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Results: 64
A hypoxic ticket to the bone metastatic niche.
Sakari Vanharanta
Feb 12, 2020
Hypoxia is a well-characterized driver of aggressive cancer phenotypes, including metastasis. Accumulating evidence suggests that, in addition to having local effects, the consequences of tumour hypoxia can be systemic, leading...
Circulating Tumor Cells
Circulating tumor cells (CTC) are the source of metastases, but only an infinitesimal fraction of them eventually succeed in colonizing a distant organ. New results show that CD44-dependent aggregation in the circulation...
Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer.
Sakari Vanharanta, Christina B Marney, Weiping Shu, Manuel Valiente, Yilong Zou, Aldo Mele, Robert B Darnell, Joan Massagué
Feb 06, 2020
The mechanisms through which cancer cells lock in altered transcriptional programs in support of metastasis remain largely unknown. Through integrative analysis of clinical breast cancer gene expression datasets, cell line...
RNA binding proteins Breast Cancer Chromosomes Genes human human biology Medicine metastasis MOUSE 3' Untranslated Regions Alternative Splicing Amino Acid Motifs Animals Binding Sites Brain Neoplasms Breast Neoplasms Cell Line Tumor Disease Progression Female Gene Expression Regulation Neoplastic Humans Introns Mice Mice Nude Neoplasm Metastasis RNA Interference RNA-Binding Proteins Transcription Genetic Transcriptome Wnt Proteins
Genomic control of metastasis
Abstract: Metastasis remains the leading cause of cancer-associated mortality, and a detailed understanding of the metastatic process could suggest new therapeutic avenues. However, how metastatic phenotypes arise at the genomic...
Genomic control of metastasis.
Metastasis remains the leading cause of cancer-associated mortality, and a detailed understanding of the metastatic process could suggest new therapeutic avenues. However, how metastatic phenotypes arise at the genomic level has...
Can a 'rewards-for-exercise app' increase physical activity, subjective well-being and sleep quality? An open-label single-arm trial among university staff with low to moderate physical activity levels.
Sakari Lemola, Anna Gkiouleka, Brieze Read, Anu Realo, Lukasz Walasek, Nicole KY Tang, Mark T Elliott
Apr 23, 2021
Endogenous HIF2A reporter systems for high-throughput functional screening.
M Nazhif Zaini, Saroor A Patel, Saiful E Syafruddin, Paulo Rodrigues, Sakari Vanharanta
Sep 08, 2018
Tissue-specific transcriptional programs control most biological phenotypes, including disease states such as cancer. However, the molecular details underlying transcriptional specificity is largely unknown, hindering the...
Basic Helix-Loop-Helix Transcription Factors CRISPR-Cas Systems Carcinogenesis Carcinoma Renal Cell Cell Line Tumor Feasibility Studies Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Knock-In Techniques Gene Regulatory Networks Genes Reporter Genetic Testing HEK293 Cells High-Throughput Screening Assays Humans Kidney Neoplasms Transcription Genetic
Therapy-induced tumour secretomes promote resistance and tumour progression.
Anna C Obenauf, Yilong Zou, Andrew L Ji, Sakari Vanharanta, Weiping Shu, Hubing Shi, Xiangju Kong, Marcus C Bosenberg, Thomas Wiesner, Neal Rosen, Roger S Lo, Joan Massagué
Feb 12, 2020
Drug resistance invariably limits the clinical efficacy of targeted therapy with kinase inhibitors against cancer. Here we show that targeted therapy with BRAF, ALK or EGFR kinase inhibitors induces a complex network of secreted...
Adenocarcinoma Anaplastic Lymphoma Kinase Animals Cell Line Tumor Cell Movement Cell Proliferation Cell Survival Clone Cells Disease Progression Down-Regulation Drug Resistance Neoplasm Enzyme Activation ErbB Receptors Female Humans Lung Neoplasms Melanoma Metabolome Mice Neoplasm Metastasis Protein Kinase Inhibitors Proto-Oncogene Proteins B-raf Proto-Oncogene Proteins c-akt Proto-Oncogene Proteins c-fos Receptor Protein-Tyrosine Kinases Signal Transduction Tumor Microenvironment
Towards a cancer mission in Horizon Europe
Anton Berns, Ulrik Ringborg, Julio E Celis, Manuel Heitor, Neil K Aaronson, Nancy Abou-Zeid, Hans-Olov Adami, Kathi Apostolidis, Michael Baumann, Alberto Bardelli, René Bernards, Yvonne Brandberg, Carlos Caldas, Fabien Calvo, Caroline Dive, Angelika Eggert, Alexander Eggermont, Carolina Espina, Frederik Falkenburg, Jérôme Foucaud, Douglas Hanahan, Ulrike Helbig, Bengt Jönsson, Mette Kalager, Sakari Karjalainen, Miklós Kásler, Pamela Kearns, Klas Kärre, Denis Lacombe, Francesco de Lorenzo, Françoise Meunier, Gerd Nettekoven, Simon Oberst, Péter Nagy, Thierry Philip, Richard Price, Joachim Schüz, Eric Solary, Peter Strang, Josep Tabernero, Emile Voest
Sep 04, 2020
A comprehensive translational cancer research approach focused on personalized and precision medicine, and covering the entire cancer research-care-prevention continuum has the potential to achieve in 2030 a 10-year...
