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Expression and cellular localization of hepcidin mRNA and protein in normal rat brain.
Ruma Raha-Chowdhury, Animesh Alexander Raha, Serhiy Forostyak, Jing-Wei Zhao, Simon Russell William Stott, Adrian Bomford
Sep 29, 2016
BACKGROUND: Hepcidin is a peptide hormone belonging to the defensin family of cationic antimicrobial molecules that has an essential role in systemic iron homeostasis. The peptide is synthesised by hepatocytes and transported in...
Investigation of CD26, a potential SARS-CoV-2 receptor, as a biomarker of age and pathology.
Animesh Alexander Raha, Subhojit Chakraborty, James Henderson, Elizabeta Mukaetova-Ladinska, Shahid Zaman, John Trowsdale, Ruma Raha-Chowdhury
Feb 05, 2021
OBJECTIVE: In some individuals, coronavirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection leads to a variety of serious inflammatory symptoms, including blood clotting and acute respiratory distress....
Corona virus COVID-19 Covid-19 biomarker SARS-CoV-2 infection type 2 diabetes mellitus age-related dementia dipeptidyl peptidase 4 (DPP4) Adult Age Factors Aged Aged 80 and over Animals Biomarkers covid-19 Comorbidity Dementia Diabetes mellitus Type 2 Dipeptidyl Peptidase 4 Duodenum Gene Expression Host-Pathogen Interactions Humans Mice Inbred C57BL Middle Aged SARS-CoV-2
Interplay of Ferritin Accumulation and Ferroportin Loss in Ageing Brain
Animesh Alexander Raha, Anwesha Biswas, James Henderson, Subhojit Chakraborty, Anthony Holland, Robert P Friedland, Elizabeta Mukaetova-Ladinska, Shahid Zaman, Ruma Raha-Chowdhury
Mar 18, 2022
Iron accumulates in the ageing brain and in brains with neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and Down syndrome (DS) dementia. However, the mechanisms...
Alzheimer’s disease (AD) Down syndrome (DS) Parkinson’s disease (PD) basal ganglia ferritin Hepcidin Locus Coeruleus neurodegeneration Substantia Nigra Alzheimer Disease Brain Cation Transport Proteins Down Syndrome Ferritins Hepcidins Humans Iron Neurodegenerative Diseases Parkinson Disease Protein Aggregates
Impaired Iron Homeostasis and Haematopoiesis Impacts Inflammation in the Ageing Process in Down Syndrome Dementia.
Ruma Raha-Chowdhury, Animesh Alexander Raha, James Henderson, Seyedeh Deniz Ghaffari, Monika Grigorova, Jessica Beresford-Webb, Kieren Allinson, Subhojit Chakraborty, Anthony Holland, Shahid H Zaman
Aug 02, 2021
Down syndrome (DS) subjects are more likely to develop the clinical features of Alzheimer's disease (AD) very early in the disease process due to the additional impact of neuroinflammation and because of activation of innate...
Iron ferritin Alzheimer’s disease Hepcidin iron homeostasis Choroid Plexus trisomy 21 Olig2 RUNX1 S100β accelerating ageing down syndrome dementia erythroid-megakaryocyte
Published by: Journal of clinical medicine
Neuroprotective Effect of TREM-2 in Aging and Alzheimer's Disease Model.
Animesh Alexander Raha, James W Henderson, Simon RW Stott, Romina Vuono, Simona Foscarin, Robert P Friedland, Shahid H Zaman, Ruma Raha-Chowdhury
Sep 22, 2016
Alzheimer’ disease choroid plexus macrophages immunomodulation innate immunity Myelination Neurogenesis Neuroinflammation neuroplasticity neuroprotective soluble TREM2 aging Alzheimer Disease Amyloid beta-Protein Precursor Animals Brain Cells Cultured Humans Lipopolysaccharides MACROPHAGES Membrane Glycoproteins meninges Mice Inbred C57BL Mice Transgenic Microglia Neurogenesis Neurons Neuroprotection Presenilin-1 RNA Messenger Rats Sprague-Dawley Receptors Immunologic
Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory.
Chondroitin sulfate (CS) proteoglycans in perineuronal nets (PNNs) from the central nervous system (CNS) are involved in the control of plasticity and memory. Removing PNNs reactivates plasticity and restores memory in models of...
