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Results: 36
Conserved features of non-primate bilaminar disc embryos and the germline.
Post-implantation embryo development commences with a bilaminar disc in most mammals, including humans. Whereas access to early human embryos is limited and subject to greater ethical scrutiny, studies on non-primate embryos...
Pluripotency and X chromosome dynamics revealed in pig pre-gastrulating embryos by single cell analysis.
Priscila Ramos-Ibeas, Fei Sang, Qifan Zhu, Walfred WC Tang, Sarah Withey, Doris Klisch, Liam Wood, Matt Loose, M Azim Surani, Ramiro Alberio
Apr 09, 2019
High-resolution molecular programmes delineating the cellular foundations of mammalian embryogenesis have emerged recently. Similar analysis of human embryos is limited to pre-implantation stages, since early post-implantation...
Specification and epigenomic resetting of the pig germline exhibit conservation with the human lineage.
Qifan Zhu, Fei Sang, Sarah Withey, Walfred Tang, Sabine Dietmann, Doris Klisch, Priscila Ramos-Ibeas, Haixin Zhang, Cristina E Requena, Petra Hajkova, Matt Loose, M Azim Surani, Ramiro Alberio
Feb 18, 2021
Investigations of the human germline and programming are challenging because of limited access to embryonic material. However, the pig as a model may provide insights into transcriptional network and epigenetic reprogramming...
Product diversity linked to substrate usage in chain elongation by mixed-culture fermentation
Marta Coma, Ramiro Vilchez-Vargas, Hugo Roume, Ruy Jauregui, Dietmar H. Pieper, Korneel Rabaey
Jun 21, 2016
Acetate and ethanol can be converted to caproic acid by microorganisms through reverse β-oxidation. There is limited insight into the versatility of chain elongation in view of different starting substrates, including even- and...
Product diversity linked to substrate usage in chain elongation by mixed-culture fermentation
Marta Coma, Ramiro Vilchez-Vargas, Hugo Roume, Ruy Jauregui, Dietmar H. Pieper, Korneel Rabaey
Jun 21, 2016
Acetate and ethanol can be converted to caproic acid by microorganisms through reverse β-oxidation. There is limited insight into the versatility of chain elongation in view of different starting substrates, including even- and...
Principles of early human development and germ cell program from observed model systems
T Kobayashi, H Zhang, WC Tang, N Irie, S Withey, D Klisch, A Sybirna, S Dietmann, DA Contreras, R Webb, C Allegrucci, R Alberio, MA Surani, A Surani
Aug 01, 2017
Animals Bone Morphogenetic Proteins Cell Differentiation Cell Lineage Embryoid Bodies Embryonic Development Epigenesis Genetic Female Gastrulation Gene Dosage Germ Cells Germ Layers Humans In Vitro Techniques Macaca fascicularis Male Models Animal Models Biological Pluripotent Stem Cells Positive Regulatory Domain I-Binding Factor 1 Primitive Streak Repressor Proteins SOXF Transcription Factors Swine Wnt Signaling Pathway
Allelic expression imbalance of PIK3CA mutations is frequent in breast cancer and prognostically significant.
An Orphan CpG Island Drives Expression of a let-7 miRNA Precursor with an Important Role in Mouse Development.
Martha V Koerner, Kashyap Chhatbar, Shaun Webb, Justyna Cholewa-Waclaw, Jim Selfridge, Dina De Sousa, Bill Skarnes, Barry Rosen, Mark Thomas, Joanna Bottomley, Ramiro Ramires-Solis, Christopher Lelliott, David J Adams, Adrian Bird
Feb 08, 2021
Most human genes are associated with promoters embedded in non-methylated, G + C-rich CpG islands (CGIs). Not all CGIs are found at annotated promoters, however, raising the possibility that many serve as promoters for...
Regulation of blood-brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide.
Lesley Hoyles, Matthew G Pontifex, Ildefonso Rodriguez-Ramiro, M Areeb Anis-Alavi, Khadija S Jelane, Tom Snelling, Egle Solito, Sonia Fonseca, Ana L Carvalho, Simon R Carding, Michael Müller, Robert C Glen, David Vauzour, Simon McArthur
Jan 10, 2022
BACKGROUND: Communication between the gut microbiota and the brain is primarily mediated via soluble microbe-derived metabolites, but the details of this pathway remain poorly defined. Methylamines produced by microbial...
Regulation of blood-brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide.
Lesley Hoyles, Matthew G Pontifex, Ildefonso Rodriguez-Ramiro, M Areeb Anis-Alavi, Khadija S Jelane, Tom Snelling, Egle Solito, Sonia Fonseca, Ana L Carvalho, Simon R Carding, Michael Müller, Robert C Glen, David Vauzour, Simon McArthur
Dec 15, 2021
BACKGROUND: Communication between the gut microbiota and the brain is primarily mediated via soluble microbe-derived metabolites, but the details of this pathway remain poorly defined. Methylamines produced by microbial...
Allelic expression imbalance of PIK3CA mutations is frequent in breast cancer and prognostically significant.
