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Codon Usage and Adenovirus Fitness
Judit Giménez-Roig, Estela Núñez-Manchón, Ramon Alemany, Eneko Villanueva, Cristina Fillat
Feb 24, 2021
Vaccination is the most effective method to date to prevent viral diseases. It intends to mimic a naturally occurring infection while avoiding the disease, exposing our bodies to viral antigens to trigger an immune response that...
Transgene codon usage drives viral fitness and therapeutic efficacy in oncolytic adenoviruses.
Estela Núñez-Manchón, Martí Farrera-Sal, Marc Otero-Mateo, Giancarlo Castellano, Rafael Moreno, David Medel, Ramon Alemany, Eneko Villanueva, Cristina Fillat
Aug 28, 2021
Arming oncolytic adenoviruses with therapeutic transgenes is a well-established strategy for multimodal tumour attack. However, this strategy sometimes leads to unexpected attenuated viral replication and a loss of oncolytic...
Intersectionalities
Shula Ramon
Jun 23, 2015
The article highlights the traumatic impact of intimate partner domestic violence (IPDV) on women, the complexity of their responses to it, its impact on their identities, and their resulting social position in Europe. An...
intimate partner domestic violence women experiencing IPDV intersectionalities European context social exclusion and social inclusion
Published by: Memorial University of Newfoundland
Intersectionalities
Shula Ramon
Jun 23, 2015
The article highlights the traumatic impact of intimate partner domestic violence (IPDV) on women, the complexity of their responses to it, its impact on their identities, and their resulting social position in Europe. An...
Published by: Memorial University of Newfoundland
Improving Park Maintenance Efficiency Using a Mobile Application
This article describes the construction and evaluation of a mobile application for use by park maintenance personnel that features an interactive map allowing for real time positioning of the user in relation to equipment...
Published by: IGI Global Scientific Publishing
Graph Representation Forecasting of Patient's Medical Conditions
Objective: Modern medicine needs to shift from a wait and react, curative discipline to a preventative, interdisciplinary science aiming at providing personalized, systemic, and precise treatment plans to patients. To this...
The Validity of Automatic Methods for Estimating Skeletal Age in Young Athletes
This study examined the validity of two automated methods (BAUSport, BoneXpert software using Fels, Greulich-Pyle, Tanner-Whithouse III protocols) for estimating skeletal age (SA) in young athletes in comparison to a reference...
Deep Learning Enables Fast and Accurate Imputation of Gene Expression
A question of fundamental biological significance is to what extent the expression of a subset of genes can be used to recover the full transcriptome, with important implications for biological discovery and clinical...
Enhanced Ceria Nanoflakes using Graphene Oxide as a Sacrificial Template for CO Oxidation and Dry Reforming of Methane
Shawn Rood, Huseyin Ahmet, Anais Gomez-Ramon, Laura Torrente-Murciano, Tomas Reina, Salvador Eslava
Mar 01, 2019
The development of novel fabrication methods to produce ceria catalysts with good high-temperature stability is critical for their implementation across a range of different applications. Herein, graphene oxide flakes are used...
Enhanced Ceria Nanoflakes using Graphene Oxide as a Sacrificial Template for CO Oxidation and Dry Reforming of Methane
Shawn Rood, Huseyin Ahmet, Anais Gomez-Ramon, Laura Torrente-Murciano, Tomas Reina, Salvador Eslava
Mar 01, 2019
The development of novel fabrication methods to produce ceria catalysts with good high-temperature stability is critical for their implementation across a range of different applications. Herein, graphene oxide flakes are used...
A Critical Period for Prefrontal Network Configurations Underlying Psychiatric Disorders and Addiction.
Ramon Guirado, Marta Perez-Rando, Antonio Ferragud, Nicolas Gutierrez-Castellanos, Juzoh Umemori, Hector Carceller, Juan Nacher, Esther Castillo-Gómez
May 23, 2020
The medial prefrontal cortex (mPFC) has been classically defined as the brain region responsible for higher cognitive functions, including the decision-making process. Ample information has been gathered during the last 40 years...
