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Dysregulation of Mitochondrial Ca2+ Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1.
Valentina Debattisti, Adam Horn, Raghavendra Singh, Erin L Seifert, Marshall W Hogarth, Davi A Mazala, Kai Ting Huang, Rita Horvath, Jyoti K Jaiswal, György Hajnóczky
Apr 21, 2020
Muscle function is regulated by Ca2+, which mediates excitation-contraction coupling, energy metabolism, adaptation to exercise, and sarcolemmal repair. Several of these actions rely on Ca2+ delivery to the mitochondrial matrix...
Atrophy autosomal recessive Calcium Injury membrane Mitochondria mitochondrial disease muscle disease Adolescent Adult Animals Calcium Calcium Signaling Calcium-Binding Proteins Cation Transport Proteins Cell Membrane Cytosol Female FIBROBLASTS Homeostasis Humans Male Mice Knockout Mitochondria Mitochondrial Membrane Transport Proteins Models Biological Muscle Contraction Muscle Weakness Muscle Skeletal Muscular Atrophy Sarcolemma Tetanus Wasting Syndrome
A quick and selective rhodamine based “smart probe” for “signal-on” optical detection of Cu<sup>2+</sup> and Al<sup>3+</sup> in water, cell imaging, computational studies and solid state analysis
Abhishek Rai, Alok Kumar Singh, Kamini Tripathi, Avinash Kumar Sonkar, Brijesh Singh Chauhan, S. Srikrishna, Tony D. James, Lallan Mishra
Aug 01, 2018
A novel rhodamine hydrazone 1 has been synthesized by the condensation of rhodamine B hydrazide with allylsalicylaldehyde and has been fully characterized using various physicochemical techniques including single crystal XRD....
chemosensor DFT Photoluminescence Real sample analysis Rhodamine /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/3100/3105 name=Instrumentation /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2500/2508 name=Surfaces, Coatings and Films /dk/atira/pure/subjectarea/asjc/2500/2506 name=Metals and Alloys /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry
Spatiotemporal blocking of the bouncy particle sampler for efficient inference in state-space models
Abstract: We propose a novel blocked version of the continuous-time bouncy particle sampler of Bouchard-Côté et al. (J Am Stat Assoc 113(522):855–867, 2018) which is applicable to any differentiable probability density. This...
Spatiotemporal blocking of the bouncy particle sampler for efficient inference in state-space models
Abstract: We propose a novel blocked version of the continuous-time bouncy particle sampler of Bouchard-Côté et al. (J Am Stat Assoc 113(522):855–867, 2018) which is applicable to any differentiable probability density. This...
Anytime parallel tempering
Abstract: Developing efficient MCMC algorithms is indispensable in Bayesian inference. In parallel tempering, multiple interacting MCMC chains run to more efficiently explore the state space and improve performance. The multiple...
Anytime parallel tempering
Abstract: Developing efficient MCMC algorithms is indispensable in Bayesian inference. In parallel tempering, multiple interacting MCMC chains run to more efficiently explore the state space and improve performance. The multiple...
A quick and selective rhodamine based “smart probe” for “signal-on” optical detection of Cu<sup>2+</sup> and Al<sup>3+</sup> in water, cell imaging, computational studies and solid state analysis
Abhishek Rai, Alok Kumar Singh, Kamini Tripathi, Avinash Kumar Sonkar, Brijesh Singh Chauhan, S. Srikrishna, Tony D. James, Lallan Mishra
Aug 01, 2018
A novel rhodamine hydrazone 1 has been synthesized by the condensation of rhodamine B hydrazide with allylsalicylaldehyde and has been fully characterized using various physicochemical techniques including single crystal XRD....
chemosensor DFT Photoluminescence Real sample analysis Rhodamine /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/3100/3105 name=Instrumentation /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2500/2508 name=Surfaces, Coatings and Films /dk/atira/pure/subjectarea/asjc/2500/2506 name=Metals and Alloys /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry
Detecting superior mutual fund managers
We examine the ex ante ability of investors to identify superior mutual fund managers among the investor set likely most able, and with the greatest incentive to do so, their rivals. Identifying actual copycat funds via...