Resuscitators' opinions on using a respiratory function monitor during neonatal resuscitation.
Kristel LAM Kuypers, Henriëtte A van Zanten, Veerle Heesters, Omar Kamlin, Laila Springer, Gianluca Lista, Francesco Cavigioli, Maximo Vento, Antonio Núñez-Ramiro, Helmut Kuester, Sebastian Horn, Danielle D Weinberg, Elizabeth E Foglia, Colin J Morley, Peter G Davis, Arjan B Te Pas
Oct 10, 2022
AIM: The aim of this study was to assess the resuscitators' opinions of the usefulness and clinical value of using a respiratory function monitor (RFM) when resuscitating extremely preterm infants with positive pressure...
Hnf4α is a key gene that can generate columnar metaplasia in oesophageal epithelium
Benjamin J. Colleypriest, Zoë D. Burke, Leonard P. Griffiths, Yu Chen, Wei-Yuan Yu, Ramiro Jover, Michael Bock, Leigh Biddlestone, Jonathan M. Quinlan, Stephen G. Ward, J. Mark Farrant, Jonathan M W Slack, David Tosh
Jan 01, 2017
Barrett's metaplasia is the only known morphological precursor to oesophageal adenocarcinoma and is characterized by replacement of stratified squamous epithelium by columnar epithelium. The cell of origin is uncertain and...
Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse.
Tia DiTommaso, Lynelle K Jones, Denny L Cottle, WTSI Mouse Genetics Program, Anna-Karin Gerdin, Valerie E Vancollie, Fiona M Watt, Ramiro Ramirez-Solis, Allan Bradley, Karen P Steel, John P Sundberg, Jacqueline K White, Ian M Smyth
Oct 14, 2020
The skin is a highly regenerative organ which plays critical roles in protecting the body and sensing its environment. Consequently, morbidity and mortality associated with skin defects represent a significant health issue. To...
Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene.
Simon Maguire, Jeanne Estabel, Neil Ingham, Selina Pearson, Edward Ryder, Damian M Carragher, Nicolas Walker, Sanger MGP Slc25a21 Project Team, James Bussell, Wai-In Chan, Thomas M Keane, David J Adams, Cheryl L Scudamore, Christopher J Lelliott, Ramiro Ramírez-Solis, Natasha A Karp, Karen P Steel, Jacqueline K White, Anna-Karin Gerdin
Feb 18, 2021
Homozygosity for Slc25a21(tm1a(KOMP)Wtsi) results in mice exhibiting orofacial abnormalities, alterations in carpal and rugae structures, hearing impairment and inflammation in the middle ear. In humans it has been hypothesised...
Alleles Animals Dicarboxylic Acid Transporters Exons Female Gene Expression Regulation Genetic Engineering Homozygote Humans Male Membrane Transport Proteins Mice Mice Knockout Mitochondrial Membrane Transport Proteins Mouth Abnormalities Mutation Otitis Media PAX9 Transcription Factor Paired Box Transcription Factors Signal Transduction
Hnf4α is a key gene that can generate columnar metaplasia in oesophageal epithelium
Benjamin J. Colleypriest, Zoë D. Burke, Leonard P. Griffiths, Yu Chen, Wei-Yuan Yu, Ramiro Jover, Michael Bock, Leigh Biddlestone, Jonathan M. Quinlan, Stephen G. Ward, J. Mark Farrant, Jonathan M W Slack, David Tosh
Jan 01, 2017
Barrett's metaplasia is the only known morphological precursor to oesophageal adenocarcinoma and is characterized by replacement of stratified squamous epithelium by columnar epithelium. The cell of origin is uncertain and...
A synthesis approach of mouse studies to identify genes and proteins in arterial thrombosis and bleeding.
Constance CFMJ Baaten, Stuart Meacham, Susanne M de Witt, Marion AH Feijge, David J Adams, Jan-Willem N Akkerman, Judith MEM Cosemans, Luigi Grassi, Steve Jupe, Myrto Kostadima, Nadine JA Mattheij, Martin H Prins, Ramiro Ramirez-Solis, Oliver Soehnlein, Frauke Swieringa, Christian Weber, Jacqueline K White, Willem H Ouwehand, Johan WM Heemskerk
Nov 22, 2018
Antithrombotic therapies reduce cardiovascular diseases by preventing arterial thrombosis and thromboembolism, but at expense of increased bleeding risks. Arterial thrombosis studies using genetically modified mice have been...
Scoping article
Thomas Hickmann, Frank Biermann, Carole-Anne Sénit, Yixian Sun, Magdalena Bexell, Mitzi Bolton, Basil Bornemann, Jacel Censoro, Aurelie Charles, Rodrigo Correa Ramiro, Dominique Coy, Frederik Dahlmann, Mark Elder, Felicitas Fritzsche, Thiago Gehre Galvão, Jarrod Grainger-Brown, Cristina Inoue, Kristina Jönsson, Montserrat Koloffon Rosas, Kerstin Krellenberg, Enayat Moallemi, Ivonne Lobos Alva, Shirin Malekpour, Dianty Ningrum, Aneliya Paneva, Lena Partzsch, Rob Raven, Eszter Szedlacsek, John Thompson, Melanie van Driel, Jéssica Viani Damasceno, Robert Webb, Sabine Weiland
Jan 24, 2024
A recent meta-analysis on the political impact of the Sustainable Development Goals (SDGs) has shown that these global goals are moving political processes forward only incrementally, with much variation across countries...
