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Results: 128
A multi-center inter-manufacturer study of the temporal stability of phase-contrast velocity mapping background offset errors.
Peter D Gatehouse, Marijn P Rolf, Karin Markenroth Bloch, Martin J Graves, Philip J Kilner, David N Firmin, Mark BM Hofman
Dec 03, 2012
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation.
Laura Broutier, Amanda Andersson-Rolf, Christopher J Hindley, Sylvia F Boj, Hans Clevers, Bon-Kyoung Koo, Meritxell Huch
Jun 28, 2016
The loyal editor effect
Rolf Fredheim
Jun 30, 2016
Global Characterisation of Coagulopathy in Isolated Traumatic Brain Injury (iTBI)
Julia K Böhm, Helge Güting, Sophie Thorn, Nadine Schäfer, Victoria Rambach, Herbert Schöchl, Oliver Grottke, Rolf Rossaint, Simon Stanworth, Nicola Curry, Rolf Lefering, Marc Maegele, CENTER-TBI Participants and Investigators
Sep 10, 2021
BACKGROUND: Trauma-induced coagulopathy in patients with traumatic brain injury (TBI) is associated with high rates of complications, unfavourable outcomes and mortality. The mechanism of the development of TBI-associated...
PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells.
David K Finlay, Ella Rosenzweig, Linda V Sinclair, Carmen Feijoo-Carnero, Jens L Hukelmann, Julia Rolf, Andrey A Panteleyev, Klaus Okkenhaug, Doreen A Cantrell
Jun 28, 2018
mTORC1 (mammalian target of rapamycin complex 1) controls transcriptional programs that determine CD8+ cytolytic T cell (CTL) fate. In some cell systems, mTORC1 couples phosphatidylinositol-3 kinase (PI3K) and Akt to the control...
3-Phosphoinositide-Dependent Protein Kinases Animals Aryl Hydrocarbon Receptor Nuclear Translocator CD8-Positive T-Lymphocytes Cell Differentiation Cell Movement Chemokines Gene Expression Regulation Glucose Glycolysis Hypoxia-Inducible Factor 1 Hypoxia-Inducible Factor 1 alpha Subunit Interleukin-2 Mechanistic Target of Rapamycin Complex 1 Mice Mice Inbred C57BL Mice Mutant Strains Mice Transgenic Multiprotein Complexes Phosphatidylinositol 3-Kinases Protein Serine-Threonine Kinases Proteins Proto-Oncogene Proteins c-akt Receptors Antigen T-Cell Receptors Chemokine TOR Serine-Threonine Kinases
Energy dissipation in the inner surf zone
The spatial and temporal variation of energy dissipation rates in breaking waves controls the mean circulation of the surf zone. As this circulation plays an important role in the morphodynamics of beaches, it is vital to...
Breaking waves Energy dissipation Inner surf zone LiDAR scanner Surface roller /dk/atira/pure/subjectarea/asjc/1900/1908 name=Geophysics /dk/atira/pure/subjectarea/asjc/1100/1107 name=Forestry /dk/atira/pure/subjectarea/asjc/1900/1910 name=Oceanography /dk/atira/pure/subjectarea/asjc/1100/1104 name=Aquatic Science /dk/atira/pure/subjectarea/asjc/2300/2303 name=Ecology /dk/atira/pure/subjectarea/asjc/2300/2312 name=Water Science and Technology /dk/atira/pure/subjectarea/asjc/1100/1111 name=Soil Science /dk/atira/pure/subjectarea/asjc/1900/1906 name=Geochemistry and Petrology /dk/atira/pure/subjectarea/asjc/1900/1904 name=Earth-Surface Processes /dk/atira/pure/subjectarea/asjc/1900/1902 name=Atmospheric Science /dk/atira/pure/subjectarea/asjc/1900/1912 name=Space and Planetary Science /dk/atira/pure/subjectarea/asjc/1900/1901 name=Earth and Planetary Sciences (miscellaneous) /dk/atira/pure/subjectarea/asjc/1900/1911 name=Palaeontology
Energy dissipation in the inner surf zone
The spatial and temporal variation of energy dissipation rates in breaking waves controls the mean circulation of the surf zone. As this circulation plays an important role in the morphodynamics of beaches, it is vital to...
