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Weighted Castelnuovo-Mumford Regularity and Weighted Global Generation
We introduce and study a notion of Castelnuovo-Mumford regularity suitable for weighted projective spaces.
Weighted Castelnuovo-Mumford Regularity and Weighted Global Generation
We introduce and study a notion of Castelnuovo-Mumford regularity suitable for weighted projective spaces.
Quantifying retention during pre-antiretroviral treatment in a large urban clinic in Uganda.
Barbara Castelnuovo, Joseph Musaazi, Rachel Musomba, Rosalind Parkes Ratanshi, Agnes N Kiragga
Jun 27, 2018
BACKGROUND: Retention studies are usually focused on patients on antiretroviral treatment (ART), however in Sub-Saharan Africa many patients get lost to program (LTP) in the pre-ART care period.. We investigated the proportion...
Structural transitions in the RNA 7SK 5' hairpin and their effect on HEXIM binding.
Konstantin Röder, Guillaume Stirnemann, Anne-Catherine Dock-Bregeon, David J Wales, Samuela Pasquali
Oct 31, 2019
7SK RNA, as part of the 7SK ribonucleoprotein complex, is crucial to the regulation of transcription by RNA-polymerase II, via its interaction with the positive transcription elongation factor P-TEFb. The interaction is induced...
Binding Sites Humans Molecular Dynamics Simulation Nucleic Acid Conformation Nucleotide Motifs Peptides Positive Transcriptional Elongation Factor B Protein Binding RNA Polymerase II RNA Small Cytoplasmic RNA-Binding Proteins Ribonucleoproteins Thermodynamics Transcription Factors Transcription Genetic
Uptake of hepatitis B-HIV co-infection screening and management in a resource limited setting.
Musomba Rachel, Castelnuovo Barbara, Claire Murphy, Charlene Komujuni, Patience Nyakato, Ponsiano Ocama, Mohammed Lamorde, Philippa Easterbrook, Rosalind Parkes Ratanshi
Jun 27, 2018
Background: WHO hepatitis B guidelines recommend testing all new HIV patients, treating them accordingly
or providing immunization. At the Infectious Diseases Institute (IDI) following an audit done in 2012, only 46%
patients...
Published by: Hepatology, medicine and policy
Describing Point of Entry into Care and Being Lost to Program in a Cohort of HIV Positive Pregnant Women in a Large Urban Centre in Uganda.
Rachel Musomba, Frank Mubiru, Shadia Nakalema, Hope Mackline, Ivan Kalule, Agnes N Kiragga, Rosalind Parkes Ratanshi, Barbara Castelnuovo
Oct 03, 2017
Psychosocial correlates of regular syphilis and HIV screening practices among female sex workers in Uganda
Richard Muhindo, Barbara Castelnuovo, Andrew Mujugira, Rosalind Parkes-Ratanshi, Nelson K. Sewankambo, Juliet Kiguli, Nazarius Mbona Tumwesigye, Edith Nakku-Joloba
Sep 17, 2020
Abstract: Background: Limited data are available regarding correlates of regular sexually transmitted infections (STIs) and HIV screening among female sex workers (FSW) in Sub-Saharan Africa. In this study, we aimed to assess...
Text message reminders and peer education increase HIV and Syphilis testing among female sex workers
Richard Muhindo, Andrew Mujugira, Barbara Castelnuovo, Nelson K Sewankambo, Rosalind Parkes-Ratanshi, Juliet Kiguli, Nazarius Mbona Tumwesigye, Edith Nakku-Joloba
Jul 29, 2021
BACKGROUND: Globally, female sex workers (FSW) are disproportionately affected by HIV and other sexually transmitted infections (STIs). However, uptake of STI and HIV testing services among FSW in sub-Saharan Africa remains low....
A situation analysis of competences of research ethics committee members regarding review of research protocols with complex and emerging study designs in Uganda.
Provia Ainembabazi, Barbara Castelnuovo, Stephen Okoboi, Walter Joseph Arinaitwe, Rosalind Parkes-Ratanshi, Pauline Byakika-Kibwika
Oct 28, 2021
Background
Over the past two decades, Uganda has experienced a significant increase in clinical research driven by both academia and industry. This has been combined with a broader spectrum of research proposals, with...
Published by: BMC medical ethics
Comparison of different cardiovascular risk tools used in HIV patient cohorts in sub-Saharan Africa; do we need to include laboratory tests?
Frank Mubiru, Barbara Castelnuovo, Steven J Reynolds, Agnes Kiragga, Harriet Tibakabikoba, Noela Clara Owarwo, Andrew Kambugu, Mohammed Lamorde, Rosalind Parkes-Ratanshi
Mar 01, 2021
INTRODUCTION: Cardiovascular disease (CVD) is the leading cause of death globally, representing 31% of all global deaths. HIV and long term anti-retroviral therapy (ART) are risk factors for development of CVD in populations of...
An observational study in an urban Ugandan clinic comparing virological outcomes of patients switched from first-line antiretroviral regimens to second-line regimens containing ritonavir-boosted atazanavir or ritonavir-boosted lopinavir.