Ultrafast pressure sensing with transient tunnelling currents
We report and systematically study large amplitude piezoresistance spikes in thin composite films under stress. These spikes are characterized by a unique double exponential decay which we demonstrate to be the signature of...
Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells.
Joseph Jose Thottacherry, Anita Joanna Kosmalska, Amit Kumar, Amit Singh Vishen, Alberto Elosegui-Artola, Susav Pradhan, Sumit Sharma, Parvinder P Singh, Marta C Guadamillas, Natasha Chaudhary, Ram Vishwakarma, Xavier Trepat, Miguel A Del Pozo, Robert G Parton, Madan Rao, Pramod Pullarkat, Pere Roca-Cusachs, Satyajit Mayor
Jan 06, 2020
Plasma membrane tension regulates many key cellular processes. It is modulated by, and can modulate, membrane trafficking. However, the cellular pathway(s) involved in this interplay is poorly understood. Here we find that...
Internet of Things (IoT) and Changing Face of Project Management
Vikram Singh Prasher
Jan 01, 0001
Internet of Things (IoT) or Industrial Internet is a modern day catchword, which over the past few years has tremendously impacted numerous aspects of almost-all the advanced technology fields. IoT framework envisions...
Internet of Things; Project management; Big Data; Cloud computing Management Human Resources Management Interpersonal and Small Group Communication Management Information Systems Management Sciences and Quantitative Methods
Published by: Harrisburg University of Science and Technology
HSCs revive their niche after transplantation.
Simón Méndez-Ferrer
Dec 11, 2020
Golan K, Singh AK et al.1 describe how mitochondrial transfer from hematopoietic stem cells (HSCs) to bone marrow (BM) mesenchymal stem cells (MSCs) helps to regenerate the stroma and its capacity to sustain hematopoietic...
The Role Of Adult Stem Cells And Tumor Necrosis Factor In Peripheral Neuropathy
Prabhjot Singh Dhadialla
Jan 01, 0001
Peripheral neuropathies are a significant cause of morbidity and mortality, with a population prevalence of 2,400 per 100,000 (2.4%) that increases in the elderly to 8,000 per 100,000 (8%)(C. N. Martyn and R. A. Hughes, 1997)....
Published by: Rockefeller University
Ultrafast pressure sensing with transient tunnelling currents
We report and systematically study large amplitude piezoresistance spikes in thin composite films under stress. These spikes are characterized by a unique double exponential decay which we demonstrate to be the signature of...
The “I” in BRICS
This paper inquires theoretically into how leaders act and react to the state role of rising power through the case study of India. It brings together role theory and leadership trait analysis, and contends that there is a...
Practical Considerations for Continuous Time-Domain Cerebrovascular Reactivity Indices in Traumatic Brain Injury
Literature pertaining to traumatic brain injury care involves the mediation and control of secondary brain injury mechanisms, chief among these is cerebral autoregulation. Cerebral autoregulation is frequently assessed through...
Traumatic brain injury cerebral autoregulation Linearity continuous monitoring Cerebrovascular Reactivity (Cvrx)
Published by: Frontiers in neurology
The development of a dynamic, six-axis spine simulator
Background Context
Although a great deal of research has been completed to characterize the stiffness of spinal specimens, there remains a limited understanding of the spine in 6 df and there is a lack of data from...
Although a great deal of research has been completed to characterize the stiffness of spinal specimens, there remains a limited understanding of the spine in 6 df and there is a lack of data from...
Association Between Processed Electroencephalogram-Based Objectively Measured Depth of Sedation and Cerebrovascular Response
Logan Froese, Joshua Dian, Alwyn Gomez, Carleen Batson, Amanjyot Singh Sainbhi, Frederick A. Zeiler
Sep 03, 2021
Background: Current understanding of the impact that sedative agents have on neurovascular coupling, cerebral blood flow (CBF) and cerebrovascular response remains uncertain. One confounding factor regarding the impact of...
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