The Validity of Automatic Methods for Estimating Skeletal Age in Young Athletes
This study examined the validity of two automated methods (BAUSport, BoneXpert software using Fels, Greulich-Pyle, Tanner-Whithouse III protocols) for estimating skeletal age (SA) in young athletes in comparison to a reference...
Long-Term Sustained Effect of Liver-Targeted Adeno-Associated Virus Gene Therapy for Mitochondrial Neurogastrointestinal Encephalomyopathy.
Javier Torres-Torronteras, Raquel Cabrera-Pérez, Ferran Vila-Julià, Carlo Viscomi, Yolanda Cámara, Michio Hirano, Massimo Zeviani, Ramon Martí
Jul 04, 2018
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is caused by mutations in TYMP, the gene encoding the enzyme thymidine phosphorylase (TP). TP dysfunction results in systemic accumulation of the noxious TP...
AAV MNGIE Mitochondria thymidine phosphorylase Animals Carcinogenesis Deoxyuridine Dependovirus Female Gene Dosage Genetic Therapy Genetic Vectors Intestinal Pseudo-Obstruction Kaplan-Meier Estimate Liver Male Mice Mitochondria Liver Muscular Dystrophy Oculopharyngeal Ophthalmoplegia Thymidine Thymidine Phosphorylase Time Factors Transgenes
A Critical Period for Prefrontal Network Configurations Underlying Psychiatric Disorders and Addiction
Ramon Guirado, Marta Perez-Rando, Antonio Ferragud, Nicolas Gutierrez-Castellanos, Juzoh Umemori, Hector Carceller, Juan Nacher, Esther Castillo-Gómez
Apr 21, 2020
The medial prefrontal cortex (mPFC) has been classically defined as the brain region responsible for higher cognitive functions, including the decision-making process. Ample information has been gathered during the last 40 years...
MethylCal
Eguzkine Ochoa, Verena Zuber, Nora Fernandez-Jimenez, Jose Ramon Bilbao, Graeme R Clark, Eamonn R Maher, Leonardo Bottolo
May 03, 2019
Bisulfite amplicon sequencing has become the primary choice for single-base methylation quantification of multiple targets in parallel. The main limitation of this technology is a preferential amplification of an allele and...
MiR-221 influences effector functions and actin cytoskeleton in mast cells.
Ramon J Mayoral, Lorenzo Deho, Nicole Rusca, Nenad Bartonicek, Harpreet Kaur Saini, Anton J Enright, Silvia Monticelli
Jan 23, 2018
Mast cells have essential effector and immunoregulatory functions in IgE-associated allergic disorders and certain innate and adaptive immune responses, but the role of miRNAs in regulating mast cell functions is almost...
3T3 Cells Actin Cytoskeleton Actins Animals Base Sequence Bone Marrow Cells Cell Adhesion Cell Degranulation Cell Differentiation Cell Movement Cell Proliferation Cyclin-Dependent Kinase Inhibitor p27 Down-Regulation FIBROBLASTS Gene Knockdown Techniques Lentivirus Mast Cells Mice Mice Inbred C57BL MicroRNAs Molecular Sequence Data Oligonucleotide Array Sequence Analysis Up-Regulation
The chronic and evolving neurological consequences of traumatic brain injury.
Lindsay Wilson, William Stewart, Kristen Dams-O'Connor, Ramon Diaz-Arrastia, Lindsay Horton, David K Menon, Suzanne Polinder
Jun 22, 2018
Traumatic brain injury (TBI) can have lifelong and dynamic effects on health and wellbeing. Research on the long-term consequences emphasises that, for many patients, TBI should be conceptualised as a chronic health condition....
Predictive evolution of metabolic phenotypes using model-designed environments.
