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Interview with Sam Foster
Sam Foster
Jan 01, 0001
In his April 15, 2015 interview with Rebecca Masters, Sam Foster rates the Presidency of Anthony DiGiorgio and recalls the evolution of Winthrop. Included, Foster shares his opinions on Winthrop's strengths and weaknesses and...
Published by: Winthrop University
Interview with Sam J. Ervin - OH 123
Sam J. Ervin, Jr.
Jan 01, 0001
In his March 7, 1981 interview with John Cissell, Sam Ervin recounts his work as a U.S. Senator for North Carolina. Ervin explains his defense of Jim Crow Laws and his involvement in an investigative committee that unveiled the...
Published by: Winthrop University
Sam Granick, 1949
The Rockefeller University
Jan 01, 0001
Sam Granick. The structural and functional relationships between heme and chlorophyll
Lecture delivered May 19, 1949
Posted with permission
Published by: Charles C. Thomas
Author Sam Kean Entertained Dacus Library Friends at Winthrop
Winthrop University
Jan 01, 0001
Popular science author Sam Kean told Dacus Friends of the Library members at their Oct. 5 annual meeting that he was fascinated by how mercury displayed properties of both a liquid and a metal. He is now author of the popular...
Published by: Winthrop University
B-hadron production in NNLO QCD
We calculate, for the first time, the NNLO QCD corrections to identified
heavy hadron production at hadron colliders. The calculation is based on a
flexible numeric framework which allows the calculation of any distribution of
a...
Restriction endonuclease TseI cleaves A:A and T
Long Ma, Kai Chen, David J Clarke, Christopher P Nortcliffe, Geoffrey G Wilson, J Michael Edwardson, A Jennifer Morton, Anita C Jones, David TF Dryden
Feb 13, 2020
The type II restriction endonuclease TseI recognizes the DNA target sequence 5'-G^CWGC-3' (where W = A or T) and cleaves after the first G to produce fragments with three-base 5'-overhangs. We have determined that it is a...
Sir Sam Edwards. 1 February 1928 — 7 July 2015
Sam Edwards was one of the leading physicists of the second half of...
Mark Warner
Apr 19, 2017
Recurrent histone mutations in T-cell acute lymphoblastic leukaemia.
Grace Collord, Inigo Martincorena, Matthew D Young, Letizia Foroni, Niccolo Bolli, Michael R Stratton, George S Vassiliou, Peter J Campbell, Sam Behjati
Apr 30, 2018
Mutations affecting key modifiable histone type 3 (H3; Supplementary Table 1) residues are frequent oncogenic events in certain solid tumours (Feinberg, et al 2016), and have also recently been implicated in a subset of acute...
Interview with Booker T. Brown - OH 689
This interview was conducted by Dr. George Garrison with Booker T. Brown with a focus on the History of Emmett Scott High School. Emmett Scott was the segregated high school for African-Americans, which was named after Emmett...
Published by: Winthrop University
Novel filler materials for composite out-of-plane joints
In the manufacture of the out-of-plane joints of composite stiffened panels, such as the connection between skin and T, I, omega shaped stiffeners, a filler material is needed to fill the void between the flanges, web and skin....
A cell atlas of human thymic development defines T cell repertoire formation.
Jong-Eun Park, Rachel A Botting, Cecilia Domínguez Conde, Dorin-Mirel Popescu, Marieke Lavaert, Daniel J Kunz, Issac Goh, Emily Stephenson, Roberta Ragazzini, Elizabeth Tuck, Anna Wilbrey-Clark, Kenny Roberts, Veronika R Kedlian, John R Ferdinand, Xiaoling He, Simone Webb, Daniel Maunder, Niels Vandamme, Krishnaa T Mahbubani, Krzysztof Polanski, Lira Mamanova, Liam Bolt, David Crossland, Fabrizio de Rita, Andrew Fuller, Andrew Filby, Gary Reynolds, David Dixon, Kourosh Saeb-Parsy, Steven Lisgo, Deborah Henderson, Roser Vento-Tormo, Omer A Bayraktar, Roger A Barker, Kerstin B Meyer, Yvan Saeys, Paola Bonfanti, Sam Behjati, Menna R Clatworthy, Tom Taghon, Muzlifah Haniffa, Sarah A Teichmann
Mar 19, 2020
The thymus provides a nurturing environment for the differentiation and selection of T cells, a process orchestrated by their interaction with multiple thymic cell types. We used single-cell RNA sequencing to create a cell...
