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G-Quadruplexes
Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention...
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Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
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RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia.
In hypoxic stress conditions, glycolysis enzymes assemble into singular cytoplasmic granules called glycolytic (G) bodies. G body formation in yeast correlates with increased glucose consumption and cell survival. However, the...
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Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
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Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor.
Theoretical models of G protein-coupled receptor (GPCR) concentration-response relationships often assume an agonist producing a single functional response via a single active state of the receptor. These models have largely...
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Existence of equivariant biharmonic maps
Peter Hornung, Roger Moser
Jan 01, 0001
We consider two compact Riemannian manifolds M and N and a compact Lie group G that acts on both by isometries. Under certain assumptions on the structure of M and of the quotient space M/G, we construct equivariant biharmonic...
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Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders

The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...

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Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders

The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...

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Existence of equivariant biharmonic maps
Peter Hornung, Roger Moser
Jan 01, 0001
We consider two compact Riemannian manifolds M and N and a compact Lie group G that acts on both by isometries. Under certain assumptions on the structure of M and of the quotient space M/G, we construct equivariant biharmonic...
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Correction to
The article "The effect of cationically modified phosphorylcholine polymers on human osteoblasts in vitro and their effect on bone formation in vivo", written by Jonathan M. Lawton, Mariam Habib, Bingkui Ma, Roger A. Brooks...
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THE CONCISE GUIDE TO PHARMACOLOGY 2021/22
Stephen Ph Alexander, Arthur Christopoulos, Anthony P Davenport, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, Jamie A Davies, Maria Pia Abbracchio, Wayne Alexander, Khaled Al-Hosaini, Magnus Bäck, Nicholas M Barnes, Ross Bathgate, Jean-Martin Beaulieu, Kenneth E Bernstein, Bernhard Bettler, Nigel JM Birdsall, Victoria Blaho, Francois Boulay, Corinne Bousquet, Hans Bräuner-Osborne, Geoffrey Burnstock, Girolamo Caló, Justo P Castaño, Kevin J Catt, Stefania Ceruti, Paul Chazot, Nan Chiang, Bice Chini, Jerold Chun, Antonia Cianciulli, Olivier Civelli, Lucie H Clapp, Réjean Couture, Zsolt Csaba, Claes Dahlgren, Gordon Dent, Khuraijam Dhanachandra Singh, Steven D Douglas, Pascal Dournaud, Satoru Eguchi, Emanuel Escher, Edward J Filardo, Tung Fong, Marta Fumagalli, Raul R Gainetdinov, Marc de Gasparo, Craig Gerard, Marvin Gershengorn, Fernand Gobeil, Theodore L Goodfriend, Cyril Goudet, Karen J Gregory, Andrew L Gundlach, Jörg Hamann, Julien Hanson, Richard L Hauger, Debbie L Hay, Akos Heinemann, Morley D Hollenberg, Nicholas D Holliday, Mastgugu Horiuchi, Daniel Hoyer, László Hunyady, Ahsan Husain, Adriaan P Ijzerman, Tadashi Inagami, Kenneth A Jacobson, Robert T Jensen, Ralf Jockers, Deepa Jonnalagadda, Sadashiva Karnik, Klemens Kaupmann, Jacqueline Kemp, Charles Kennedy, Yasuyuki Kihara, Takio Kitazawa, Pawel Kozielewicz, Hans-Jürgen Kreienkamp, Jyrki P Kukkonen, Tobias Langenhan, Katie Leach, Davide Lecca, John D Lee, Susan E Leeman, Jérôme Leprince, Xaria X Li, Tom Lloyd Williams, Stephen J Lolait, Amelie Lupp, Robyn Macrae, Janet Maguire, Jean Mazella, Craig A McArdle, Shlomo Melmed, Martin C Michel, Laurence J Miller, Vincenzo Mitolo, Bernard Mouillac, Christa E Müller, Philip Murphy, Jean-Louis Nahon, Tony Ngo, Xavier Norel, Duuamene Nyimanu, Anne-Marie O'Carroll, Stefan Offermanns, Maria Antonietta Panaro, Marc Parmentier, Roger G Pertwee, Jean-Philippe Pin, Eric R Prossnitz, Mark Quinn, Rithwik Ramachandran, Manisha Ray, Rainer K Reinscheid, Philippe Rondard, G Enrico Rovati, Chiara Ruzza, Gareth J Sanger, Torsten Schöneberg, Gunnar Schulte, Stefan Schulz, Deborah L Segaloff, Charles N Serhan, Leigh A Stoddart, Yukihiko Sugimoto, Roger Summers, Valerie P Tan, David Thal, Walter Wally Thomas, Pieter BMWM Timmermans, Kalyan Tirupula, Giovanni Tulipano, Hamiyet Unal, Thomas Unger, Celine Valant, Patrick Vanderheyden, David Vaudry, Hubert Vaudry, Jean-Pierre Vilardaga, Christopher S Walker, Ji Ming Wang, Donald T Ward, Hans-Jürgen Wester, Gary B Willars, Trent M Woodruff, Chengcan Yao, Richard D Ye
Sep 16, 2021
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with...
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The optimal neglect of inflation
This paper argues that UK monetary policymakers did not respond to the inflation rate during most of the “Great Moderation” that ran from the early 1990s to the mid-2000s. We derive a generalisation of the New Keynesian Phillips...
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How Marketers Conduct Mixed Methods Research
Roger Baran
Mar 17, 2016
The complimentary nature of qualitative and quantitative research methods are examined with respect to a study assessing the market's view of a training and development institute in the Middle East. The qualitative portion...
CBA Dean, Wife Establish Endowment for International Learning Experiences
Winthrop University
Jan 01, 0001
The Roger and Elizabeth Weikle International Opportunities Endowment will support adjunct faculty or students for international study or learning experiences. Roger Weikle will retire in June after 41 years at Winthrop.
Published by: Winthrop University
Epilepsy in adults with mitochondrial disease
OBJECTIVE: The aim of this work was to determine the prevalence and progression of epilepsy in adult patients with mitochondrial disease. METHODS: We prospectively recruited a cohort of 182 consecutive adult patients attending a...
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