts, C Plager, L Pondrom, X Portell, O Poukhov, N Pounder, F Prakoshyn, A Pronko, J Proudfoot, F Ptohos, G Punzi, J Pursley, J Rademacker, A Rahaman, A Rakitin, S Rappoccio, F Ratnikov, B Reisert, V Rekovic, N van Remortel, P Renton, M Rescigno, S Richter, F Rimondi, L Ristori, WJ Robertson, A Robson, T Rodrigo, E Rogers, S Rolli, R Roser, M Rossi, R Rossin, C Rott, A Ruiz, J Russ, V Rusu, H Saarikko, S Sabik, A Safonov, WK Sakumoto, G Salamanna, O Salto, D Saltzberg, C Sanchez, L Santi, S Sarkar, L Sartori, K Sato, P Savard, A Savoy-Navarro, T Scheidle, P Schlabach, EE Schmidt, P Schmidt, M Schmitt, T Schwarz, L Scodellaro, AL Scott, A Scribano, F Scuri, A Sedov, S Seidel, Y Seiya, A Semenov, L Sexton-Kennedy, I Sfiligoi, MD Shapiro, T Shears, PF Shepard, D Sherman, M Shimojima, M Shochet, Y Shon, I Shreyber, A Sidoti, P Sinervo, A Sisakyan, J Sjolin, A Skiba, AJ Slaughter, K Sliwa, JR Smith, FD Snider, R Snihur, M Soderberg, A Soha, S Somalwar, V Sorin, J Spalding, M Spezziga, F Spinella, T Spreitzer, P Squillacioti, M Stanitzki, A Staveris-Polykalas, RS Denis, B Stelzer, O Stelzer-Chilton, D Stentz, J Strologas, D Stuart, JS Suh, A Sukhanov, K Sumorok, H Sun, T Suzuki, A Taffard, R Takashima, Y Takeuchi, K Takikawa, M Tanaka, R Tanaka, N Tanimoto, M Tecchio, PK Teng, K Terashi, S Tether, J Thom, AS Thompson, E Thomson, P Tipton, V Tiwari, S Tkaczyk, D Toback, S Tokar, K Tollefson, T Tomura, D Tonelli, M Tonnesmann, S Torre, D Torretta, S Tourneur, W Trischuk, R Tsuchiya, S Tsuno, N Turini, F Ukegawa, T Unverhau, S Uozumi, D Usynin, A Vaiciulis, S Vallecorsa, A Varganov, E Vataga, G Velev, G Veramendi, V Veszpremi, R Vidal, I Vila, R Vilar, T Vine, I Vollrath, I Volobouev, G Volpi, F Wurthwein, P Wagner, RG Wagner, RL Wagner, W Wagner, R Wallny, T Walter, Z Wan, SM Wang, A Warburton, S Waschke, D Waters, WC Wester, B Whitehouse, D Whiteson, AB Wicklund, E Wicklund, G Williams, HH Williams, P Wilson, BL Winer, P Wittich, S Wolbers, C Wolfe, T Wright, X Wu, SM Wynne, A Yagil, K Yamamoto, J Yamaoka, T Yamashita, C Yang, UK Yang, YC Yang, WM Yao, GP Yeh, J Yoh, K Yorita, T Yoshida, GB Yu, I Yu, SS Yu, JC Yun, L Zanello, A Zanetti, I Zaw, F Zetti, X Zhang, J Zhou, S Zucchelli, CDF Collaboration
Dec 15, 2021
The production cross-sections of $J/\psi$ mesons in proton-proton collisions
at a centre-of-mass energy of $\sqrt{s}=5$ TeV are measured using a data sample
corresponding to an integrated luminosity of...
Large scale genomic rearrangements in selected Arabidopsis thaliana T-DNA lines are caused by T-DNA insertion mutagenesis.