Impaired Iron Homeostasis and Haematopoiesis Impacts Inflammation in the Ageing Process in Down Syndrome Dementia.
Ruma Raha-Chowdhury, Animesh Alexander Raha, James Henderson, Seyedeh Deniz Ghaffari, Monika Grigorova, Jessica Beresford-Webb, Kieren Allinson, Subhojit Chakraborty, Anthony Holland, Shahid H Zaman
Sep 20, 2021
Down syndrome (DS) subjects are more likely to develop the clinical features of Alzheimer's disease (AD) very early in the disease process due to the additional impact of neuroinflammation and because of activation of innate...
Transplantation of Neural Precursors Derived from Induced Pluripotent Cells Preserve Perineuronal Nets and Stimulate Neural Plasticity in ALS Rats.
Serhiy Forostyak, Oksana Forostyak, Jessica CF Kwok, Nataliya Romanyuk, Monika Rehorova, Jan Kriska, Govindan Dayanithi, Ruma Raha-Chowdhury, Pavla Jendelova, Miroslava Anderova, James W Fawcett, Eva Sykova
May 18, 2021
A promising therapeutic strategy for amyotrophic lateral sclerosis (ALS) treatment is stem cell therapy. Neural progenitors derived from induced pluripotent cells (NP-iPS) might rescue or replace dying motoneurons (MNs)....
ALS iPS motoneuron death neurodegeneration plasticity Proteoglycans Stem Cells Transplantation Amyotrophic Lateral Sclerosis Animals Apoptosis Regulatory Proteins Cells Cultured Humans Induced Pluripotent Stem Cells Male Nerve Growth Factors Nerve Regeneration Neural Stem Cells Neuronal Plasticity Peripheral Nerves Rats Rats Sprague-Dawley Stem Cell Transplantation Tenascin Versicans
Gender Differences in Giving and the Anticipation Regarding Giving in Dictator Games
Research on altruistic behaviour and associated anticipatory beliefs, as well as related gender differences, is limited. Using data from Chowdhury and Jeon, who vary a common show-up fee and incentivize recipients to...
Gender Differences in Giving and the Anticipation Regarding Giving in Dictator Games
Research on altruistic behaviour and associated anticipatory beliefs, as well as related gender differences, is limited. Using data from Chowdhury and Jeon, who vary a common show-up fee and incentivize recipients to...
Hepcidin Increases Cytokines in Alzheimer’s Disease and Down’s Syndrome Dementia
Animesh Alexander Raha, Seyedeh Deniz Ghaffari, James Henderson, Subhojit Chakraborty, Kieren Allinson, Robert P. Friedland, Anthony Holland, Shahid H. Zaman, Elizabeta B. Mukaetova-Ladinska, Ruma Raha-Chowdhury
May 20, 2021
The liver-derived hormone hepcidin, a member of the defensin family of antimicrobial peptides, plays an important role in host defense and innate immunity due to its broad antibacterial and antiviral properties. Ferritin, an...
Transplantation of Neural Precursors Derived from Induced Pluripotent Cells Preserve Perineuronal Nets and Stimulate Neural Plasticity in ALS Rats
Serhiy Forostyak, Oksana Forostyak, Jessica C. F. Kwok, Nataliya Romanyuk, Monika Rehorova, Jan Kriska, Govindan Dayanithi, Ruma Raha-Chowdhury, Pavla Jendelova, Miroslava Anderova, James W. Fawcett, Eva Sykova
Dec 22, 2020
A promising therapeutic strategy for amyotrophic lateral sclerosis (ALS) treatment is stem cell therapy. Neural progenitors derived from induced pluripotent cells (NP-iPS) might rescue or replace dying motoneurons (MNs)....
Interplay of Ferritin Accumulation and Ferroportin Loss in Ageing Brain
Animesh Alexander Raha, Anwesha Biswas, James Henderson, Subhojit Chakraborty, Anthony Holland, Robert P Friedland, Elizabeta Mukaetova-Ladinska, Shahid Zaman, Ruma Raha-Chowdhury
Jan 28, 2022
Iron accumulates in the ageing brain and in brains with neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and Down syndrome (DS) dementia. However, the mechanisms...
