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Analysis of genetic networks regulating refractive eye development in collaborative cross progenitor strain mice reveals new genes and pathways underlying human myopia
Abstract: Background: Population studies suggest that genetic factors play an important role in refractive error development; however, the precise role of genetic background and the composition of the signaling pathways...
Analysis of genetic networks regulating refractive eye development in collaborative cross progenitor strain mice reveals new genes and pathways underlying human myopia.
BACKGROUND: Population studies suggest that genetic factors play an important role in refractive error development; however, the precise role of genetic background and the composition of the signaling pathways underlying...
Evolutionary conservation of pathways Gene-based genome-wide association analysis Genetic networks genetic variation Myopia RNA-seq Refractive eye development Signaling pathways Animals Chromosomes Human Collaborative Cross Mice Eye Gene Regulatory Networks Genetic Predisposition to Disease Humans Mice Myopia Refraction Ocular Retina Signal Transduction
Genome-wide association studies for corneal and refractive astigmatism in UK Biobank demonstrate a shared role for myopia susceptibility loci.
Previous studies have suggested that naturally occurring genetic variation contributes to the risk of astigmatism. The purpose of this investigation was to identify genetic markers associated with corneal and refractive...
Astigmatism Biological Specimen Banks Cornea Corneal Diseases Female Genetic Predisposition to Disease Genome-Wide Association Study Guanine Nucleotide Exchange Factors Humans Male Middle Aged Myopia Nuclear Proteins Polymorphism Single Nucleotide Ubiquitin-Protein Ligases United Kingdom White People
A commonly occurring genetic variant within the NPLOC4-TSPAN10-PDE6G gene cluster is associated with the risk of strabismus.
Denis Plotnikov, Rupal L Shah, Jamille N Rodrigues, Phillippa M Cumberland, Jugnoo S Rahi, Pirro G Hysi, Denize Atan, Cathy Williams, Jeremy A Guggenheim, UK Biobank Eye and Vision Consortium
Jul 18, 2019
Strabismus refers to an abnormal alignment of the eyes leading to the loss of central binocular vision. Concomitant strabismus occurs when the angle of deviation is constant in all positions of gaze and often manifests in early...
Adult Aged Animals Case-Control Studies Child Cohort Studies Cyclic Nucleotide Phosphodiesterases Type 6 Female Genome-Wide Association Study Humans Male Mice Middle Aged Multigene Family Mutation Nuclear Proteins Polymorphism Single Nucleotide Retina Risk Factors strabismus Tetraspanins Visual Acuity
Genome-wide Association Study for Vitamin D Levels Reveals 69 Independent Loci.
Despoina Manousaki, Ruth Mitchell, Tom Dudding, Simon Haworth, Adil Harroud, Vincenzo Forgetta, Rupal L Shah, Jian'an Luan, Claudia Langenberg, Nicholas J Timpson, J Brent Richards
Jan 14, 2021
We aimed to increase our understanding of the genetic determinants of vitamin D levels by undertaking a large-scale genome-wide association study (GWAS) of serum 25 hydroxyvitamin D (25OHD). To do so, we used imputed genotypes...
Meta-analysis investigating the role of interleukin-6 mediated inflammation in type 2 diabetes.
Nicholas Bowker, Rupal L Shah, Stephen J Sharp, Jian'an Luan, Isobel D Stewart, Eleanor Wheeler, Manuel AR Ferreira, Aris Baras, Nicholas J Wareham, Claudia Langenberg, Luca A Lotta
Oct 07, 2020
Genetic Interleukin-6 Trans-ethnic Type 2 diabetes Adiposity Biomarkers Blood Glucose Body Weights and Measures Cytokines Diabetes mellitus Type 2 Disease Susceptibility Genetic Predisposition to Disease Humans Inflammation Inflammation Mediators Interleukin-6 Odds Ratio Receptors Interleukin-6 Risk Factors Signal Transduction
Hydration and N-acetyl-l-cysteine alter the microstructure of human nail and bovine hoof
This work aimed to (a) characterize the microstructure and porosity of human nail and bovine hoof by mercury intrusion porosimetry and SEM image analysis, (b) study the effects of hydration and of N-acetyl-l-cysteine treatment...
Eugene L. Opie, 1910
The Rockefeller University
Jan 01, 0001
Eugene L. Opie, M.D. Inflammation
Lecture delivered February 10th, 1910
Bacterial Infection inflammation reaction macrophage Lymphatic Vessels polynuclear leucocytes enzyme
Published by: J.B. Lippincott Company
Hydration and N-acetyl-l-cysteine alter the microstructure of human nail and bovine hoof
This work aimed to (a) characterize the microstructure and porosity of human nail and bovine hoof by mercury intrusion porosimetry and SEM image analysis, (b) study the effects of hydration and of N-acetyl-l-cysteine treatment...
Corinna PMG 655 (= P.Oxy. 2370) fr.1 l. 13 κόσμ[εισα λόγυ]ς
L Prauscello
May 02, 2017
0. Fr. 1 of P.Oxy. 2370 (= MP3
249; LDAB 573), published by Lobel in 1956, is so far the only papyrus
fragment among those extant in Boeotian dialect1
whose authorship can be securely ascribed to
Corinna thanks to the overlap...