Breaking waves Energy dissipation Inner surf zone LiDAR scanner Surface roller /dk/atira/pure/subjectarea/asjc/1900/1908 name=Geophysics /dk/atira/pure/subjectarea/asjc/1100/1107 name=Forestry /dk/atira/pure/subjectarea/asjc/1900/1910 name=Oceanography /dk/atira/pure/subjectarea/asjc/1100/1104 name=Aquatic Science /dk/atira/pure/subjectarea/asjc/2300/2303 name=Ecology /dk/atira/pure/subjectarea/asjc/2300/2312 name=Water Science and Technology /dk/atira/pure/subjectarea/asjc/1100/1111 name=Soil Science /dk/atira/pure/subjectarea/asjc/1900/1906 name=Geochemistry and Petrology /dk/atira/pure/subjectarea/asjc/1900/1904 name=Earth-Surface Processes /dk/atira/pure/subjectarea/asjc/1900/1902 name=Atmospheric Science /dk/atira/pure/subjectarea/asjc/1900/1912 name=Space and Planetary Science /dk/atira/pure/subjectarea/asjc/1900/1901 name=Earth and Planetary Sciences (miscellaneous) /dk/atira/pure/subjectarea/asjc/1900/1911 name=Palaeontology
Social scientific knowledge in times of crisis
Crisis, by its very nature, requires decisive intervention. However, important questions can be obscured by the very immediacy of the crisis condition. What is the nature of the crisis? How it is defined (and by whom)? And...
Ventricular Volume Load Reveals the Mechanoelastic Impact of Communicating Hydrocephalus on Dynamic Cerebral Autoregulation.
A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.
Grégory Menchon, Andrea E Prota, Daniel Lucena-Agell, Pascal Bucher, Rolf Jansen, Herbert Irschik, Rolf Müller, Ian Paterson, J Fernando Díaz, Karl-Heinz Altmann, Michel O Steinmetz
Aug 20, 2018
Microtubule-targeting agents (MTAs) like taxol and vinblastine are among the most successful chemotherapeutic drugs against cancer. Here, we describe a fluorescence anisotropy-based assay that specifically probes for ligands...
Synthesis and Exciton Dynamics of Triplet Sensitized Conjugated Polymers.
Rolf Andernach, Hendrik Utzat, Stoichko D Dimitrov, Iain McCulloch, Martin Heeney, James R Durrant, Hugo Bronstein
Feb 15, 2018
We report the synthesis of a novel polythiophene-based host-guest copolymer incorporating a Pt-porphyrin complex (TTP-Pt) into the backbone for efficient singlet to triplet polymer exciton sensitization. We elucidated the...
Improving experimental phases for strong reflections prior to density modification.
Experimental phasing of diffraction data from macromolecular crystals involves deriving phase probability distributions. These distributions are often bimodal, making their weighted average, the centroid phase, improbable, so...
[13C]bicarbonate labelled from hyperpolarized [1-13C]pyruvate is an in vivo marker of hepatic gluconeogenesis in fasted state.
Emine Can, Jessica AM Bastiaansen, Dominique-Laurent Couturier, Rolf Gruetter, Hikari AI Yoshihara, Arnaud Comment
Feb 11, 2022
Cancer Surveillance Guideline for individuals with PTEN hamartoma tumour syndrome
Chrystelle Colas, Sjaak Pouwels, Nicoline Hoogerbrugge, Tanya Bisseling, Virginie Bubien, Frederic Caux, Nathalie Chabbert-Buffet, Sophie Da Mota Gomes, Martin Gotthardt, Marleen Kets, Katherine L. Lachlan, Thera P. Links, Michel Longy, Ritse Mann, Leo Schultze Kool, Robert K. Semple, Ian Stock, Marc Tischkowitz, Janet Vos, Marjolijn Ligtenberg, Rianne Oostenbrink, Rolf Sijmons, Gareth Evans, Emma Woodward, Eamonn Maher, Rosalie E. Ferner, Stefan Aretz, Isabel Spier, Verena Steinke-Lange, Elke Holinski-Feder, Evelin Schröck, Thierry Frebourg, Claude Houdayer, Pierre Wolkenstein, Vincent Bours, Eric Legius, Bruce Poppe, Kathleen Claes, Robin de Putter, Ignacio Blanco Guillermo, Gabriel Capella, Joan Brunet Vidal, Conxi Lázaro, Judith Balmaña, Hector Salvador Hernandez, Carla Oliveira, Manuel Teixeira, Svetlana Bajalica-Lagercrantz, Emma Tham, Jan Lubinski, Karolina Ertmanska, Bela Melegh, Mateja Krajc, Ana Blatnik, Sirkku Peltonen, Marja Hietala
Feb 09, 2021
Abstract: PTEN hamartoma tumour syndrome is a diverse multi-system disorder predisposing to the development of hamartomatous growths, increasing risk of breast, thyroid, renal cancer, and possibly increasing risk of endometrial...
[13C]bicarbonate labelled from hyperpolarized [1-13C]pyruvate is an in vivo marker of hepatic gluconeogenesis in fasted state.