Paula Jouhten, Dimitrios Konstantinidis, Filipa Pereira, Sergej Andrejev, Kristina Grkovska, Sandra Castillo, Payam Ghiachi, Gemma Beltran, Eivind Almaas, Albert Mas, Jonas Warringer, Ramon Gonzalez, Pilar Morales, Kiran R Patil
Oct 06, 2022
Adaptive evolution under controlled laboratory conditions has been highly effective in selecting organisms with beneficial phenotypes such as stress tolerance. The evolution route is particularly attractive when the organisms...
Association between DNA methylation and ADHD symptoms from birth to school age
Alexander Neumann, Esther Walton, Silvia Alemany, Charlotte Cecil, Juan Ramon González, Dereje D Jima, Jari Lahti, Samuli T Tuominen, Edward D Barker, Elisabeth Binder, Doretta Caramaschi, Ángel Carracedo, Darina Czamara, Jorunn Evandt, Janine F Felix, Bernard F Fuemmeler, Kristine B Gutzkow, Cathrine Hoyo, Jordi Julvez, Eero Kajantie, Hannele Laivuori, Rachel Maguire, Léa Maitre, Susan K Murphy, Mario Murcia, Pia M Villa, Gemma Sharp, Jordi Sunyer, Katri Raikkönen, Marian Bakermans-Kranenburg, Marinus van IJzendoorn, Mònica Guxens, Caroline L Relton, Henning Tiemeier
Nov 12, 2020
Association between CT-texture-derived tumor heterogeneity, outcomes, and BRCA mutation status in patients with high-grade serous ovarian cancer.
Andreas Meier, Harini Veeraraghavan, Stephanie Nougaret, Yulia Lakhman, Ramon Sosa, Robert A Soslow, Elizabeth J Sutton, Hedvig Hricak, Evis Sala, Hebert A Vargas
Jan 02, 2019
PURPOSE: To assess the associations between inter-site texture heterogeneity parameters derived from computed tomography (CT), survival, and BRCA mutation status in women with high-grade serous ovarian cancer (HGSOC). MATERIALS...
BRCA mutation status high-grade serous ovarian cancer Radiomics texture analysis Tumor heterogeneity Adult Aged Aged 80 and over Cystadenocarcinoma Serous Female Humans Middle Aged Mutation Neoplasm Grading Ovarian Neoplasms Radiographic Image Interpretation Computer-Assisted Retrospective Studies Tomography X-Ray Computed Ubiquitin-Protein Ligases
The Mitochondria-Targeted Antioxidant MitoQ Modulates Mitochondrial Function and Endoplasmic Reticulum Stress in Pancreatic β Cells Exposed to Hyperglycaemia.
Irene Escribano-Lopez, Celia Bañuls, Noelia Diaz-Morales, Francesca Iannantuoni, Susana Rovira-Llopis, Ramon Gomis, Milagros Rocha, Antonio Hernandez-Mijares, Michael P Murphy, Victor M Victor
Mar 19, 2019
BACKGROUND/AIMS: Mitochondria-targeted antioxidants such as mitoquinone (MitoQ) have demonstrated protective effects against oxidative damage in several diseases. The increase in reactive oxygen species (ROS) production during...
ER stress MitoQ MITOCHONDRIAL DYSFUNCTION Oxidative Stress Pancreatic β cells Type 2 diabetes Animals antioxidants Cell Line Tumor Endoplasmic reticulum stress Glucose Hyperglycemia Insulin-Secreting Cells Mitochondria Organophosphorus Compounds Oxidative Stress Rats Reactive Oxygen Species Signal Transduction Ubiquinone
Predictive evolution of metabolic phenotypes using model-designed environments.
Paula Jouhten, Dimitrios Konstantinidis, Filipa Pereira, Sergej Andrejev, Kristina Grkovska, Sandra Castillo, Payam Ghiachi, Gemma Beltran, Eivind Almaas, Albert Mas, Jonas Warringer, Ramon Gonzalez, Pilar Morales, Kiran R Patil
Nov 05, 2022
Adaptive evolution under controlled laboratory conditions has been highly effective in selecting organisms with beneficial phenotypes such as stress tolerance. The evolution route is particularly attractive when the organisms...
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