Learn to Train Like You Fight
This qualitative study includes nine semi-structured interviews with cybersecurity experts from different security-related organizations who are familiar with cybersecurity exercises. Its contribution to cybersecurity workforce...
Published by: IGI Global Scientific Publishing
Comparison of high versus low frequency cerebral physiology for cerebrovascular reactivity assessment in traumatic brain injury
Eric P. Thelin, Rahul Raj, Bo-Michael Bellander, David Nelson, Anna Piippo-Karjalainen, Jari Siironen, Päivi Tanskanen, Gregory Hawryluk, Mohammed Hasen, Bertram Unger, Frederick A. Zeiler
Sep 30, 2020
Abstract: Current accepted cerebrovascular reactivity indices suffer from the need of high frequency data capture and export for post-acquisition processing. The role for minute-by-minute data in cerebrovascular reactivity...
Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer.
Sakari Vanharanta, Weiping Shu, Fabienne Brenet, A Ari Hakimi, Adriana Heguy, Agnes Viale, Victor E Reuter, James J-D Hsieh, Joseph M Scandura, Joan Massagué
Feb 13, 2020
Inactivation of the von Hippel-Lindau tumor suppressor gene, VHL, is an archetypical tumor-initiating event in clear cell renal carcinoma (ccRCC) that leads to the activation of hypoxia-inducible transcription factors (HIFs)....
Animals Base Sequence Carcinoma Renal Cell Cell Line Tumor DNA Methylation Gene Expression Regulation Neoplastic Histones Humans Hypoxia-Inducible Factor 1 Kidney Neoplasms Mice Mice Inbred NOD Mice SCID Neoplasm Metastasis Polycomb Repressive Complex 2 Receptors CXCR4 Sequence Analysis DNA Transcription Factors Von Hippel-Lindau Tumor Suppressor Protein
Comparison of high versus low frequency cerebral physiology for cerebrovascular reactivity assessment in traumatic brain injury
Eric P Thelin, Rahul Raj, Bo-Michael Bellander, David Nelson, Anna Piippo-Karjalainen, Jari Siironen, Päivi Tanskanen, Gregory Hawryluk, Mohammed Hasen, Bertram Unger, Frederick A Zeiler
Sep 25, 2019
Current accepted cerebrovascular reactivity indices suffer from the need of high frequency data capture and export for post-acquisition processing. The role for minute-by-minute data in cerebrovascular reactivity monitoring...
Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism.
Albert M Li, Gregory S Ducker, Yang Li, Jose A Seoane, Yiren Xiao, Stavros Melemenidis, Yiren Zhou, Ling Liu, Sakari Vanharanta, Edward E Graves, Erinn B Rankin, Christina Curtis, Joan Massagué, Joshua D Rabinowitz, Craig B Thompson, Jiangbin Ye
Jan 31, 2020
Breast cancer is the most common cancer among American women and a major cause of mortality. To identify metabolic pathways as potential targets to treat metastatic breast cancer, we performed metabolomics profiling on the...
HIRA loss transforms FH-deficient cells.
Lorea Valcarcel-Jimenez, Connor Rogerson, Cissy Yong, Christina Schmidt, Ming Yang, Monica Cremades-Rodelgo, Victoria Harle, Victoria Offord, Kim Wong, Ariane Mora, Alyson Speed, Veronica Caraffini, Maxine Gia Binh Tran, Eamonn R Maher, Grant D Stewart, Sakari Vanharanta, David J Adams, Christian Frezza
Nov 21, 2022
Fumarate hydratase (FH) is a mitochondrial enzyme that catalyzes the reversible hydration of fumarate to malate in the tricarboxylic acid (TCA) cycle. Germline mutations of FH lead to hereditary leiomyomatosis and renal cell...
Comparison of high versus low frequency cerebral physiology for cerebrovascular reactivity assessment in traumatic brain injury
Eric P. Thelin, Rahul Raj, Bo-Michael Bellander, David Nelson, Anna Piippo-Karjalainen, Jari Siironen, Päivi Tanskanen, Gregory Hawryluk, Mohammed Hasen, Bertram Unger, Frederick A. Zeiler
Aug 25, 2020
Abstract: Current accepted cerebrovascular reactivity indices suffer from the need of high frequency data capture and export for post-acquisition processing. The role for minute-by-minute data in cerebrovascular reactivity...