Is treat-to-target really working in rheumatoid arthritis? a longitudinal analysis of a cohort of patients treated in daily practice (RA BIODAM).
Sofia Ramiro, Robert Bm Landewé, Désirée van der Heijde, Alexandre Sepriano, Oliver FitzGerald, Mikkel Ostergaard, Joanne Homik, Ori Elkayam, J Carter Thorne, Margaret Larche, Gianfranco Ferraccioli, Marina Backhaus, Gilles Boire, Bernard Combe, Thierry Schaeverbeke, Alain Saraux, Maxime Dougados, Maurizio Rossini, Marcello Govoni, Luigi Sinigaglia, Alain G Cantagrel, Cornelia F Allaart, Cheryl Barnabe, Clifton O Bingham, Paul P Tak, Dirkjan van Schaardenburg, Hilde Berner Hammer, Rana Dadashova, Edna Hutchings, Joel Paschke, Walter P Maksymowych
Feb 25, 2020
OBJECTIVES: To investigate whether following a treat-to-target (T2T)-strategy in daily clinical practice leads to more patients with rheumatoid arthritis (RA) meeting the remission target. METHODS: RA patients from 10 countries...
Remission rheumatoid arthritis treat-to-target Adult Aged Antirheumatic Agents Arthritis Rheumatoid Blood Sedimentation C-Reactive Protein Clinical Decision-Making Cohort Studies Female Humans Longitudinal Studies Male Middle Aged Patient Care Planning Remission Induction Rheumatoid Factor Tumor Necrosis Factor Inhibitors
Scoping article
Thomas Hickmann, Frank Biermann, Carole-Anne Sénit, Yixian Sun, Magdalena Bexell, Mitzi Bolton, Basil Bornemann, Jacel Censoro, Aurelie Charles, Rodrigo Correa Ramiro, Dominique Coy, Frederik Dahlmann, Mark Elder, Felicitas Fritzsche, Thiago Gehre Galvão, Jarrod Grainger-Brown, Cristina Inoue, Kristina Jönsson, Montserrat Koloffon Rosas, Kerstin Krellenberg, Enayat Moallemi, Ivonne Lobos Alva, Shirin Malekpour, Dianty Ningrum, Aneliya Paneva, Lena Partzsch, Rob Raven, Eszter Szedlacsek, John Thompson, Melanie van Driel, Jéssica Viani Damasceno, Robert Webb, Sabine Weiland
Jan 24, 2024
A recent meta-analysis on the political impact of the Sustainable Development Goals (SDGs) has shown that these global goals are moving political processes forward only incrementally, with much variation across countries...
The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1 -mutated acute myeloid leukemia
Dimitrios Papaioannou, Andreas Petri, Oliver M. Dovey, Sara Terreri, Eric Wang, Frances A. Collins, Lauren A. Woodward, Allison E. Walker, Deedra Nicolet, Felice Pepe, Prasanthi Kumchala, Marius Bill, Christopher J. Walker, Malith Karunasiri, Krzysztof Mrózek, Miranda L. Gardner, Virginia Camilotto, Nina Zitzer, Jonathan L. Cooper, Xiongwei Cai, Xiaoqing Rong-Mullins, Jessica Kohlschmidt, Kellie J. Archer, Michael A. Freitas, Yi Zheng, Robert J. Lee, Iannis Aifantis, George Vassiliou, Guramrit Singh, Sakari Kauppinen, Clara D. Bloomfield, Adrienne M. Dorrance, Ramiro Garzon
Nov 24, 2020
Mouse large-scale phenotyping initiatives
Abdel Ayadi, Marie-Christine Birling, Joanna Bottomley, James Bussell, Helmut Fuchs, Martin Fray, Valérie Gailus-Durner, Simon Greenaway, Richard Houghton, Natasha Karp, Sophie Leblanc, Christoph Lengger, Holger Maier, Ann-Marie Mallon, Susan Marschall, David Melvin, Hugh Morgan, Guillaume Pavlovic, Ed Ryder, William C Skarnes, Mohammed Selloum, Ramiro Ramirez-Solis, Tania Sorg, Lydia Teboul, Laurent Vasseur, Alison Walling, Tom Weaver, Sara Wells, Jacqui K White, Allan Bradley, David J Adams, Karen P Steel, Martin Hrabě de Angelis, Steve D Brown, Yann Herault
Oct 14, 2020
Two large-scale phenotyping efforts, the European Mouse Disease Clinic (EUMODIC) and the Wellcome Trust Sanger Institute Mouse Genetics Project (SANGER-MGP), started during the late 2000s with the aim to deliver a comprehensive...
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