BACKGROUND: Experimental proof of gene function assignments in plants is based on mutant analyses. T-DNA insertion lines provided an invaluable resource of mutants and enabled systematic reverse genetics-based investigation of...
Effects of Frequent Interaction with Non-Native Speakers on English Dialect
Keiko Hirano
Nov 19, 2013
/T,d/ deletion was chosen as a speech token to test modifications to usage by native speakers of English due to frequent interactions with non-native anglophones in Japan. Approximately 250 tokens per each of thirty-nine...
Published by: Atlantic Provinces Linguistic Association
Effects of Frequent Interaction with Non-Native Speakers on English Dialect
Keiko Hirano
Nov 19, 2013
/T,d/ deletion was chosen as a speech token to test modifications to usage by native speakers of English due to frequent interactions with non-native anglophones in Japan. Approximately 250 tokens per each of thirty-nine...
Published by: Atlantic Provinces Linguistic Association
Extracellular Lactate
James T Grist, Lorna B Jarvis, Zoya Georgieva, Sara Thompson, Harpreet Kaur Sandhu, Keith Burling, Ashley Clarke, Sarah Jackson, Mark Wills, Ferdia A Gallagher, Joanne L Jones
Feb 23, 2018
Following activation, T cells rapidly divide and acquire effector functions. This energetically demanding process depends upon the ability of T cells to undergo metabolic remodeling from oxidative phosphorylation to aerobic...
T Lymphocytes in Histiocytic Sarcomas of Flat-Coated Retriever Dogs.
Flat-Coated Retriever dogs are predisposed to the development of histiocytic sarcoma (HS), a poorly differentiated, highly malignant neoplasm. The authors have previously documented a significant lymphocytic infiltrate in such...
The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling.
Donald T Gracias, Erietta Stelekati, Jennifer L Hope, Alina C Boesteanu, Travis A Doering, Jillian Norton, Yvonne M Mueller, Joseph A Fraietta, E John Wherry, Martin Turner, Peter D Katsikis
Aug 14, 2019
We found upregulation of expression of the microRNA miR-155 in primary effector and effector memory CD8(+) T cells, but low miR-155 expression in naive and central memory cells. Antiviral CD8(+) T cell responses and viral...
Animals CD8-Positive T-Lymphocytes Cell Proliferation Flow Cytometry Gene Expression Profiling Gene Regulatory Networks Immunoblotting Immunologic Memory Interferon Regulatory Factor-7 Interferons Mice Mice Inbred C57BL Mice Knockout MicroRNAs Oligonucleotide Array Sequence Analysis Orthomyxoviridae Orthomyxoviridae Infections RNA Interference Reverse Transcriptase Polymerase Chain Reaction STAT1 Transcription Factor Signal Transduction Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling Proteins
High fidelity analysis to predict failure in T-joints
Composite T-joints and similar skin-stiffener joints have a central role in aerospace structures. However, their accurate numerical analysis is still a great challenge due to their complex geometry and stress state during...
High fidelity analysis to predict failure in T-joints
Composite T-joints and similar skin-stiffener joints have a central role in aerospace structures. However, their accurate numerical analysis is still a great challenge due to their complex geometry and stress state during...
An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression.
Asis Palazon, Petros A Tyrakis, David Macias, Pedro Veliça, Helene Rundqvist, Susan Fitzpatrick, Nikola Vojnovic, Anthony T Phan, Niklas Loman, Ingrid Hedenfalk, Thomas Hatschek, John Lövrot, Theodoros Foukakis, Ananda W Goldrath, Jonas Bergh, Randall S Johnson
May 31, 2018
Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during adaptation to the hypoxic tumor microenvironment. Deletion analyses of the two key HIF isoforms found that HIF-1α, but not HIF-2α, was...
HIF transcription factors VEGF angiogenesis cytotoxic T cells Hypoxia Immunotherapy Animals Breast Neoplasms CD8-Positive T-Lymphocytes Cell Line Tumor Cells Cultured Disease Progression Female Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Hypoxia-Inducible Factor 1 alpha Subunit Mice Inbred C57BL Mice Knockout Neoplasms Experimental Neovascularization Pathologic T-Lymphocytes Cytotoxic Vascular Endothelial Growth Factor A
Carcinomas assemble a filamentous CXCL12-keratin-19 coating that suppresses T cell-mediated immune attack.
Zhikai Wang, Philip Moresco, Ran Yan, Jiayun Li, Ya Gao, Daniele Biasci, Min Yao, Jordan Pearson, Jaclyn F Hechtman, Tobias Janowitz, Raza M Zaidi, Matthew J Weiss, Douglas T Fearon
Feb 20, 2022
Cancer immunotherapy frequently fails because most carcinomas have few T cells, suggesting that cancers can suppress T cell infiltration. Here, we show that cancer cells of human pancreatic ductal adenocarcinoma (PDA)...
A small number of anti-CD3 molecules on dendritic cells stimulate DNA synthesis in mouse T lymphocytes
Resting T cells enter cell cycle when challenged with anti-CD3 mAb and accessory cells that bear required Fc receptor (FcR). Presentation of anti-CD3 is though to be a model for antigens presented by accessory cells to the TCR...
Published by: Rockefeller University
Does the PI3K pathway promote or antagonize regulatory T cell development and function?
Regulatory T cells (Tregs) prevent autoimmunity and inflammation by suppressing the activation of other T cells and antigen presenting cells. The role of phosphoinositide 3-kinase (PI3K) signaling in Treg is controversial. Some...
Interview with Willie T. "Dub" Massey - OH 138
Willie T. Massey
Jan 01, 0001
In his April 27th, 1981 interview with Phil O'Quinn, Rev. Willie T. "Dub" Massey recollects his involvement in the Civil Rights Movement as one of the Friendship 9 protestors and non-violent activists. Massey retells the...
Friendship nine Friendship 9 Grassroots movement sit-in non-violent protests Rock Hill McCrory's discrimination Segregation Jim Crow NAACP Jail No Bail law
Published by: Winthrop University
Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ
T cells recognize peptides that are bound to MHC molecules on the surface of different types of antigen-presenting cells (APC). Antigen presentation most often is studied using T cells that have undergone priming in situ, or...
Antigen Presentation dendritic cell Immunogenicity major histocompatibility complex restriction t lymphocyte activation
Published by: Rockefeller University
S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate.
Petros A Tyrakis, Asis Palazon, David Macias, Kian L Lee, Anthony T Phan, Pedro Veliça, Jia You, Grace S Chia, Jingwei Sim, Andrew Doedens, Alice Abelanet, Colin E Evans, John R Griffiths, Lorenz Poellinger, Ananda W Goldrath, Randall S Johnson
Dec 14, 2016
R-2-hydroxyglutarate accumulates to millimolar levels in cancer cells with gain-of-function isocitrate dehydrogenase 1/2 mutations. These levels of R-2-hydroxyglutarate affect 2-oxoglutarate-dependent dioxygenases. Both...
Animals CD8-Positive T-Lymphocytes Cell Differentiation DNA DNA Methylation Dioxygenases Glutarates Histones Homeostasis Hypoxia Hypoxia-Inducible Factor 1 alpha Subunit Ketoglutaric Acids Lymphocyte Activation Lysine Mice Oxygen Protein Stability Receptors Antigen T-Cell Von Hippel-Lindau Tumor Suppressor Protein
Small amounts of superantigen, when presented on dendritic cells, are sufficient to initiate T cell responses
Dendritic cells are potent antigen-presenting cells for several primary immune responses and therefore provide an opportunity for evaluating the amounts of cell-associated antigens that are required for inducing T cell-mediated...
antigen expression B lymphocyte dendritic cell human cell ymphocyte proliferation t lymphocyte activation
Published by: Rockefeller University
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