Eva Agnes Odongpiny Laker, Maria Sarah Nabaggala, Arvind Kaimal, Damalie Nalwanga, Barbara Castelnuovo, Abdu Musubire, Agnes Kiragga, Mohammed Lamorde, Rosalind Parkes- Ratanshi
Sep 06, 2019
BACKGROUND: The World Health Organisation approved boosted atazanavir as a preferred second line protease inhibitor in 2010. This is as an alternative to the current boosted lopinavir. Atazanavir has a lower genetic barrier than...
Antiretroviral treatment Long-Term (ALT) cohort
Barbara Castelnuovo, Frank Mubiru, Agnes N Kiragga, Rachel Musomba, Olive Mbabazi, Paul Gonza, Andrew Kambugu, Rosalind Parks Ratanshi
Jun 27, 2018
PURPOSE: Little information is available on patients on antiretroviral treatment (ART) after a long-term period from sub-Saharan Africa, with the longest follow-up and related outcomes being after 10 years on ART. At the...
HIV antiretroviral treatment cohort profile long tern outcomes Adult Alkynes Antiretroviral Therapy Highly Active Benzoxazines CD4 Lymphocyte Count Cyclopropanes Drug Combinations Female Follow-Up Studies HIV Infections HIV-1 Humans Lamivudine Male Nevirapine Prospective Studies RNA Viral Time Uganda Viral Load Zidovudine
Perceptions and Attitudes Toward an Interactive Voice Response Tool (Call for Life Uganda) Providing Adherence Support and Health Information to HIV-Positive Ugandans
Phoebe Kajubi, Rosalind Parkes-Ratanshi, Adelline Twimukye, Agnes Bwanika Naggirinya, Maria Sarah Nabaggala, Agnes Kiragga, Barbara Castelnuovo, Rachel King
Jan 05, 2023
BACKGROUND: The continuing decline in AIDS-related deaths in the African region is largely driven by the steady scale-up of antiretroviral therapy. However, there are challenges to retaining people living with HIV on treatment....
Coarse-Grained Simulations Complemented by Atomistic Molecular Dynamics Provide New Insights into Folding and Unfolding of Human Telomeric G-Quadruplexes.
Petr Stadlbauer, Liuba Mazzanti, Tristan Cragnolini, David J Wales, Philippe Derreumaux, Samuela Pasquali, Jiří Šponer
Feb 15, 2019
G-quadruplexes are the most important noncanonical DNA architectures. Many quadruplex-forming sequences, including the human telomeric sequence d(GGGTTA)n, have been investigated due to their implications in cancer and other...
Text message reminders and peer education increase HIV and Syphilis testing among female sex workers
Richard Muhindo, Andrew Mujugira, Barbara Castelnuovo, Nelson K. Sewankambo, Rosalind Parkes-Ratanshi, Juliet Kiguli, Nazarius Mbona Tumwesigye, Edith Nakku-Joloba
May 07, 2021
Abstract: Background: Globally, female sex workers (FSW) are disproportionately affected by HIV and other sexually transmitted infections (STIs). However, uptake of STI and HIV testing services among FSW in sub-Saharan Africa...
HIV and syphilis testing behaviors among heterosexual male and female sex workers in Uganda.
Richard Muhindo, Andrew Mujugira, Barbara Castelnuovo, Nelson K Sewankambo, Rosalind Parkes-Ratanshi, Juliet Kiguli, Nazarius Mbona Tumwesigye, Edith Nakku-Joloba
Sep 11, 2020
BACKGROUND: In Sub-Saharan Africa where HIV disproportionately affects women, heterosexual male sex workers (HMSW) and their female clients are at risk of acquiring or transmitting HIV and other STIs. However, few studies have...
A situation analysis of competences of research ethics committee members regarding review of research protocols with complex and emerging study designs in Uganda.
Provia Ainembabazi, Barbara Castelnuovo, Stephen Okoboi, Walter Joseph Arinaitwe, Rosalind Parkes-Ratanshi, Pauline Byakika-Kibwika
Nov 09, 2021
BACKGROUND: Over the past two decades, Uganda has experienced a significant increase in clinical research driven by both academia and industry. This has been combined with a broader spectrum of research proposals, with respect...
Describing Point of Entry into Care and Being Lost to Program in a Cohort of HIV Positive Pregnant Women in a Large Urban Centre in Uganda.
Rachel Musomba, Frank Mubiru, Shadia Nakalema, Hope Mackline, Ivan Kalule, Agnes N Kiragga, Rosalind Parkes Ratanshi, Barbara Castelnuovo
Nov 18, 2020
Published by: AIDS research and treatment
Psychosocial correlates of regular syphilis and HIV screening practices among female sex workers in Uganda
Richard Muhindo, Barbara Castelnuovo, Andrew Mujugira, Rosalind Parkes-Ratanshi, Nelson K Sewankambo, Juliet Kiguli, Nazarius Mbona Tumwesigye, Edith Nakku-Joloba
Oct 22, 2019
BACKGROUND: Limited data are available regarding correlates of regular sexually transmitted infections (STIs) and HIV screening among female sex workers (FSW) in Sub-Saharan Africa. In this study, we aimed to assess the...
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