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Results: 167
Loss of SMAD3 Promotes Vascular Remodeling in Pulmonary Arterial Hypertension via MRTF Disinhibition.
Diana Zabini, Elise Granton, Yijie Hu, Maria Zena Miranda, Ulrike Weichelt, Sandra Breuils Bonnet, Sébastien Bonnet, Nicholas W Morrell, Kim A Connelly, Steeve Provencher, Bahil Ghanim, Walter Klepetko, Andrea Olschewski, Andras Kapus, Wolfgang M Kuebler
Jan 04, 2019
RATIONALE: Vascular remodeling in pulmonary arterial hypertension (PAH) results from smooth muscle cell hypertrophy and proliferation of vascular cells. Loss of BMPR-II (bone morphogenetic protein receptor 2) signaling and...
SMAD3 myocardin-related transcription factor pulmonary arterial hypertension Vascular Remodeling Animals Cell Movement Cell Proliferation Disease Models Animal Down-Regulation Humans Hypertension Pulmonary Male Muscle Cells Random Allocation Rats Rats Sprague-Dawley Sensitivity and Specificity Smad3 Protein Transcription Factors Transfection Transforming Growth Factor beta Vascular Remodeling
Dynamics of DNA Breathing and Folding for Molecular Recognition and Computation
Gregoire Bonnet
Jan 01, 0001
This thesis is centered on the development of the molecular beacon, as a new DNA probe for DNA genotyping, D N A computation and biophysical studies of DNA conformations. Molecular beacons are single-stranded DNA molecules that...
Published by: Rockefeller University
Subcellular localisation modulates ubiquitylation and degradation of Ascl1.
Caused motion across child languages
Previous research on motion expression indicates that typological properties influence how speakers select and express information in discourse (Slobin, 2004; Talmy, 2000). The present study further addresses this question by...
Expanding the light absorption of poly(3-hexylthiophene) by end-functionalization with π-extended porphyrins.
Michèle Chevrier, Sébastien Richeter, Olivier Coulembier, Mathieu Surin, Ahmad Mehdi, Roberto Lazzaroni, Rachel C Evans, Philippe Dubois, Sébastien Clément
Jul 03, 2018
Poly(3-hexylthiophene)s end-functionalized with π-extended porphyrins have been synthesized in a one-pot procedure. The polymers show a broad absorption profile extending to 700 nm and a fibrillar microstructure, which can be...
Life Turned Against Itself
Jean-Sébastien Hardy
Dec 20, 2016
Michel Henry is known to be the contemporary thinker who has given the most privileged status and the deepest philosophical significance to affectivity. His whole work—from his interpretation of Biran’s ontology of subjectivity...
Published by: Memorial University of Newfoundland
Empirical phylogenies and species abundance distributions are consistent with preequilibrium dynamics of neutral community models with gene flow
Community characteristics reflect past ecological and evolutionary dynamics. Here, we investigate whether it is possible to obtain realistically shaped modeled communities-that is with phylogenetic trees and species abundance...
Quantifying individual specialization using tracking data
Many predictive models of spatial and temporal distribution (e.g. in response to climate change or species introductions) assume that species have one environmental niche that applies to all individuals. However, there is...
Universal optimal geometry of minimal phoretic pumps
Abstract: Unlike pressure-driven flows, surface-mediated phoretic flows provide efficient means to drive fluid motion on very small scales. Colloidal particles covered with chemically-active patches with nonzero phoretic...
The role of selection and evolution in changing parturition date in a red deer population.
Timothée Bonnet, Michael B Morrissey, Alison Morris, Sean Morris, Tim H Clutton-Brock, Josephine M Pemberton, Loeske E B Kruuk
Dec 06, 2019
Changing environmental conditions cause changes in the distributions of phenotypic traits in natural populations. However, determining the mechanisms responsible for these changes-and, in particular, the relative contributions...
Life Turned Against Itself
Jean-Sébastien Hardy
Dec 20, 2016
Michel Henry is known to be the contemporary thinker who has given the most privileged status and the deepest philosophical significance to affectivity. His whole work—from his interpretation of Biran’s ontology of subjectivity...
Published by: Memorial University of Newfoundland
Bone marrow niches in haematological malignancies.
Simón Méndez-Ferrer, Dominique Bonnet, David P Steensma, Robert P Hasserjian, Irene M Ghobrial, John G Gribben, Michael Andreeff, Daniela S Krause
Mar 05, 2020
Updates on the hematologic tumor microenvironment and its therapeutic targeting.
Dorian Forte, Daniela S Krause, Michael Andreeff, Dominique Bonnet, Simón Méndez-Ferrer
Sep 23, 2019
In this review article, we present recent updates on the hematologic tumor microenvironment following the 3rd Scientific Workshop on the Haematological Tumour Microenvironment and its Therapeutic Targeting organized by the...
The Chromatin Protein DUET/MMD1 Controls Expression of the Meiotic Gene TDM1 during Male Meiosis in Arabidopsis.
Meiosis produces haploid cells essential for sexual reproduction. In yeast, entry into meiosis activates transcription factors which trigger a transcriptional cascade that results in sequential co-expression of early, middle and...
The role of selection and evolution in changing parturition date in a red deer population.
Timothée Bonnet, Michael B Morrissey, Alison Morris, Sean Morris, Tim H Clutton-Brock, Josephine M Pemberton, Loeske EB Kruuk
May 03, 2021
Changing environmental conditions cause changes in the distributions of phenotypic traits in natural populations. However, determining the mechanisms responsible for these changes-and, in particular, the relative contributions...
Climatic and societal impacts of a "forgotten" cluster of volcanic eruptions in 1108-1110 CE.
Sébastien Guillet, Christophe Corona, Francis Ludlow, Clive Oppenheimer, Markus Stoffel
May 23, 2020
Recently revised ice core chronologies for Greenland have newly identified one of the largest sulfate deposition signals of the last millennium as occurring between 1108 and 1113 CE. Long considered the product of the 1104 CE...
Published by: Scientific reports
Gravettian cranial morphology and human group affinities during the European Upper Palaeolithic.
Aurélien Mounier, Yann Heuzé, Mathilde Samsel, Sergey Vasilyev, Laurent Klaric, Sébastien Villotte
Dec 22, 2020
Archaeologically defined Upper Palaeolithic (UP, 45,000-10,000 years ago) "cultures" are often used as proxies to designate fossil populations. While recent genomic studies have partly clarified the complex relationship between...
Climatic and societal impacts of a "forgotten" cluster of volcanic eruptions in 1108-1110 CE.
Sébastien Guillet, Christophe Corona, Francis Ludlow, Clive Oppenheimer, Markus Stoffel
Jun 22, 2020
Recently revised ice core chronologies for Greenland have newly identified one of the largest sulfate deposition signals of the last millennium as occurring between 1108 and 1113 CE. Long considered the product of the 1104 CE...
Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks.
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