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Does Soluble TREM2 Protect Against Alzheimer's Disease?
Triggering Receptor Expressed in Myeloid Cells 2 (TREM2) is a pattern recognition receptor on myeloid cells, and is upregulated on microglia surrounding amyloid plaques in Alzheimer's disease (AD). Rare, heterozygous...
The Revd George Lewis
Abstract
In 1727 the Revd George Lewis (c. 1663–1729) donated a wooden cabinet containing a diverse collection of items, including many manuscripts, to Cambridge University...
Catherine Ansorge
Dec 10, 2018
Inherited and Sporadic Amyotrophic Lateral Sclerosis and Fronto-Temporal Lobar Degenerations arising from Pathological Condensates of Phase Separating Proteins.
Michael Fernandopulle, GuoZhen Wang, Jonathon Nixon-Abell, Seema Qamar, Varun Balaji, Ryuta Morihara, Peter H St George-Hyslop
Jul 08, 2019
ANXA11 Amyotrophic Lateral Sclerosis FUS TDP-43 biological condensates fronto-temporal dementia gelation Hydrogels local RNA translation neuronal transport granules phase separation Stress granules Amyotrophic Lateral Sclerosis Annexins Biological Transport DNA-Binding Proteins Frontotemporal Lobar Degeneration Humans Intracellular Membranes Mutation Missense Neurodegenerative Diseases Neurons Protein Processing Post-Translational RNA-Binding Protein FUS Temporal Lobe
The physiological and pathological biophysics of phase separation and gelation of RNA binding proteins in amyotrophic lateral sclerosis and fronto-temporal lobar degeneration.
Peter St George-Hyslop, Julie Qiaojin Lin, Akinori Miyashita, Emma C Phillips, Seema Qamar, Suzanne J Randle, GuoZhen Wang
Sep 05, 2018
Amyotrophic Lateral Sclerosis arginine methylation Cation-pi interactions frontotemporal dementia phase separation RNA binding proteins Amyotrophic Lateral Sclerosis biophysics Cytoplasmic Granules DNA-Binding Proteins frontotemporal dementia Frontotemporal Lobar Degeneration Humans Mutation Neurodegenerative Diseases Protein Domains Protein Processing Post-Translational RNA-Binding Protein FUS RNA-Binding Proteins Temporal Lobe
George Fish School Yearbook - The Dolphin 1960
The George Fish School operated in in Fort Mill, SC from 1926 through 1968. George Fish was a Rosenwald school that served as a segregated African Americans school until it was integrated in 1968. The school originally served...
Published by: George Fish School
George Fish School Yearbook - The Dolphin 1962 and 1963
This Dolphin Yearbook combines the Class of 1962 and the Class of 1963 into one yearbook.
The George Fish School operated in in Fort Mill, SC from 1926 through 1968. George Fish was a Rosenwald school that served as a segregated...
Published by: George Fish School
George Fish School Yearbook - The Dolphin 1961
The George Fish School operated in in Fort Mill, SC from 1926 through 1968. George Fish was a Rosenwald school that served as a segregated African Americans school until it was integrated in 1968. The school originally served...
Published by: George Fish School
Longitudinal evaluation of Tau-P301L transgenic mice reveals no cognitive impairments at 17 months of age.
Brianne A Kent, Christopher J Heath, Chi Hun Kim, Rosemary Ahrens, Paul E Fraser, Peter St George-Hyslop, Timothy J Bussey, Lisa M Saksida
Feb 16, 2018
INTRODUCTION: Tau is a microtubule-associated binding protein implicated in neurodegenerative tauopathies, including frontotemporal dementia (FTD) and Alzheimer's disease (AD). These diseases result in the intracellular...
George Fish School Yearbook - The Dolphin 1964 and 1965
This Dolphin Yearbook combines the Class of 1964 and the Class of 1965 into one yearbook.
The George Fish School operated in in Fort Mill, SC from 1926 through 1968. George Fish was a Rosenwald school that served as a segregated...
Published by: George Fish School
Interview with Peter Berg
Peter Berg
Jan 01, 0001
In his December 1993 interview with Ron Chepesiuk, Peter Berg detailed his part in the '60s radical movement and his more recent activities with the Planet Drum Foundation. Berg described his involvement in the Digger movement...
San Francisco Nonviolent Anarchy Shasta Bioregion Planet Drum Foundation Rachel Carson's Silent Spring bioregionalism Ecology environmental movement Digger CONSERVATION industrial growth economy Capitalism Black Liberation Movement McCarthyism Thalhimer sit-in Mairowitz's The Radical Soap Opera guerilla theatre LSD peyote San Francisco Co-Existence Bagel Shop Free Speech Movement Sexism homophobia Haight Ashbury Oral History
Published by: Winthrop University
Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death.
Craig Hughes, Minee L Choi, Jee-Hyun Yi, Seung-Chan Kim, Anna Drews, Peter St George-Hyslop, Clare Bryant, Sonia Gandhi, Kwangwook Cho, David Klenerman
Mar 25, 2020
Published by: Communications biology
Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death.
