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Results: 11
View Article
Complex Networks of Prion-Like Proteins Reveal Cross Talk Between Stress and Memory Pathways in Plants.
Sampurna Garai
,
Citu
,
Sneh L Singla-Pareek
,
Sudhir K Sopory
,
Charanpreet Kaur
,
Gitanjali Yadav
Aug 11, 2021
Prions are often considered as molecular memory devices, generating reproducible memory of a conformational change. Prion-like proteins (PrLPs) have been widely demonstrated to be present in plants, but their role in plant...
Oryza sativa
complex network analysis
multi-omics
prion-like domains
Retrotransposons
stress biology
stress memory
transposons
Published by:
View Article
Peripheral mechanisms of arthritic pain
Sampurna Chakrabarti
,
Minji Ai
,
Frances MD Henson
,
Ewan St John Smith
Jul 28, 2020
Arthritis
in vitro
Large animals
Pain models
Sensory neurons
Published by:
View Article
Mechanism of Secondary Nucleation at the Single Fibril Level from Direct Observations of Aβ42 Aggregation.
Manuela R Zimmermann
,
Subhas C Bera
,
Georg Meisl
,
Sourav Dasadhikari
,
Shamasree Ghosh
,
Sara Linse
,
Kanchan Garai
,
Tuomas PJ Knowles
Sep 21, 2021
Amyloid
Published by:
View Article
Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner.
Sampurna Chakrabarti
,
Luke A Pattison
,
Kaajal Singhal
,
James RF Hockley
,
Gerard Callejo
,
Ewan St John Smith
Nov 17, 2018
Digging behavior
dorsal root ganglion neurons
Inflammation
Joint pain
sensitization
TRPV1
Animals
Anti-Inflammatory Agents
Non-Steroidal
Arthralgia
Capsaicin
Cells
Cultured
Disease Models
Animal
Female
Freund's Adjuvant
Ganglia
Spinal
Hindlimb
Inflammation
Isoquinolines
Mice
Inbred C57BL
Motor Activity
Receptor
trkA
Sensory Receptor Cells
TRPV Cation Channels
Urea
gamma-Aminobutyric Acid
Published by:
View Article
Functional Characterization of Ovine Dorsal Root Ganglion Neurons Reveal Peripheral Sensitization after Osteochondral Defect.
Sampurna Chakrabarti
,
Minji Ai
,
Katherine Wong
,
Karin Newell
,
Frances MD Henson
,
Ewan St John Smith
Sep 05, 2021
Knee
neuron
osteochondral defect
Pain
sheep model
Animals
Capsaicin
Female
Ganglia
Spinal
Humans
Neurons
Pain
Sheep
TRPV Cation Channels
Published by:
View Article
In silico screening of GMQ-like compounds reveals guanabenz and sephin1 as new allosteric modulators of acid-sensing ion channel 3.
Gerard Callejo
,
Luke A Pattison
,
Jack C Greenhalgh
,
Sampurna Chakrabarti
,
Evangelia Andreopoulou
,
James RF Hockley
,
Ewan St John Smith
,
Taufiq Rahman
Feb 03, 2020
acid
acid-sensing ion channel
GMQ
Protons
Sephin1
Acid Sensing Ion Channels
Allosteric Regulation
Animals
CHO Cells
Computer Simulation
Cricetinae
Cricetulus
Dose-Response Relationship
Drug
Drug Evaluation
Preclinical
guanabenz
Guanidines
Protein Structure
Secondary
Quinazolines
Published by:
View Article
Intraarticular Adeno-Associated Virus Serotype AAV-PHP.S-Mediated Chemogenetic Targeting of Knee-Innervating Dorsal Root Ganglion Neurons Alleviates Inflammatory Pain in Mice.
Sampurna Chakrabarti
,
Luke A Pattison
,
Balint Doleschall
,
Rebecca H Rickman
,
Helen Blake
,
Gerard Callejo
,
Paul A Heppenstall
,
Ewan St John Smith
May 13, 2020
Animals
Dependovirus
Disease Models
Animal
Ganglia
Spinal
Genetic Therapy
Inflammation
Knee Joint
Mice
Neurons
Pain
Pain Management
Published by:
View Article
Sensitization of knee-innervating sensory neurons by tumor necrosis factor-α-activated fibroblast-like synoviocytes
Sampurna Chakrabarti
,
Zoe Hore
,
Luke A Pattison
,
Sylvine Lalnunhlimi
,
Charity N Bhebhe
,
Gerard Callejo
,
David C Bulmer
,
Leonie S Taams
,
Franziska Denk
,
Ewan St John Smith
Apr 14, 2020
Animals
Cells
Cultured
Coculture Techniques
FIBROBLASTS
Humans
Knee Joint
Mice
Pain
Sensory Receptor Cells
Synovial Membrane
Synoviocytes
Tumor Necrosis Factor-alpha
Published by:
View Article
Probing the unfolded protein response in long-lived naked mole-rats.
Zhen Du
,
Sampurna Chakrabarti
,
Yavuz Kulaberoglu
,
Ewan St John Smith
,
Christopher M Dobson
,
Laura S Itzhaki
,
Janet R Kumita
Jun 25, 2020
Ageing
ER stress
Naked mole-rat
Protein homeostasis
Unfolded Protein Response
Animals
Apoptosis
Cells
Cultured
Endoplasmic Reticulum
Endoplasmic reticulum stress
Endoplasmic Reticulum-Associated Degradation
Female
FIBROBLASTS
Gene Expression Regulation
Kidney
longevity
Male
Mice
Mole Rats
Protein Folding
Protein Serine-Threonine Kinases
RNA Splicing
Unfolded Protein Response
X-Box Binding Protein 1
Published by:
View Article
The material properties of naked mole-rat hyaluronan.
Yavuz Kulaberoglu
,
Bharat Bhushan
,
Fazal Hadi
,
Sampurna Chakrabarti
,
Walid T Khaled
,
Kenneth S Rankin
,
Ewan St John Smith
,
Daniel Frankel
May 08, 2019
Animals
Brain
Humans
Hyaluronic Acid
Lung
Microscopy
Atomic Force
Mole Rats
Skin
Published by:
View Article
The leaf economics spectrum of triploid and tetraploid C4 grass Miscanthus x giganteus.
Shuai Li
,
Christopher A Moller
,
Noah G Mitchell
,
Duncan G Martin
,
Erik J Sacks
,
Sampurna Saikia
,
Nicholas R Labonte
,
Brian S Baldwin
,
Jesse I Morrison
,
John N Ferguson
,
Andrew DB Leakey
,
Elizabeth A Ainsworth
Sep 20, 2022
C4 photosynthesis
ploidy
genotypic variation
leaf mass per area
Poaceae
Ecosystem
Tetraploidy
Triploidy
Photosynthesis
Plant Leaves
Nitrogen
Published by: