Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site.
Marijke Brams,
Cedric Govaerts,
Kumiko Kambara,
Kerry L Price,
Radovan Spurny,
Anant Gharpure,
Els Pardon,
Genevieve L Evans,
Daniel Bertrand,
Sarah CR Lummis,
Ryan E Hibbs,
Jan Steyaert,
Chris Ulens
Feb 28, 2020
Pentameric ligand-gated ion channels (pLGICs) or Cys-loop receptors are involved in fast synaptic signaling in the nervous system. Allosteric modulators bind to sites that are remote from the neurotransmitter binding site, but...