Craig Hughes, Minee L Choi, Jee-Hyun Yi, Seung-Chan Kim, Anna Drews, Peter St George-Hyslop, Clare Bryant, Sonia Gandhi, Kwangwook Cho, David Klenerman
Jan 20, 2020
Regulation of membrane fluidity by
<scp>RNF145</scp>
‐triggered degradation of the lipid hydrolase
<scp>ADIPOR2</scp>
Norbert Volkmar, Christian M Gawden‐Bone, James C Williamson, Jonathon Nixon‐Abell, James A West, Peter H St George‐Hyslop, Arthur Kaser, Paul J Lehner
Aug 22, 2022
Seeking the Wealth of Self
Michael George
Mar 16, 2022
Michael George teaches Religion and Culture, and Ethics at St. Thomas University in Fredericton, New Brunswick. He is interested in helping to promote the project of Integrative Bioethics, which he considers to be a possible...
Published by: Memorial University of Newfoundland
George Fish School Yearbook - The Dolphin 1966 and 1967
This Dolphin Yearbook combines the Class of 1966 and the Class of 1967 into one yearbook.
The George Fish School operated in in Fort Mill, SC from 1926 through 1968. George Fish was a Rosenwald school that served as a segregated...
Published by: George Fish School
Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies.
Marcus Pickhardt, Thomas Neumann, Daniel Schwizer, Kari Callaway, Michele Vendruscolo, Dale Schenk, Peter St George-Hyslop, Eva M Mandelkow, Christopher M Dobson, Lisa McConlogue, Eckhard Mandelkow, Gergely Tóth
Oct 01, 2015
Seeking the Wealth of Self
Michael George
Mar 16, 2022
Michael George teaches Religion and Culture, and Ethics at St. Thomas University in Fredericton, New Brunswick. He is interested in helping to promote the project of Integrative Bioethics, which he considers to be a possible...
Published by: Memorial University of Newfoundland
Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition.
Yi Shen, Francesco Simone Ruggeri, Daniele Vigolo, Ayaka Kamada, Seema Qamar, Aviad Levin, Christiane Iserman, Simon Alberti, Peter St George-Hyslop, Tuomas PJ Knowles
Feb 24, 2021
Membrane-less organelles resulting from liquid-liquid phase separation of biopolymers into intracellular condensates control essential biological functions, including messenger RNA processing, cell signalling and...
Vigilin interacts with signal peptide peptidase.
Stephen Hsueh-Jeng Lu, Amy Hye Won Jeon, Gerold Schmitt-Ulms, Seema Qamar, Roger Dodd, Beth McDonald, Yi Li, William Meadows, Katie Cox, Christopher Bohm, Fusheng Chen, Paul Fraser, Peter St George-Hyslop
Nov 06, 2012
Spatially non-uniform condensates emerge from dynamically arrested phase separation.
Nadia A Erkamp, Tomas Sneideris, Hannes Ausserwöger, Daoyuan Qian, Seema Qamar, Jonathon Nixon-Abell, Peter St George-Hyslop, Jeremy D Schmit, David A Weitz, Tuomas P J Knowles
Mar 13, 2023
The formation of biomolecular condensates through phase separation from proteins and nucleic acids is emerging as a spatial organisational principle used broadly by living cells. Many such biomolecular condensates are not...
Published by: Nature Communications
SORL1 mutations in early- and late-onset Alzheimer disease.
Michael L Cuccaro, Regina M Carney, Yalun Zhang, Christopher Bohm, Brian W Kunkle, Badri N Vardarajan, Patrice L Whitehead, Holly N Cukier, Richard Mayeux, Peter St George-Hyslop, Margaret A Pericak-Vance
Feb 07, 2019
OBJECTIVE: To characterize the clinical and molecular effect of mutations in the sortilin-related receptor (SORL1) gene. METHODS: We performed whole-exome sequencing in early-onset Alzheimer disease (EOAD) and late-onset...
1109 Neurosciences Biomedical Basic Science Human Genome Alzheimer's Disease Clinical Research Dementia Brain Disorders Neurodegenerative aging Genetics Acquired Cognitive Impairment Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) Neurological 2.1 Biological and endogenous factors
Ultra-rare mutations in SRCAP segregate in Caribbean Hispanic families with Alzheimer disease.
Badri N Vardarajan, Giuseppe Tosto, Roger Lefort, Lei Yu, David A Bennett, Philip L De Jager, Sandra Barral, Dolly Reyes-Dumeyer, Peter L Nagy, Joseph H Lee, Rong Cheng, Martin Medrano, Rafael Lantigua, Ekaterina Rogaeva, Peter St George-Hyslop, Richard Mayeux
Mar 22, 2018
OBJECTIVE: To identify rare coding variants segregating with late-onset Alzheimer disease (LOAD) in Caribbean Hispanic families. METHODS: Whole-exome sequencing (WES) was completed in 110 individuals from 31 Caribbean Hispanic...
George E. Banister
Casandra Gutierrez
Apr 01, 2021
Whenever we think about African American history, we put our focus straight to slavery or the civil rights era, though it is much more than that. African American history in San Antonio has impacted the city’s business and...
Published by: Digital Commons @ Texas A&M University-San Antonio
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