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Results: 327
Application of the relationship between pharmacokinetics and pharmacodynamics in drug development and therapeutic equivalence:
Ioannis Loisios-Konstantinidis, Rafael L.M. Paraiso, Nikoletta Fotaki, Mark McAllister, Rodrigo Cristofoletti, Jennifer Dressman
Apr 01, 2019
Objectives
The objective of this review was to provide an overview of pharmacokinetic/pharmacodynamic (PK/PD) models, focusing on drug‐specific PK/PD models and highlighting their value added in drug development and...
The objective of this review was to provide an overview of pharmacokinetic/pharmacodynamic (PK/PD) models, focusing on drug‐specific PK/PD models and highlighting their value added in drug development and...
The use of PBPK/PD to establish clinically relevant dissolution specifications for zolpidem immediate release tablets
Rafael L.M. Paraiso, Rachel H. Rose, Nikoletta Fotaki, Mark McAllister, Jennifer B. Dressman
Dec 01, 2020
Background: Zolpidem is a non-benzodiazepine hypnotic agent which has been shown to be effective in inducing and maintaining sleep in adults and is one of the most frequently prescribed hypnotics in the world. For drugs that...
Application of the relationship between pharmacokinetics and pharmacodynamics in drug development and therapeutic equivalence:
Ioannis Loisios-Konstantinidis, Rafael L.M. Paraiso, Nikoletta Fotaki, Mark McAllister, Rodrigo Cristofoletti, Jennifer Dressman
Apr 01, 2019
Objectives
The objective of this review was to provide an overview of pharmacokinetic/pharmacodynamic (PK/PD) models, focusing on drug‐specific PK/PD models and highlighting their value added in drug development and...
The objective of this review was to provide an overview of pharmacokinetic/pharmacodynamic (PK/PD) models, focusing on drug‐specific PK/PD models and highlighting their value added in drug development and...
The use of PBPK/PD to establish clinically relevant dissolution specifications for zolpidem immediate release tablets
Rafael L.M. Paraiso, Rachel H. Rose, Nikoletta Fotaki, Mark McAllister, Jennifer B. Dressman
Dec 01, 2020
Background: Zolpidem is a non-benzodiazepine hypnotic agent which has been shown to be effective in inducing and maintaining sleep in adults and is one of the most frequently prescribed hypnotics in the world. For drugs that...
Rafael Lorente de No, 1946
The Rockefeller University
Jan 01, 0001
Rafael Lorente de Nó. Correlation of Nerve Activity with Polarization Phenomena
Lecture delivered October 24th, 1946
Posted with permission
Published by: The Science Press Priniting Company
Novel imaging method to quantify stratum corneum in dermatopharmacokinetic studies
Purpose: Tape-stripping the stratum corneum (SC) is used in the assessment of dermatopharmacokinetics (DPK). The amount of SC per tape can be determined gravimetrically, but a novel imaging method offers advantages in terms of...
Energetics and kinetics of light-driven oxygen evolution at semiconductor electrodes
L.M. Peter
Feb 01, 2013
Light-driven water-splitting (photoelectrolysis) at semiconductor electrodes continues to excite interest as a potential route to produce hydrogen as a sustainable fuel, but surprisingly little is known about the kinetics and...
Potential prediction of formulation performance in paediatric patients using biopharmaceutical tools and simulation of clinically relevant administration scenarios of nifedipine and lorazepam
Aims: This study explores the impact of paediatric patient related factors and choice of formulation on the dissolution characteristics of nifedipine and lorazepam, 2 drug substances regularly applied in very young patients...
Energetics and kinetics of light-driven oxygen evolution at semiconductor electrodes
L.M. Peter
Feb 01, 2013
Light-driven water-splitting (photoelectrolysis) at semiconductor electrodes continues to excite interest as a potential route to produce hydrogen as a sustainable fuel, but surprisingly little is known about the kinetics and...
Environmental Awareness, Oligopolistic Competition, and Foreign Direct Investment
In most developing countries, local companies have more expensive polluting production technology than those in developed countries. On the other hand, there is a growing concern to produce and consume ecological goods in the...
Published by: IGI Global Scientific Publishing
Potential prediction of formulation performance in paediatric patients using biopharmaceutical tools and simulation of clinically relevant administration scenarios of nifedipine and lorazepam
Aims: This study explores the impact of paediatric patient related factors and choice of formulation on the dissolution characteristics of nifedipine and lorazepam, 2 drug substances regularly applied in very young patients...
In situ detection of free and trapped electrons in dye-sensitized solar cells by photo-induced microwave reflectance measurements
In order to study the behavior of photoinjected electrons in dye-sensitized solar cells (DSC), steady-state microwave reflectance measurements (33 GHz, Ka band) have been carried out on a working cell filled with electrolyte....
Novel imaging method to quantify stratum corneum in dermatopharmacokinetic studies
Purpose: Tape-stripping the stratum corneum (SC) is used in the assessment of dermatopharmacokinetics (DPK). The amount of SC per tape can be determined gravimetrically, but a novel imaging method offers advantages in terms of...
Screening of Radiological Images Suspected of Containing Lung Nodules
This paper presents a study about screening large radiological image streams produced in hospitals for earlier detection of lung nodules. Being one of the most difficult classification tasks in the literature, our objective is...
