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René J. Dubos, 1940

The Rockefeller University

Jan 01, 0001

René J. Dubos. Utilization of Selective Microbial Agents in the Study of Biological Problems Lecture delivered March 21, 1940 Posted with permission

Louis Pasteur Fermentation microbiology bacterial enzymes polysaccharidases

Published by: The Science Press Printing Company

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Effect of cell separation on gene expression and DNA methylation profiles in intestinal epithelial cells

M Molitor, J Postberg, V Orth, M Zilbauer, AC Jenke

Mar 18, 2013

RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display...

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Reducing the Negative Effects of Psychological Contract Breach during Management-Imposed Change

Robert Blomme, Melanie De Ruiter, René Schalk

Oct 30, 2015

Employees' experiences of psychological contract breach (PCB) contribute substantially to the failure of change initiatives. Consequently, if organizational leaders want to successfully implement change efforts, it is imperative...

Management Science Business and Management Management Science Government and Law

Published by: IGI Global Scientific Publishing

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Medical Utopias

René J. Dubos

Jan 01, 0001

This article by Dr. Dubos was based on a Lowell Lecture in a series on "Disease and the Advancement of Basic Science" published under this title (edited by Dr. H. K. Beecher) by the Harvard University Press. The lecture appeared...

René Dubos basic sciences Human ecology

Published by: The Rockefeller Institute Press

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Digital technology and the conservation of nature.

Koen Arts, René van der Wal, William M Adams

Jun 10, 2016

digital conservation Information and Communication Technology (ICT) The Information Age nature conservation Biodiversity Innovation

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On the Design of Food Effect Studies in Adults for Extrapolating Oral Drug Absorption Data to Infants

Marina Statelova, Konstantinos Goumas, Nikoletta Fotaki, René Holm, Mira Symillides, Christos Reppas, Maria Vertzoni

Jan 01, 2020

In the present investigation, it was explored whether food effect on drug absorption in adults is similar with the food effect after administration of an infant meal with the drug product to adults. After confirming lack of...

food effect Ibuprofen Infant Formula infants paracetamol /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science

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Usefulness of the Beagle Model in the Evaluation of Paracetamol and Ibuprofen Exposure after Oral Administration to Pediatric Populations

Marina Statelova, René Holm, Nikoletta Fotaki, Christos Reppas, Maria Vertzoni

Jun 05, 2023

The present study aimed to explore the usefulness of beagle dogs in combination with physiologically based pharmacokinetic (PBPK) modeling in the evaluation of drug exposure after oral administration to pediatric populations...

beagle bioavailability study extrapolation to pediatric populations food effect Ibuprofen Infant Formula paracetamol Pediatrics physiologically based pharmacokinetic (PBPK) model /dk/atira/pure/subjectarea/asjc/1300/1313 name=Molecular Medicine /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science /dk/atira/pure/subjectarea/asjc/3000/3002 name=Drug Discovery

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Investigating the Impact of Outsourcing on IT Flexibility

Sjaak Brinkkemper, Rogier van de Wetering, Deborah Tarenskeen, René Bakker

Apr 01, 2022

Modern healthcare organizations try to leverage their IT infrastructures to enhance the efficiency of processes and the quality of patient services. The flexibility of the IT infrastructure is a critical factor in the process of...

Health Information Systems Medicine and Healthcare Health Information Systems

Published by: IGI Global Scientific Publishing

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Usefulness of the Beagle Model in the Evaluation of Paracetamol and Ibuprofen Exposure after Oral Administration to Pediatric Populations

Marina Statelova, René Holm, Nikoletta Fotaki, Christos Reppas, Maria Vertzoni

Jun 05, 2023

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Factors Affecting Successful Extrapolation of Ibuprofen Exposure from Adults to Pediatric Populations After Oral Administration of a Pediatric Aqueous Suspension

Marina Statelova, René Holm, Nikoletta Fotaki, Christos Reppas, Maria Vertzoni

Nov 12, 2020

The importance of physiologically based pharmacokinetic (PBPK) model refinement with data acquired in adults using a pediatric formulation under age-relevant dosing conditions in order to extrapolate drug exposure to infants...

children food effect Ibuprofen infants oral absorption physiologically based pharmacokinetic (PBPK) modeling /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science

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Strong Wet and Dry Adhesion by Cupped Microstructures.