Emine Can, Jessica AM Bastiaansen, Dominique Couturier, Rolf Gruetter, Hikari AI Yoshihara, Arnaud Comment
Jan 10, 2022
Guidelines for the Li–Fraumeni and heritable TP53 -related cancer syndromes
Svetlana Bajalica Lagercrantz, Carla Oliveira, Rita Magenheim, D. Gareth Evans, Nicoline Hoogerbrugge, Marjolijn Ligtenberg, Marleen Kets, Rianne Oostenbrink, Rolf Sijmons, Gareth Evans, Emma Woodward, Marc Tischkowitz, Eamonn Maher, Rosalie E. Ferner, Stefan Aretz, Isabel Spier, Verena Steinke-Lange, Elke Holinski-Feder, Evelin Schröck, Thierry Frebourg, Claude Houdayer, Chrystelle Colas, Pierre Wolkenstein, Vincent Bours, Eric Legius, Bruce Poppe, Kathleen Claes, Robin de Putter, Ignacio Blanco Guillermo, Gabriel Capella, Joan Brunet Vidal, Conxi Lázaro, Judith Balmaña, Hector Salvador Hernandez, Manuel Teixeira, Svetlana Bajalica-Lagercrantz, Emma Tham, Jan Lubinski, Karolina Ertmanska, Bela Melegh, Mateja Krajc, Ana Blatnik, Sirkku Peltonen, Marja Hietala
Feb 09, 2021
Abstract: Fifty years after the recognition of the Li–Fraumeni syndrome (LFS), our perception of cancers related to germline alterations of TP53 has drastically changed: (i) germline TP53 alterations are often identified among...
Cancer Surveillance Guideline for individuals with PTEN hamartoma tumour syndrome
Chrystelle Colas, Sjaak Pouwels, Nicoline Hoogerbrugge, Tanya Bisseling, Virginie Bubien, Frederic Caux, Nathalie Chabbert-Buffet, Sophie Da Mota Gomes, Martin Gotthardt, Marleen Kets, Katherine L. Lachlan, Thera P. Links, Michel Longy, Ritse Mann, Leo Schultze Kool, Robert K. Semple, Ian Stock, Marc Tischkowitz, Janet Vos, Marjolijn Ligtenberg, Rianne Oostenbrink, Rolf Sijmons, Gareth Evans, Emma Woodward, Eamonn Maher, Rosalie E. Ferner, Stefan Aretz, Isabel Spier, Verena Steinke-Lange, Elke Holinski-Feder, Evelin Schröck, Thierry Frebourg, Claude Houdayer, Pierre Wolkenstein, Vincent Bours, Eric Legius, Bruce Poppe, Kathleen Claes, Robin de Putter, Ignacio Blanco Guillermo, Gabriel Capella, Joan Brunet Vidal, Conxi Lázaro, Judith Balmaña, Hector Salvador Hernandez, Carla Oliveira, Manuel Teixeira, Svetlana Bajalica-Lagercrantz, Emma Tham, Jan Lubinski, Karolina Ertmanska, Bela Melegh, Mateja Krajc, Ana Blatnik, Sirkku Peltonen, Marja Hietala
Jun 12, 2021
Abstract: PTEN hamartoma tumour syndrome is a diverse multi-system disorder predisposing to the development of hamartomatous growths, increasing risk of breast, thyroid, renal cancer, and possibly increasing risk of endometrial...
Multienzyme Cellulose Films as Sustainable and Self-Degradable Hydrogen Peroxide-Producing Material
Davide Califano, Marco A.S. Kadowaki, Vincenzo Calabrese, Rolf Alexander Prade, Davide Mattia, Karen J. Edler, Igor Polikarpov, Janet L. Scott
Dec 14, 2020
The use of hydrogen peroxide-releasing enzymes as a component to produce alternative and sustainable antimicrobial materials has aroused interest in the scientific community. However, the preparation of such materials...
/dk/atira/pure/subjectarea/asjc/1500/1502 name=Bioengineering /dk/atira/pure/subjectarea/asjc/2500/2502 name=Biomaterials /dk/atira/pure/subjectarea/asjc/2500/2507 name=Polymers and Plastics /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry /dk/atira/pure/sustainabledevelopmentgoals/responsible_consumption_and_production name=SDG 12 - Responsible Consumption and Production
The effect of gadolinium-based contrast agent administration on magnetic resonance fingerprinting-based T 1 relaxometry in patients with prostate cancer
Nikita Sushentsev, Joshua D. Kaggie, Guido Buonincontri, Rolf F. Schulte, Martin J. Graves, Vincent J. Gnanapragasam, Tristan Barrett
Nov 24, 2020
Abstract: Magnetic resonance fingerprinting (MRF) is a rapidly developing fast quantitative mapping technique able to produce multiple property maps with reduced sensitivity to motion. MRF has shown promise in improving the...
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