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4 + T Cells
Daisy H. Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T. Hawkins, Len R. Stephens, Simon T. Barry, Klaus Okkenhaug
Mar 22, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells.
Daisy H Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T Hawkins, Len R Stephens, Simon T Barry, Klaus Okkenhaug
Feb 03, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
CD4-Positive T-Lymphocytes Animals Mice Inbred C57BL Mice Multiprotein Complexes Receptors Antigen T-Cell Interleukin-2 Lymphocyte Activation Specific Pathogen-Free Organisms Signal Transduction Cell Differentiation Gene Knockout Techniques Class I Phosphatidylinositol 3-Kinases CRISPR-Cas Systems Gene Editing
Regulation of Human γδ T Cells by BTN3A1 Protein Stability and ATP-Binding Cassette Transporters
DA Rhodes, Hung-Chang Chen, James C Williamson, Alfred Hill, Jack Yuan, Sam Smith, Harriet Rhodes, John Trowsdale, Paul J Lehner, Thomas Herrmann, Matthias Eberl
Jul 04, 2018
Activation of human Vγ9/Vδ2 T cells by ‘phosphoantigens’ (pAg), the microbial metabolite (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP) and the endogenous isoprenoid intermediate isopentenyl pyrophosphate (IPP)...
1 Underpinning research 1.1 Normal biological development and functioning 2.1 Biological and endogenous factors 2 Aetiology Generic Health Relevance ATP Binding Cassette Transporter 1 ATP Binding Cassette Transporter Subfamily G Member 1 ATP Binding Cassette Transporter Subfamily G Member 2 Antigen Presentation Antigens CD Butyrophilins Diphosphates HLA Antigens HeLa Cells Humans Interferon-gamma Lymphocyte Activation Neoplasm Proteins Protein Stability Receptors Antigen T-Cell gamma-delta T-Lymphocytes
Optimisation and Characterisation of Anti-Fouling Ternary SAM Layers for Impedance-Based Aptasensors
Anna Miodek, Edward Regan, Nikhil Bhalla, Neal A.E. Hopkins, Sarah A. Goodchild, Pedro Estrela
Sep 29, 2015
An aptasensor with enhanced anti-fouling properties has been developed. As a case study, the aptasensor was designed with specificity for human thrombin. The sensing platform was developed on screen printed electrodes and is...
Extracellular Lactate
James T Grist, Lorna B Jarvis, Zoya Georgieva, Sara Thompson, Harpreet Kaur Sandhu, Keith Burling, Ashley Clarke, Sarah Jackson, Mark Wills, Ferdia A Gallagher, Joanne L Jones
Feb 23, 2018
Following activation, T cells rapidly divide and acquire effector functions. This energetically demanding process depends upon the ability of T cells to undergo metabolic remodeling from oxidative phosphorylation to aerobic...
T Lymphocytes in Histiocytic Sarcomas of Flat-Coated Retriever Dogs.
Flat-Coated Retriever dogs are predisposed to the development of histiocytic sarcoma (HS), a poorly differentiated, highly malignant neoplasm. The authors have previously documented a significant lymphocytic infiltrate in such...
Novel filler materials for composite out-of-plane joints
In the manufacture of the out-of-plane joints of composite stiffened panels, such as the connection between skin and T, I, omega shaped stiffeners, a filler material is needed to fill the void between the flanges, web and skin....
The Grizzly, May 9, 2019
Courtney A DuChene, William Wehrs, Sam Isola, Johnny Myers, Thomas Bantley, David Mendelsohn, Thomas Garlick, Zack Muredda
Jan 01, 0001
Kingston Out, Varner in for Bear Bash Ursinus Reacts to Symbol of Hatred Q&A with President Blomberg Ursinus Graduates First Wave of Education Studies Majors Breakaway Student Productions' One Act Festival Premieres Four...
