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The druggable schizophrenia genome
Codon usage optimization in pluripotent embryonic stem cells
Abstract: Background: The uneven use of synonymous codons in the transcriptome regulates the efficiency and fidelity of protein translation rates. Yet, the importance of this codon bias in regulating cell state-specific...
A brain proteomic investigation of rapamycin effects in the <i>Tsc1</i><sup>+/-</sup> mouse model.
Hippocampus Frontal Lobe Animals Mice Mice Mutant Strains Tuberous sclerosis Disease Models Animal Sirolimus Tumor Suppressor Proteins Nerve Tissue Proteins Proteomics Tuberous Sclerosis Complex 1 Protein
Published by: Molecular autism
The potential of immune biomarkers to advance personalized medicine approaches for schizophrenia.
A brain proteomic investigation of rapamycin effects in the Tsc1+/- mouse model.
BACKGROUND: Tuberous sclerosis complex (TSC) is a rare monogenic disorder characterized by benign tumors in multiple organs as well as a high prevalence of epilepsy, intellectual disability and autism. TSC is caused by...
Total syntheses of linear polythiazole/oxazole plantazolicin A and its biosynthetic precursor plantazolicin B.
Functional patient-derived cellular models for neuropsychiatric drug discovery.
Mental health disorders are a leading cause of disability worldwide. Challenges such as disease heterogeneity, incomplete characterization of the targets of existing drugs and a limited understanding of functional interactions...
Risk Stratification and Treatment in Smoldering Multiple Myeloma.
Smoldering multiple myeloma is a heterogeneous asymptomatic precursor to multiple myeloma. Since its identification in 1980, risk stratification models have been developed using two main stratification methods: clinical...
Chronic Pain and Sleep Disorders in Primary Care.
BACKGROUND: Chronic pain (CP) and sleep disorders (SD) are highly prevalent in the general population. However, comprehensive data regarding the prevalence and characteristics of pain and SD in primary care are rare. METHODS...
Enhancer Priming Enables Fast and Sustained Transcriptional Responses to Notch Signaling.
Drosophila notch signaling burst duration ENHANCER enhancer priming Live imaging transcriptional bursting Animals Animals Genetically Modified Binding Sites Drosophila Proteins Drosophila melanogaster Embryo Nonmammalian Embryonic Development Enhancer Elements Genetic Gene Expression Regulation Developmental Nuclear Proteins Phosphoproteins Receptors Notch Regulatory Sequences Nucleic Acid Signal Transduction Transcription Factors Transcription Genetic Transcriptional Activation Twist-Related Protein 1
Specification and epigenetic programming of the human germ line.
Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a unique gene regulatory network in germline-competent...
Proteomic Profiling as a Diagnostic Biomarker for Discriminating Between Bipolar and Unipolar Depression.
Sarah Kittel-Schneider, Tim Hahn, Frieder Haenisch, Rhiannon McNeill, Andreas Reif, Sabine Bahn
May 04, 2020
INTRODUCTION: Affective disorders are a major global burden, with approximately 15% of people worldwide suffering from some form of affective disorder. In patients experiencing their first depressive episode, in most cases it...
Disabling de novo DNA methylation in embryonic stem cells allows an illegitimate fate trajectory.
Masaki Kinoshita, Meng Amy Li, Michael Barber, William Mansfield, Sabine Dietmann, Austin Smith
Sep 01, 2021
Genome remethylation is essential for mammalian development but specific reasons are unclear. Here we examined embryonic stem (ES) cell fate in the absence of de novo DNA methyltransferases. We observed that ES cells deficient...
Patients' perceptions of information and education for renal replacement therapy
BACKGROUND: Selection of an appropriate renal replacement modality is of utmost importance for patients with end stage renal disease. Previous studies showed provision of information to and free modality choice by patients to be...
Dexamethasone modulates Salmonella enterica serovar Typhimurium infection in vivo independently of the glucocorticoid-inducible protein annexin-A1.
Tomoko Smyth, Sabine Tötemeyer, Sean Haugland, Chrissie Willers, Sarah Peters, Duncan Maskell, Clare Bryant
Aug 10, 2017
Salmonella enterica serovar Typhimurium (S. Typhimurium) infection causes an inflammatory response through activation of Toll-like receptor 4 by lipopolysaccharide. Dexamethasone, a glucocorticoid analogue, suppresses...
A carrier-assisted ChIP-seq method for estrogen receptor-chromatin interactions from breast cancer core needle biopsy samples.
Wilbert Zwart, Rutger Koornstra, Jelle Wesseling, Emiel Rutgers, Sabine Linn, Jason S Carroll
May 02, 2019
BACKGROUND: The Estrogen Receptor alpha (ERα) is the key transcriptional regulator in luminal breast cancer and is therefore the main target for adjuvant treatment of this subtype. Luminal gene signatures are dictated by the...
Species- and tissue-specific differences in ROS metabolism during exposure to hypoxia and hyperoxia plus recovery in marine sculpins.
Animals that inhabit environments that fluctuate in oxygen must not only contend with disruptions to aerobic metabolism, but also the potential effects of reactive oxygen species (ROS). The goal of this study was to compare...
Dynamic Diastereomerism on Chiral Surfaces.
Adsorption of chiral molecules on chiral surfaces implies diastereomerism, evident in the adoption of distinct adsorption geometries. We show here that this diastereomerism produces a signature in the motion of chiral molecules...
Energy use in social housing residents in the UK and recommendations for developing energy behaviour change interventions
This paper presents a qualitative exploration of domestic energy consumption practices in the UK social housing sector, and perceived effectiveness of varying intervention techniques in motivating energy reductions. The study...
behaviour change decision-making Energy saving social housing sustainability /dk/atira/pure/subjectarea/asjc/2100/2105 name=Renewable Energy, Sustainability and the Environment /dk/atira/pure/subjectarea/asjc/2300/2300 name=General Environmental Science /dk/atira/pure/subjectarea/asjc/1400/1408 name=Strategy and Management /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
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