Yue Wang, Victor Kang, Eduard Arzt, Walter Federle, René Hensel

Apr 15, 2021

Recent advances in bio-inspired microfibrillar adhesives have resulted in technologies that allow reliable attachment to a variety of surfaces. Because capillary and van der Waals forces are considerably weakened underwater...

cupped microstructures polyurethane self-sealing two-photon lithography wet adhesion

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On the Design of Food Effect Studies in Adults for Extrapolating Oral Drug Absorption Data to Infants

Marina Statelova, Konstantinos Goumas, Nikoletta Fotaki, René Holm, Mira Symillides, Christos Reppas, Maria Vertzoni

Jan 01, 2020

food effect Ibuprofen Infant Formula infants paracetamol /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science

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Such stuff as dreams are made on

Frank CP van der Horst, René van der Veer, Robbie Duschinsky

Mar 27, 2020

Dream interpretation attachment defensive exclusion grief and mourning psychoanalysis Dreams grief Humans Object Attachment Psychoanalytic Interpretation

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Discovery of a weak topological insulating state and van Hove singularity in triclinic RhBi 2

Kyungchan Lee, Gunnar F. Lange, Lin-Lin Wang, Brinda Kuthanazhi, Thaís V. Trevisan, Na Hyun Jo, Benjamin Schrunk, Peter P. Orth, Robert-Jan Slager, Paul C. Canfield, Adam Kaminski

Mar 25, 2021

Abstract: Time reversal symmetric (TRS) invariant topological insulators (TIs) fullfil a paradigmatic role in the field of topological materials, standing at the origin of its development. Apart from TRS protected strong TIs, it...

article /639/301/119/2792/4128 /639/766/119/995 article

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Cover Image for Successful Extrapolation of Paracetamol Exposure from Adults to Infants After Oral Administration of a Pediatric Aqueous Suspension Is Highly Dependent on the Study Dosing Conditions

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Successful Extrapolation of Paracetamol Exposure from Adults to Infants After Oral Administration of a Pediatric Aqueous Suspension Is Highly Dependent on the Study Dosing Conditions

Marina Statelova, René Holm, Nikoletta Fotaki, Christos Reppas, Maria Vertzoni

Nov 01, 2020

Extending licensed drug use to the pediatric population has become an essential part of the drug development process. Nonetheless, ethical concerns limit clinical testing in pediatric populations and data collected from oral...

food effect infants oral absorption paracetamol physiologically based pharmacokinetic (PBPK) modeling /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science

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Social expectations as a possible mechanism for adult personality change

Yuzhan Hang, Lydia Gabriela Speyer, Aja Louise Murray, Michelle Luciano, René Mõttus

Feb 27, 2023

OBJECTIVE: Personality traits change in both mean levels and variance across the life span but the mechanisms underlying these developmental trends remain unclear. Social Investment Principle (SIP) suggests that social...

mean-level Personality development social expectations social investment principle variance

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Neurotechnologies Applied to Society's Perception of Cyber-Physical Systems (CPS) in Smart Cities

David Juárez-Varón, René Gaón, Ana Mengual-Recuerda, Camilo Vera-Sepúlveda

Jan 01, 2024

This study aims to quantify the perception of value and acceptance by citizens of the use of cyber-physical systems (CPS) in transportation systems and smart cities using neurotechnologies. The work has been developed in the...

Semantic Web Computer Science and Information Technology Web Technologies

Published by: IGI Global Scientific Publishing

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Successful Extrapolation of Paracetamol Exposure from Adults to Infants After Oral Administration of a Pediatric Aqueous Suspension Is Highly Dependent on the Study Dosing Conditions

Marina Statelova, René Holm, Nikoletta Fotaki, Christos Reppas, Maria Vertzoni

Nov 01, 2020

food effect infants oral absorption paracetamol physiologically based pharmacokinetic (PBPK) modeling /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science

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Factors Affecting Successful Extrapolation of Ibuprofen Exposure from Adults to Pediatric Populations After Oral Administration of a Pediatric Aqueous Suspension

Marina Statelova, René Holm, Nikoletta Fotaki, Christos Reppas, Maria Vertzoni

Nov 12, 2020

children food effect Ibuprofen infants oral absorption physiologically based pharmacokinetic (PBPK) modeling /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science

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Cover Image for Geographic variation in breeding system and environment predicts melanin-based plumage ornamentation of male and female Kentish plovers

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Geographic variation in breeding system and environment predicts melanin-based plumage ornamentation of male and female Kentish plovers

Araceli Argüelles Ticó, Clemens Kupper, Robert N. Kelsh, András Kosztolányi, Tamas Szekely, René E. van Dijk

Jan 01, 2016

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MA-XRF imaging on René Magritte's La condition humaine

AT da Silva, S Legrand, G van der Snickt, R Featherstone, K Janssens, G Bottinelli

Aug 29, 2017

Abstract Magritte’s composition La condition humaine, 1935 was found to conceal under its paint layers an entire quarter of a lost composition by the artist, until recently only known from a small black/white...

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