Longitudinal associations of physical activity and sedentary time with cardiometabolic risk factors in children.
Juuso Väistö, Eero A Haapala, Anna Viitasalo, Theresia M Schnurr, Tuomas O Kilpeläinen, Panu Karjalainen, Kate Westgate, Hanna-Maaria Lakka, David E Laaksonen, Ulf Ekelund, Søren Brage, Timo A Lakka
Nov 22, 2018
BACKGROUND: There are few prospective studies on the associations of changes in objectively measured vigorous physical activity (VPA∆ ), moderate-to-vigorous physical activity (MVPA∆ ), light physical activity (LPA∆ ), and...
A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma.
Saiful E Syafruddin, Paulo Rodrigues, Erika Vojtasova, Saroor A Patel, M Nazhif Zaini, Johanna Burge, Anne Y Warren, Grant D Stewart, Tim Eisen, Dóra Bihary, Shamith A Samarajiwa, Sakari Vanharanta
Feb 21, 2019
Animals Carcinogenesis Carcinoma Renal Cell Cell Line Tumor Cell Proliferation Enhancer Elements Genetic Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Regulatory Networks HEK293 Cells Humans Kidney Kidney Neoplasms Kruppel-Like Factor 6 Lipid Metabolism Male Mice Mice Inbred NOD Mice Nude Mice SCID Proto-Oncogene Proteins c-sis Signal Transduction Sterol Regulatory Element Binding Protein 1 Sterol Regulatory Element Binding Protein 2 TOR Serine-Threonine Kinases Xenograft Model Antitumor Assays
NF-κB-Dependent Lymphoid Enhancer Co-option Promotes Renal Carcinoma Metastasis.
Paulo Rodrigues, Saroor A Patel, Louise Harewood, Ioana Olan, Erika Vojtasova, Saiful E Syafruddin, M Nazhif Zaini, Emma K Richardson, Johanna Burge, Anne Y Warren, Grant D Stewart, Kourosh Saeb-Parsy, Shamith A Samarajiwa, Sakari Vanharanta
Jul 25, 2018
Metastases, the spread of cancer cells to distant organs, cause the majority of cancer-related deaths. Few metastasis-specific driver mutations have been identified, suggesting aberrant gene regulation as a source of metastatic...
Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression.
Marco Sciacovelli, Aurelien Dugourd, Lorea Valcarcel Jimenez, Ming Yang, Efterpi Nikitopoulou, Ana SH Costa, Laura Tronci, Veronica Caraffini, Paulo Rodrigues, Christina Schmidt, Dylan Gerard Ryan, Timothy Young, Vincent R Zecchini, Sabrina H Rossi, Charlie Massie, Caroline Lohoff, Maria Masid, Vassily Hatzimanikatis, Christoph Kuppe, Alex Von Kriegsheim, Rafael Kramann, Vincent Gnanapragasam, Anne Y Warren, Grant D Stewart, Ayelet Erez, Sakari Vanharanta, Julio Saez-Rodriguez, Christian Frezza
Jan 22, 2023
Metabolic reprogramming is critical for tumor initiation and progression. However, the exact impact of specific metabolic changes on cancer progression is poorly understood. Here, we integrate multimodal analyses of primary and...
A 2 year physical activity and dietary intervention attenuates the increase in insulin resistance in a general population of children
Timo A Lakka, Niina Lintu, Juuso Väistö, Anna Viitasalo, Taisa Sallinen, Eero A Haapala, Tuomo T Tompuri, Sonja Soininen, Panu Karjalainen, Theresia M Schnurr, Santtu Mikkonen, Mustafa Atalay, Tuomas O Kilpeläinen, Tomi Laitinen, David E Laaksonen, Kai Savonen, Soren Brage, Ursula Schwab, Jarmo Jääskeläinen, Virpi Lindi, Aino-Maija Eloranta
Oct 29, 2020
AIMS/HYPOTHESIS: We studied for the first time the long-term effects of a combined physical activity and dietary intervention on insulin resistance and fasting plasma glucose in a general population of predominantly...
The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer.
Saroor A Patel, Shoko Hirosue, Paulo Rodrigues, Erika Vojtasova, Emma K Richardson, Jianfeng Ge, Saiful E Syafruddin, Alyson Speed, Evangelia K Papachristou, David Baker, David Clarke, Stephenie Purvis, Ludovic Wesolowski, Anna Dyas, Leticia Castillon, Veronica Caraffini, Dóra Bihary, Cissy Yong, David J Harrison, Grant D Stewart, Mitchell J Machiela, Mark P Purdue, Stephen J Chanock, Anne Y Warren, Shamith A Samarajiwa, Jason S Carroll, Sakari Vanharanta
Jul 09, 2022
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