Ursinus College Collegeville Pennsylvania newspaper Sean Kingston Elle Varner student government Brock Blomberg Hillel Alexandra Frisch Education Department Breakaway Student Productions Jason Bennett fraternities Football Sam Ragland lacrosse cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis.
Frank Penkava, Martin Del Castillo Velasco-Herrera, Matthew D Young, Nicole Yager, Lilian N Nwosu, Arthur G Pratt, Alicia Lledo Lara, Charlotte Guzzo, Ash Maroof, Lira Mamanova, Suzanne Cole, Mirjana Efremova, Davide Simone, Andrew Filer, Chrysothemis C Brown, Andrew L Croxford, John D Isaacs, Sarah Teichmann, Paul Bowness, Sam Behjati, M Hussein Al-Mossawi
Nov 20, 2020
Psoriatic arthritis (PsA) is a debilitating immune-mediated inflammatory arthritis of unknown pathogenesis commonly affecting patients with skin psoriasis. Here we use complementary single-cell approaches to study leukocytes...
High fidelity analysis to predict failure in T-joints
Composite T-joints and similar skin-stiffener joints have a central role in aerospace structures. However, their accurate numerical analysis is still a great challenge due to their complex geometry and stress state during...
The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling.
Donald T Gracias, Erietta Stelekati, Jennifer L Hope, Alina C Boesteanu, Travis A Doering, Jillian Norton, Yvonne M Mueller, Joseph A Fraietta, E John Wherry, Martin Turner, Peter D Katsikis
Aug 14, 2019
We found upregulation of expression of the microRNA miR-155 in primary effector and effector memory CD8(+) T cells, but low miR-155 expression in naive and central memory cells. Antiviral CD8(+) T cell responses and viral...
Animals CD8-Positive T-Lymphocytes Cell Proliferation Flow Cytometry Gene Expression Profiling Gene Regulatory Networks Immunoblotting Immunologic Memory Interferon Regulatory Factor-7 Interferons Mice Mice Inbred C57BL Mice Knockout MicroRNAs Oligonucleotide Array Sequence Analysis Orthomyxoviridae Orthomyxoviridae Infections RNA Interference Reverse Transcriptase Polymerase Chain Reaction STAT1 Transcription Factor Signal Transduction Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling Proteins
High fidelity analysis to predict failure in T-joints
Composite T-joints and similar skin-stiffener joints have a central role in aerospace structures. However, their accurate numerical analysis is still a great challenge due to their complex geometry and stress state during...
An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression.
Asis Palazon, Petros A Tyrakis, David Macias, Pedro Veliça, Helene Rundqvist, Susan Fitzpatrick, Nikola Vojnovic, Anthony T Phan, Niklas Loman, Ingrid Hedenfalk, Thomas Hatschek, John Lövrot, Theodoros Foukakis, Ananda W Goldrath, Jonas Bergh, Randall S Johnson
May 31, 2018
Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during adaptation to the hypoxic tumor microenvironment. Deletion analyses of the two key HIF isoforms found that HIF-1α, but not HIF-2α, was...
HIF transcription factors VEGF angiogenesis cytotoxic T cells Hypoxia Immunotherapy Animals Breast Neoplasms CD8-Positive T-Lymphocytes Cell Line Tumor Cells Cultured Disease Progression Female Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Hypoxia-Inducible Factor 1 alpha Subunit Mice Inbred C57BL Mice Knockout Neoplasms Experimental Neovascularization Pathologic T-Lymphocytes Cytotoxic Vascular Endothelial Growth Factor A
Biomarker changes with systolic anterior motion of the mitral valve in cats with hypertrophic cardiomyopathy.
Joonbum Seo, Jessie Rosie Payne, Jose Novo Matos, Wesley Wynne Fong, David J Connolly, Virginia Luis Fuentes
Sep 23, 2021
BACKGROUND: N-terminal pro B-type natriuretic peptide (NT-proBNP) and cardiac troponin-I (cTnI) are biomarkers commonly evaluated in cats with suspected heart disease. Many cats with hypertrophic cardiomyopathy (HCM) have...
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