Floer Simple Manifolds and L-Space Intervals
An oriented three-manifold with torus boundary admits either no L-space Dehn filling, a unique L-space filling, or an interval of L-space fillings. In the latter case, which we call “Floer simple,” we construct an invariant...
L q -spectra of self-affine measures
Abstract: We study L q -spectra of planar self-affine measures generated by diagonal matrices. We introduce a new technique for constructing and understanding examples based on combinatorial estimates for the exponential growth...
S-2-Amino-4-cyanobutanoic acid (β-cyanomethyl-L-Ala) as an atom-efficient solubilising synthon for L-glutamine
Glutamine (Gln) is often a difficult amino acid to incorporate during solution-phase peptide synthesis, owing to poor solubility and unwanted dehydrations as side-reactions. Current approaches to solving these problems are...
Frank L. Horsfall, Jr., 1952
The Rockefeller University
Jan 01, 0001
Frank L. Horsfall, Jr. Experiments on chemical alteration of virus infections.
Lecture delivered November 20, 1952
Posted with permission
Published by: Academic Press Inc., Publishers
Rapid sensing of l-leucine by human and murine hypothalamic neurons
Nicholas Heeley, Peter Kirwan, Tamana Darwish, Marion Arnaud, Mark L Evans, Florian T Merkle, Frank Reimann, Fiona M Gribble, Clemence Blouet
Apr 05, 2018
OBJECTIVE: Dietary proteins are sensed by hypothalamic neurons and strongly influence multiple aspects of metabolic health, including appetite, weight gain, and adiposity. However, little is known about the mechanisms by which...
S-2-Amino-4-cyanobutanoic acid (β-cyanomethyl-L-Ala) as an atom-efficient solubilising synthon for L-glutamine
Glutamine (Gln) is often a difficult amino acid to incorporate during solution-phase peptide synthesis, owing to poor solubility and unwanted dehydrations as side-reactions. Current approaches to solving these problems are...
Microbial regulation of the L cell transcriptome.
Tulika Arora, Rozita Akrami, Ramona Pais, Linda Bergqvist, Bengt R Johansson, Thue W Schwartz, Frank Reimann, Fiona M Gribble, Fredrik Bäckhed
Apr 26, 2018
L cells are an important class of enteroendocrine cells secreting hormones such as glucagon like peptide-1 and peptide YY that have several metabolic and physiological effects. The gut is home to trillions of bacteria affecting...
Dr. Herman L. Frick Promotion
Winthrop News Service
Jan 01, 0001
Dr. Herman L. Frick, superintendent of Winthrop Training School, was named Director of Teacher Education and Graduate Study at Winthrop in October 1946 Dr. Frick worked at Winthrop from 1941 to 1949 except for 1944-1946 when he...
Winthrop College of Education Winthrop Training School Higher Education Teacher Education and Professional Development
Published by: Winthrop University
Γ-Convergence of an Ambrosio-Tortorelli approximation scheme for image segmentation
Given an image u0, the aim of minimising the Mumford-Shah functional is to find a decomposition of the image domain into sub-domains and a piecewise smooth approximation u of u0 such that u varies smoothly within each...
Mortality risk prediction of high-sensitivity C-reactive protein in suspected acute coronary syndrome
Amit Kaura, Adam Hartley, Vasileios Panoulas, Ben Glampson, Anoop SV Shah, Jim Davies, Abdulrahim Mulla, Kerrie Woods, Joe Omigie, Anoop D Shah, Mark R Thursz, Paul Elliott, Harry Hemmingway, Bryan Williams, Folkert W Asselbergs, Michael O'Sullivan, Graham M Lord, Adam Trickey, Jonathan AC Sterne, Dorian O Haskard, Narbeh Melikian, Darrel P Francis, Wolfgang Koenig, Ajay M Shah, Rajesh Kharbanda, Divaka Perera, Riyaz S Patel, Keith M Channon, Jamil Mayet, Ramzi Khamis
Mar 28, 2022
BACKGROUND: There is limited evidence on the use of high-sensitivity C-reactive protein (hsCRP) as a biomarker for selecting patients for advanced cardiovascular (CV) therapies in the modern era. The prognostic value of mildly...
L<sup>q</sup>-spectra of self-affine measures
Abstract
We study L
q
-spectra of planar...
Γ-Convergence of an Ambrosio-Tortorelli approximation scheme for image segmentation
Given an image u0, the aim of minimising the Mumford-Shah functional is to find a decomposition of the image domain into sub-domains and a piecewise smooth approximation u of u0 such that u varies smoothly within each...
L(3)mbt and the LINT complex safeguard cellular identity in the Drosophila ovary.
Maintenance of cellular identity is essential for tissue development and homeostasis. At the molecular level, cell identity is determined by the coordinated activation and repression of defined sets of genes. The tumor...
L<sup>q</sup>-spectra of self-affine measures
Abstract
We study L
q
-spectra of planar...
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