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Rebecca C. Lancefield, 1941
The Rockefeller University
Jan 01, 0001
Rebecca C. Lancefield. Specific Relationship of Cell Composition to Biological Activity of Hemolytic Streptococci
Lecture delivered May 15th, 1941
Posted with permission
Published by: The Science Press Printing Company
Letter from Editor
Rebecca Jacobs
Jan 01, 0001
This is the introductory letter from Assistant Editor Rebecca Jacobs.
Magazine Literary Magazine Arts Magazine art poetry prose Creative Nonfiction Photography Creative Writing Creative Writing Nonfiction
Published by: Winthrop University
Organ-preserving approaches in oesophageal cancer.
Rebecca C Fitzgerald
Sep 19, 2018
Oesophagectomy is part of the mainstay of treatment for oesophageal cancer. Because most affected patients are elderly and have associated comorbidities, surgery is challenging. Furthermore, recovery from surgery can take up to...
Selective loss of TGFbeta Smad-dependent signalling prevents cell cycle arrest and promotes invasion in oesophageal adenocarcinoma cell lines.
In cancer, Transforming Growth Factor beta (TGFbeta) increases proliferation and promotes invasion via selective loss of signalling pathways. Oesophageal adenocarcinoma arises from Barrett's oesophagus, progresses rapidly and is...
Adenocarcinoma Barrett Esophagus Cell Cycle Cell Line Tumor Cell Proliferation Enzyme Activation Enzyme Inhibitors Esophageal Neoplasms Extracellular Matrix Extracellular Signal-Regulated MAP Kinases Gene Expression Regulation Humans JNK Mitogen-Activated Protein Kinases Neoplasm Invasiveness Phosphatidylinositol 3-Kinases Signal Transduction Smad3 Protein Transcription Genetic Transforming Growth Factor beta
Screening for Barrett's Oesophagus
PURPOSE OF REVIEW: The targeted approach adopted for Barrett's oesophagus (BO) screening is sub-optimal considering the large proportion of BO cases that are currently missed. We reviewed the literature highlighting recent...
Ingested asbestos in filtered beer, in addition to occupational exposure, as a causative factor in oesophageal adenocarcinoma.
Oesophageal adenocarcinoma has become much more common over the past 50 years, particularly in Britain, with an unexplained male to female ratio of > 4:1. Given the use of asbestos filtration in commercial brewing and reports of...
Early Diagnosis of Gastroesophageal Cancers and the Cytosponge
In the Perspective article in the March issue of Cellular and Molecular Gastroenterology and Hepatology,1 the Cytosponge erroneously was cited during the publication process as a Medtronic device (Medtronic, Minneapolis, MN). We...
Screening for Barrett's Esophagus
New improved methods are required for the early detection of esophageal adenocarcinoma in order to reduce mortality from this aggressive cancer. In this review we discuss different screening methods which are currently under...
MUC16 Mutations and Prognosis in Gastric Cancer
Gastric cancer is a global health problem; although incidence rates are declining, it remains the third most common cause of cancer death worldwide. Patients with advanced disease have limited treatment options, and most will...
Cancer development
The cellular origins of a precancerous condition called Barrett's oesophagus have been unclear. Tracking and analysis of epithelial cells at the affected site could shed light on the problem. See Letter p.529
A precancerous...
Alternatives to Traditional Per-Oral Endoscopy for Screening.
Barrett's esophagus (BE) predisposes patients to esophageal adenocarcinoma. 3 to 6% of individuals with gastro-esophageal reflux disease are estimated to have BE but only 20 to 25% of BE patients are currently diagnosed. The...
Genomic instability signals offer diagnostic possibility in early cancer detection
Emerging evidence from the large numbers of cancer genomes analyzed in recent years indicates that chromosomal instability (CI), a well-established hallmark of cancer cells is detectable in precancerous lesions. In this opinion...
Medicine is the ultimate personalised technology.
