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Results: 141
Evaluating parameters affecting drug fate at the intramuscular injection site
Intramuscular (IM) injections are a well-established method of delivering a variety of therapeutics formulated for parenteral administration. While the wide range of commercial IM pharmaceuticals provide a wealth of...
Evaluating parameters affecting drug fate at the intramuscular injection site
Intramuscular (IM) injections are a well-established method of delivering a variety of therapeutics formulated for parenteral administration. While the wide range of commercial IM pharmaceuticals provide a wealth of...
A strategy to improve selectivity and targeting to epithelial-derived cancer cells
Examination of genomic and proteomic changes associated with ras-driven epithelial to mesenchymal transformation (EMT) of polarized epithelial cells has led to an improved understanding of surface-expressed structures and...
A strategy to improve selectivity and targeting to epithelial-derived cancer cells
Examination of genomic and proteomic changes associated with ras-driven epithelial to mesenchymal transformation (EMT) of polarized epithelial cells has led to an improved understanding of surface-expressed structures and...
Oral drug delivery research in Europe
Randall J. Mrsny
Jul 20, 2012
The oral delivery of drugs is considered by decision-makers in the pharmaceutical industry to be the most appealing route of administration. This belief has led to the identification of many very successful drugs, but also to...
Oral drug delivery research in Europe
Randall J. Mrsny
Jul 20, 2012
The oral delivery of drugs is considered by decision-makers in the pharmaceutical industry to be the most appealing route of administration. This belief has led to the identification of many very successful drugs, but also to...
Sustained release formulations of rhVEGF<sub>165</sub> produce a durable response in a murine model of peripheral angiogenesis
Local delivery of therapeutic angiogenic agents that stimulate blood vessel formation represents a promising strategy for the treatment of peripheral vascular disease (PVD). At present, requirements for temporal and spatial...
Unsaturated glycoceramides as molecular carriers for mucosal drug delivery of GLP-1
Randall Mrsny, Yvonne M. te Welscher, Daniel J.-F. Chinnapen, Lydia Kaoutzani, Wayne I. Lencer
Feb 10, 2014
The incretin hormone Glucagon-like peptide 1 (GLP-1) requires delivery by injection for the treatment of Type 2 diabetes mellitus. Here, we test if the properties of glycosphingolipid trafficking in epithelial cells can be...
Three Board of Trustee Candidates Elected by S.C. General Assembly
Winthrop University
Jan 01, 0001
Donna Glenn Holley of Congressional District 2 and Ashlye Wilkerson `05 of Congressional District 6 were re-elected on April 2. Randy Imler `87, `00 will replace long-time member Bob Thompson in the at-large seat, which was...
Published by: Winthrop University
In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies
Hanne Kinnunen Bown, Catherine Bonn, Stefan T. Yohe, Daniela Bumbaca Yadav, Thomas W. Patapoff, Ann L. Daugherty, Randall J. Mrsny
Mar 10, 2018
Monoclonal antibodies (mAbs), which are now more frequently administered by subcutaneous (SC) injection rather than intravenously, have become a tremendously successful drug format across a wide range of therapeutic areas....
In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies
Hanne Kinnunen Bown, Catherine Bonn, Stefan T. Yohe, Daniela Bumbaca Yadav, Thomas W. Patapoff, Ann L. Daugherty, Randall J. Mrsny
Mar 10, 2018
Monoclonal antibodies (mAbs), which are now more frequently administered by subcutaneous (SC) injection rather than intravenously, have become a tremendously successful drug format across a wide range of therapeutic areas....
Unsaturated glycoceramides as molecular carriers for mucosal drug delivery of GLP-1
Randall Mrsny, Yvonne M. te Welscher, Daniel J.-F. Chinnapen, Lydia Kaoutzani, Wayne I. Lencer
Feb 10, 2014
The incretin hormone Glucagon-like peptide 1 (GLP-1) requires delivery by injection for the treatment of Type 2 diabetes mellitus. Here, we test if the properties of glycosphingolipid trafficking in epithelial cells can be...
Case-controlled structure validation.
Although many factors influence the quality of a macromolecular crystal structure, validation criteria are usually only calibrated using one of these factors, the resolution. For many purposes this is sufficient, but there are...
Law Enforcement and Military Members
This chapter seeks to assist law enforcement by providing an empirical review of research on the relationship between military service and risk of dangerousness—to self (suicide) or others (violent crime). Risk posed by military...
Published by: Digital Commons @ Texas A&M University-San Antonio
Dendritic Cells Mediate the Dual Effects of IFN alpha/beta in HCV Immunity
Randy Longman
Jan 01, 0001
Hepatitis C virus (HCV) infects an estimated 170 million people and is responsible for considerable morbidity and mortality worldwide. Successful resolution of infection is achieved naturally in approximately 30% of infected...
Published by: Rockefeller University
Improvement of molecular-replacement models with Sculptor.
In molecular replacement, the quality of models can be improved by transferring information contained in sequence alignment to the template structure. A family of algorithms has been developed that make use of the...
Law Enforcement and Military Members
This chapter seeks to assist law enforcement by providing an empirical review of research on the relationship between military service and risk of dangerousness—to self (suicide) or others (violent crime). Risk posed by military...
Published by: Digital Commons @ Texas A&M University-San Antonio
Sustained release formulations of rhVEGF<sub>165</sub> produce a durable response in a murine model of peripheral angiogenesis
Local delivery of therapeutic angiogenic agents that stimulate blood vessel formation represents a promising strategy for the treatment of peripheral vascular disease (PVD). At present, requirements for temporal and spatial...
The Grizzly, October 27, 1978
Jack Hauler, Thomas A. Reilly, Stephen M. Lange, Colin Gillis, Mark Woodland, Keith Wright, Brian Barlow, Jennifer Bassett, Jonathan Cowie, James Wilson, Raymond Dougherty, Mark Angelo, Wesley Emmons, John O'Neill, Ranelle Petrucelli, Ken Rider
Jan 01, 0001
Bomberger Tower Razed Homecoming Brings Crowning, Presentations Self Study Continues Hockey Ties Nation's Best No Tickets at Door Campus Sunshine to Set? Ravine "Paradise" Revisited Portrait of the Professor: Randy...
Ursinus College Collegeville Pennsylvania newspaper Bomberger Memorial Hall Homecoming Mary Beth Kramer Middle States self study field hockey alcohol policy ProTheatre Dorla Dean Slider student government pollution Football Soccer Randy Davidson Bruce Springsteen Bob Dylan Doris J. Schattschneider M. C. Escher William Smith Philadelphia Orchestra General Motors Automobiles cross country Don Paolicelli cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Structural basis for the specificity of renin-mediated angiotensinogen cleavage.
The renin-angiotensin cascade is a hormone system that regulates blood pressure and fluid balance. Renin-mediated cleavage of the angiotensin I peptide from the N terminus of angiotensinogen (AGT) is the rate-limiting step of...
Angiotensinogen and the Modulation of Blood Pressure.
The angiotensin peptides that control blood pressure are released from the non-inhibitory plasma serpin, angiotensinogen, on cleavage of its extended N-terminal tail by the specific aspartyl-protease, renin. Angiotensinogen had...
Experimental phasing
Developments in protein crystal structure determination by experimental phasing are reviewed, emphasizing the theoretical continuum between experimental phasing, density modification, model building and refinement. Traditional...
Maximum-likelihood determination of anomalous substructures.
A fast Fourier transform (FFT) method is described for determining the substructure of anomalously scattering atoms in macromolecular crystals that allows successful structure determination by X-ray single-wavelength anomalous...
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