Computer Vision & Image Processing Computer Science and Information Technology Computer Vision and Machine Perception
Published by: IGI Global Scientific Publishing
Multiagent Intelligent Tutoring System for Financial Literacy
Financial literacy is a theme that integrates public policies for the social development of a country and an element to be worked on from different aspects to improve people’s living standards, providing well-being. In this...
Published by: IGI Global Scientific Publishing
In situ detection of free and trapped electrons in dye-sensitized solar cells by photo-induced microwave reflectance measurements
In order to study the behavior of photoinjected electrons in dye-sensitized solar cells (DSC), steady-state microwave reflectance measurements (33 GHz, Ka band) have been carried out on a working cell filled with electrolyte....
Co-delivery of buparvaquone and polymyxin B in a nanostructured lipid carrier for leishmaniasis treatment
L.M Monteiro, Raimar Löbenberg, Nikoletta Fotaki, Gabriel Lima Barros de Araujo, P.C Cotrim, Nádia Araci Bou-Chacra
Sep 01, 2019
Objectives: This study aimed to describe the preparation and in vitro evaluation of a surface-modified nanostructured lipid carrier (NLC) using chitosan and dextran for co-delivery of buparvaquone (BPQ) and polymyxin B (PB)...
Buparvaquone Chitosan Dextran Leishmaniasis Nanostructured lipid carrier Polymyxin B /dk/atira/pure/subjectarea/asjc/2400/2404 name=Microbiology /dk/atira/pure/subjectarea/asjc/2700/2723 name=Immunology and Allergy /dk/atira/pure/subjectarea/asjc/2400/2403 name=Immunology /dk/atira/pure/subjectarea/asjc/2700/2726 name=Microbiology (medical)
Co-delivery of buparvaquone and polymyxin B in a nanostructured lipid carrier for leishmaniasis treatment
L.M Monteiro, Raimar Löbenberg, Nikoletta Fotaki, Gabriel Lima Barros de Araujo, P.C Cotrim, Nádia Araci Bou-Chacra
Sep 01, 2019
Objectives: This study aimed to describe the preparation and in vitro evaluation of a surface-modified nanostructured lipid carrier (NLC) using chitosan and dextran for co-delivery of buparvaquone (BPQ) and polymyxin B (PB)...
Buparvaquone Chitosan Dextran Leishmaniasis Nanostructured lipid carrier Polymyxin B /dk/atira/pure/subjectarea/asjc/2400/2404 name=Microbiology /dk/atira/pure/subjectarea/asjc/2700/2723 name=Immunology and Allergy /dk/atira/pure/subjectarea/asjc/2400/2403 name=Immunology /dk/atira/pure/subjectarea/asjc/2700/2726 name=Microbiology (medical)
Transcription, Editing, and Switching of Antibody Genes
Rafael Casellas
Jan 01, 0001
B lymphocytes are the antibody producing cells of the immune system. During B cell lymphopoiesis in the bone marrow, immunoglobulin molecules are assembled from V, D, and J gene segments through a process known as V(D)J...
Published by: Rockefeller University
Ruthenium(II) dichloro or dithiocyanato complexes with 4,4′:2′,2″:4″,4‴-quaterpyridinium ligands
O.A. Blackburn, B.J. Coe, M. Helliwell, Y.T. Ta, L.M. Peter, H. Wang, J.A. Anta, E. Guillén
Feb 13, 2013
Fourteen new complexes of the form cis-[Ru IIX 2(R 2qpy 2+) 2] 4+ (R 2qpy 2+ = a 4,4′:2′,2″:4″,4‴-quaterpyridinium ligand, X = Cl - or NCS -) have been prepared and isolated as their PF 6 - salts. Characterisation involved...
Ruthenium(II) dichloro or dithiocyanato complexes with 4,4′:2′,2″:4″,4‴-quaterpyridinium ligands
O.A. Blackburn, B.J. Coe, M. Helliwell, Y.T. Ta, L.M. Peter, H. Wang, J.A. Anta, E. Guillén
Feb 13, 2013
Fourteen new complexes of the form cis-[Ru IIX 2(R 2qpy 2+) 2] 4+ (R 2qpy 2+ = a 4,4′:2′,2″:4″,4‴-quaterpyridinium ligand, X = Cl - or NCS -) have been prepared and isolated as their PF 6 - salts. Characterisation involved...
Historical reflections at the intersection of past and future:Celebrating 50 years of Management Learning
Management Learning marks its 50th anniversary in 2020. The journal has a long history of publishing critical, reflexive scholarship on organizational learning and knowledge. This special issue is a forum to celebrate and build...
50th anniversary critical management education historical organization studies learning reflexivity /dk/atira/pure/subjectarea/asjc/1800/1800 name=General Decision Sciences /dk/atira/pure/subjectarea/asjc/1400/1408 name=Strategy and Management /dk/atira/pure/subjectarea/asjc/1400/1405 name=Management of Technology and Innovation
Mechanisms of Choice in X-Chromosome Inactivation.
Early in development, placental and marsupial mammals harbouring at least two X chromosomes per nucleus are faced with a choice that affects the rest of their lives: which of those X chromosomes to transcriptionally inactivate....
An Experimental Evaluation of a Teaching Approach for Statistical Process Control in Computer Courses
In organizations that are seeking a high degree of maturity, it is necessary to achieve a statistical control of software processes and to know their behavior and operational performance. The approach adopted for the research...
Published by: IGI Global Scientific Publishing
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