Modern medicine combines science with the art of communicating and caring for individual patients. Talking with patients to identify the best clinical management has always been central to what clinicians do in all healthcare...
Barrett's oesophagus and oesophageal adenocarcinoma.
Oesophageal adenocarcinoma (OAC) has increased dramatically in Western countries, including the UK, over the past 30 years. It usually presents de novo, but is often preceded by Barrett's oesophagus (BO), a premalignant...
Early detection and therapeutics.
Early detection, including cancer screening and surveillance, is emerging as one of the most important topics in modern oncology. Because symptomatic presentation remains the predominant route to cancer diagnosis, there is a...
Current advances in understanding the molecular profile of hereditary diffuse gastric cancer and its clinical implications.
Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome attributed to germline CDH1 mutations that carries a high risk for early onset DGC. HDGC raises a significant health issue due to its high...
Hereditary diffuse gastric cancer synthetic lethality Signet ring carcinoma CDH1 pathogenic variant Second-hit mechanism Cytoplasm Humans Adenocarcinoma Stomach Neoplasms Cadherins Mutation
Published by: Journal of experimental & clinical cancer research : CR
Genetic progression of Barrett's oesophagus to oesophageal adenocarcinoma.
Barrett's oesophagus (BE) is the premalignant condition associated with the development of oesophageal adenocarcinoma (OAC). Diagnostically, p53 immunohistochemistry remains the only biomarker recommended clinically to aid...
Adenocarcinoma Aneuploidy Barrett Esophagus Chromothripsis DNA Copy Number Variations DNA-Binding Proteins Disease Progression Esophageal Neoplasms Genomic Instability Humans Membrane Proteins Mutation Myosins Nerve Tissue Proteins Nuclear Proteins Precancerous Conditions Semaphorins Smad4 Protein Transcription Factors Tumor Suppressor Protein p53 Tumor Suppressor Proteins
Barrett's esophagus and cancer risk
Barrett's esophagus (BE) is the only known precursor to esophageal adenocarcinoma (EAC), whose incidence has increased sharply in the last 4 decades. The annual conversion rate of BE to cancer is significant, but small. The...
Research advances in esophageal diseases
Over the last year, significant steps have been made toward understanding the pathogenesis of esophageal diseases and translating this knowledge to clinical practice. Gastroesophageal reflux disease (GERD) is the most common...
Role of TFF3 as an adjunct in the diagnosis of Barrett's esophagus using a minimally invasive esophageal sampling device-The CytospongeTM.
The incidence of esophageal carcinoma continues to increase whilst its prognosis remains poor. The most dramatic reduction in mortality is likely to follow early diagnosis of the preinvasive precursor lesion, Barrett's esophagus...
Acceptability, Accuracy, and Safety of Disposable Transnasal Capsule Endoscopy for Barrett's Esophagus Screening.
Sarmed S Sami, Prasad G Iyer, Prachi Pophali, Magnus Halland, Massimiliano di Pietro, Jacobo Ortiz-Fernandez-Sordo, Jonathan R White, Michele Johnson, Indra Neil Guha, Rebecca C Fitzgerald, Krish Ragunath
Sep 08, 2018
BACKGROUND & AIMS: Screening for Barrett's esophagus (BE) with conventional esophagogastroduodenoscopy (C-EGD) is expensive. We assessed the performance of a clinic-based, single use transnasal capsule endoscope (EG Scan II) for...
Current advances in understanding the molecular profile of hereditary diffuse gastric cancer and its clinical implications.
Evolutionary dynamics in pre-invasive neoplasia.
Christopher Abbosh, Subramanian Venkatesan, Samuel M Janes, Rebecca C Fitzgerald, Charles Swanton
Sep 21, 2018
Mutational processes occur in normal tissues from conception throughout life. Field cancerization describes the preconditioning of an area of epithelium to tumor growth. Pre-invasive lesions may arise in these fields, however...
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