Choroid Plexus Acts as Gatekeeper for TREM2, Abnormal Accumulation of ApoE, and Fibrillary Tau in Alzheimer's Disease and in Down Syndrome Dementia.
Hepcidin Increases Cytokines in Alzheimer's Disease and Down's Syndrome Dementia
Animesh Alexander Raha, Seyedeh Deniz Ghaffari, James Henderson, Subhojit Chakraborty, Kieren Allinson, Robert P Friedland, Anthony Holland, Shahid H Zaman, Elizabeta B Mukaetova-Ladinska, Ruma Raha-Chowdhury
May 27, 2021
The liver-derived hormone hepcidin, a member of the defensin family of antimicrobial peptides, plays an important role in host defense and innate immunity due to its broad antibacterial and antiviral properties. Ferritin, an...
Impaired Iron Homeostasis and Haematopoiesis Impacts Inflammation in the Ageing Process in Down Syndrome Dementia
Ruma Raha-Chowdhury, Animesh Alexander Raha, James Henderson, Seyedeh Deniz Ghaffari, Monika Grigorova, Jessica Beresford-Webb, Kieren Allinson, Subhojit Chakraborty, Anthony Holland, Shahid H. Zaman
Jul 02, 2021
Down syndrome (DS) subjects are more likely to develop the clinical features of Alzheimer’s disease (AD) very early in the disease process due to the additional impact of neuroinflammation and because of activation of innate...
R/BHC
BACKGROUND: Although the use of clustering methods has rapidly become one of the standard computational approaches in the literature of microarray gene expression data analysis, little attention has been paid to uncertainty in...
The Expansion of Approximant /r/ in Dutch
Renée Van Bezooijen
Sep 30, 2014
In present-day Standard Dutch as spoken in the Netherlands, three main categories of pronunciation variants of Irl can be distinguished, namely alveolar /r/, uvular /r/, and approximant /r/. Approximant /r/, the focus of this...
Published by: Atlantic Provinces Linguistic Association
Alphonse R. Dochez, 1925
The Rockefeller University
Jan 01, 0001
Alphonse R. Dochez. Etiology of Scarlet Fever
Lecture delivered January 17th, 1925
Posted with permission
Published by: J.B. Lippincott Company
Florence R. Sabin, 1915
The Rockefeller University
Jan 01, 0001
Prof. Florence R. Sabin. The Method of Growth of the Lymphatic System
Lecture delivered December 18th, 1915
Published by: J.B. Lippincott Company
Personality Antecedents of EWoM in Determining Online Customer Purchase Behavior
Electronic word of mouth (EWoM) is similar to the standard word of mouth- the only difference is, the use of Internet as a base in EWoM. By understanding the personality antecedents of EWoM, the consumer buyer beahviour could be...
Published by: IGI Global Scientific Publishing
RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors.
Parasvi S Patel, Karan Joshua Abraham, Kiran Kumar Naidu Guturi, Marie-Jo Halaby, Zahra Khan, Luis Palomero, Brandon Ho, Shili Duan, Jonathan St-Germain, Arash Algouneh, Francesca Mateo, Samah El Ghamrasni, Haithem Barbour, Daniel R Barnes, Jonathan Beesley, Otto Sanchez, Hal K Berman, Grant W Brown, El Bachir Affar, Georgia Chenevix-Trench, Antonis C Antoniou, Cheryl H Arrowsmith, Brian Raught, Miquel Angel Pujana, Karim Mekhail, Anne Hakem, Razqallah Hakem
Feb 15, 2021
Germline mutations in BRCA1 and BRCA2 (BRCA1/2) genes considerably increase breast and ovarian cancer risk. Given that tumors with these mutations have elevated genomic instability, they exhibit relative vulnerability to certain...
The Expansion of Approximant /r/ in Dutch
Renée Van Bezooijen
Sep 30, 2014
In present-day Standard Dutch as spoken in the Netherlands, three main categories of pronunciation variants of Irl can be distinguished, namely alveolar /r/, uvular /r/, and approximant /r/. Approximant /r/, the focus of this...
Published by: Atlantic Provinces Linguistic Association
Bayesian Spatial Modelling with R-INLA
The principles behind the interface to continuous domain spatial models in the R- INLA software package for R are described. The integrated nested Laplace approximation (INLA) approach proposed by Rue, Martino, and Chopin (2009)...
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